To make a clinical evaluation of patients with squamous carcinoma of the oral cavity.The clinical condition of 72 patients with squamous carcinoma of the mouth, hospitalized at the Institute of Oral and Maxillo-Facial Surgery, 2nd University of Naples, Italy, between 1992 and 1996, were examined. The patients were evaluated system by system, staged by TNM-UICC and classified by ASA and by the Karnofsky and Burchenal and the Zubrod et al. Performance status methods.Evaluation by the two methods produced different results. Of the patients examined, 34.5% showed more than one systemic disorder. 51.4% were in ASA classes 3-4.The presence of a disease with poor prognosis associated with advanced neoplastic stage (stages III-IV; 69.4% of the total) precluded radical surgery in 32% of patients, who were treated with chemotherapy and/or radiotherapy.
The proto-oncogene c-Met has been suggested to be associated with progression of squamous cell carcinoma of the head and neck. The aims of the present study were to assess the prevalence of c-Met expression in oral squamous cell carcinoma (OSCC) and to verify whether c-Met can be considered a marker of prognosis in these patients. In a retrospective study, a cohort of 84 OSCC patients was investigated for c-Met expression and its cellular localization by immunohistochemistry. After grouping for c-Met expression, OSCC patients were statistically analyzed for the variables age, gender, histological grading, tumor node metastasis, staging and overall survival rate. Univariate and multivariate statistics were used for data analysis. Sixty-nine cases (82.2%) of OSCC showed immunopositivity, with a mainly membranous expression and scattered areas also showing a cytoplasmic localization, whereas 15 cases (17.8%) did not show c-Met. No statistical association was found between c-Met expression and any variables considered at baseline, apart from the higher number of c-Met positivity in females (p = 0.026). Among positive tumors, well-differentiated areas showed low or absent cytoplasmic expression, while low-differentiated areas showed both membranous and cytoplasmic positivity. In terms of prognostic significance, c-Met expression was found to have an independent association with a poorer overall survival rate (p = 0.036). On the basis of these results, it is possible to suggest c-Met as an early marker of poor prognosis, a hallmark of aggressive biological behavior in OSCC, suggested to be useful in identifying cases of OSCC before the relapse.
Among the various cases of etherotophy, the only and multiple, that has observed, the Authors consider only a few among the significant ones and with endosinusal localization-after examining the probable mechanism patogenetic we pay attention to the necessity of an exact diagnostic judgement and on the opportunity of a precocious and exact treatment.
The aim of the present study was to investigate the diagnostic and prognostic potential of proteomic signatures in saliva of patients with oral squamous cell carcinoma (OSCC).Data from SELDI-TOF mass spectrometry of saliva from 45 OSCC patients and 30 healthy controls were analyzed by means of univariate and multivariate statistical approaches, in order to identify proteomic OSCC signatures, reduce dimensionality and build models for discriminating between OSCC and controls, as well as predict nodal status.The saliva proteome presents significant modifications in OSCC patients; some of them seem to be related to nodal involvement, and may be useful for knowledge advancement regarding oral carcinogenesis and definition of diagnostic and prognostic biomarkers. Our attempt to create a predictive model using different artificial neural networks (i.e. feed-forward (FF), radial basis function (RBF), vector quantization (VQ)) demonstrated that such biostatistical tools are powerful but not all network architectures have similar performance. RBF architecture showed the best diagnostic performance (91.89%), whereas FF had the best (77.27%) prognostic accuracy (distinguishing between N(-) and N(+)).Searching for potential biomarkers among differently expressed peptides is a challenge requiring for appropriate strategies that still remain to be defined. A number of factors may potentially impair results, e.g.: (i) a group's definition for adequate comparison; (ii) reduction of data dimensionality and selection of variables to be tested in predictive models; (iii) selection of the biostatistical tool for predictive models.
A rare case of primary malignant melanoma of the oral cavity is reported and a literature review of etiopathogenesis, biological bases and prognosis is made. The hypotheses to explain the very severe prognosis of malignant melanoma of the oral cavity with respect to that of skin are discussed. The therapeutic approaches are described as well as the frequent difficulty to perform them in relation to the anatomical region and the wide extension of the tumoral lesion.
'/%3e%3c/defs%3e%3cpath fill='%23012169' d='M0 0h10080v5040H0z'/%3e%3cpath stroke='%23fff' stroke-width='.6' d='m0 0 6 3m0-3L0 3' clip-path='url(%23b)' transform='scale(840)'/%3e%3cpath stroke='%23e4002b' stroke-width='.4' d='m0 0 6 3m0-3L0 3' clip-path='url(%23c)' transform='scale(840)'/%3e%3cpath stroke='%23fff' stroke-width='840' d='M2520 0v2520M0 1260h5040'/%3e%3cpath stroke='%23e4002b' stroke-width='504' d='M2520 0v2520M0 1260h5040'/%3e%3cg fill='%23fff'%3e%3cuse xlink:href='%23d' x='2520' y='3780'/%3e%3cuse xlink:href='%23a' x='7560' y='4200'/%3e%3cuse xlink:href='%23a' x='6300' y='2205'/%3e%3cuse xlink:href='%23a' x='7560' y='840'/%3e%3cuse xlink:href='%23a' x='8680' y='1869'/%3e%3cuse xlink:href='%23e' x='8064' y='2730'/%3e%3c/g%3e%3c/svg%3e)