Abstract A new nanocomposite composed of ultrathin Na 3 V 2 (PO 4 ) 3 /N‐doped carbon sheets with stable sandwich structure is reported. The material is synthesized using laminar vanadium metal‐organic frameworks (V‐MOFs) as the precursor and multifunction sodium lignosulfonate (SLS) as the organic ligand for the V‐MOFs and the carbon source. The synthetic mechanism and the influence of the SLS and Na contents on the electrochemical properties are investigated, and the Na‐ion insertion/extraction mechanism in the sandwich framework structure is established. The nanocomposite with the molar ratio: V 2 O 5 /SLS/Na 2 CO 3 =2 : 1.5 : 1.7, used as a cathode material for sodium‐ion batteries, not only exhibits the best discharge capacity (117.3 mA h g −1 at the 0.1 C rate), but also ultra‐high rate performances (82 mAh g −1 at 100 C, 78 mAh g −1 at 200 C and 54 mAh g −1 at 250 C) and a long cycling life (retains 40 mAh g −1 at 200 C over 6000 cycles) because of its unique nanostructure.
Abstract The binding of p53-binding protein 1 (53BP1) to damaged chromatin is a critical event in non-homologous DNA end joining (NHEJ)-mediated DNA damage repair. Although several molecular pathways explaining how 53BP1 binds damaged chromatin have been described, the precise underlying mechanisms are still unclear. Here we report that a newly identified H4K16 monomethylation (H4K16me1) mark is involved in 53BP1 binding activity in the DNA damage response (DDR). During the DDR, H4K16me1 rapidly increases as a result of catalyzation by the histone methyltransferase G9a-like protein (GLP). H4K16me1 shows an increased interaction level with 53BP1, which is important for the timely recruitment of 53BP1 to DNA double-strand breaks. Differing from H4K16 acetylation, H4K16me1 enhances the 53BP1–H4K20me2 interaction at damaged chromatin. Consistently, GLP knockdown markedly attenuates 53BP1 foci formation, leading to impaired NHEJ-mediated repair and decreased cell survival. Together, these data support a novel axis of the DNA damage repair pathway based on H4K16me1 catalysis by GLP, which promotes 53BP1 recruitment to permit NHEJ-mediated DNA damage repair.
Layered iron phosphate with uniform morphology has been synthesized by a precipitation method with yeast cells as a biosurfactant. The yeast cells are used to regulate the nucleation and growth of layered iron phosphate. The uniform layered structure is characterized by small-angle x-ray diffraction (SAXD), scanning electron microscopy (SEM) and atomic force microscopy (AFM) analyses. Fourier transform infrared spectroscopy (FT-IR) is used to analyze the chemical bond linkages in organic?inorganic hybrid iron phosphate. The likely synthetic mechanism of nucleation and oriented growth is discussed. The electrical conductivity of hybrid iron phosphate heat-treated at different temperatures is presented.
We study the impact of the Nd-doping on the grain formation, the crystal structure, and the fluorescence of the Yttrium Aluminum Garnet (YAG). The results show that Nd-doping leads to the YAG lattice expansion and distortion, and hence to an increase in defect concentration. This is attributed to substitution of larger Nd3+ ions for smaller Y3+ ions. As a result, the fluorescence intensity of Nd:YAG increases and reaches a maximum at 3 at% Nd. Above 3 at% Nd, the lattice distortion becomes more evident, and the Nd3+ ions segregate on the surface of grains and thus the fluorescence intensity decreases. Above 8 at% Nd, a large fraction of Nd3+ ions cannot enter the YAG lattice, but reside on the surface of grains instead, leading to formation of disordered clad layers. Above 10 at% Nd, a high degree of disorder in the structure is induced by the Nd3+ segregation both in the interior and boundary of grains. Above 15 at% Nd, Schottky and Frenkel defects appear due to the lattice distortion. In general, at Nd > 3 at% the Nd3+ segregation and concentration quenching cause the attenuation of the fluorescence of Nd:YAG.
