This study compared the growth and development of the physique and physical fitness of young Japanese males who belong to sports clubs and those who did not based on longitudinal data obtained over four years. Physique and physical fitness tests were administered to 253 healthy male technical college students four times from the 9 to 12 grade. Subjects were divided into two groups: those who did not belong to an extra-curricular sports club (control group: CG, n = 126), and those who belonged to sports clubs (exercise group: EG, n = 127). Sit-ups, side-stepping, 20 m shuttle run, 50 m run and handball throwing tests and a total score were superior in the EG compared to the CG. Differences between the two groups in body mass, Rohrer’s index, six physical fitness tests (except for a handgrip and 50 m run), and the total score increased with grade. The CG was inferior in overall physical fitness to the EG, especially in whole body endurance. It is highly possible that sports club activities significantly and positively affect the growth and development young males during the growth period under 19-years-old and that inactivity inhibits the development of whole body endurance. Normal 0 0 2 false false false EN-US JA X-NONE
Endothelial cells form the inner lining of blood and lymphatic vessels. In mice, only tumors of the blood vessel endothelium (haemangiomas) have been thus far reported. Here we describe a highly reproducible method for the induction of benign tumors of the lymphatic endothelial cells (lymphangiomas) in mice by intraperitoneal injection of incomplete Freund's adjuvant. Morphological and histopathological studies of the lesions revealed the presence of cells at various levels of vascular development. The lymphangiomas developed in the peritoneal cavity and expressed the endothelial markers CD31/PECAM (platelet endothelial cell adhesion molecule), CD54/ICAM-1 (InterCellular Adhesion Molecule-1), and CD102/ICAM-2, as well as the vascular endothelial growth factor (VEGF) receptor Flk-1, the endothelial cell specific receptors Tie-1 and Tie-2 and the lymphatic endothelial cell specific Flt4 receptor as shown byin situhybridization. The Flk-1 and Flt4 receptors were also identified in immunoblots of the tumors and in cells cultured from them. When induced in β-galactosidase knock-in Flt4+/−mice, the tumor endothelia could be stained blue in a number of tumor cells although the staining was of lower intensity than in normal lymphatic vessels. The tumor-derived cells could be propagatedin vitroand they spontaneously differentiated, forming vessel-like structures. Murine lymphangiomas thus represent a highly reproducible and convenient source of lymphatic endothelial cells.
The present report describes the successful isolation procedure and some physico-chemical properties of an unknown blue-violet fluorescent substance existing in spinach leaves. Through the isolation steps of water extraction of leaves (200kg), active carbon adsorption, extraction by organic solvents, and column chromatographies with various adsorbents and ion exchange resins, a purified compound was obtained in colorless planeary crystal of long parallelogram (40mg; mp. 195°C; C13H17O9N1). The UV-, IR- and NMR-spectra, the results of organic tests, and behaviors on chromatographies and electrophoreses are presented.
