Yoshihiro Shimada

Setsunan University

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Studies on monochlorobenzene poisoning

Okayama Igakkai Zasshi (Journal of Okayama Medical Association) (1988)

Yoshihiro Shimada

Pregnant mice were exposed to 500ppm of monochlorobenzene, 500ppm of trichloroethylene and 1000ppm of 1, 1, 1-trichloroethane for 1 hour. The transfer of each solvent to the fetus through the placenta was investigated by gas chromatographic equilibration. The distribution of solvents among organs of the mother was also investigated.Monochlorobenzene just after exposure was in the desending order of concentrations in the adipose tissue, liver, kidneys and brain of mothers. This order was the same as that of non-pregnant mice. It was shown that these three organic solvents transferred from the mother to the fetus. Concentrations of monochlorobenzene and trichloroethylene were higher in the placenta than in the blood. The concentration of 1, 1, 1-trichloroethane was slightly lower in the placenta than in the blood. The ratio of transfer of these three organic solvents from the placenta to fetuses was about 1/3. The transferability to the placenta and fetuses, and to the liver, kidneys and brain, of monochlorobenzene was higher than that of trichloroethylene.

10.4044/joma1947.100.1-2_147

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Citations (1)

Diurnal Changes in Mineral Concentrations of Xylem Exudate in Tomato Plants and Their Concentrations as Affected by Sunlight Intensity and Plant Ages.

Journal of the Japanese Society for Horticultural Science (1993)

Masaharu Masuda Yoshihiro Shimada

トマトの根かち地上部への養分輸送濃度の日変化ならびにその濃度に及ぼす光照度と苗齢の影響を調べるため, 同一培養液で生育する株を地際より約5cmの部位で切断し1時間木部いっ泌液を採取して主要5成分の無機分析を行った.1.株を1時間ごとに24時間にわたって切断したところ, いっ泌液量は明け方から増加し始め, 午前9時~正午に最高となった. いっ泌液の硝酸態窒素は濃度変化が最も小さく明け方にわずかに高くなった. リンは濃度変化が最も大きく最高値は最低値の3倍となった. すなわち, その濃度は夕方から急速に上昇し,午後10時頃に最高となり, その後, 徐々に低下して午前10時頃に最低となった. 一方, カリはリンとは対照的に明け方から濃度が上昇し午前10時頃に最高となり, その後, 徐々に低下して午後8時頃に最低となった. カルシウムとマグネシウムは夜間にわずかに高まる傾向にあった.2.自然光の30%に遮光すると, 処理3時間後の正午には, いっ泌液量が低下し, 成分濃度は無遮光区よりわずかに高くなった. しかし, 午後6時および午前0時にはリンを除いて, どの成分濃度も無遮光区の濃度より低くなった. リン濃度は遮光処理によって常に高まり, 無遮光区との差は時間の経過とともに拡大した.3.いっ泌液成分濃度の苗齢による差を2,3,4か月齢のトマトで比較した. 同一齢における成分濃度の真昼と真夜中の差は上述1の結果とほぼ一致した.硝酸態窒素, リン, カルシウムおよびマグネシウムの濃度は齢が進むほど低下したが, カリ濃度は, 齢が進んでもほとんど低下しなかった.

Exudate

Sunlight

Light intensity

Intensity

10.2503/jjshs.61.839

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Citations (14)

Amount of residual fluorine in the mouth and occurrence of unpleasant symptoms after the topical application of fluoride

JOURNAL OF DENTAL HEALTH (1981)