High purity and uniform sized cobalt microspheres were prepared via solvothermal method by using acetate cobalt as and ethanol as raw materials through one step reaction under 250 ℃ . The samples were characterized by XRD, SEM and magnetic measurements. The effects of time and temperature on products were studied. The extension of the reaction time has no effect on the crystal, but only some tiny changes on the morphology of cobalt spheres and with the increasing of temperature, the cobalt crystal transforms from hcp-Co to fcc-Co. The cocercivity of the cobalt material obtained is up to 230 Oe which is higher than that of the available cobalt magnetic materials. In addition, this method has advantages such as relatively lower synthesis temperature, easier operation, shorter reaction time and lower power consumption.
Correction for ‘Modification of Li2MnSiO4 cathode materials for lithium-ion batteries: a review’ by Qiaohuan Cheng et al., J. Mater. Chem. A, 2017, 5, 10772–10797.
Prophylactic central neck dissection (pCND) in patients with well-differentiated primary papillary thyroid carcinoma (PTC) has become controversial. Several attempts have been made to predict central compartment lymph node metastasis (CLNM) based on clinical and conventional ultrasonic parameters. This study aimed to develop a decision tree (DT) model for predicting the risk of CLNM in patients with PTC based on clinical and preoperative multimodal ultrasound (US) characteristics.A total of 148 PTC nodules confirmed by surgical pathology at Beijing Tiantan Hospital were retrospectively analyzed. All nodules underwent multimodal US examinations preoperatively from January 2020 to September 2021. Correlation analysis of CLNM with clinical characteristics as well as multimodal US parameters of PTC lesions based on gray-scale US, color Doppler flow imaging (CDFI), superb microvascular imaging (SMI), contrast-enhanced ultrasound (CEUS), and shear wave elastography (SWE) technology was carried out. Finally, the chi-squared automatic interaction detector (CHAID) with a 10-fold cross-validation was used to establish DTs for CLNM prediction. The area under the curve was calculated to compare the predictive performance.Univariate analysis indicated that CLNM was positively correlated with thyroglobulin level, maximum size, taller-than-wide, the number of microcalcifications greater than or equal to 5, contact capsule, abnormal cervical lymph node on conventional US, noncentripetal perfusion, delayed clearance, the average shear wave velocity (SWV mean), and the SWV ratio (P<0.05). The multimodal US DT based on taller-than-wide, contact capsule, abnormal cervical lymph node on conventional US, and centripetal enhancement as independent variables showed good discrimination: the sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve were 80.0%, 76.7%, 78.4%, and 0.837 [95% confidence interval (CI): 0.771-0.902]. There was a significant difference between the multimodal and conventional US DTs (P=0.009).Our results indicated that the DT based on the preoperative multimodal US characteristics of PTCs has a reasonable predictive ability for CLNM and can be conveniently used for clinical decision-making of individualized treatment in patients with well-differentiated PTC.
Objective
To explore the relationship between life values and prosocial tendencies of medical students and the mediating effect of empathy.
Methods
From March to June 2018, 528 medical students were selected from five medical colleges including Shanghai Jiao Tong University School of Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai University of Medicine&Health Sciences, Nanjing Medical University, Inner Mongolia Medical University. Using the College Students' Life Values Scale, the Adolescent Prosocial Tendency Scale, and the Jefferson's Empathy Scale (JSE) to investigate. And the structural equation model was used to research the mediating effect of empathy on relationship between life values and prosocial tendencies.
Results
There was a positive correlation between the life values and empathy and it's three dimensions, as well as prosocial tendencies, the correlation coefficient is between 0.19 and 0.55.There was a positive correlation between empathy and perspective taking and prosocial tendencies, the correlation coefficients are 0.32 and 0.61 respectively; While there was no correlation between emotional nursing and transpositional consideration and prosocial tendencies. Path analysis revealed that life values predicted directly prosocial tendencies(β=0.57, P<0.01), and predicted prosocial tendencies through empathy(β=0.17, P <0.01).
Conclusions
The empathy may be associated with life values and prosocial tendencies and play a partial mediating effect between life values and prosocial tendencies in medical students.
Key words:
Medical students; Life values; Prosocial tendencies; Empathy
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