DataExpo GAKG DeepReport Navigation

Copyright©2015-2024 Acemap, Inc. Shanghai Jiao Tong University. All rights reserved.

沪ICP备18028330号

YO

Yasuo Ohno

Tohoku University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Ken Nakazawa

Saitama Medical University

Kazuhide Inoue

Kyushu University

Makoto Usami

Muroran Institute of Technology

Akira Takanaka

Showa Pharmaceutical University

Shogo Ozawa

Aichi Gakuin University

Toru Kawanishi

Tokyo Institute of Technology

Atsuko Miyajima

National Institute of Health Sciences

Yoshiro Saito

National Institute of Health Sciences

Momoko Sunouchi

National Institute of Health Sciences

Kaoru Sato

National Institute of Health Sciences

Cooperative Institutions

National Institute of Health Sciences

The University of Tokyo

Osaka University

Kyoto University

National Institute of Health Sciences

Nagoya University

Tohoku University

Tokyo Medical and Dental University

Hokkaido University

Kyushu University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

On the sum formula for the $q$-analogue of non-strict multiple zeta values

Proceedings of the American Mathematical Society (2007)

Yasuo Ohno Jun-ichi Okuda

In this article, the $q$-analogues of the linear relations of non-strict multiple zeta values called "the sum formula" and "the cyclic sum formula" are established.

10.1090/s0002-9939-07-08994-0

Cite

Citations (34)

The Novel Compounds That Activate Farnesoid X Receptor: the Diversity of Their Effects on Gene Expression

Journal of Pharmacological Sciences (2008)

Takuo Suzuki Norimasa Tamehiro Yoji Sato Tetsu Kobayashi Akiko Ishii‐Watabe

Farnesoid X receptor

Chenodeoxycholic acid

CYP8B1

Small heterodimer partner

10.1254/jphs.08006fp

Cite

Citations (35)

Stratifin as a Novel Diagnostic Biomarker in Serum for Diffuse Alveolar Damage

Research Square (Research Square) (2021)

Noriaki Arakawa Atsuhito Ushiki Mitsuhiro Abe S. Matsuyama Yoshinobu Saito

Abstract Among the various histopathological patterns of drug-induced interstitial lung disease (DILD), diffuse alveolar damage (DAD) is associated with poor prognosis. However, there is no reliable biomarker for its accurate diagnosis. Here, we show stratifin/14-3-3σ (SFN) as a biomarker candidate found in a proteomic analysis. The study included two independent cohorts and controls ( n = 432 samples). SFN was specifically elevated in DILD patients with DAD, and was superior to the known biomarkers, KL-6 and SP-D, in discrimination of DILD patients with DAD from patients with other DILD patterns or other lung diseases, including bacterial pneumonia. SFN was also increased in serum from patients with idiopathic DAD, and in lung tissues and bronchoalveolar lavage fluid of patients with DAD. In vitro analysis using the A549 cell line suggested that extracellular release of SFN occurred via p53 activation. We conclude that serum SFN is a promising biomarker for DAD diagnosis.

Diffuse alveolar damage

Diagnostic biomarker

10.21203/rs.3.rs-690487/v1

Cite

Citations (0)

Blood & Vessel (1984)

Takeshi Motomiya Kôji Watanabe Keiko Iyeki Yoshiki Tokuyasu Harumizu Sakurada

Coronary thrombolysis or percutaneous transluminal coronary recanalization (PTCR) has recently been established as a treatment of acute myocardial infarction (AMI). This study was performed to elucidate the changes in plasma levels of β-thromboglobulin (β-TG), fibrinopeptides and prostaglandins before and after the PTCR. Twenty-six AMI patients within 6 hours after its onset, 53±12.1 (SD) years of age were subjected for the PTCR using with urokinase (680, 000±124, 000 IU). Eleven patients among 26 undergone PTCR were selected for the determination of plasma levels of β-TG, thromboxane B2 (TXB2), 6-keto-PGF1α, fibrinopeptide A (FpA) and FpBβ 15-42 before and serially after PTCR.Successful recanalization was obtained in 18 out of 26 cases (69.2%). β-TG was elevated both in successful and unsuccessful cases suggesting platelet activation in AMI. Those who achieved good recanalization demonstrated a sharp rise of β-TG probably due to wash-out phenomenon shortly after the recanalization. β-TG returned to the normal range within 1-7 days (Fig. 1) TXB2 was increased in both groups, higher in the recanalized group and gradually returned to the normal range in several days. Two out of 5 recanalized cases demonstrated wash-out phenomenon. 6-keto-PGF1α levels were also increased in AMI which became normalized in a day. FpA was increased in both groups in the acute stage of AMI suggesting the hypercoagulable state and gradually decreased to the normal range. FpBβ made a peak at the termination of PTCR, higher in the recanalized cases suggesting better fibrinolysis, and rapidly decreased in a day. A typical case of successful PTCR was shown in Figure 2. Marked rises in β-TG and TXB2 shortly after PTCR may indicate recanalization of the obstructed coronary artery.

