Richard G. Hibbs

Jacobs (United States)

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Victor J. Ferrans

National Heart Lung and Blood Institute

George E. Burch

Tulane University

Andrew L. Corwin

Thammasat University

John J. Walsh

Yale University

Jeffrey P. Ellison

Jacksonville College

S. Acharya

KIIT University

V J Ferrans

National Institutes of Health

D. E. Nikitopoulos

Louisiana State University

William C. Black

University of Tennessee at Knoxville

Donald G. Weilbaecher

Houston Methodist

Cooperative Institutions

United States Naval Medical Research Unit III

National Institutes of Health

Centers for Disease Control and Prevention

Tulane University

Naval Medical Research Command

Naval Medical Research Unit Six

Johns Hopkins University

Glenn Research Center

Louisiana State University

Ain Shams University

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Electron microscopic observations on lysosomes and related cytoplasmic components of normal and pathological cardiac muscle

The Anatomical Record (1965)

Richard G. Hibbs Victor J. Ferrans John J. Walsh George E. Burch

Abstract An electron microscopic investigation was made on lysosomes and morphologically related structures found in cardiac muscle. The tissues used in this investigation were obtained from normal and functionally altered rat hearts and human hearts from patients with cardiomyopathy. Structures morphologically similar to lysosomes were encountered in all hearts, but were especially numerous in the damaged hearts, both human and rat. These structures were extremely variable in size, the smaller ones being located in the Golgi region where they appeared to originate. Lipofuscin granules were especially numerous in pathological hearts, and have several morphological features in common with lysosomes. Other bodies were also frequently encountered in these cells which in many ways resembled lysosomes, but contained mitochondria, fragments of mitochondria and myelin figures. The structural similarities between lysosomes and these other elements lead us to consider the possibility that the latter structures may be modified, degenerate, or simply functional stages of lysosomes.

Lipofuscin

Cardiac muscle

Organelle

10.1002/ar.1091530207

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Citations (55)

Idiopathic Myocardiopathy of the Puerperium (Postpartal Heart Disease)

Circulation (1965)

John Walsh George E. Burch William C. Black Victor J. Ferrans Richard G. Hibbs

It should be clearly understood that no evidence was uncovered to indicate an unequivocal etiology for this uncommon disease. One is tempted to qualify "uncommon" in that it no longer connotes the same extreme degree of rarity that would appear from medical literature. Over the same period that these cases were collected an equal number were recognized but unavailable for study for various reasons. Unfortunately, the size of our series precludes statistical analysis. The apparent tendencies to hypercholesteremia, blood-group predilection, and increased incidence of abnormal hemoglobin types are in need of further exploration. One would be remiss not to note at this point that at least one report 20 related several instances of familial incidence of postpartal heart disease. We are more certain of the significance of malnutrition as a factor in the genesis of this syndrome, although we are unable to assign a precise role. Similarly, the deleterious effects on such patients of hypertension, pyelonephritis, and full-term pregnancy have impressed us, although we can make no judgment as to their frequency of occurrence. Probably, as so often happens, we are most certain of our single pre-investigatory premise that postpartal heart disease is a serious and pernicious syndrome, quite different from that described in most of the literature. That prolonged bed rest is not a panacea is obvious. It is of sufficient merit, however, to warrant use in all such patients, for periods up to 1 year at least.

Etiology

10.1161/01.cir.32.1.19

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Citations (120)

Heat Transfer in a Two-Pass Internally Ribbed Turbine Blade Coolant Channel With Cylindrical Vortex Generators

Volume 3: Heat Transfer; Electric Power; Industrial and Cogeneration (1996)

Richard G. Hibbs Sumanta Acharya Yi Chen Dimitris E. Nikitopoulos T. A. Myrum

The effect of vortex generators on the mass (heat) transfer from the ribbed passage of a two pass turbine blade coolant channel is investigated with the intent of optimizing the vortex generator geometry so that significant enhancements in mass/heat transfer can be achieved. In the experimental configuration considered, ribs are mounted on two opposite walls: all four walls along each pass are active and have mass transfer from their surfaces but the ribs are non-participating. Mass transfer measurements, in the form of Sherwood number ratios, are made along the centerline and in selected inter-rib modules. Results are presented for Reynolds number in the range of 5,000 to 40,000. pitch to rib height ratios of 10.5 and 21, and vortex generator-rib spacing to rib height ratios of 0.55 and 1.5. Centerline and spanwise averaged Sherwood number ratios are presented along with contours of the Sherwood number ratios. Results indicate that the vortex generators lead to substantial increases in the local mass transfer rates, particularly along the side walls, and modest increases in the average mass transfer rates. The vortex generators have the effect of making the inter-rib profiles along the ribbed walls more uniform. Along the side walls, horseshoe vortices that characterize the vortex generator wake are associated with significant mass transfer enhancements. The wake effects and the levels of enhancement decrease somewhat with increasing Reynolds number and decreasing pitch.

