To improve the ability of infrared dim small target detection algorithm based on traditional infrared patch-image (IPI) model, a new detection model based on total variation and multiple noise constraints is proposed. We firstly transform the original infrared image into an IPI, and then the total variational regularization constrains the background patch-image in order to reduce the noise on the target image. In the meantime, the edge information of the image can be preserved to avoid excessive smoothness of the restored background image. Additionally, considering the lack of noise distribution in the patch-image, the combined and norm are introduced to describe the noise more accurately. The experimental results show that the proposed method can suppress the background clutter better and improve detection performance effectively.
Microcystin (MC) is the byproduct of cyanobacteria metabolism that is associated with oxidative stress and heart damage. This study aimed to investigate the effect of ginsenoside Rg3 on MC-induced cardiotoxicity. A mouse model of myocardial infarction was constructed by oral MC administration. H9C2 cells were used for in vitro analysis. Cellular oxidative stress, apoptosis, and the relationship between miR-128-3p and double minute 4 protein (MDM4) were analyzed. MiR-128-3p expression was upregulated in vitro and in vivo after MC treatment, which was downregulated after Rg3 treatment. Left ventricular ejection fraction (LVEF) and left ventricular systolic pressure (LVSP) were increased and left ventricular end–diastolic pressure (LVEDP) was decreased after Rg3 treatment. Moreover, Rg3 alleviated MC-induced pathological changes and apoptosis in myocardial tissues. Meanwhile, Rg3 treatment decreased the lactate dehydrogenase (LDH) and malondialdehyde (MDA) levels and inhabited cell apoptosis and oxidative stress in MC-treated myocardial cells. MiR-128-3p overexpression attenuated the protective effect of Rg3 on MC-induced cardiotoxicity. MiR-128-3p negatively regulated MDM4 expression. This study revealed that Rg3 alleviated MC-induced cardiotoxicity through the miR-128-3p/MDM4 axis, which emphasized the potential of Rg3 as a therapeutic agent for MC-induced cardiotoxicity, and miR-128-3p as a target for the Rg3 therapy.
Predicting the structure of protein-peptide complexes using computational approaches is a difficult problem whose major challenges are properly dealing with molecular flexibility and conformational changes both of the receptor and ligand. Although significant improvements have been achieved in the modeling of side chains, methods for the backbone flexibility in docking still need improvement. In this study a new method is presented for docking peptide into receptor in a full flexible docking manner. It is a parallel approach that combines all the processes during the docking of a folding peptide with a flexible receptor.
The subaerial and subaqueous volcanic rock eruption was significant different in lithology,texture and structure,erosive property,occurence,contact with underlying strata,pore and fissure development etc.Two sets of volcanic reservoirs in Kalagang Formation and Ha'erjiawu Formation were developed during Carboniferous System in Santanghu Basin.By studying the characters of volcanic geochemistry,lithology,erosion,lithofacies types and structure etc,it is considered that the environment of the volcanic rocks of Kalagang Formation is subaerial eruption.It is water-land transition eruption,but main environment is subaqueous.In consideration of its reservoir space development,the integral analysis shows that the properties of volcano rock reservoir which is erupted in subaerial is better than that of subaqueous.
This paper presents a non-linear finite element procedure for shape finding of form structures and studies an approach wherein the engineer recognises formable curved surfaces focusing on the engineer's own imagination and creativity before turning to numerical analysis to assist in the design. With the investigation of a simple numerical method of locating geodesic lines, a convenient shape finding approach is presented. Another purpose of this paper is to present a method by which compression shell shapes can be obtained by inverting the loads on the tension shape obtained by loading a cable net system. This work parallels the physical models used by H. Isler for his work on thin concrete shells. The paper gives examples of the mesh shapes generated and the computer visualisation of several examples. It demonstrates that the computer modelling is a suitable alternative to the physical modelling process. The numerical results given show that the computer software is reliable, and provides the designer with a useful tool for membrane design.
In patients with lumbar spinal stenosis (LSS), prolonged compression of the epidural venous plexus heightens the risk of bleeding and hematoma during minimally invasive surgery. While absorbable fluid gelatin, an animal protein-based hemostatic agent, is available, its effectiveness in lumbar endoscopic unilateral laminotomy with bilateral decompression (LE-ULBD) remains debated. Our research aims to conduct a prospective randomized controlled trial to investigate the effectiveness and safety of this hemostatic material in patients undergoing LE-ULBD for LSS. From October 2023 to July 2024, a total of 90 patients with LSS who underwent LE-ULBD were enrolled in this study. The 90 patients were randomly divided into two groups: fluid gelatin group (45 cases, using fluid gelatin) and null-fluid gelatin group (45 cases, not using fluid gelatin). Primary outcomes included the success rate of achieving hemostasis within 3 min and symptomatic postoperative epidural hematoma (SPEH). Secondary outcomes encompassed surgical time, intraoperative blood loss, perioperative blood loss, length of stay, and complications. Independent sample t tests were used to compare continuous data. Chi-squared tests and Fisher's exact probability tests were used to analyze the categorical data. The success rate of achieving hemostasis within 3 min (p < 0.05) was significantly higher in fluid gelatin group compared to that in the null-fluid gelatin group, and perioperative blood loss (p < 0.05) and surgical time (p < 0.05) were notably lower in the fluid gelatin group. However, there were no statistically significant differences between the two groups regarding intraoperative blood loss, length of stay, and complications, such as SPEH, allergy, and thrombus. In patients with LSS undergoing LE-ULBD surgery, using fluid gelatin can achieve rapid intraoperative hemostasis, shorten surgical time, and reduce perioperative blood loss without causing complications. Therefore, the conventional use of fluid gelatin in LE-ULBD surgery is an effective and safe strategy.
Purpose: To build a medical talent training mode based on “integration of production and education, integration of science and education and integration of theory and practice”. Solutions: The talent training mode based on “integration of production and education, integration of science and education and integration of theory and practice” is finally built by taking “integration of science and education, integration of production and education, integration of theory and practice” as the focus of improving the quality of talent training to strengthen deep cooperation between universities and industries of talent training and deepen school-enterprise cooperation, taking students’ participation in scientific research as an effective form of education to strengthen the construction of practical teaching bases, and using the project-based teaching methods such as PAD Class and flipped classroom to promote the close combination of theoretical and practical teaching. Results: This model underlines students and cultivates their ability to find and solve problems in practice, and enhances their post competence and comprehensive professional ability. Conclusion: The education mode in medical talent training of “integration of production and education, integration of science and education, and integration of theory and practice” is an effective way to train high-quality application-oriented undergraduate talents to improve students’ career planning ability and employment competitiveness.
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