10.2491/jjsth1970.15.427

Cite

Citations (0)

WEIGHTED LONESUM MATRICES AND THEIR GENERATING FUNCTION

Integers (2014)

Ken Kamano Yasuo Ohno Shûji Yamamoto

10.1515/9783110298161.385

Cite

Citations (2)

On congruence properties of poly-Bernoulli numbers with negative upper-indices

arXiv (Cornell University) (2024)

Yasuo Ohno Mika Sakata

For any integer $k$, M.Kaneko defined $k$-th poly-Bernoulli numbers as a kind of generalization of classical Bernoulli numbers using $k$-th polylogarithm. In case when $k$ is positive, $k$-th poly-Bernoulli numbers is a sequence of rational numbers as same as classical Bernoulli numbers. On the other hand, in case when $k$ is negative, it is a sequence of positive integers, and many combinatoric and number theoretic properties has been investigated. In the present paper, the negative case is treated, and their congruence and $p$-adic properties are discussed. Beside of them, application of the results to obtain a congruence property for the number of lonesum matrices is also mentioned.

Congruence (geometry)

10.48550/arxiv.2409.18404

Cite

Citations (0)

THE SECOND PHASE VALIDATION STUDY OF ALTERNATIVE METHOD TO THE EYE IRRITATION TEST 8.Evaluation of Cytotoxicity Test in SIRC Cells

The Journal of Toxicological Sciences (1995)

Masato Hatao Noriko Murakami Kazutami Sakamoto Y. Takino M. Ohnuma

Eye irritation

Skin irritation

Cite

Citations (0)

On the parity of poly-Euler numbers

Yasuo Ohno Yoshitaka Sasaki

Poly-Euler numbers are introduced in [9] via special values of an L-function as a generalization of the Euler numbers. In this article, poly-Euler numbers with negative index are mainly treated, and the parity of them is shown as the main theorem. Furthermore the divisibility of poly-Euler numbers are also discussed. x1. Introduction

Parity (physics)

Euler number (physics)

Divisibility rule

Cite

Citations (14)

ON A KIND OF DUALITY OF MULTIPLE ZETA-STAR VALUES

International Journal of Number Theory (2010)

Masanobu Kaneko Yasuo Ohno

A duality-type relation for height one multiple zeta-star values is established. A conjectural generalization to the case of arbitrary height is also presented.

Star (game theory)

Duality (order theory)

10.1142/s179304211000385x

Cite

Citations (33)

Identification and characterization of lysophosphatidylcholine 14:0 as a biomarker for drug-induced lung disease

Scientific Reports (2022)

Kosuke Saito Akihiko Gemma Koichiro Tatsumi Noboru Hattori Atsuhito Ushiki

Abstract Drug-induced interstitial lung disease (DILD) occurs when drug exposure causes inflammation of the lung interstitium. DILD can be caused by different types of drugs, and some DILD patterns results in a high mortality rate; hence, DILD poses a serious problem in clinical practice as well as drug development, and strategies to diagnose and distinguish DILD from other lung diseases are necessary. We aimed to identify novel biomarkers for DILD by performing lipidomics analysis on plasma samples from patients with acute and recovery phase DILD. Having identified lysophosphatidylcholines (LPCs) as candidate biomarkers for DILD, we determined their concentrations using validated liquid chromatography/mass spectrometry biomarker assays. In addition, we evaluated the ability of LPCs to discriminate patients with acute phase DILD from those with recovery phase DILD, DILD-tolerant, or other lung diseases, and characterized their association with clinical characteristics. Lipidomics analysis revealed a clear decrease in LPC concentrations in the plasma of patients with acute phase DILD. In particular, LPC(14:0) had the highest discriminative index against recovery phase and DILD-tolerant patients. LPC(14:0) displayed no clear association with causal drugs, or subjects’ backgrounds, but was associated with disease severity. Furthermore, LPC(14:0) was able to discriminate between patients with DILD and other lung diseases, including idiopathic interstitial pneumonia and lung disease associated with connective tissue disease. LPC(14:0) is a promising biomarker for DILD that could improve the diagnosis of DILD and help to differentiate DILD from other lung diseases, such as idiopathic interstitial pneumonia and connective tissue disease.

10.1038/s41598-022-24406-z

Cite

Citations (10)

More pages