Background.Diabetes mellitus is a growing global health challenge and affects patients of all ages.Treatment aims to keep blood glucose levels close to normal and to prevent or delay complications.However, adherence to antidiabetic medicines is often unsatisfactory. Purpose. Here, we established and internally validated a medication nonadherence risk nomogram for use in Chinese type 2 diabetes mellitus (T2DM) patients.Methods.This cross-sectional study was carried out from July -December 2020 on randomly selected T2DM patients visiting a diabetes clinic and included 753 participants.Adherence was analyzed based on an 8-item Morisky Medication Adherence Scale (MMAS-8).Other data, including patient demographics, treatment, complications, and comorbidities were also collected on questionnaires.Optimization of feature selection to develop the medication nonadherence risk model was achieved using the least absolute shrinkage and selection operator regression model (LASSO).A prediction model comprising features selected from LASSO model was designed by applying multivariable logistic regression analysis.The decision curve analysis, calibration plot, and C-index were utilized to assess the performance of the model in terms of discrimination, calibration, and clinical usefulness.Bootstrapping validation was applied for internal validation.Results.The prediction nomogram comprised several factors including sex, marital status, education level, employment, distance, self-monitoringofbloodglucose, disease duration, and dosing frequency of daily hypoglycemics (pills, insulin, or glucagon-like peptide-1).The model exhibited good calibration and good discrimination (C-index = 0.79, 95% confidence interval: 0.75-0.83).In the validation samples, a high C-index (0.75) was achieved.Results of the decision curve analysis revealed that the nonadherence nomogram could be applied in clinical practice in cases where the intervention is decided at a nonadherence possibility threshold of 12%.Conclusion.The number of patients who adhere to anti-diabetes
Abstract After the colonial invasion of East Asia, numerous Koreans, Vietnamese, and Japanese went to China and began a long anticolonial struggle. During this period, they chose to write and communicate in a fourth language, Baihua 白話, for anticolonial purposes. While writing in Baihua, they brought the grammar and word order of their mother tongues into Baihua, creating “Korean-style vernacular Chinese,” “Japanese-style vernacular Chinese,” and “Vietnamese-style vernacular Chinese.” The emergence of these hybridized Baihuas is related to the anticolonialists’ cooperation with the Kuomintang government, the oppression of the Kuomintang government, and the authority of Literary Sinitic and Baihua. As a form of subversion of and resistance to the authority of Literary Sinitic and Baihua, the hybrid Baihuas thus constructed served as an anticolonial third space.
This paper studies the existence of a kind of general Logistic population which live in a large capacity and polluted environment with capture by comparability principle. It gives the conditions for β - extinction、 β - persistence and extinction in finite time, and the maximal harvesting rate when the population is β - persistence is obtained.
In this paper,we construct an excellent balanced multiwavelet and apply it to Image compression technology.we use multiwavelet theory and the mathematical balanced multiwavelet theory to construct a balanced multiwavelet based on the CL multiwavelet(BMW-CLB),which has more advantages than other single-wavelets and multiwavelets on image compression ratio.
Objective: To evaluate systematically the effectiveness and safety of treatment of type 2 diabetes with huangqi injection.Method: Reviewing the literatures of random case control test on type 2 diabetes treatment with huangqi injection selecting eligible research,taking quality assessment with Jadad appraisement,analyzing related data with heterogeneity test,Meta-analysis,funnel plots,sensitivity analysis methods.Result: 4 research issues were in accordance with these criteria and either was 1 by Jadad assessment and low quality.Overall effective rate comparison RR(99%CI) of huangqi injection according to symptoms to treat type 2 diabetes equaled 1.58(1.20,2.09).Conclusion: Meta-analysis show that modified huangqi injection according to symptoms diabetes is safe and effective for type 2 diabetes.The factors such as low quality eligible studies reduced the reliability and the validity.The evidence is not very abundant to prove the safety and the availability of treatment of type 2 diabetes with huangqi injection.
Objectives:To investigate the regulative effects of the Jingui Shenqi bolus(JGSQB) on glucocorticoid receptor(GR),β-defensin-2(BD-2) and their mRNA expressions in the airway epithelial cells and lung tissues of mice with renal-yang asthenia(RYA).Methods:The RYA mice were induced by giving adenine intragestrically,as well as adding the JGSQB in the JGSQB group.The GR,BD-2 and their mRNA expressions were detected respectively by immunohistochemistry and in situ hybridization.Results:Compared with the NS group,the GR and mRNA expressions were down-regulated(P0.05),and the BD-2 and mRNA were up-regulated(P0.05) in the airway epithelial cells and lung tissues with inflammation change in the RYA mice.Compared with the RYA group,the GR and its mRNA expression were up-regulated with inflammation decrease(P0.05),and no effects on the BD-2 and its mRNA(P 0.05)in the airway epithelial cells and lung tissues in the JGSQB mice.Conclusion:JGSQB could up-regulate GR and mRNA expressions and inhibit the inflammation,these may be the molecular mechanism of the JGSQB to treat RYA syndrome.
'/%3e%3cuse xlink:href='%23a' transform='rotate(23.036 .093 25.536)'/%3e%3cuse xlink:href='%23a' transform='rotate(45.87 1.273 16.18)'/%3e%3cuse xlink:href='%23a' transform='rotate(69.945 .996 12.078)'/%3e%3cuse xlink:href='%23a' transform='rotate(20.66 -19.689 31.932)'/%3e%3c/svg%3e)