Y. Khageswara Rao

Guizhou Electric Power Design and Research Institute

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K. Appalanaidu

Indian Institute of Chemical Technology

Tulshiram L. Dadmal

Government Vidarbha Institute of Science and Humanities

Ravindra M. Kumbhare

Indian Institute of Chemical Technology

Umesh B. Kosurkar

Indian Institute of Chemical Technology

T. Anjana Devi

National Institute of Technology Manipur

Debabrata Chowdhury

University of Cincinnati Medical Center

M. Janaki Ramaiah

Koneru Lakshmaiah Education Foundation

Xingxing Zhou

First Affiliated Hospital of Wenzhou Medical University

Minghe Cao

Wuhan University of Technology

Jagadeesh Babu Nanubolu

Indian Institute of Chemical Technology

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Indian Institute of Chemical Technology

University of Hyderabad

Wuhan University of Technology

Academy of Scientific and Innovative Research

South China University of Technology

Sanya University

State Key Laboratory of Advanced Technology For Materials Synthesis and Processing

Fujian Agriculture and Forestry University

Zhejiang University

Sichuan University

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Sodium alginate and bovine serum albumin co-combined improved the cryopreservation quality of boar sperm through the PI3K-AKT pathway

Reproduction Fertility and Development (2025)

Jing Wang Y. Khageswara Rao Chen Du Ao Wang Yanling Wu

Context The occurrence of apoptosis due to transient oxidative damage to spermatozoa presents a significant challenge in semen preservation. At present, the addition of protective agents is the primary method for mitigating this damage and involves the addition of protective agents. Aims This study aims to elucidate the mechanism of action of cryopreservation and to identify high-quality combinatorial cryopreservation dilutions. Methods In this study, two protective agents, bovine serum albumin (BSA) and sodium alginate (SA), were combined to evaluate the effectiveness of these novel additives in protecting porcine sperm from damage during cryopreservation. The mechanism of action of the SA and BSA combination was further elucidated at the molecular level, with key proteins being identified through proteomic analysis. Key results The findings indicated that sperm treated with 2 mg/mL SA and 5 mg/mL BSA exhibited optimal motility parameters, superior functional integrity and the most effective ability to alleviate oxidative stress. Combined with proteomic data, the results suggested that these additives regulate improvements in sperm quality by mediating the activity of the PI3K-AKT pathway. Conclusions This study found that the combination of SA and BSA provides an effective protective effect for frozen sperm preservation. Implications The findings offer theoretical and technical support for the use of composite additive to protect sperm from damage, which is crucial for enhancing the quality of pig semen and improving reproductive outcomes.

Bovine serum albumin

10.1071/rd24127

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Synthesis of novel fluoro 1,2,3-triazole tagged amino bis(benzothiazole) derivatives, their antimicrobial and anticancer activity

Medicinal Chemistry Research (2014)

Ravindra M. Kumbhare Tulshiram L. Dadmal Rajesh Pamanji Umesh B. Kosurkar Loka Reddy Velatooru

Benzothiazole

Cancer cell lines

1,2,4-Triazole

Triazole

10.1007/s00044-014-1006-0

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Citations (32)

ChemInform Abstract: Microwave Assisted Synthesis of 2‐Aminooxazolo[4,5‐b]pyridine Derivatives via Intramolecular C—O Bond Formation in Aqueous Medium.

ChemInform (2014)

Umesh B. Kosurkar Tulshiram L. Dadmal K. Appalanaidu Y. Khageswara Rao Jagadeesh Babu Nanubolu

Aqueous medium

10.1002/chin.201431162

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Defect chemistry and dielectric behavior of Sr0.99Ce0.01Ti1−xO3 ceramics with high permittivity

Ceramics International (2018)

Xingxing Zhou Minghe Cao Zhijian Wang Y. Khageswara Rao Qu Luo

Dielectric loss

10.1016/j.ceramint.2018.03.221

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Citations (18)

Microwave assisted synthesis of 2-aminooxazolo [4,5-b] pyridine derivatives via intramolecular C–O bond formation in aqueous medium

Tetrahedron Letters (2014)

Umesh B. Kosurkar Tulshiram L. Dadmal K. Appalanaidu Y. Khageswara Rao Jagadeesh Babu Nanubolu

Aqueous medium

10.1016/j.tetlet.2013.12.090

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Distributed collaborative optimal dispatch of distribution system with multi-stakeholders

2022 IEEE 5th International Electrical and Energy Conference (CIEEC) (2023)

Ning Nan Keyang Chen Min Xie Zhou Cheng Jianan Ye

In recent years, to achieve energy conservation and emission reduction and the clean transformation of energy structure, the user-side distributed energy has developed rapidly, and the coupled operation characteristics of cooling, heating and power have become increasingly prominent. The distribution system with multiple stakeholders has received extensive attention. However, the change of distribution pattern will bring many problems to the optimal operation of power system. This paper introduces the analysis target cascading (ATC) theory and proposes a coordinated and optimized scheduling model with distribution network operators, distributed energy providers., and combined cooling heating and power (CCHP) load integrators as the main stakeholders by exchanging contact variable information. Based on the detailed technical model of the internal components of each stakeholder., the linkage variables between each stakeholder and the distribution network operator are decoupled and solved in parallel to improve the computational efficiency. The model considers the access of wind-light-storage and combined cooling., heating and power generation systems., which is conducive to the realization of multi-energy complementary operation of the distribution system and the transformation of energy structure.

Operator (biology)

10.1109/cieec58067.2023.10167020

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Correction: Fluorinated thiazolidinols cause cell death in A549 lung cancer cells via PI3K/AKT/mTOR and MAPK/ERK signalling pathways

MedChemComm (2016)

Ravindra M. Kumbhare Tulshiram L. Dadmal Dinesh Kumar M. Janaki Ramaiah Anudeep Kota

Correction for “Fluorinated thiazolidinols cause cell death in A549 lung cancer cells via PI3K/AKT/mTOR and MAPK/ERK signalling pathways” by Ravindra M. Kumbhare et al., Med. Chem. Commun., 2016, DOI: 10.1039/c5md00603a.

10.1039/c6md90027e

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Isoxazole derivatives of 6-fluoro-N-(6-methoxybenzo[d]thiazol-2-yl)benzo[d]thiazol-2-amine and N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine: regulation of cell cycle and apoptosis by p53 activation via mitochondrial-dependent pathways

MedChemComm (2014)

Ravindra M. Kumbhare Tulshiram L. Dadmal T. Anjana Devi Dinesh Kumar Umesh B. Kosurkar

The compounds depicted were shown to induce DNA damage and activate p53, which in turn activates Bax and decreases Bcl2 levels. This resulted in apoptosis in Colo205 cells.

Isoxazole

10.1039/c4md00279b

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Citations (11)

ChemInform Abstract: MICHAEL REACTIONS OF 1,1‐BIS(BENZENESULFONYL)ETHENE

Chemischer Informationsdienst (1983)

Y. Khageswara Rao M. Nagarajan

10.1002/chin.198346150

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Kinetics and mechanism of catalyzed Boudouard reaction

Carbon (1972)

Bharat Jalan Y. Khageswara Rao

10.1016/0008-6223(72)90426-5

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