Pyroptosis has attracted attention due to its role in various cancers. Recently, gasdermins (GSDMs) involved in pyroptosis have been reported to be associated with several types of cancers. However, the role of GSDMs expression in the diagnosis and prognosis of gastric cancer (GC) is still not well understood. We analyzed the transcriptional and prognostic information and the role of GSDMs in patients with GC from TIMER, UALCAN, Human Protein Atlas (HPA), GEPIA, and Kaplan-Meier Plotter databases. The cBioPortal platform was used to discover the genetic alterations, significance, and networks of GSDMs. Furthermore, STRING, Cytoscape, and TIMER were used to explore functional enrichment and immunomodulation. GSDMB, GSDMC, GSDMD, and GSDME were more highly expressed in GC than in normal tissues in the TIMER database. Moreover, survival analyses in two databases showed that high expression of GSDME was related to shorter overall survival (OS) in patients with GC. Additionally, functional enrichment revealed that GSDMs may be involved in endopeptidase activity, peptidase regulatory activity, and cysteine peptidase activity. GSDMs correlated with infiltration levels of immune cells in GC, and GSDME correlated with the infiltrating level of CD4+ T, CD8+ T, neutrophils, macrophages, and dendritic cells. This study indicated the potential diagnostic and prognostic value of GSDMs in GC. Our results showed that GSDME could play a significant oncogenic role in GC diagnosis and prognosis. However, our bioinformatics analyses should be validated in further prospective studies.
Sustainability is growing in importance worldwide and has come to be considered a specifically challenging issue in both economic and managerial objectives (Chouinard, Ellison, & Ridgeway, 2011). This research was designed to know what college students think in terms of moral responsibility of corporate sustainability. We used interview, online research, and survey to implement our research. We found out most people have clearer attitudes on immoral events than moral events; energy is a topic that most people concerned; and college students care about corporate social compliance and they want to pay more for sustainable products. We hope our research can popularize the concept of "Moral responsibility of corporate sustainability" to our audience; help more corporate companies to realize the importance of sustainability as college students perceive them; and build a clear goal and actionable structure to pass the sustainable companies' value to every employee correctly.
The traction load of high-speed railway is a special load with single-phase, mobile, high power and impulsive, which features the strong rules of train schedule but still with the uncertainty in time and space. In order to comprehensively analyze the non-parametric probabilistic characteristics and correlation of traction load of a new high-speed railway. Based on the method of optimal bin width and bandwidth, the discrete and continuous probability density functions (PDF) of traction load are studied by using the histogram of optimal bin width and diffusion-based kernel density estimator (DKDE) respectively. In addition, the spatial and temporal correlation of traction load, as well as the auto correlation function (ACF) and partial auto correlation function (PACF) of traction load time series are analyzed. The measured data of traction station on a new high-speed railway was used to verify the previously methods. This paper provides a new idea for the randomness and correlation analysis of traction load.
Abstract The tripartite ParABS system mediates chromosome segregation in the majority of bacterial species. Typically, DNA-bound ParB proteins around the parS sites condense the chromosomal DNA into a higher-order multimeric nucleoprotein complex for the ParA-driven partition. Despite extensive studies, the molecular mechanism underlying the dynamic assembly of the partition complex remains unclear. Herein, we demonstrate that Bacillus subtilis ParB (Spo0J), through the multimerization of its N-terminal domain, forms phase-separated condensates along a single DNA molecule, leading to the concurrent organization of DNA into a compact structure. Specifically, in addition to the co-condensation of ParB dimers with DNA, the engagement of well-established ParB condensates with DNA allows for the compression of adjacent DNA and the looping of distant DNA. Notably, the presence of CTP promotes the formation of condensates by a low amount of ParB at parS sites, triggering two-step DNA condensation. Remarkably, parS-centered ParB-DNA co-condensate constitutes a robust nucleoprotein architecture capable of withstanding disruptive forces of tens of piconewton. Overall, our findings unveil diverse modes of DNA compaction enabled by phase-separated ParB and offer new insights into the dynamic assembly and maintenance of the bacterial partition complex.
Paraffin wax (PW) has significant potential for spacecraft thermal management, but low thermal conductivity and leakage issues make it no longer sufficient for the requirements of evolving spacecraft thermal control systems. Although free-state expanded graphite (EG) as a thermal conductivity enhancer can ameliorate the above problems, it remains challenging to achieve higher thermal conductivity (K) (>8 W/(m·K)) at filler contents below 10 wt.% and to mitigate the leakage problem. Two preparations of thermally conductive shape-stabilized PW/EG composites, using the pressure-induced method and prefabricated skeleton method, were designed in this paper. The expanded graphite formed a nanoscale porous structure by different methods, which enhanced the capillary action between the graphite flake layers, improved the adsorption and encapsulation of EG, and alleviated the leakage problem. The thermal conductivity and the latent heat of the phase-change materials (PCM) prepared by the two methods mentioned above are 9.99 W/(m·K), 10.70 W/(m·K) and 240.06 J/g, 231.67 J/g, respectively, at EG loading by 10 wt.%, and the residual mass fraction was greater than 99% after 50 cycles of high and low temperature. In addition, due to the excellent thermal management capability of PW/EG, the operating temperature of electronic components can be stably maintained at 68–71 °C for about 15 min and the peak temperature can be reduced by at least 23 °C when the heating power of the electronic components is 10 w. These provide novel and cost-effective methods to further improve the management capability of spacecraft thermal control systems.
Nowadays, e-sports interpretation major has been well-received by college students.In the process of choosing a major, e-sports interpretation major has become a popular choice for many college students, which also puts forward higher requirements for the e-sports interpretation course in universities. The e-sports explanation has experienced a full legendary development process from its debut to its prominence. The course teaching of e-sports interpretation in colleges and universities in the new era has profound characteristics, which are mainly reflected in the wide coverage of professional personnel training, the organic connection with general education courses, and the application of practical as the value orientation. At the same time, the comprehensive cultivation of students' professional ability, the multi-level enhancement of talents' theoretical literacy, and the systematic consolidation of curriculum standards can be further implemented as the optimization strategy of curriculum teaching.
A topological insulator is a quantum material which possesses conducting surfaces and an insulating bulk. Despite extensive researches on the properties of Dirac surface states, the characteristics of bulk states have remained largely unexplored. Here we report the observation of spinor-dominated magnetoresistance anomalies in β-Ag2Se, induced by a magnetic-field-driven band topological phase transition. These anomalies are caused by intrinsic orthogonality in the wave-function spinors of the last Landau bands of the bulk states, in which backscattering is strictly forbidden during a band topological phase transition. This new type of longitudinal magnetoresistance, purely controlled by the wave-function spinors of the last Landau bands, highlights a unique signature of electrical transport around the band topological phase transition. With further reducing the quantum limit and gap size in β-Ag2Se, our results may also suggest possible device applications based on this spinor-dominated mechanism and signify a rare case where topology enters the realm of magnetoresistance control. A defining characteristic of non-trivial topological materials is the bulk-boundary correspondence, and the majority of research activities has tended to centre around the surface states. Here, the authors conduct electrical transport measurements on β-Ag2Se observing anomalies in the magnetoresistance measurements, which they contend has a direct connection to the non-trivial topological nature of β-Ag2Se.
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