Our purpose was to review the outcome of the patients with primary duodenal adenocarcinoma and determine factors influencing survival.Over a 10-year period, 43 patients with this disease were identified. Data were analyzed to assess the outcomes of treatment and predictors of survival.Patients had symptoms present for an average of 6 months. The most common symptom was obstructive jaundice, observed in 55.8% of the cases. Based on symptomology, primary duodenal adenocarcinoma may be classified into three categories: icteric, obstructive and illusive. The upper gastrointestinal contrast study and esophagogastroduodenoscopy were the most effective diagnostic tests, showing an accuracy of 79.5% and 86.8%, respectively. A curative resection was performed in 28 of the 43 patients (65.1%), a conventional pancreatoduodenectomy in 11, segmental duodenal resection in 16 and gastroduodenectomy in 1. The overall 5-year survival rate was 27%, which was 42 percent after curative resection.The respectability of the primary lesion was associated with increased survival. An aggressive surgical approach should be pursued. Pancreaticoduodenectomy is usually required for tumors of the first and second portion of the duodenum. Segmental resection may be appropriate for selected patients, especially for cancers of the distal duodenum.
Sepsis is defined as a complex clinical syndrome caused by a serious infection followed by an amplified and deregulated inflammatory response. The complex syndrome is associated with a high rate of morbidity and mortality, despite substantial clinical advances. A vaccine derived from the outer membrane proteins of the Gram‑negative bacteria Pseudomonas aeruginosa (PA‑MSHA) has been demonstrated to exhibit immune modulatory properties. In the present study, the effect of the PA‑MSHA vaccine on the inflammatory response induced by serum from septic patients in peripheral blood mononuclear cells was determined. It was observed that PA‑MSHA pretreatment inhibits the production of septic serum‑induced tumor necrosis factor‑α. In addition, PA‑MSHA treatment increases interleukin‑10 levels and promotes the generation of CD4+CD25+Foxp3+ T cells. Thus, the results of the current study provide mechanistic insight relevant to the potential application of PA‑MSHA in the treatment of sepsis.
In this paper,we mainly reviewed the research progress of etiology in inguinal hernia..Through the basic research on the nosazontology, it is respected to provide a new way for the protection and therapy of the Inguinal Hernia.
Objectives[WT5”BZ] To study on the counts of MV and the expressions of VEGF, bFGF and their relationships in gallbladder carcinoma and extrahepatic cholangiocarcinoma.[WT5”HZ] Method[WT5”BZ] The stains of MV, VEGF and bFGF were completed by the immunohistochemical method of avidin-bitin complex in routine paraffin-embeded sections.[WT5”HZ] Results[WT5”BZ] The quantity of MV was 66±27 /HP,and the positive rate of VEGF、bFGF was 50% and 53%, respectively in 40 cases with gallbladder carcinoma. The quantity of MV was 75±19/HP,and the postive rate of VEGF、bFGF was 55% and 57%,respectively in 42 cases with extrahepatic cholangiocarcinoma. The quantities of MV and the positive rates of VEGF、bFGF were significantly lower in cases of well-differentiation and without metastasis than that of poorly-or undifferentiation and with metastasis. The quantities of MV were significantly higher in the cases of VEGF(+), bFGF (+) or VEGF(+)bFGF(+)than that of VEGF(-)、or bFGF(-),or VEGF(-)bFGF(-).The positive correlations were found among the scores of the positive cell rates of VEGF, bFGF and the counts of MV in gallbladder carcinoma and extrahepatic cholangiocarcinoma.[WT5”HZ] Conclusions[WT5”BZ] The counts of MV and the expression of VEGF, bFGF closely related to the biological behaviors, metastasis and prognosis of gallbladder carcinoma and extrahepatic cholangiocarcinoma. VEGF and bFGF play important role in the angiogenesis of biliary tract carcinoma. [WT5”HZ]
Abstract Situs inversus is an uncommon anomaly with rare incidence. Some cases of situs inversus totalis have been described with different types of associations. Here we report a case of situs inversus with carcinoma of the gastric cardia.
Associations between adiponectin (ADIPOQ) genetic polymorphisms (rs2241766 G/T and rs266729 G/C) and cancer risk have been extensively studied in the past decade, while conflicting results were reported. Therefore, this study would explore the associations by using a meta-analysis. The databases of Medline, Embase, and Wangfang were retrieved, and the latest updated time was 1 August 2012. Effect sizes of odds ratio and 95 % confidence interval (OR and 95 % CI) were calculated by using a fixed- or random-effect model. A total of 12 studies with 10,368 participants were identified for association between ADIPOQ rs2241766 G/T and risk of cancer, and ten studies with 12,665 participants were for association between ADIPOQ rs266729 G/C and risk of cancer. Overall combined analyses indicated that neither ADIPOQ rs2241766 G/T nor rs266729 G/C was associated with risk of cancer incidence (OR (95 % CI), 0.89 (0.61-1.30) for GG vs. TT and 0.94 (0.83-1.06) for G carriers vs. T carriers for rs2241766 G/T; 0.99 (0.85-1.16) for GG vs. CC and 0.96 (0.87-1.06) for G carriers vs. C carriers for rs266729 G/C). When stratified analyses were conducted according to the participants' ethnicity, sources of controls, types of cancer, and sample size, we found that G allele of ADIPOQ rs2241766 G/T was significantly associated with decreased risk of cancer based on population-based case-control studies (OR (95 % CI), 0.65 (0.50-0.85) for GG vs. TT and 0.88 (0.79-0.98) for G carriers vs. T carriers). In contrast, there was no association between rs266729 G/C polymorphism and risk of cancer when subgroup analyses were conducted. In summary, this meta-analysis indicated that ADIPOQ rs2241766 G/T rather than rs266729 G/C polymorphism was closely associated with risk of cancer development.
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