Yuting Liu

Shandong University

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Quan Yuan

Sichuan University

Weiqing Liu

Indiana University – Purdue University Indianapolis

Qijun Zhao

Sichuan University

Jun Yu

Chinese University of Hong Kong

Weimin Lin

University of Cambridge

Yuan Wang

Dalian Medical University

Jian Qi

Nanchong Central Hospital

Yuchen Guo

First Hospital of Jilin University

Yi Zhang

Howard Hughes Medical Institute

Feng Wang

Peking Union Medical College Hospital

Cooperative Institutions

Montserrat Volcano Observatory

Sichuan University

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

State Key Laboratory of Oral Diseases

University of Chinese Academy of Sciences

Shandong University

Wuhan University

Peking University

Guangzhou Medical University

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Point in, Box Out: Beyond Counting Persons in Crowds

2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) (2019)

Yuting Liu Miaojing Shi Qijun Zhao Xiaofang Wang

Modern crowd counting methods usually employ deep neural networks (DNN) to estimate crowd counts via density regression. Despite their significant improvements, the regression-based methods are incapable of providing the detection of individuals in crowds. The detection-based methods, on the other hand, have not been largely explored in recent trends of crowd counting due to the needs for expensive bounding box annotations. In this work, we instead propose a new deep detection network with only point supervision required. It can simultaneously detect the size and location of human heads and count them in crowds. We first mine useful person size information from point-level annotations and initialize the pseudo ground truth bounding boxes. An online updating scheme is introduced to refine the pseudo ground truth during training; while a locally-constrained regression loss is designed to provide additional constraints on the size of the predicted boxes in a local neighborhood. In the end, we propose a curriculum learning strategy to train the network from images of relatively accurate and easy pseudo ground truth first. Extensive experiments are conducted in both detection and counting tasks on several standard benchmarks, e.g. ShanghaiTech, UCF_CC_50, WiderFace, and TRANCOS datasets, and the results show the superiority of our method over the state-of-the-art.

Ground truth

Minimum bounding box

Bounding overwatch

10.1109/cvpr.2019.00663

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Citations (213)

Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes

Cell stem cell (2014)

Li Shen Azusa Inoue Jin He Yuting Liu Falong Lu

DNA demethylation

5-Hydroxymethylcytosine

10.1016/j.stem.2014.09.002

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Citations (217)

An Efficient Probe-Based Quantitative PCR Assay Targeting Human-Specific DNA in ST6GALNAC3 for the Quantification of Human Cells in Preclinical Animal Models

Molecular Biotechnology (2024)

Jinfeng Ren Peng Liu Lang Hu Ruoning Yang Yuting Liu

genomic DNA

Assay sensitivity

10.1007/s12033-024-01115-8

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Citations (0)

Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations

Nature Communications (2020)

Yuan Wang Peng Deng Yuting Liu Yunshu Wu Yaqian Chen

Abstract Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) is an essential intermediate in the tricarboxylic acid (TCA) cycle. Studies have revealed that αKG extends the lifespan of worms and maintains the pluripotency of embryonic stem cells (ESCs). Here, we show that the administration of αKG increases the bone mass of aged mice, attenuates age-related bone loss, and accelerates bone regeneration of aged rodents. αKG ameliorates the senescence-associated (SA) phenotypes of bone marrow MSCs derived from aged mice, as well as promoting their proliferation, colony formation, migration, and osteogenic potential. Mechanistically, αKG decreases the accumulations of H3K9me3 and H3K27me3, and subsequently upregulates BMP signaling and Nanog expression. Collectively, our findings illuminate the role of αKG in rejuvenating MSCs and ameliorating age-related osteoporosis, with a promising therapeutic potential in age-related diseases.

