Paul Cross

Bangor University

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Alberto Lopes

Royal Cornwall Hospital Trust

Raj Naik

Queen Elizabeth Hospital

Gareth Edwards‐Jones

Bangor University

Davey L. Jones

Bangor University

Cristiano Palego

Bangor University

Marek Ziebart

University College London

Jan‐Peter Müller

University College London

Zhenhong Li

Chang'an University

Richard J. Edmondson

Manchester Academic Health Science Centre

A. Prysor Williams

Bangor University

Cooperative Institutions

Newcastle University

Queen Elizabeth Hospital

Bangor University

University College London

University of Newcastle Australia

UK Centre for Ecology & Hydrology

Ain Shams University

John Wiley & Sons (United States)

University of Manchester

Centro de Innovación de Infraestructuras Inteligentes (Spain)

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True double capsules in oil-based (Trilucent) breast implants

British Journal of Plastic Surgery (2002)

R.James I. Colville Neil R. McLean Paul Cross

10.1054/bjps.2002.3813

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Citations (17)

Advanced Ovarian Cancer Displays Functional Intratumor Heterogeneity That Correlates to Ex Vivo Drug Sensitivity

International Journal of Gynecological Cancer (2016)

R O’Donnell Angelika Kaufmann Laura Woodhouse Aiste McCormick Paul Cross

Epithelial ovarian cancer is recognized to be heterogeneous but is currently treated with a single treatment strategy. Successful patient stratification of emerging chemotherapy agents is dependent upon the availability of reliable biomarkers indicative of the entire tumor.The aim of this study was to evaluate intertumor and intratumor heterogeneity within a series of epithelial ovarian cancer using homologous recombination (HR) DNA repair status.Primary cultures generated from ascites and solid tumor from multiple intra-abdominal sites were characterized by their morphology and expression of protein markers. Results were compared with Formalin fixed paraffin embedded tissue pathology.Homologous recombination function was determined by quantification of nuclear Rad51 foci. Growth inhibition (sulforhodamine B) assays were used to calculate the GI50 for cisplatin and rucaparib.Ascites with matched solid tumor were cultured from 25 patients.Concordance in functional HR status between ascites and solid tumor subcultures was seen in only 13 (52%) of 25 patients. Heterogeneity in HR status was seen even in patients with homogeneous histological subtype. Homologous recombination defective cultures were significantly more sensitive to cisplatin and rucaparib.Additionally, intertumor and intratumor heterogeneity was seen between the expression of epithelial and ovarian markers (EpCAM, cytokeratin, CA125, MOC-31, and vimentin). There was no relationship between heterogeneity of HR functional status and antigen expression.Intertumor and intratumor functional HR heterogeneity exists that cannot be detected using histological classification. This has implications for biomarker-directed treatment.

Ex vivo

10.1097/igc.0000000000000745

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Citations (10)

Estimating the prevalence of food risk increasing behaviours in UK kitchens

PLoS ONE (2017)

Anna K. Jones Paul Cross Michael Burton Caroline Millman S. O’Brien

Foodborne disease poses a serious threat to public health. In the UK, half a million cases are linked to known pathogens and more than half of all outbreaks are associated with catering establishments. The UK Food Standards Agency (FSA) has initiated the UK Food Hygiene Rating Scheme in which commercial food establishments are inspected and scored with the results made public. In this study we investigate the prevalence of food risk increasing behaviours among chefs, catering students and the public. Given the incentive for respondents to misreport when asked about illegal or illicit behaviours we employed a Randomised Response Technique designed to elicit more accurate prevalence rates of such behaviours. We found 14% of the public not always hand-washing immediately after handling raw meat, poultry or fish; 32% of chefs and catering students had worked within 48 hours of suffering from diarrhoea or vomiting. 22% of the public admitted having served meat "on the turn" and 33% of chefs and catering students admitted working in kitchens where such meat was served; 12% of the public and 16% of chefs and catering students admitted having served chicken at a barbeque when not totally sure it was fully cooked. Chefs in fine-dining establishment were less likely to wash their hands after handling meat and fish and those who worked in award winning restaurants were more likely to have returned to work within 48 hours of suffering from diarrhoea and vomiting. We found no correlation between the price of a meal in an establishment, nor its Food Hygiene Rating Score, and the likelihood of any of the food malpractices occurring.

10.1371/journal.pone.0175816

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Citations (41)

Retroperitoneal myxoid liposarcoma presenting with hypercalcaemia.

Journal of Clinical Pathology (1989)

Paul Cross B A Enoch

Hypercalcaemia

10.1136/jcp.42.3.330

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Citations (4)

REVIEW: Nutrient stripping: the global disparity between food security and soil nutrient stocks

Journal of Applied Ecology (2013)

