GW24-e3942 Correlation Analysis between Concentration of Serum Uric Acid and Risk Factors of Cardiovascular Disease in Population of Healthy Examination
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Abstract:
Objectives
To analyse relationship between the concentration of serum uric acid and its risk factors of cardiovascular disease among population of healthy examination.Methods
Totally 445 subjects were investigated during physical examination by recording genders and age, measuring height, weight, body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP), concentrations of serum uric acid (SUA), total cholesterol (TC), triglycerides (TG), serum high density lipoprotein cholesterol (HDL-C), serum low density lipoprotein cholesterol (LDL-C) and fasting blood glucose (FBG). The physical examination results were analysed with statistical method.Results
The concentration of SUA was (309.30 ± 82.16) μmol/L in these population, The concentration of SUA was significantly higher in male than female [(340.20 ± 70.41) μmol/L vs. (231.93 ± 53.57) μmol/L, P < 0.01]. Multiple regression analysis showed significant correlation of serum uric acid level and TC, HDL-C, SBP and BMI (p < 0.01).Conclusions
Concentration of SUA is high in population of healthy examination. High concentration of SUA is significantly correlated with cardiovascular risk factors.Keywords:
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The relationships of total cholesterol and the proportion of cholesterol in individual lipoprotein classes to coronary heart disease are complex. To help simplify these relationships, cholesterol values are often combined into one summary estimate to form a single risk factor with a relationship to disease that is more easily described. Although summary estimates result in convenient expressions relating cholesterols to coronary heart disease, there is the potential for sacrificing information by ignoring the joint configuration of cholesterols that make up these estimates. We investigated the extent of this possibility for the ratio of total cholesterol to high-density lipoprotein cholesterol and the ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol. The findings suggest that the summary estimates are useful expressions for combining cholesterol information and are strong predictors of coronary heart disease. Clinicians who choose to use a summary estimate for screening purposes should recognize that a single ratio estimate is not always as informative as the joint configuration of the cholesterols that make up the estimate. This possibility is most clearly exhibited for the ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol, and it may become more apparent in future studies as the capabilities of exploring lipoprotein cholesterol relationships improve.
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Plasma high density lipoprotein cholesterol (HDL-C) was evaluated in 15 rabbits fed cholesterol supplemented diets to assess its protective effect on the atherogenic process. From a baseline level of 29 +/- 11 mg/dl (mean +/- SD) the maximum attained for HDL-C was twofold in only three rabbits, whereas total cholesterol (TC) increased 20 fold. Plasma TC/HDL-C ratio rose 80 fold from the baseline (2.4 +/- 0.9) and it was the best parameter that correlated with aortic cholesterol accumulation and pathological scores. Aortic TC content increased 10 fold and free cholesterol/cholesterol esters ratio decreased 20 fold. Pathological studies showed that aortic lesion scores rose from 0 to 4. It can be concluded that the high correlations obtained when TC/HDL-C ratio was plotted against both aortic cholesterol deposition and lesion scores, support the theory of the reverse cholesterol transport and the effectiveness of this index to predict the degree of the atherogenic process. On the other hand, the poor response of HDL-C in this model encourages future research using drugs to increase this parameter in order to normalize TC/HDL-C ratio and avoid lesions.
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We studied the pathway of cholesterol efflux from fibroblasts by testing plasma samples from obese and lean subjects. Plasma samples were incubated with [3H]cholesterol-labeled human skin fibroblasts for 1 h to ensure uniform labeling of all of the high density lipoprotein (HDL) subfractions. Supernatants were then transferred to unlabeled cells and the displacement of labeled cholesterol within HDL subfractions by unlabeled cellular cholesterol was analyzed in short-term experiments. Plasma samples of obese subjects were characterized by a lower content of total apolipoprotein A-I (apoA-I) and α1-HDL and a lower overall capacity to take up labeled cholesterol. In plasma of lean subjects, preβ2-HDL and α1-HDL appeared to be the most active particles in the initial uptake of unlabeled cellular cholesterol. By contrast, in plasmas of obese subjects, the preβ1-HDL appeared to be most active in taking up unlabeled cellular cholesterol and transferring [3H]cholesterol. There were negative correlations between body mass index (BMI) and apoA-I and α1-HDL concentrations, and with the apparent increments of cellular cholesterol uptake within preβ2-HDL and α1-HDL, as well as with the overall capacity to promote cholesterol efflux. By contrast, BMI was positively correlated with the apparent increment in cellular cholesterol within preβ1-HDL. While cholesterol efflux was correlated with total plasma apoA-1, there were no such correlations with the concentration of any individual HDL subfraction. We conclude that the pattern of cholesterol transfer between fibroblasts and high density lipoprotein particles is influenced by body fatness and may be a factor in the abnormal metabolism of HDL in obesity.—Sasahara, T., P. Nestel, N. Fidge, and D. Sviridov. Cholesterol transport between cells and high density lipoprotein subfractions from obese and lean subjects.
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Journal Article Vitamin E Does Not Modify HDL-Cholesterol Get access Donald R. Howard, M.D., Donald R. Howard, M.D. Department of Pathology and Laboratory Medicine, Maine Medical Center, Portland, Maine Search for other works by this author on: Oxford Academic Google Scholar Clark A. Rundell, Ph.D., Clark A. Rundell, Ph.D. Department of Pathology and Laboratory Medicine, Maine Medical Center, Portland, Maine Search for other works by this author on: Oxford Academic Google Scholar John G. Batsakis, M.D. John G. Batsakis, M.D. Department of Pathology and Laboratory Medicine, Maine Medical Center, Portland, Maine Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 77, Issue 1, 1 January 1982, Pages 86–89, https://doi.org/10.1093/ajcp/77.1.86 Published: 01 January 1982 Article history Received: 09 June 1981 Accepted: 24 July 1981 Published: 01 January 1982
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Objective To explore the factors influencing blood lipids in urban schoolchildren. Methods There 257 schoolchildren aged 9～16 were randomly chosen in Pingdingshan City by multi-stage sampling. Blood pressure was measured. Fasting blood was collected to determine its total cholesterol(TC),triglyceride(TG),high-density lipoprotein high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C).The dietary status,behavior,sports-time and family history of the children were obtained. Results The blood concentrations (mmol/L) of total cholesterol(TC), triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C) were 3.51±0.77、0.96±0.32、1.76±0.62、1.15±0.24. The body mass index(BMI). Blood lipids was influenced by fat of body, waist-hip ratio,family history of blood lipid disease. Multiple regression analysis showed that the levels of total cholesterol (TC), triglyceride(TG), and low-density lipoprotein cholesterol(LDL-C) were positively correlated with body mass index(BMI) and the fat of body;but the level of high-density lipoprotein cholesterol(HDL-C) was negatively correlated with body mass index(BMI) and waist-hip ratio. Conclusion The factors of body mass index(BMI),the fat of body,waist-hip ratio,family history of blood lipids disease greatly influence blood lipids. Thus measures be taken to control abnomal blood lipids in children for prevention of cardiovascular disease at early stage.
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