A case of non-Hodgkin's lymphoma occurred in the right mandible of 7-year-old boy is presented. He consulted the dental hospital, Hokkaido University with a chief complaint of swelling of the mandible. Histopathological and immunohistochcmical investigations showed that the lesion was malignant lymphoma, lymphoblastic (WF) or diffuse lymphoma, lymphoblastic type (LSG), and T cell phenotype. The clinical classification was stage IIIE, and radiotherapy and chemotherapy were performed. He is still alive without tumor for 6 years from the clinical onset of the disease.
doi: 10.1111/j.1741‐2358.2012.00654.x Relationships between higher‐level functional capacity and dental health behaviors in community‐dwelling older adults Objective: The aim of the present study was to elucidate relationships between higher‐level functional capacity and dental health behaviours in community‐dwelling older adults. Background: In ageing society, it is necessary to promote oral health in the elderly, because good oral health is a significant contributing factor to good general health. Higher‐level functional capacity has been considered a crucial factor for successful independent living in the elderly. We hypothesised that functional capacity is a significant indicator of dental health behaviours. Methods: Three hundred and thirty‐eight adults aged 65 years or older were enrolled in this study. Higher‐level functional capacity was evaluated using the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG‐index). Univariate and multivariate models were constructed with dental health behaviours, such as regular visits to a dentist, brushing frequency and use of extra cleaning devices, as the dependent variable, and the total TMIG‐index score and its subcategory scores as the principal independent variable. Results: Univariate logistic regression analysis demonstrated a significant correlation between low TMIG‐index and ‘intellectual activity’ subcategory scores to lack of regular visits to a dentist and not using extra cleaning devices. Using a multivariate model, significant relationships remained after adjusting for a number of variables including demographics, medical status, lifestyle and number of remaining teeth. Conclusion: Intellectual activity of higher‐level functional capacity may be an accurate indicator of dental health behaviours in community‐dwelling older adults. Intellectual activity should be taken into consideration to effectively promote oral health behaviours and oral hygiene in elderly persons living independently.
Bài báo này trình bày kết quả nghiên cứu ảnh hưởng của cốt liệu mịn được chế tạo từ tro bay thay thế cát tự nhiên tới tính chất của vữa xi măng. Vữa sử dụng cốt liệu từ tro bay có kích thước từ 4,5 mm đến 0,14 mm cho tính chất tốt hơn vữa sử dụng cốt liệu từ tro bay kích thước nhỏ hơn 2,5 mm và lượng hạt dưới kích thước 0,14 mm lớn hơn 25 %. Hàm lượng cốt liệu từ tro bay thay thế cát tăng thì khối lượng riêng của vữa giảm tương ứng, nhu cầu nước cho vữa tăng nguyên nhân do các hạt cốt liệu từ tro bay có độ rỗng xốp và hút nước lớn. Cường độ nén của vữa ở tuổi 28 ngày tương đương mẫu đối chứng khi sử dụng 40 % hạt cốt liệu từ tro bay thay cát tự nhiên. Kết quả nghiên cứu này là bước đầu chứng minh khả năng ứng dụng sử dụng hạt cốt liệu từ tro bay thay thế cát tự nhiên để chế tạo vữa và bê tông.
We have developed a novel method to produce large numbers of neural stem cells and neurons directly from embryonic stem (ES) cells. The method is composed of three culture stages. In the first stage, floating ES cell colonies are cultured in astrocyte-conditioned medium to directly differentiate neural stem cells from ES cells, resulting in neural stem spheres. In the second stage, neural stem spheres are cultured as adhesive cells to produce neural stem cells by cell migration. In the third stage, neural stem cells are cultured as monolayers, which proliferate in the presence of fibroblast growth factor 2 and epidermal growth factor and differentiate into neurons in astrocyte-conditioned medium.
Abstract: The effects of nerve growth factor (NGF) on induction of Na + , K + ‐ATPase were examined in a rat pheochromocytoma cell line, PC12h. Na + , K + ‐ATPase activity in a crude particulate fraction from the cells increased from 0.37 ± 0.02(n = 19) to 0.55 ± 0.02 (n = 20) (means ± SEM, μmol P i /min/mg of protein) when cultured with NGF for 5–11 days. The increase caused by NGF was prevented by addition of specific anti‐NGF antibodies. Epidermal growth factor and insulin had only a small effect on induction of Na + , K + ‐ATPase. A concentration of basic fibroblast growth factor three times higher than that of NGF showed a similar potency to NGF. The molecular form of the enzyme was judged as only the α form in both the untreated and the NGF‐treated cells by a simple pattern of low‐affinity interaction with cardiotonic steroids: inhibition of enzyme activity by strophanthidin ( K i ∼ 1 m M ) and inhibition of Rb + uptake by ouabain ( K i ∼ 100μ M ). As a consequence, during differentiation of PC12h cells to neuron‐like cells, NGF increases the α form of Na + , K + ‐ATPase, but does not induce the α(+) form of the enzyme, which has a high sensitivity for cardiotonic steroid and is a characteristic form in neurons.
Granulocyte-macrophage colony-stimulating factor-differentiated bone marrow-derived dendritic cells were stimulated with the synthetic lipopeptide S-(2,3-bispalmitoyloxypropyl)-CGDPKHSPKSF (FSL-1) or the Escherichia coli lipopolysaccharide. FSL-1 induced the production of TNF-alpha and IL-12 by C57BL/6-derived bone marrow-derived dendritic cells but not by bone marrow-derived dendritic cells from Toll-like receptor 2-deficient (TLR2(-/-)) mice. Lipopolysaccharide induced the production of TNF-alpha and IL-12 by bone marrow-derived dendritic cells derived from either type of mice. FSL-1 did not induce production of IL-10 by bone marrow-derived dendritic cells from either type of mice, whereas lipopolysaccharide induced small amounts of IL-10 by bone marrow-derived dendritic cells from both types of mice. The upregulation by FSL-1 of the expression of CD80, CD86 and the MHC class II molecule IA(b) was dose- and time-dependent on the surfaces of C57BL/6-derived bone marrow-derived dendritic cells but not on the surface of TLR2(-/-)-derived bone marrow-derived dendritic cells. Lipopolysaccharide upregulated the expression of these molecules on the surfaces of bone marrow-derived dendritic cells from both types of mice. The expression of CD11c on the surfaces of C57BL/6-derived bone marrow-derived dendritic cells was upregulated by stimulation with both FSL-1 and lipopolysaccharide up to 12 h; thereafter, the expression was downregulated. The results suggest that FSL-1 can accelerate maturation of bone marrow-derived dendritic cells and this FSL-1 activity is mediated by TLR2.