Mitsuo Tsukada Masaki Iwakura Yoshihiro Shimada

This study was undertaken to determine the amount of fluorine that remained in the mouth after the topical application of fluoride and to survey whether the topical application of fluoride induced any unpleasant symptoms by using a questionnaire. A total of 44 females aged 18 to 27 years, who attended a dental hygienist school in Sendai City, participated in this study. Using the double blind method, topical applications of both 2% NaF solution and placebo (normal saline solution) were made at an interval of 5 days. The subjects were instructed to apply 2ml of the solution and to use a cotton applicator according to a modified Muhler's technique. After the topical application was over, the residual solution, the cotton applicators and cotton rolls used for treatment and the saliva secreted during treatment were all collected individually. The fluorine content of these samples was determined with a fluorine-ion electrode. The mean amount of residual fluorine in the mouth was 1.83mg per person, ranging from 0.70-3.19mg, and 0.037mg per kilogram of body weight, ranging from 0.012-0.067mg.Two days after the treatment, a questionnaire survey was also carried out and anyone who complained of any unpleasant symptoms was interviewed. There was no statistically significant difference between the two kinds of topical solution. When the mean amount of residual fluorine per kilogram of body weight was compared between the group complaining of unpleasant symptoms and the other, there was no significant difference but the latter showed a higher value than the former. The majority of those that complained of unpleasant symptoms referred to the strain and fatigue induced by the clinical practice.From these findings, it was assumed that the occurrence of unpleasant symptoms was caused by the mental and physical stress involved with clinical practice rather than by acute fluoride poisoning by injestion.

Fluorine

Dry mouth

10.5834/jdh.31.151

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Development of Expert System for Estimation of Weld Flaw by Ultrasonic Testing.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A (1993)

Ri-ichi Murakami Yoshihiro Shimada Sai Ueda

Development of an expert system for ultrasonic testing can contribute to improvement and standardization of inspection level if the technique and experience of the UT engineer can be incorporated as the knowledge database. Then, it is considered that such an expert system will be a way to solve the shortage of UT engineers in the near future. The present system has been originally developed as a system having a knowledge base system and inference engine which are combined with a blackboard model and frame model. In the developed expert system, which is unified with a man-machine interface, it may be advantageous to use a production rule and a forward inference. The inference was performed in two steps. The candidates for weld flaw were firstly inferred from the welding condition, and then the final flaw was determined from the UT data. When the present expert system was applied to diagnosis of the weld flaw of the welding structure, the results obtained by the present system agreed with those obtained by the UT engineer up to about 90%. It can then be confirmed that the expert system is available as a method of inference for weld flaws, using ultrasonic testing data.

Economic shortage

10.1299/kikaia.59.580

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A Case of Liver Hemangioma Diagnosed by Needle Biopsy on Account of The Difficulty of Macroscopic Diagnosis

Acta gastro-enterologica belgica (1980)

Toshio Ito Shozo Kiyotoshi Hiroyasu Hirakawa Fumio Munetomo K Yoshino

10.11280/gee1973b.22.309

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Molecular cloning and chromosomal localization of the human thrombopoietin gene

FEBS Letters (1994)

Yoshiaki Sohma Hiromichi Akahori Naohiko Seki Tada-aki Hori Kinya Ogami

The complete gene for human thrombopoietin (TPO) has been cloned by screening a human genomic library using human TPO cDNA as a probe. This gene is 6.2 kb in length and contains six exons and five introns. It is shown that the human genome contains a single copy of the human TPO gene according to Southern blotting analysis. The transcription initiation site was determined by S1 nuclease mapping. The human TPO gene expressed TPO activity when transfected into COS-1 cells. The human TPO gene has been mapped to chromosome 3q27 by in situ hybridization using a biotin-labeled probe.

Cloning (programming)

10.1016/0014-5793(94)01008-0

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Citations (239)

The Caries Reducing Effect of Mouth Rinsing with a Dilute NaF Solution

JOURNAL OF DENTAL HEALTH (1978)

