Persistent lactation, as the result of mammary cellular anabolism and secreting function, is dependent on substantial mobilization or catabolism of body reserves under nutritional deficiency. However, little is known about the biochemical mechanisms for nutrition-restricted lactating animals to simultaneously maintain the anabolism of mammary cells while catabolism of body reserves. In present study, lactating sows with restricted feed allowance (RFA) (n = 6), 24% feed restriction compared with the control (CON) group (n = 6), were used as the nutrition-restricted model. Microdialysis and mammary venous cannulas methods were used to monitor postprandial dynamic changes of metabolites in adipose and mammary tissues. At lactation d 28, the RFA group showed higher (P < 0.05) loss of body weight and backfat than the CON group. Compared with the CON group, the adipose tissue of the RFA group had higher (P < 0.05) extracellular glutamate and insulin levels, increased (P < 0.05) lipolysis related genes (HSL and ATGL) expression, and decreased (P < 0.05) glucose transport and metabolism related genes (VAMP8, PKLR and LDHB) expression. These results indicated that under nutritional restriction, reduced insulin-mediated glucose uptake and metabolism and increased lipolysis in adipose tissues was related to extracellular high glutamate concentration. As for mammary glands, compared with the CON group, the RFA group had up-regulated (P < 0.05) expression of Notch signaling ligand (DLL3) and receptors (NOTCH2 and NOTCH4), higher (P < 0.05) extracellular glutamate concentration, while expression of cell proliferation related genes and concentrations of most metabolites in mammary veins were not different (P > 0.05) between groups. Accordingly, piglet performance and milk yield did not differ (P > 0.05) between groups. It would appear that activation of Notch signaling and adequate supply of glutamate might assist mammogenesis. Mammary cell proliferation and catabolism of adipose tissues in nutrition-restricted lactating sows were associated with extracellular high glutamate levels.
This study was conducted to investigate topological changes in large-scale functional connectivity (FC) and structural connectivity (SC) networks in acute mild traumatic brain injury (mTBI) and determine their potential relevance to cognitive impairment.Seventy-one patients with acute mTBI (29 males, 42 females, mean age 43.54 years) from Nanjing First Hospital and 57 matched healthy controls (HC) (33 males, 24 females, mean age 46.16 years) from the local community were recruited in this prospective study. Resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) were acquired within 14 days (mean 3.29 days) after the onset of mTBI. Then, large-scale FC and SC networks with 116 regions from the automated anatomical labeling (AAL) brain atlas were constructed. Graph theory analysis was used to analyze global and nodal metrics. Finally, correlations were assessed between topological properties and neurocognitive performances evaluated by the Montreal Cognitive Assessment (MoCA). Bonferroni correction was performed out for multiple comparisons in all involved analyses.Compared with HC, acute mTBI patients had a higher normalized clustering coefficient (γ) for FC (Cohen's d=4.076), and higher γ and small worldness (σ) for SC (Cohen's d=0.390 and Cohen's d=0.395). The mTBI group showed aberrant nodal degree (Dc), nodal efficiency (Ne), and nodal local efficiency (Nloc) for FC and aberrant Dc, nodal betweenness (Bc), nodal clustering coefficient (NCp) and Ne for SC mainly in the frontal and temporal, cerebellum, and subcortical areas. Acute mTBI patients also had higher functional-structural coupling strength at both the group and individual levels (Cohen's d=0.415). These aberrant global and nodal topological properties at functional and structural levels were associated with attention, orientation, memory, and naming performances (all P<0.05).Our findings suggested that large-scale FC and SC network changes, higher correlation between FC and SC and cognitive impairment can be detected in the acute stage of mTBI. These network aberrances may be a compensatory mechanism for cognitive impairment in acute mTBI patients.
Discuss the relationship between the X-ray repair cross complementing gene group 1 (XRCC1) 399 point polymorphisms and risk of hepatocellular carcinoma occurrence.Search the domestic and abroad database to obtain the related cases of XRCC1 gene polymorphisms and risk of hepatocellular carcinoma occurrence, and use the analysis software Review Manager 4. 2. 8 to perform the comprehensive statistic processing and heterogeneity test for each research data included in this meta analysis and calculate the combined OR value (with 95% CI).There were 7 literatures conformed to the inclusion criteria. A total of 1133 hepatocellular carcinoma cases and 1747 control cases were included. The meta analysis results showed that compared with the wild-type homozygous Arg/Arg, the combined OR (95% CI) of variant heterozygous genotype Arg/Gln and (Arg/Gln + Gln/Gln) were both 1.00 (0.68, 1.47), and the combined OR (95% CI) of variant homozygous genotype was 1.02 (0.60, 1.72). The relationship between XRCC1 399 point polymorphisms and the risk of hepatocellular carcinoma occurrence was of no statistical significance.No statistically significant relationship between the genotype of XRCC1 399 point polymorphism and the risk of hepatocellular carcinoma occurrence was found.
Objective Our aim was to investigate the significance of c-peptide(c-p),glycosylated hemoglobin(HbA1 c) and glucosylated serum protein(GSP) level change in diagnosis and therapy of diabetes mellitus and its complication.Methods 30 cases health control and 148 cases of diabetes mellitus were selected.Fasting blood glucose(FBG),c-peptide(c-p),HbA1c,and GSP were measured by biochemical and chemiluminescence immunoassay methods.Blood glucose and c-peptide were determined at 2 hours after taking 75 g glucose for assessing the changes of islet β cell function.Results The levels of C-P,HbA1c,GSP,FBG and 2 hBG in type 2 diabetes mellitus(T2DM) and its complication(including diabetic retinopathy,diabetic nephropathy,coronary heart disease accompanied with diabetes mellitus) were significantly higher than those of the normals,and the differences have statistic significance(P0.01),The degree of the items level changes were correlation with the degree of DM and complication.FBG and 2 hC-P items changes was no significant difference in impaired glucose tolerance(IGT)(P0.05),There was a positive correlation among HbAlc(r=0.86),GSP(r=0.67) and C-P(r=0.89) with T2DM,There was no significance difference between T2DM and its complication.Conclusion The results of the several items showed a fine correlation between diabetes mellitus and its complication,It can reflect actually the degrees of DM and its complication from various aspects,The higher level of C-P,HbA1c and GSP were the dangerous factor for diabetes mellitus and its complication,It is great validity for analysis in diagnosis and therapy monitor the degrees of diabetes mellitus and its complication.
