Objective To explore the relationship between hypersensitive C-reactive protein(hs-CRP)and the stenosis degree of the coronary artery in patients with acute coronary syndrome(ACS).Methods Sixty patients with ACS confirmed by coronary angiography and 50 controls with a chest pain but no ischemic changes in ECG and no coronary heart disease confirmed by coronary angiography were recruited in this study.The level of hs-CRP was measured by immunoturbidimetric assay.Results The level of hs-CRP in patients with ACS was higher than that in controls;hs-CRP in patients with multiple-vessel diseases was higher than that in patients with single-vessel disease;and hs-CRP in patients with coronary occlusion was higher than that in patients with coronary stenosis.Conclusion The level of hs-CRP could be an index to indicate the stenosis range and degree of the coronary artery.
To assess Thrombolysis In Myocardial Infarction (TIMI) flow of the nation-produced tirofiban in patients with ST-segment elevation myocardial infarction (STEMI) during primary Percutaneous Coronary Intervention (PCI).
Methods
120 patients with STEMI during primary PCI from Nov 2006 to June 2009 were divided into two groups, tirofiban+PCI group of 60 cases (51 males and 9 females) with mean age (60.11±10.96) years old, and the other primary PCI group of 60 cases (42 males and 18 females) with mean age (64.33±11.91) years. The TIMI flow before and after operation were observed in all cases angiographically.
Results
By using tirofiban before operation improved TIMI flow, a greater percentage of TIMI 1 grade flow was achieved in the tirofiban+PCI group compared with the primary PCI group before operation (13.3.8% vs 3.3%, p>0.05). There was no difference of TIMI 3 grade flow between the two groups after operation, TIMI 2 grade flow was lesser in tirofiban+PCI group (6.7% vs 3.4%, p>0.05).Reperfusion arrhythmia was lesser in tirofiban+PCI group (3.4% vs 6.7%).
Conclusion
Tirofiban may improve TIMI flow of the IRA in patients with STEMI during emergency PCI.
To evaluate the current practice of medications that have been proven effective by evidence-based medicine on inpatients with ST segment elevation ACS in China.
Methods
1307 in-patients with ST segment elevation ACS from 64 hospitals across China were received different therapies in hospitals and a standard questionnaire was used to get information of the patients including demographic, treatments and in-hospital outcomes. We analysed the status of application of reperfusion and aspirin, ACEI, β-blocker, LWMH, Clopidogrel and cholesterol lowering agents on ST segment elevation ACS patients.
Results
1. The were no significant differences in baseline characteristics between the patients from tertiary hospitals and that from the secondary hospitals. 2. 30.9%–69.4% received reperfusion therapies. 1.3%–62.7% received primary PCI, 1.9%–45.8% received Thrombolysis, and nearly 46.2% did not receive any form of reperfusion. Reperfusion therapy was more often used in tertiary hospitals (48.2%) than in secondary hospitals (6.46%). Thrombolysis was more often in secondary hospitals than that in tertiary hospitals (36.8% vs 14.6%) 3. Percentage of medications in ST ACS patients in different areas: aspirin (88.0%–98). 6%), ACEI (60.5%–84). 4%), β-blocker (55.8%–84.4%), LWMH54.2%–94.2%), Clopidogrel (14.3–88.6), cholesterol lowering agents Statins (51.9%–90.9%); 4. Major in-hospital events and death rates were significantly higher in secondary hospitals than in tertiary hospitals; 5. Mortality and congestive heart failure rate were significantly higher in patients with no reperfusion therapy compared to patients underwent reperfusion. The incidence of combined outcomes (death or MI, and death, MI or Stroke) was also higher in patients without reperfusion therapy 6. Multivariate logistic regression analysis showed that age>75 years, hypertension, diabetes, reperfusion, aspirin, β-blocker, ACEI/ARB inhibitor use were associated independently with in-hospital mortality.
Conclusion
In the most tertiary hospitals in China the application of medications being proved effective by evidence-based medicine in clinical practice is better than that of the secondary hospitals, but there is a big gap between guidelines and current management of ST segment elevation ACS in China, and the application status in China could be further improved.
To analyse relationship between the concentration of serum uric acid and its risk factors of cardiovascular disease among population of healthy examination.