Yoshihiro Shimada Okiuji Takagi Hiroyuki Inoue

This study was undertaken to estimate the DMF reducing effect of mouth rinsing with a 0.01% NaF solution. Schoolchildren aged 6 to 10 years of three elementary schools in Sendai were selected and studied for two years. The children were divided into three experimental groups by schools: Group A was the control group with no rinsing, Group B was an unsupervised fluoride-rinsing group where the children were instructed to rinse their mouths for 30 seconds with 10 ml of 0.01% NaF solution every evening at home, and Group C was a supervised fluoride-rinsing group where the children rinsed their mouths 30 seconds with a 7 to 10 ml of 0.05% NaF solution after every school lunch under supervision of the school teachers.The base-line data of the three groups were well balanced (Table 1). Many children of Group B stopped rinsing during the experimental period because of loss of interest. The children of Group B were therefore divided into two groups, experiment completed and experiment interrupted (Table 2). The post-experimental data are shown in Table 4.The comparison between two-year DMF increments of the groups is presented in Tables 5 to 10. The new DMF teeth and surfaces of Group B-completed were reduced by a statistically significant difference of 28.6 to 32.0%, but there was no such reduction in Group B-interrupted. The difference between the DMF increments of Group B-completed and -interrupted was statistically significant. The new DMF teeth and surfaces of Group C were reduced by a significant difference of 14.5 to 29.6%. The reduction effect of Group B-completed was larger than Group C, but the difference was not significant, except for the new DMFS rate.From these findings it was concluded that the DMF reducing effect of daily mouth rinsing with a 0.01% NaF solution was a significant difference of about 30%.

10.5834/jdh.28.1

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Citations (4)

Differences in urinary trichloroethylene metabolites of animals.

PubMed (1979)

Masana Ogata Kazuko Norichika Yoshihiro Shimada Tadamichi MEGURO

Differences in urinary excretion of trichloroethylene were studied in rabbits, rats and mice. Trichloretylene (1 m mole/kg) was injected intra-peritoneally, then urinary trichloroacetic acid and trichloroethanol glucuronide were measured. The results were: 1. The ratio of total excretion of trichloroethylene metabolites to the administered trichloroethylene decreased in the order of mice, rats and rabbits. 2. The ratio of total trichloroethanol to trichloroacetic acid in urine decreased in the order of rabbits (69.2), mice (12.8) and rats (2.3). The high ratio in rabbits was due to the extremely small amount of trichloroacetic acid in the urine. 3. Differences in these two urinary metabolites in the three kinds of animals and in human subjects were discussed.

Trichloroacetic acid

Source

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Citations (3)

A Case Showing Peculiar Reddish Markings Followed by Kalk's Patchy Markings on Liver Surface

Kanzo (1974)

Masahiro Kubota Yoshihiro Shimada Tatsuya Itoshima Wataru Ohta Takemichi Inoue

H. Kalkは肝表面に赤色の区域が斑点状に散在する肝を大斑紋肝と称し,これが肝硬変に高頻度に進展することを認めた.しかし腹腔鏡的にいかなる病変が大斑紋肝に移行するかについては未だ明らかでない.我々は腹腔鏡検査を繰返し,大斑紋肝への経過を追求できた1例を報告する.症例は20才の男で,慢性肝炎活動型の組織像を呈した例である.第1回の腹腔鏡検査では肝表面に特異な赤色網状紋理(著者らの腹腔鏡分類で4番地)を認め,第3回(8ヵ月後)には肝表面に1～3mm大のやや盛り上った赤褐色の斑紋(7番地)の出現を認めたが,特異な赤色紋理は残っていた.第1回から1年3ヵ月後の第4回の腹腔鏡検査では,特異な赤色紋理は消失し,白色の結合織帯に変化し,これらにとり囲まれた斑紋は数が増し,一部に結節が出現した.このように斑紋肝の前段階として特異な赤色網状紋理(4番地)が観察された症例を報告した.

10.2957/kanzo.15.94

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Citations (3)

Flow Analysis in a Multiple-Disk Laminar Flow Fan.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B (1993)

Junichiro FUKUTOMI Yoshihiro Shimada Yoshiyuki NAKASE Kunio Yasuda

It is expected that a multiple-disk laminar flow fan has a very low noise level since it has no blade. But, in general, this fan has low efficiency in utilizing shear force. This paper presents a quasi three-dimensional flow analysis for the improvement of performance of a laminar flow fan. For the flow in the meridional plane, a nonviscous flow analysis using the streamline curvature method is utilized. On the other hand, the flow between parallel disks is analyzed by means of the angular momentum theory utilizing an expression for the local friction factor. The two kinds of calculations are successively repeated until the solution converges. Hence, the quasi three-dimensional flow in the laminar flow fan is analyzed. Moreover, the effects of flow rate and axial inclination angle of disk inner diameter on the flow are investigated.

Laminar flow reactor

10.1299/kikaib.59.3140

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