Vortex generator

Sherwood number

Heat transfer enhancement

10.1115/96-gt-474

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Citations (15)

Epidemic of Febrile Disease in Berbera, Somalia

Richard G. Hibbs Andrew L. Corwin Scott A. Thornton Manuel Lluberas R Sanderson

Abstract : In April 1989 an epidemic of febrile illness occurred in Berbera, northern Somalia, several weeks after heavy rainfall, flooding and increase in mosquito populations. A malaria epidemic was ongoing in nearby Djibouti. Malnutrition and diarrhoea were endemic. Symptoms were influenza-like, lasted approximately 1 month and progressed to shock and death in about 700 persons between April 4- June 20, 1989. A WHO team detected falciparum malaria among 16/ 25 patients, all negative by Widal tests. In July 1989 a U.S. Navy team administered a questionnaire and obtained blood samples from 100 outpatients at the District Hospital. Peripheral smears were positive from malaria in 16/82 patients (13 falciparum). An additional patient, still symptomatic, had confirmed falciparum malaria which resolved with treatment (fansidar). IgM antibody to dengue virus was detected in only 3%. IgG antibodies were detected for Dengue virus in 59% West Nile Fever virus in 34%, Yellow Fever virus in 30%, Rift Valley Fever and Congo-Crimean Haemorrhagic Fever viruses in 7% each, Chickungunya virus in 4%, Ebola and Marburg viruses in 1% each, Rickettsia conorii and Coxiella burnetii in 40% each and Rickettsia typhi in 13%. The agent responsible for the epidemic could not be confirmed, but serological evidence of arboviral and rickettsial infection requires that these agents be considered in future epidemics.

Rickettsia conorii

Rickettsia typhi

Rift Valley Fever

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The fine structure of human eccrine sweat glands

American Journal of Anatomy (1958)

Richard G. Hibbs

Eccrine sweat

10.1002/aja.1001030204

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Citations (101)

HISTOCHEMICAL AND ELECTRON MICROSCOPICAL STUDIES ON THE CARDIAC NECROSES PRODUCED BY SYMPATHOMIMETIC AGENTS*

Annals of the New York Academy of Sciences (1969)

Victor J. Ferrans Richard G. Hibbs John Walsh George E. Burch

10.1111/j.1749-6632.1969.tb16737.x

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Citations (115)

Prussia and the poor, or, Orservations [i.e. Observations] upon the systematized relief of the poor at Elberfeld, in contrast with that of England, founded upon a visit and personal inquiry, with an appendix, containing, ...

Williams & Norgate eBooks (1876)

Richard G. Hibbs

Poor relief

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Special Issue: Significance of Tissue Chromaffin Cells and Mast Cells in Man

Circulation Research (1960)

John H. Phillips George E. Burch Richard G. Hibbs

Tissue mast cells have been a source of great curiosity since their conclusive description by Ehrlich over 80 years ago. They have been implicated in a vast majority of connective tissue reactions both of physiologic and pathologic nature. In some species at least, mast cells have been implicated in the production, storage and release of potent cardiovascular substances including heparin, serotonin and histamine. The present report is directed particularly toward man. Evidence is presented suggesting that human tissue cells previously lumped into one large group on the basis of granular metachromasia and termed tissue mast cells, represent at least two morphologically distinct cellular types. Difference in function of these cells may be great. There is evidence that one type may be a local tissue source for epinephrine, norepinephrine, or both. It is suggested that mast cells as a whole may represent a spectrum of cell types having numerous differences in ultrastructure and function. It is believed that their continued study in various physiologic and pathologic states should prove fruitful.

Metachromasia

Cell type

10.1161/01.res.8.4.692

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Citations (25)

Abdominal tuberculosis: a reply

Transactions of the Royal Society of Tropical Medicine and Hygiene (1995)

Richard G. Hibbs

Journal Article Abdominal tuberculosis: a reply Get access R.G. Hibbs R.G. Hibbs Commanding Officer US Naval Medical Research Unit No. 3 PSC 452, Box 5000 FPO AE 09835-0007, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 89, Issue 2, March-April 1995, Page 238, https://doi.org/10.1016/0035-9203(95)90514-6 Published: 01 March 1995

Officer

10.1016/0035-9203(95)90514-6

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Citations (1)

Electron Microscopy of Human Tissue Mast Cells

JAMA (1960)

Richard G. Hibbs

Tissue mast cells have been a source of curiosity since their first description by Ehrlich, in 1877.1,2A voluminous literature, including several reviews,3-8has accumulated over the succeeding years. In general, mast cells have been shown to contain heparin, histamine, and serotonin.9-11There are great species variations, however. For example, serotonin has only been identified in mast cells of the mouse and rat. Many physiologic phenomena involving mast cells have been described. Riley6believes that a local mast-cell cycle may play a part in the deposition, absorption, and redeposition of fibrils in the connective tissue. This is among the betterknown physiologic functions of these cells. Regardless of the vast amount of data accumulated on the subject, it is apparent that the role of mast cells in normal connective tissue metabolism remains a mystery. Even less well understood is the function of these cells in pathologic alterations

Mast (botany)

10.1001/jama.1960.63030050006012

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Citations (44)