Methods
Totally 445 subjects were investigated during physical examination by recording genders and age, measuring height, weight, body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP), concentrations of serum uric acid (SUA), total cholesterol (TC), triglycerides (TG), serum high density lipoprotein cholesterol (HDL-C), serum low density lipoprotein cholesterol (LDL-C) and fasting blood glucose (FBG). The physical examination results were analysed with statistical method.
Results
The concentration of SUA was (309.30 ± 82.16) μmol/L in these population, The concentration of SUA was significantly higher in male than female [(340.20 ± 70.41) μmol/L vs. (231.93 ± 53.57) μmol/L, P < 0.01]. Multiple regression analysis showed significant correlation of serum uric acid level and TC, HDL-C, SBP and BMI (p < 0.01).
Conclusions
Concentration of SUA is high in population of healthy examination. High concentration of SUA is significantly correlated with cardiovascular risk factors.
To understand the relationship between hyperuricemia and cardiovascular disease risk factors in men.
Methods
40 cases with hyperuricemia (HUA) screened out from a company on-the-job personnel healthy medical information, and 60 cases with normal serum uric acid levels (NUA) were randomly selected from the same healthy medical information. Two groups of cardiovascular risk factors were compared with. After an accurate clinical examination and a biochemical evaluation,the results were analysed.
Results
Participants with hyperuricemia compared to those with normal serum uric acid levels had higher in SBP, DBP, TC, LDL- C and BMI (p < 0.05). Multiple regression analysis showed significant correlation of serum uric acid level and BMI, TC (p < 0.01 ).
Conclusions
Serum uric acid concentration are significantly association with cardiovascular disease (CVD) risk factors, and increase risk of CVD.
Objective
This study investigated the application value of waist-to-height ratio (WHtR), body mass index (BMI), and waist-to-hip ratio (WHR) in screening for type 2 diabetes mellitus (T2DM) and high risk of T2DM.
Methods
A total of 7 582 subjects aged 40-75 years were randomly selected and stratified based on the results of an oral glucose tolerance test (OGTT) administered during a standard screening for T2DM in the Shougang community. Three anthropometric indices (WHtR, BMI, and WHR) were compared, with the optimal cutoffs for WHtR, BMI, and WHR identified using receiver operating characteristic curve (ROC) analysis. Using multivariate logistic regression analysis and the area under the curve (AUC) of ROC, the associations between BMI, WHR, and WHtR and T2DM were analyzed by group: normal glucose tolerance group (n= 3 080), T2DM high-risk group (n= 2 992 cases), and T2DM group (n= 1 510).
Results
Logistic regression analysis showed that BMI, WHR, WHtR, and family history of diabetes were positively correlated with T2DM and high risk of T2DM (P<0.05 and P<0.01, respectively); WHtR was most significant, with odds ratios of 90.409 and 69.285, respectively. WHtR had the greatest AUC under the ROC in men, whereas BMI had the greatest AUC in women. The optimal cutoffs values for the detection of T2DM were 0.51, 25.47 kg/m2, and 0.91 for WHtR, BMI, and WHR in men, respectively, and 0.52, 24.95 kg/m2, and 0.86 for WHtR, BMI, and WHR in women, respectively. WHtR was more efficient than WHR and BMI based on the AUC. The optimal cutoff values for detecting a high risk for T2DM were 0.51, 25.30 kg/m2, and 0.91 for WHtR, BMI, and WHR in men and 0.51, 24.81 kg/m2, and 0.86 for WHtR, BMI, and WHR in women, respectively.
Conclusion
Waist-to-height ratio may be a more effective index for diagnosing type 2 diabetes mellitus and identifying individuals at high risk for T2DM than BMI or WHR.
Key words:
Diabetes mellitus, type 2; Body mass index; Waist-hip ratio; Waist-height ratio
To assess the safety of GP IIb/IIIa antagonists tirofiban in patients with ST elevation myocardial infarction (STEMI) during emergency Percutaneous Coronary Intervention (PCI).
Method
120 patients with STEMI during emergency PCI, divided into two groups, tirofiban+PCI group (n=60) and primary PCI group (n=60). The two groups are compared on their major adverse cardiovascular events (MACE) rates which consisted of death, new onset myocardial infarction, persistent myocardial ischeamic state, Cardiac function (1eft ventricular ejection fraction) after operation, compression haemostasia time and adverse drug effect while in hospital.