Homeobox protein NANOG

Senescence

10.1038/s41467-020-19360-1

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Citations (163)

Influence of Population Biomass Accumulation During Different Growth Periods on Agronomic Traits and Cotton Yield

Agronomy (2024)

Junfeng Ding Mingyu Ji Jawaher Alkahtani Hanjia Li Yuting Liu

Increased output per unit area is the main goal of cotton producers worldwide, and the determination of biomass for high-yield cotton production is most important index. Cotton plants were grown at five densities (2.25, 3.0, 3.75, 4.5, and 5.25 × 104 plants ha−1). The relationships between the lint yield, construction of vegetative and reproductive organs and the population biomass were investigated. The results indicated that the maximum lint yield could be obtained at an appropriate population biomass before peak flowering and that the maximum lint yield increased with the biomass after peak flowering. When a lint yield above 1875.0 kg ha−1 was achieved, the biomass was at 657.0, 2317.3 and 5398.0 kg ha−1 for peak squaring, early flowering and peak flowering, respectively, whereas it surpassed 11,977.4 kg ha−1 and 15,365.8 kg ha−1 for the biomass at peak boll-setting and during the boll open period, respectively. This study indicated that moderate biomass accumulation before peak flowering and higher population biomass accumulation after peak flowering could achieve high lint yield because of the construction of optimum plant height, maximum and suitable LAI, maximum fruiting branches and boll weight before peak flowering, the highest effective fruiting node number and the population boll number after peak flowering. The results suggest that agronomic measurements could be implemented according to population biomass dynamics of high yield during the main growth stages.

Lint

10.3390/agronomy14112625

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Citations (0)

The AlkB Family of Fe (II)/Alpha-Ketoglutarate-Dependent Dioxygenases Modulates Embryogenesis through Epigenetic Regulation

Current Stem Cell Research & Therapy (2018)

Yuting Liu Quan Yuan Liang Xie

The study of epigenetic regulation has made substantial progress in recent years. The AlkB family in E. coli was identified as a type of DNA repair enzyme that removes alkyl adducts from nucleobases. Recently, nine mammalian homologs, ALKBH1-9, have been successfully identified and defined as diverse demethylases. ALKBH1, ALKBH5, ALKBH8 and ALKBH9 act as RNA demethylases, while ALKBH2-3 and ALKBH7 correct methyl and etheno adducts in DNA. Moreover, ALKBH4 focuses primarily on actin. Disorders of AlkB family level in mammals induce many types of diseases.In this review, we will elaborate on the structure and biological function of the members of the AlkB family. We will also focus on the latest progress of the research on the mammalian AlkB family, particularly on new breakthroughs, and present the relevant disorders or diseases induced by an abnormal level of the AlkB family.The AlkB family plays a crucial role in embryogenesis and differentiation. The aberrant level of the AlkB family leads to many types of diseases. The members of the AlkB family may serve as potential cancer markers and possible therapeutic targets in the future.

AlkB

10.2174/1574888x12666171027105532

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Citations (22)

Probing the Catalytic Sites and Activation Mechanism of Photoreceptor Phosphodiesterase Using Radiolabeled Phosphodiesterase Inhibitors

Journal of Biological Chemistry (2009)

