ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelectivity of action of alkylating agents and drug resistance. 4. Synthesis of tritium-labeled chlorambucil and a study of its cellular uptake by drug-sensitive and drug-resistant strains of the Yoshida ascites sarcoma in vitroBridget T. Hill, Michael Jarman, and Kenneth R. HarrapCite this: J. Med. Chem. 1971, 14, 7, 614–618Publication Date (Print):July 1, 1971Publication History Published online1 May 2002Published inissue 1 July 1971https://pubs.acs.org/doi/10.1021/jm00289a012https://doi.org/10.1021/jm00289a012research-articleACS PublicationsRequest reuse permissionsArticle Views92Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Chlorambucil

Drug action

Mechanism of Action

10.1021/jm00289a012

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An Intercomparison of in Vitro Assays for Assessing Cytotoxicity after a 24 Hour Exposure to Anti-Cancer Drugs

Tumori Journal (1983)

H. Thomas Rupniak Lorraine Y. Dennis Bridget T. Hill

Employing a tumourigenic mouse cell line, we have measured the effects of four anti-cancer drugs (methotrexate, vincristine, cis-platinum and adriamycin) upon tumour cell survival as assessed by three independent procedures. The results from two short-term procedures based upon dye exclusion and labeling index determinations were compared with data from the relatively long-term clonogenic or colony-forming assay. The dye exclusion procedure demonstrated the poorest correlation with the clonogenic assay, whereas labeling index measurements exhibited qualitative but not quantitative correspondence with results from the clonogenic assay. These short-term procedures cannot therefore be considered accurate sbustitutes for a clonogenic assay, which remains the method of choice for assessing cytotoxic effects of anti-cancer drugs.

Clonogenic assay

10.1177/030089168306900106

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Preclinical antitumour activity of F 11782, a novel dual catalytic inhibitor of topoisomerases

British Journal of Cancer (2000)

Anna Kruczynski Chantal Etiévant Dominique Perrin Thierry Imbert Françis C. Colpaert

F 11782 is a novel inhibitor of topoisomerases I and II, with an original mechanism of action (Perrin et al, 2000). This study, aimed to define its anticancer efficacy against a series of murine and human tumour models, has provided evidence of major antitumour activity for F 11782. This was demonstrated as a high level of activity against the P388 leukaemia, as reflected by increased survival of 143–457%, when administered i.p., p.o. or i.v. as single or multiple doses, and proved consistently superior to etoposide or camptothecin tested concurrently. Single or multiple i.p. doses of F 11782 also proved highly active against the s.c. grafted B16 melanoma, significantly increasing survival (P < 0.001) and inhibiting tumour growth (T/C of 0.3%), again superior to etoposide tested concurrently. Furthermore, F 11782 inhibited the number of pulmonary metastatic foci of the B16F10 melanoma by 99%. In human tumour xenograft studies, multiple i.p. doses of F 11782 resulted in major inhibitory activity against MX-1 (breast) tumours (T/C of 0.1%), as well as causing definite tumour regressions, whereas none resulted from similar experimental treatments with etoposide. Significant activity was also recorded with F 11782 against the relatively refractory LX-1 (lung) xenografts, with an optimal T/C value of 19%. It was notable that the antitumour activity of F 11782 was consistently demonstrated over a wide range of 2–6 dose levels, providing evidence of its good overall tolerance. In conclusion, these results emphasize the preclinical interest of this novel molecule and support its further preclinical development. © 2000 Cancer Research Campaign http://www.bjcancer.com

Camptothecin

10.1054/bjoc.2000.1428

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Expression of drug resistance in Chinese hamster ovary (CHO) cells following X-ray pre-treatment in vitro.

Biochemical Society Transactions (1991)

Siobhán McClean Richard D. H. Whelan Louise K. Hosking Bridget T. Hill

Conference Article| August 01 1991 Expression of drug resistance in Chinese hamster ovary (CHO) cells following X-ray pre-treatment in vitro. SIOBHAN McCLEAN; SIOBHAN McCLEAN 1Laboratory of Cellular Chemotherapy, Imperial Cancer Research Fund, P.O. Box 123, Lincoln's Inn Fields, London, WC2A 3PX, U.K. Search for other works by this author on: This Site PubMed Google Scholar RICHARD D. H. WHELAN; RICHARD D. H. WHELAN 1Laboratory of Cellular Chemotherapy, Imperial Cancer Research Fund, P.O. Box 123, Lincoln's Inn Fields, London, WC2A 3PX, U.K. Search for other works by this author on: This Site PubMed Google Scholar LOUISE K. HOSKING; LOUISE K. HOSKING 1Laboratory of Cellular Chemotherapy, Imperial Cancer Research Fund, P.O. Box 123, Lincoln's Inn Fields, London, WC2A 3PX, U.K. Search for other works by this author on: This Site PubMed Google Scholar BRIDGET T. HILL BRIDGET T. HILL 1Laboratory of Cellular Chemotherapy, Imperial Cancer Research Fund, P.O. Box 123, Lincoln's Inn Fields, London, WC2A 3PX, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1991 Biochemical Society1991 Biochem Soc Trans (1991) 19 (3): 278S. https://doi.org/10.1042/bst019278s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation SIOBHAN McCLEAN, RICHARD D. H. WHELAN, LOUISE K. HOSKING, BRIDGET T. HILL; Expression of drug resistance in Chinese hamster ovary (CHO) cells following X-ray pre-treatment in vitro.. Biochem Soc Trans 1 August 1991; 19 (3): 278S. doi: https://doi.org/10.1042/bst019278s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1991 Biochemical Society1991 Article PDF first page preview Close Modal You do not currently have access to this content.

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10.1042/bst019278s

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The cell cycle and its significance for cancer treatment

Cancer Treatment Reviews (1975)

Bridget T. Hill Renato Baserga

Clonogenic assay

Cancer Therapy

10.1016/s0305-7372(75)80001-6

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Citations (104)