Yuting Liu

Shandong University

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i-10 index

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Quan Yuan

Sichuan University

Weiqing Liu

Indiana University – Purdue University Indianapolis

Qijun Zhao

Sichuan University

Jun Yu

Chinese University of Hong Kong

Weimin Lin

University of Cambridge

Yuan Wang

Dalian Medical University

Jian Qi

Nanchong Central Hospital

Yuchen Guo

First Hospital of Jilin University

Yi Zhang

Howard Hughes Medical Institute

Feng Wang

Peking Union Medical College Hospital

Cooperative Institutions

Montserrat Volcano Observatory

Sichuan University

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

State Key Laboratory of Oral Diseases

University of Chinese Academy of Sciences

Shandong University

Wuhan University

Peking University

Guangzhou Medical University

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Periplaneta americana extract promotes osteoblast differentiation of human alveolar bone marrow mesenchymal stem cells

Oral Diseases (2022)

Jie Xu Bin Zhao Weimin Lin Yuting Liu Xiao Zhang

This study aims to investigate the effects of Traditional Chinese medicine, Periplaneta americana extract (PAE), on osteoblast differentiation of human alveolar bone marrow-derived mesenchymal stem cells (hABMMSCs).Human alveolar bone marrow-derived mesenchymal stem cells were treated with different concentrations of PAE. Cell Counting Kit-8 (CCK-8) assay and transwell migration assay were conducted to evaluate cell proliferation and migration, respectively. Alkaline phosphatase (ALP) staining, ALP activity assay, and Alizarin red S staining were performed to detect osteogenesis in hABMMSCs. In addition, real-time quantitative polymerase chain reaction (RT-qPCR) and western blot (WB) assay were performed to evaluate expression levels of osteogenic markers. Finally, RNA sequencing analysis and WB were carried out to elucidate the underlying mechanism.A total of 0.1 mg/ml PAE promoted cell proliferation and migration. PAE also increased ALP activity and mineralized nodule formation of hABMMSCs. In addition, PAE upregulated the expression of osteogenesis-related genes (RUNX2, COL1A1, and BGLAP). RNA-sequencing analysis revealed that PAE activated the focal adhesion signaling pathway. Treatment with Defactinib, an inhibitor of FAK, attenuated the effects induced by PAE.PAE could enhance osteoblast differentiation of hABMMSCs through focal adhesion signaling pathway, suggesting a therapeutic potential for the alveolar bone defect.

RUNX2

10.1111/odi.14470

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Citations (1)

Heterozygous deletion of Cul4b in female mice leads to ovulatory dysfunction and female infertility

Genes & Diseases (2024)

Yufeng Wang Yuting Liu Wei Jiang Yu Song Yongxin Zou

Female infertility

10.1016/j.gendis.2024.101381

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Citations (1)

Real-world data medical knowledge graph: construction and applications

Artificial Intelligence in Medicine (2020)

Linfeng Li Peng Wang Jun Yan Yao Wang Simin Li

Clustering coefficient

10.1016/j.artmed.2020.101817

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Citations (195)

Bivalent inhibitors of the BTB E3 ligase KEAP1 enable instant NRF2 activation to suppress acute inflammatory response

Cell chemical biology (2023)

Mengchen Lu Jianai Ji Yifei Lv J. Zhao Yuting Liu

KEAP1

Proinflammatory cytokine

10.1016/j.chembiol.2023.12.005

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Citations (4)

Mn‐functionalized ZIF‐67 for Sensitive Colorimetric Detection of Artemisinin and Ascorbic Acid

ChemistrySelect (2024)

