Iciar Martı́nez

Umeå University

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Harkaitz Eguiraun

University of the Basque Country

Marit Aursand

Norwegian Institute of Marine Research

Ragnar L. Olsen

UiT The Arctic University of Norway

Ragni Ofstad

Nofima

Ricardo I. Pérez‐Martín

Instituto de Investigacións Mariñas

Inger Beate Standal

SINTEF

Mercedes Careche

Instituto de Ciencia y Tecnología de Alimentos y Nutrición

Carmen Piñeiro

Consejo Superior de Investigaciones Científicas

Karmele López de Ipiña

University of the Basque Country

Ingrid S. Gribbestad

St Olav's University Hospital

Cooperative Institutions

Nofima

SINTEF

Instituto de Investigacións Mariñas

Norwegian University of Science and Technology

UiT The Arctic University of Norway

Consejo Superior de Investigaciones Científicas

University of the Basque Country

Instituto de Investigacao das Pescas e do Mar

Ifremer

Karolinska Institutet

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Protein Signatures to Trace Seafood Contamination and Processing

Foods (2020)

Iciar Martı́nez Isabel Sánchez‐Alonso Carmen Piñeiro Mercedes Careche Mónica Carrera

This review presents some applications of proteomics and selected spectroscopic methods to validate certain aspects of seafood traceability. After a general introduction to traceability and the initial applications of proteomics to authenticate traceability information, it addresses the application of proteomics to trace seafood exposure to some increasingly abundant emergent health hazards with the potential to indicate the geographic/environmental origin, such as microplastics, triclosan and human medicinal and recreational drugs. Thereafter, it shows the application of vibrational spectroscopy (Fourier-Transform Infrared Spectroscopy (FTIR) and Fourier-Transform Raman Spectroscopy (FT Raman)) and Low Field Nuclear Magnetic Resonance (LF-NMR) relaxometry to discriminate frozen fish from thawed fish and to estimate the time and temperature history of frozen fillets by monitoring protein modifications induced by processing and storage. The review concludes indicating near future trends in the application of these techniques to ensure seafood safety and traceability.

Traceability

10.3390/foods9121751

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Citations (11)

Discrimination of contaminated fish responses by fractal dimension and entropy algorithms

Harkaitz Eguiraun Karmele López de Ipiña Iciar Martı́nez

The aim of the work was to develop a non-invasive methodology for image acquisition, processing and nonlinear trajectory analysis of the center of the fish group as a response to a stochastic event. Object detection and motion estimation were performed by an optical flow algorithm. The Fractal Dimension (FD) and the Entropy of the trajectory followed by the centroids of the groups of fish were calculated using Katz, Higuchi and Katz-Castiglionís FD and the Shannon Entropy algorithms respectively. The methodology was tested on three single cases European sea bass, two of which were similar (C1 control and C2 tagged fish) and very different from the third (C3, tagged fish in methylmercury contaminated water). Katz-Castiglioni and Shannon entropy were the most sensitive algorithms and proved to be promising tools for the non-invasive identification and quantification of differences in fish responses.

Approximate entropy

Centroid

10.1109/iwobi.2014.6913959

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Myosin isoforms in mackerel (Scomber scombrus) red and white muscles

FEBS Letters (1989)

Iciar Martı́nez R. L. Olsen Ragni Ofstad Chantal Janmot Anne d’Albis

Myosin extracts of red and white muscles from mackerel ( Scomber scombrus ) were analyzed by native electrophoresis to investigate the existence of myosin isoforms in both kind of muscles, and by two‐dimensional and SDS gel electrophoresis to study their subunit composition. Two isoforms were found in red muscle comprising one type of heavy chain and two light chains. Four isoforms were found in white muscle made up of one type of heavy chain and three types of light chains. The heavy chains from white muscle showed a higher electrophoretic mobility than that of red muscle in SDS‐PAGE. Both heavy chains had an intermediate mobility between those of slow and fast myosins from rat diaphragm.

Scomber

White (mutation)

10.1016/0014-5793(89)80891-9

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Citations (25)

Non-Linear Analyses of Fish Behaviours in Response to Aquatic Environmental Pollutants—A Review

Fishes (2023)

Harkaitz Eguiraun Iciar Martı́nez

Analysis of fish behaviour is an effective way to indirectly identify the presence of environmental pollutants that negatively affect fish life, its production and quality. Monitoring individual and collective behaviours produces large amounts of non-linear data that require tailor-suited computational methods to interpret and manage the information. Fractal dimension (FD) and entropy are two groups of such non-linear analysing methods that serve as indicators of the complexity (FD) and predictability (entropy) of the behaviours. Since behavioural complexity and predictability may be modulated by contaminants, the changes in its FD and entropy values have a clear potential to be embedded in a biological early warning system (BEWS), which may be particularly useful in Precision Fish Farming settings and to monitor wild populations. This work presents a review of the effects of a wide range of environmental contaminants, including toxic compounds, cleaning and disinfecting agents, stimulant (caffeine), anaesthetics and antibiotics, heavy metals (lead, cupper, and mercury), selenium, pesticides and persistent environmental pollutants, on the FD and entropy values of collective and individual behavioural responses of different fish species. All the revised studies demonstrate the usefulness of both FD and entropy to indicate the presence of pollutants and underline the need to consider early changes in the trend of the evolution of their values prior to them becoming significantly different from the control values, i.e., while it is still possible to identify the contaminant and preserve the health and integrity of the fish.