Yuting Liu Suzanne L. Matte Jackie D. Corbin Sharron H. Francis Rick Cote

Retinal photoreceptor phosphodiesterase (PDE6) is unique among the phosphodiesterase enzyme family not only for its catalytic heterodimer but also for its regulatory γ-subunits (Pγ) whose inhibitory action is released upon binding to the G-protein transducin. It is generally assumed that during visual excitation both catalytic sites are relieved of Pγ inhibition upon binding of two activated transducin molecules. Because PDE6 shares structural and pharmacological similarities with PDE5, we utilized radiolabeled PDE5 inhibitors to probe the catalytic sites of PDE6. The membrane filtration assay we used to quantify [3H]vardenafil binding to PDE6 required histone II-AS to stabilize drug binding to the active site. Under these conditions, [3H]vardenafil binds stoichiometrically to both the α- and β-subunits of the activated PDE6 heterodimer. [3H]vardenafil fails to bind to either the PDE6 holoenzyme or the PDE6 catalytic dimer reconstituted with Pγ, consistent with Pγ blocking access to the drug-binding sites. Following transducin activation of membrane-associated PDE6 holoenzyme, [3H]vardenafil binding increases in proportion to the extent of PDE6 activation. Both [3H]vardenafil binding and hydrolytic activity of transducin-activated PDE6 fail to exceed 50% of the value for the PDE6 catalytic dimer. However, adding a 1000-fold excess of activated transducin can stimulate the hydrolytic activity of PDE6 to its maximum extent. These results demonstrate that both subunits of the PDE6 heterodimer are able to bind ligands to the enzyme active site. Furthermore, transducin relieves Pγ inhibition of PDE6 in a biphasic manner, with only one-half of the maximum PDE6 activity efficiently attained during visual excitation. Retinal photoreceptor phosphodiesterase (PDE6) is unique among the phosphodiesterase enzyme family not only for its catalytic heterodimer but also for its regulatory γ-subunits (Pγ) whose inhibitory action is released upon binding to the G-protein transducin. It is generally assumed that during visual excitation both catalytic sites are relieved of Pγ inhibition upon binding of two activated transducin molecules. Because PDE6 shares structural and pharmacological similarities with PDE5, we utilized radiolabeled PDE5 inhibitors to probe the catalytic sites of PDE6. The membrane filtration assay we used to quantify [3H]vardenafil binding to PDE6 required histone II-AS to stabilize drug binding to the active site. Under these conditions, [3H]vardenafil binds stoichiometrically to both the α- and β-subunits of the activated PDE6 heterodimer. [3H]vardenafil fails to bind to either the PDE6 holoenzyme or the PDE6 catalytic dimer reconstituted with Pγ, consistent with Pγ blocking access to the drug-binding sites. Following transducin activation of membrane-associated PDE6 holoenzyme, [3H]vardenafil binding increases in proportion to the extent of PDE6 activation. Both [3H]vardenafil binding and hydrolytic activity of transducin-activated PDE6 fail to exceed 50% of the value for the PDE6 catalytic dimer. However, adding a 1000-fold excess of activated transducin can stimulate the hydrolytic activity of PDE6 to its maximum extent. These results demonstrate that both subunits of the PDE6 heterodimer are able to bind ligands to the enzyme active site. Furthermore, transducin relieves Pγ inhibition of PDE6 in a biphasic manner, with only one-half of the maximum PDE6 activity efficiently attained during visual excitation.

Transducin

Vardenafil

10.1074/jbc.m109.018606

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Citations (13)

Endoplasmic reticulum stress restrains hepatocyte growth factor expression in hepatic stellate cells and rat acute liver failure model

Chemico-Biological Interactions (2017)

Yuting Liu Xiongxiong Pan Shu Li Yue Yu Jianliang Chen

Thapsigargin

Hepatic stellate cell

Tunicamycin

ATF4

10.1016/j.cbi.2017.08.015

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Citations (17)

A new ent‐atis‐16‐ene type diterpenol from Euphorbia sieboldiana

Chinese Journal of Chemistry (1991)

Yili Ding Zhong‐Jian Jia Qiguang Wang Jihong Chen Yuting Liu

Abstract From the acetone extract of the root of Euphorbia sieboldiana , a new ent ‐atis‐16‐ene type diterpenol was isolated and its structure was demonstrated as ent ‐atis‐16‐ene‐13 α‐hydroxy‐3,14‐dione (1) based on the chemical as well as NMR and MS spectroscopic evidences, and finally confirmed by X‐ray diffraction.

Euphorbia

Ene reaction

Euphorbiaceae

10.1002/cjoc.19910090206

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Citations (2)

The Hsp90 inhibitor SNX-2112 induces apoptosis of human hepatocellular carcinoma cells: The role of ER stress

Biochemical and Biophysical Research Communications (2014)

Xiao Wang Shaoxiang Wang Yuting Liu Weichao Ding Kai Zheng

Hsp90 inhibitor

Tunicamycin

Viability assay

Calnexin

10.1016/j.bbrc.2014.02.081

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Citations (35)