Xinyi Wang Zihan Cheng Yuting Liu Wang Li L Chen

Abstract Artemisinin (Art) is the first‐choice medicine for treating malaria. It also shows good therapeutic effects in antibacterial and antitumor treatment. Therefore, a simple and efficient method for detecting Art is of great significance. Mn‐functionalized ZIF‐67 (Mn@ZIF‐67) hybrid materials were synthesized using a post‐synthesis modification method. Due to the introduction of Mn 2+ , Mn@ZIF‐67 possesses higher peroxidase/oxidase like dual‐mimic enzymes activity than ZIF‐67, which can catalyze Art and generate peroxyl radicals. Based on this fact, Mn@ZIF‐67 was used to detect Art in the presence of TMB. A good linear relationship between absorption intensities at 652 nm and Art concentrations was obtained in the range of 0–22 μM with a detection limit of 200 nM. Ascorbic acid (AA), due to its reducibility, can inhibit peroxidase/oxidase mimetics activity of Mn@ZIF‐67 and the blue Mn@ZIF‐67‐TMB solution fades gradually with the addition of AA. Mn@ZIF‐67‐TMB acting as a colorimetric sensor, AA can be sensitively detected ranging from 0–30 μM, and the detection limit is 50 nM. Coexisting substances don't interfere with the detection of Art or AA. This sensing platform provides a highly sensitive and selective colorimetric method for monitoring AA and Art in serum, thereby demonstrating remarkable practicality.

Colorimetry

Prussian blue

Linear range

10.1002/slct.202402650

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Citations (1)

EZH2 regulates sFRP4 expression without affecting the methylation of sFRP4 promoter DNA in colorectal cancer cell lines

Experimental and Therapeutic Medicine (2020)

Yuting Liu Jun Yu Yang Xie Mengying Li Feng Wang

Abnormal activation of the Wnt signaling pathway is found in 90% of colorectal cancers (CRCs). Secreted frizzled-related protein 4 (sFRP4) serves as an antagonist of the canonical Wnt signaling pathway. Epigenetic alterations, including changes in DNA methylation and histone methylation, may influence the expression of sFRP4. Polycomb group (PcG) proteins are epigenetic transcriptional repressors that selectively repress gene expression by forming polycomb repressive complexes (PRCs). Enhancer of zeste homolog 2 (EZH2), the core component of PRC2, is a histone-lysine N-methyltransferase that interacts with DNA methyltransferases. In the present study, the promoter DNA methylation status of sFRP4 in CRC cell lines was analyzed and the underlying mechanisms of action governing this modification was investigated. Firstly, the DNA methylation status of the sFRP4 promoter in CRC cell lines was assessed using methylation-specific PCR. Subsequently, the mRNA and protein levels of sFRP4 were measured using real-time qPCR and western blot analysis, respectively, to determine whether the DNA methylation status of the sFRP4 promoter is correlated with its transcriptional levels. To screen for important epigenetic modifiers that may regulate the promoter DNA methylation status of sFRP4, the expression levels of PcG proteins were examined by gene array analysis. ChIP-qPCR was performed to test whether the selected PcG proteins directly bind the promoter region of sFRP4. Finally, the downregulated PcG proteins EZH2, chromobox 7 (CBX7) and jumonji and AT-rich interaction domain containing 2 (JARID2) were identified and their association with sFRP4 expression levels and Wnt/β-catenin signaling pathway activity were investigated. The present study revealed that sFRP4 was hypermethylated in the promoter region and downregulated during the progression of the CRC cell lines from Dukes A to Dukes C. Expression levels of PcG proteins EZH2, CBX7 and JARID2 were upregulated and positively associated with the aberrantly activated Wnt signaling pathway in the CRC cell lines. EZH2, CBX7 and JARID2 were all enriched in the sFRP4 promoter region in CRC cells. EZH2 downregulation did not affect the promoter DNA methylation status of sFRP4 but increased its expression levels and decreased CRC cell proliferation. DNA methylation controls the expression of sFRP4. EZH2 regulates sFRP4 expression without affecting the DNA hypermethylation of the sFRP4 promoter and influences CRC cell proliferation and Wnt/β-catenin signaling pathway activities.