Result
Major adverse cardiovascular events (MACE) rates in tirofiban+PCI group was higher than that of primary PCI group (10% vs 6.7%); Postoperative heart function was better in tirofiban+PCI group than that in primary PCI group (56.97±8.41 vs 54.15±7.11): There was no difference in severe haemorrhage between the two groups.The bleeding event rates were of higher tendency in tirofiban+PCI group. (8.3% vs 3.3%). APTT and compression haemostasia time of tirofiban+PCI group were significant when prolonged (53.97±10.58 vs 32.51±6.31) p<0.05), but no more bleeding and heamatom events occurred during prolongation.
Conclusion
GPII b/III a antagonists tirofiban+PCI is a possible safe and effective reperfusion method with STEMI during emergency PCI.
Objective
To investigate changes in bone mineral density (BMD) and analyze its related factors in community populations to provide the early diagnosis of osteoporosis (OP) and give right guidance to prevent osteoporosis.
Methods
The quantitative ultrasound BMD analyzer was used to measure BMD of heel in 8 711 adults in community. At the same time a questionnaire survey was conducted among these subjects. The data were analyzed by Logistic stepwise regression analysis.
Results
With the age changing, males and females tended to have different BMD variation. Male and female's BMD peak values were respectively in 35-age group, 30-age group and decreased as age increased. T value of BMD was different between male and female (-1.40(-2.0- -0.7)vs -1.3(-2.0- -0.5))(P<0.001). Both men and women had a higher incidence of low bone mass (53.34% vs 47.46%), and the difference was significant (P<0.001), whereas the incidence of osteoporosis after 55 years of age between men and women was statistically significance (P<0.05). BMD was the lowest for female than for male in 50- age group, and the prevalence rate of OP was remarkably increased. Analysis of related factors of BMD showed that body mass index (BMI), age, diabetes and menopause were risk facts.
Conclusion
The BMD among adults is related to many factors, in which the age, BMI and menopause are the most important factors. Much attention should be paid to low bone mass phenomenon, timely monitoring, timely intervention, develop healthy working and living habits, is important to the prevention of osteoporosis and its complications.
Key words:
Osteoporosis; Bone density; Calcaneus
To study the relationship of physical exercise and chest pain recurrence of CAD, and if physical exercise could reduce rate of chest pain recurrence and improve quality of life.
Methods
64 hospitals across China mainland, involving 2401 patients, 50 out-patients with CAD in each hospital were included and standard questionnaires were used to get relative information on patients’ demographic, physical exercise, chest pain recurrence et al.
Results
It existed significant differences between exercise and chest pain recurrence.
Conclusions
Appropriate physical exercise could reduce rate of chest pain recurrence.
To analyse relationship between the concentration of serum uric acid and its risk factors of cardiovascular disease among population of healthy examination.
Methods
Totally 24 22 subjects were investigated during physical examination by recording genders and age, measuring height, weight, body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP), concentrations of serum uric acid (SUA), total cholesterol (TC), triglycerides (TG), serum high density lipoprotein cholesterol (HDL-C), serum low density lipoprotein cholesterol (LDL-C) and fasting blood glucose (FBG). We analysed the relationship of concentration of serum uric acid and its influencing factors.
Results
The concentration of SUA was (353.75 ± 76.07) μmol/L) in these population, The concentration of SUA was significantly higher in male than in female [(374.11 ± 70.81) μmol/L vs.(256.60 ± 52.44) μmol/L, P < 0.01]. Partial correlation analysis of cardiovascular risk factors with concentration of SUA after controlling for other risk factors. Among male there was a significantly positive correlativity among concentration of SUA and BMI (r’ = 0.193, P < 0.01), DBP (r’ = 0.043, P < 0.01), TG (r’ = 0.141, P < 0.01). Age (r’ = 0.202, P < 0.01), FBG (r’ = 0.071, P < 0.01) were significantly negative correlated with concentration of SUA. There was no correlativity between concentration of SUA and SBP. TC, LDL-C, HDL-C. Among female BMI (r’ = 0.212, P < 0.01)* and LDL-C (r’ = 0.142, P < 0.05) were significantly positively correlated with concentration of SUA, while the rest were no correlativity.
Conclusions
Concentration of SUA is high in population of healthy examination. High concentration of SUA is significantly correlated with multiple cardiovascular risk factors.
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