Predictability

10.3390/fishes8060311

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HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma.

bioRxiv (Cold Spring Harbor Laboratory) (2024)

Juan Yuan Subhamita Maitra Eirini Antoniou Jiacheng Zhu Wenyu Li

The role of HIF2α, encoded by EPAS1, in neuroblastoma remains controversial. Here we demonstrate that induction of high levels of HIF2α in MYCN-amplified neuroblastoma cells results in a rapid and profound reduction of the oncoprotein MYCN. This is followed by an upregulation of genes characteristic of noradrenergic cells in the adrenal medulla. Additionally, upon induction of HIF2α, the proliferation rate drops substantially, and cells develop elongated neurite-like protrusions, indicative of differentiation. In vivo HIF2α induction in established xenografts significantly attenuates tumour growth. Notably, analysis of sequenced neuroblastoma patient samples, revealed a negative correlation between EPAS1 and MYCN expression and a strong positive correlation between EPAS1 expression, high expression levels of noradrenergic markers, and improved patient outcome. This was paralleled by analysis of human adrenal medulla datasets wherein EPAS1 expression was prominent in populations with high expression levels of genes characteristic of noradrenergic chromaffin cells. Our findings show that high levels of HIF2α in neuroblastoma, leads to drastically reduced MYCN protein levels, cell cycle exit, and noradrenergic cell differentiation. Taken together, our results challenge the dogma that HIF2α acts as an oncogene in neuroblastoma and rather suggest that HIF2α has potential tumour suppressor capacity in this particular disease.

10.1101/2024.11.20.624001

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Myosin heavy chain degradation during post mortem storage of Atlantic cod (Gadus morhua L.)

Food Chemistry (2009)

Pål Anders Wang Iciar Martı́nez Ragnar L. Olsen

Myofibril

Protein Degradation

Cathepsin L

10.1016/j.foodchem.2009.01.031

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Citations (30)

Myosin isoforms in red and white muscles of some marine teleost fishes

Journal of Muscle Research and Cell Motility (1990)

Iciar Martı́nez Ragni Ofstad R. L. Olsen

Haddock

Mallotus

White (mutation)

Marine fish

10.1007/bf01745216

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Citations (20)

Eliminación de compuestos organoclorados para potabilización de aguas

Iciar Martı́nez

Los compuestos organoclorados constituyen un grave problema en la contaminacion de nuestros recursos hidricos. El uso de estos compuestos esta muy extendido y en algunos casos su sustitucion es dificil. Dentro de este tipo de compuestos se encuentran los plaguicidas cuya concentracion en aguas potables se encuentra limitada por la legislacion. Los plaguicidas se clasifican como sustancias toxicas y se establece que la concentracion maxima admisible es 0,0001 mg/L por sustancia individualizada. Este trabajo de investigacion tiene como objeto de estudio la eliminacion en agua de dos plaguicidas tomados como modelo, lindano y alacloro, mediante los procesos de oxidacion humeda y oxidacion en agua supercritica. Desde los anos ochenta se ha venido desarrollando la oxidacion en agua supercritica. Esta tecnologia para destruir contaminantes aprovecha las propiedades que presenta el agua en condiciones de presion y temperatura por encima de su punto critico (221 bar y 374oC). Es un tratamiento adecuado para aguas residuales con alto contenido organico y con compuestos refractorios. Constituye una alternativa a otros procesos como la incineracion. Cuando se emplean condiciones de operacion situadas por debajo del punto critico, el proceso se conoce como oxidacion humeda. Para la obtencion de los datos experimentales se utilizo una instalacion a nivel de planta piloto, que operaba en continuo y que podia trabajar hasta presiones de 300 bar y temperaturas de 550oC. Se realizaron una serie de modificaciones en las instalacion experimental con un objetivo fundamental: mantener constante la temperatura en la zona de reaccion y adecuar la instalacion para el estudio cinetico. Tanto en codniciones subcriticas como supercriticas, se vario el tiempo de residencia en el reactor que es funcion del volumen del reactor, del caudal de agua de alimentacion, asi como de las condiciones de operacion. Se estudi

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LOW MOLECULAR WEIGHT METABOLITES IN WHITE MUSCLE FROM COD (GADUS MORHUA) AND HADDOCK (MELANOGRAMMUS AEGLEFINUS) ANALYZED BY HIGH RESOLUTION 1H NMR SPECTROSCOPY

Inger Beate Standal Ingrid S. Gribbestad Tone F. Bathen Marit Aursand Iciar Martı́nez

LOW MOLECULAR WEIGHT METABOLITES IN WHITE MUSCLE FROM COD (GADUS MORHUA) AND HADDOCK (MELANOGRAMMUS AEGLEFINUS) ANALYZED BY HIGH RESOLUTION 1H NMR SPECTROSCOPY

Haddock

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The role of environmental biotechnology in exploring, exploiting, monitoring, preserving, protecting and decontaminating the marine environment

New Biotechnology (2014)

Nicolas Kalogerakis Johanne Arff İbrahim M. Banat Ole Jacob Broch Daniele Daffonchio

Directive

Marine conservation

10.1016/j.nbt.2014.03.007

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Citations (52)