Cancer Epigenetics

Histone Methylation

DNA methyltransferase

10.3892/etm.2020.9160

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Citations (6)

Recombinant growth differentiation factor 11 impairs fracture healing through inhibiting chondrocyte differentiation

Annals of the New York Academy of Sciences (2018)

Rixin Zheng Liang Xie Weiqing Liu Yuchen Guo Yuan Wang

Abstract Growth differentiation factor 11 (GDF11), a secreted member of the transforming growth factor‐β (TGF‐β) superfamily, has been reported to have the capacity to reverse age‐related pathologic changes and regulate organ regeneration after injury; however, the role of GDF11 in fracture healing and bone repair is still unclear. Here, we established a fracture model in 12‐week‐old male mice to observe two healing states: the cartilaginous callus and bony callus formation phases. Our results showed that recombinant GDF11 (rGDF11) injection inhibits cartilaginous callus maturation and hard callus formation, thereby impairing fracture healing in vivo . In vitro , rGDF11 administration inhibited chondrocyte differentiation and maturation by phosphorylating SMAD2/3 protein and inhibiting RUNX2 expression. Notably, inhibition of TGF‐β activity by a SMAD‐specific inhibitor attenuated GDF11 effects. Thus, our study demonstrates that, rather than acting as a rejuvenating agent, rGDF11 impairs fracture healing by inhibiting chondrocyte differentiation and maturation.

Growth differentiation factor

RUNX2

Callus

SOX9

10.1111/nyas.13994

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Citations (9)

An efficient qPCR assay for the quantification of human cells in preclinical animal models by targeting human specific DNA in the intron of BRCA1

Molecular Biology Reports (2023)

Kebin Liu Lang Hu Siyu Wang Xinzhu Chen Yuting Liu

10.1007/s11033-023-08853-z

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Citations (0)

Learning Residue-Aware Correlation Filters and Refining Scale Estimates with the GrabCut for Real-Time UAV Tracking

2021 International Conference on 3D Vision (3DV) (2021)

Shuiwang Li Yuting Liu Qijun Zhao Ziliang Feng

Unmanned aerial vehicle (UAV)-based tracking is attracting increasing attention and developing rapidly in applications such as agriculture, aviation, navigation, transportation and public security. Recently, discriminative correlation filters (DCF)-based trackers have stood out in UAV tracking community for their high efficiency and appealing robustness on a single CPU. However, due to limited onboard computation resources and other challenges the efficiency and accuracy of existing DCF-based approaches is still not satisfying. In this paper, inspired by residue representation, we exploit the residue nature inherent to videos and propose residue-aware correlation filters that show better convergence properties in filter learning. Moreover, we explore using segmentation by the GrabCut to improve the wildly adopted discriminative scale estimation in DCF-based trackers, which, as a mater of fact, greatly impacts the precision and accuracy of the trackers since accumulated scale error degrades the appearance model as online updating goes on. Extensive experiments are conducted on four UAV benchmarks, namely, UAV123@10fps, DTB70, UAVDT and Vistrone2018 (VisDrone2018-test-dev). The results show that our method achieves state-of-the-art performance.

Discriminative model

BitTorrent tracker

Robustness

10.1109/3dv53792.2021.00131

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Citations (22)

Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function

Cell Reports (2017)

Zhiwei Zhou Xuejie Yang Jiangping He Jing Liu Fang Wu

Polycomb repressive complex 1 (PRC1) plays essential roles in cell-fate determination. Recent studies have found that the composition of mammalian PRC1 is particularly varied and complex; however, little is known about the functional consequences of these variant PRC1 complexes on cell-fate determination. Here, we show that Kdm2b promotes Oct4-induced somatic reprogramming through recruitment of a variant PRC1 complex (PRC1.1) to CpG islands (CGIs). Furthermore, we find that bone morphogenetic protein (BMP) represses Oct4/Kdm2b-induced somatic reprogramming selectively. Mechanistically, BMP-SMAD pathway attenuates PRC1.1 occupation and H2AK119 ubiquitination at genes linked to development, resulting in the expression of mesendodermal factors such as Sox17 and a consequent suppression of somatic reprogramming. These observations reveal that PRC1.1 participates in the establishment of pluripotency and identify BMP4 signaling as a modulator of PRC1.1 function.

Reprogramming

Cell fate determination

CpG site

Polycomb-group proteins

10.1016/j.celrep.2017.10.091

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Citations (42)