Davey L. Jones Paul Cross Paul J. A. Withers Thomas H. DeLuca David A. Robinson

Summary The Green Revolution successfully increased food production but in doing so created a legacy of inherently leaky and unsustainable agricultural systems. Central to this are the problems of excessive nutrient mining. If agriculture is to balance the needs of food security with the delivery of other ecosystem services, then current rates of soil nutrient stripping must be reduced and the use of synthetic fertilisers made more efficient. We explore the global extent of the problem, with specific emphasis on the failure of macronutrient management (e.g. nitrogen, phosphorus) to deliver continued improvements in yield and the failure of agriculture to recognise the seriousness of micronutrient depletion (e.g. copper, zinc, selenium). Nutrient removals associated with the relatively immature, nutrient‐rich soils of the UK are contrasted with the mature, nutrient‐poor soils of India gaining insight into the emerging issue of nutrient stripping and the long‐term implications for human health and soil quality. Whilst nutrient deficiencies are rare in developed countries, micronutrient deficiencies are commonly increasing in less‐developed countries. Increasing rates of micronutrient depletion are being inadvertently accomplished through increasing crop yield potential and nitrogen fertiliser applications. Amongst other factors, the spatial disconnects caused by the segregation and industrialisation of livestock systems, between rural areas (where food is produced) and urban areas (where food is consumed and human waste treated) are identified as a major constraint to sustainable nutrient recycling. Synthesis and applications . This study advocates that agricultural sustainability can only be accomplished using a whole‐systems approach that thoroughly considers nutrient stocks, removals, exports and recycling. Society needs to socially and environmentally re‐engineer agricultural systems at all scales. It is suggested that this will be best realised by national‐scale initiatives. Failure to do so will lead to an inevitable and rapid decline in the delivery of provisioning services within agricultural systems.

Nutrient Management

10.1111/1365-2664.12089

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Citations (231)

Pesticide hazard trends in orchard fruit production in Great Britain from 1992 to 2008: a time‐series analysis

Pest Management Science (2012)

Paul Cross

Attempts to mitigate pesticide hazard in horticulture present policy makers and industry with complex challenges at both the national and European scale. The impact of policy initiatives and industry practice on reducing hazard is contingent upon effective monitoring of a broad spectrum of non-target endpoints. This study used the environmental impact quotient to evaluate changes in orchard fruit pesticide hazard in Great Britain. The study period corresponded to the introduction of European Directive 91/414 in 1991 and extended to 2008, the last pesticide survey year prior to the implementation of the new European Directive 2009/128/EC and regulation (EC) No. 1107/2009.Overall, pesticide hazard declined for each of the measures reported, with the environmental impact per hectare per tonne of produce declining by -21%.The UK orchard fruit industry appears to have improved efficiencies in pesticide use and is now harvesting more produce per hectare while simultaneously reducing the associated environmental impact of pesticides. The removal of toxic substances and their replacement with more benign products as a consequence of legislation appears to have played an important role in facilitating the reduction.

Hectare

Orchard

Directive

10.1002/ps.3436

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Citations (13)

AUTOMATIC CARTOGRAPHY—REPORT ON THE BRITISH CARTOGRAPHIC SOCIETY SYMPOSIUM AT SOUTHAMPTON SEPTEMBER 14th–16th, 1973

Survey Review (1974)

John W. Wright Paul Cross

10.1179/sre.1974.22.171.236

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Improving the Performance of Satellite Navigation Systems for Land Mobile Applications Through the Integration of MEMS Inertial Sensors

Proceedings of the 14th International Technical Meeting of the Satellite Division of The Institute of Navigation (ION GPS 2001) (2001)

Allison Kealy Stephen Scott-Young F. J. Leahy Paul Cross

The rapid growth of applications that rely on GPS has firmly established this technology as an essential component of personal, commercial and public infrastructure. The reality is however, that GPS does not work in all situations. To overcome the operational limitations experienced when satellite signals are obstructed, it is common practice to integrate GPS with other sensors. In addressing the practical and conceptual limitations of this approach, the potential of modern, miniaturised inertial sensors is being investigated. This paper presents some practical results obtained from a system developed for land vehicle navigation that combines GPS measurements with those available from a configuration of MicroElectro Mechanical Systems (MEMS) inertial sensors and the inherent intelligence of digital map data contained within a Geographical Information System (GIS). The map data provides additional ‘measurements’ that are used to constrain the navigation solution. With this approach, the solution is not dependent solely on the performance of the navigation sensors. Including map data in the solution allows the use of lower accuracy MEMS devices, thereby reducing the cost of the navigation system while still providing a viable and robust solution. The algorithms developed, testing procedures adopted and results obtained from field tests conducted in Melbourne, Australia are fully described in this paper. Practical results and recommendations for future algorithm development will also be presented.

Mobile mapping

Component (thermodynamics)

Dead reckoning

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Citations (10)

Motion Capture Pillow for Head-and-Neck Cancer Radiotherapy Treatment

Gareth Griffiths Paul Cross Simon Goldsworthy Benjamin Winstone Sanja Dogramadzi

An estimated 6 million patients are treated for cancer each year using radiotherapy, an effective treatment that results in 40% of patients being cured [3]. In head and neck radiotherapy, patient positioning and immobilisation is a crucial part of accurate therapy delivery. A full head and shoulder thermoplastic mask is normally used to restrain the patient which brings discomfort and cannot adapt to patient's shape changes when losing weight. In this paper, we present a soft, pillow-shaped sensor capable of capturing head motion of the patient during radiotherapy. This motion capturing pillow (MCP) is the first step in creating a soft robotic device capable of sensing and re-positioning the head and neck during radiotherapy treatment. MCP performance in terms of repeatability and hysteresis has been tested with a 3D printed head and an ABB robot simulating the human head movements in 3 degrees of freedom.

10.1109/biorob.2018.8487217

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Citations (3)

Uterine corpus metastasis in stage IA1 squamous carcinoma of the cervix

Gynecologic Oncology Case Reports (2013)

Anna McCormick Paul Cross Richard J. Edmondson

•Treatment of stage 1A1 cancer of the cervix often involves preservation of the corpus.•Rarely metastasis to the corpus can occur in these cases.

Corpus Uteri

Squamous carcinoma

10.1016/j.gynor.2013.07.006

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Citations (1)