Under the direction of western early-stage theories and recent research trend of self-esteem,it takes on several characteristics of the research field in China. Since the middle period of 1990s,Chinese developmental psychologists have studied many factors concerning self-esteem,such as parenting style,education style in school,cognition and so on.In this paper we will show you the recent progress on the study of self-esteem in China.
Objective
To evaluate the correlation between thin-section CT morphologic features and pathological vascular invasion in the clinical stage IA peripheral lung adenocarcinoma.
Methods
The preoperative thin-section CT images, clinical and pathological characteristics of 102 nodules in 98 patients were retrospectively analyzed and divided into two groups according to pathological vascular invasion. Variables including the diameter of tumor(T) and consolidation part (C) in the mix ground glass nodule(mGGN), C/T ratio, morphology and pathological classification were analyzed by two-independent samples Mann-Whitney U test or t test and χ2 test or Fisher exact probability test. Variables with significant difference in the univariate analyses were entered into multivariate analysis to explore predictors for vascular invasion.The correlation between these measurements and vascular invasion was evaluated by a ROC analysis.
Results
All of 102 nodules,36 had pathological vascular invasion and 66 without.The numbers of two groups with speculation, air bronchogram,abnormal vein,vascular convergence, pleural indentation were 30,30;26,26;35,3;35,39;32,39 and the mediandiameter of tumors were 2.1(1.0–3.0), 1.2(0.5–3.0) cm respectively. By univariateanalysis,spiculation, air bronchogram, abnormal vein, vascular convergence, pleural indentation, and diameter of tumor were significantly associated with pathological vascularinvasion(P<0.01).By multivariate logistic analysis, the statistically significant difference were found in speculation and abnormal vein(OR=33.867,8 161.063,P<0.05).The ROC analysis showed the area under curve, cut-off value, sensitivity and specificity ofthe diameter of tumor and consolidation part of mGGN and C/T ratio were 0.784, 2.05 cm, 66.7%, 78.8%; 0.886,1.08 cm, 82.4%, 90.0% and 0.861, 0.65, 79.4%, 85.0% respectively in differentiating tumors with pathological vascular invasion.
Conclusion
The spiculation sign and abnormal vein are independent predictors for vascular invasion in stage IA peripheral lung adenocarcinoma.
Key words:
Lung neoplasms; Adenocarcinoma; Tomography, X-ray computed
Objective
To analyze the delivery mode and pregnancy outcome in the old pregnant and lying-in women with scar uterus.
Methods
A total of 300 cases of elderly scar uterus pregnant and lying-in women treated in Jinan Maternal and Child Health Care Hospital from January 2015 to December 2018 were selected as observation group, and 300 cases of non-scarring uterus and pregnant women in the same age group were selected and included in the control group. The complications, outcome of the delivery, perinatal conditions and postpartum complications of the two groups were compared.
Results
There was no significant difference between the incidence of placenta and placenta between the two groups (P>0.05). The incidence of urinary disease, premature rupture of membranes and premature delivery were significantly higher than those in the control group (P 0.05). The rate of cesarean section, macrosomia and low birth weight in the observation group was significantly higher than that in the control group (P<0.05). The incidences of late postpartum hemorrhage, puerperal infection, wound healing and uterine restoration in the observation group were significantly higher than those in the control group (P<0.05).
Conclusions
Pregnancy complications and caesarean section in elderly women with scar uterus are high, while the risk of post-partum complications is high during the re-delivery, and the post-natal recovery is slow, for this pregnant and lying-in women, we should strengthen the monitoring and take effective preventive measures for the maintenance of mother-to-child safety.
Key words:
Scar uterus; Pregnancy outcome; Delivery mode
Objective To study the relation between carotid atherosclerotic plaque stability and red blood cell distribution width(RDW) in elderly cerebral infarction patients.Methods One hundred and sixty-five elderly acute cerebral infarction(ACI) patients with carotid plaques were divided into stable plaque group(n=45) and unstable plaque group(n=120) according to their color Doppler ultrasonography.Their clinical data and risk factors for cardiovascular diseases were collected,their serum levels of lipid,hemoglobin,A1c,createnine,plasma fibrinogen(Fib),hs-CRP and mean corpusculal volume were measured,and their body mass index,ankle brachial index,white blood cells and RDW were detected.Results The RDW and serum levels of hs-CRP and Fib were significantly higher in unstable plaque group than in stable plaque group(P0.05,P0.01).Spearman correlation analysis showed that the incidence of unstable carotid plaques was positively correlated with RDW(r=0.244,P0.01),hs-CRP(r=0.323,P0.01) and Fib(r=0.164,P0.05).Logistic regression analysis demonstrated that RDW was the risk factor for unstable plaques after adjustment for age,sex and other traditional cardiovascular risk factors(OR=2.020,95%CI:1.191-3.426,P0.01).Conclusion RDW is related with the stability of carotid atherosclerotic plaques and increases the risk of plaque rupture in elderly ACI patients.
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