Ian D. Sullivan

Great Ormond Street Hospital for Children NHS Foundation Trust

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John Deanfield

University College London

Catherine Bull

Murdoch Children's Research Institute

Marc R. de Leval

Great Ormond Street Hospital

Robert H. Anderson

Newcastle University

Victor Tsang

University College London

E Sowton

Guy's Hospital

Charles H. Rodeck

University College London

Martin J. Elliott

Leeds General Infirmary

Kate Brown

Great Ormond Street Hospital for Children NHS Foundation Trust

Michael Burch

Great Ormond Street Hospital

Cooperative Institutions

University College London

Great Ormond Street Hospital

Hospital for Sick Children

Great Ormond Street Hospital for Children NHS Foundation Trust

Royal Brompton Hospital

National Health Service

SickKids Foundation

University College Hospital

Imperial College London

Royal Hospital for Children

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Heart transplantation in an infant with rhabdomyoma

Pediatric Cardiology (1995)

Marcin Demkow Kasper Sørensen B. Whitehead Philip Rees Ian D. Sullivan

Rhabdomyoma

Vascular surgery

10.1007/bf00794197

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Citations (14)

Late anthracycline cardiotoxicity after childhood cancer

Cancer (2003)

Keld E. Sørensen Gill Levitt Catherine Bull I Dørup Ian D. Sullivan

Abstract BACKGROUND The objective of the current study was to examine the risk factors for progression in severity of anthracycline‐induced cardiac dysfunction, thereby providing information that is useful in refining cancer treatment regimes and guiding follow‐up. METHODS Serial echocardiograms were performed on 101 acute lymphoblastic leukemia survivors and 83 Wilms tumor survivors after a mean interval of 6.2 years and 6.7 years since last anthracycline dose, respectively, at first study, and after 10.3 years and 11.1 years, respectively, at second study. The paired data were contrasted with data from 100 normal subjects, and potential correlations with follow‐up interval, cumulative dose, cancer diagnosis, gender, age at diagnosis, and growth were explored using univariate and multiple regression techniques. RESULTS The most important predictor of worsening cardiac performance was total anthracycline dose. As a group, patients receiving < 240 mg/m 2 showed no deterioration of left ventricular end systolic stress at > 10 years from the end of treatment. CONCLUSIONS Survivors who have received low‐dose anthracycline require cardiac surveillance infrequently. In good prognosis tumors, cumulative anthracycline dose should be maintained at < 250 mg/m 2 . Cancer 2003;97:1991–8. © 2003 American Cancer Society. DOI 10.1002/cncr.11274

Cardiotoxicity

Cumulative dose

Univariate analysis

10.1002/cncr.11274

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Citations (215)

Real-time three-dimensional fetal echocardiography - optimal imaging windows

Ultrasound in Medicine & Biology (2002)

Jing Deng Ian D. Sullivan Robert Yates Michael Vogel D. McDonald

Cardiac Ultrasound

Fetal echocardiography

10.1016/s0301-5629(02)00560-4

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Citations (45)

Investigation of vascular compression of the trachea: the complementary roles of barium swallow and echocardiography.

Archives of Disease in Childhood (1993)

Michael Burch Seshadri Balaji John Deanfield Ian D. Sullivan

To determine the preferred investigation of congenital vascular compression of the trachea, preoperative investigation in 40 patients undergoing surgery 1981-91 was analysed. The importance of preoperative identification of detailed arterial anatomy in determining surgical technique was also assessed in 122 consecutive patients undergoing surgery 1952-91. Of the 40 patients (median age 5 months) seen 1981-91, barium swallow before referral suggested the diagnosis of vascular compression in 26 of 27 (96%). Angiography (1/3), bronchoscopy (0/6), and echocardiography (2/6) were generally unhelpful in diagnosing vascular compression before referral. Echocardiography was performed after referral in 18 consecutive patients since 1986 and the correct arterial anatomy was identified in 16 (88%); hyperinflation resulted in inadequate images in the two others. Barium swallow is the investigation of choice to screen for suspected vascular compression of the trachea; echocardiography at the referral centre can define the arterial anatomy in nearly all patients. Further investigation can be reserved for selected cases.

10.1136/adc.68.2.171

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Citations (21)

Interventional treatments and risk factors in patients born with hypoplastic left heart syndrome in England and Wales from 2000 to 2015

Heart (2018)

Libby Rogers Christina Pagel Ian D. Sullivan Muhammad Mustafa Victor Tsang

To describe the long-term outcomes, treatment pathways and risk factors for patients diagnosed with hypoplastic left heart syndrome (HLHS) in England and Wales.The UK's national audit database captures every procedure undertaken for congenital heart disease and updated life status for resident patients in England and Wales. Patients with HLHS born between 2000 and 2015 were identified using codes from the International Paediatric and Congenital Cardiac Code.There were 976 patients with HLHS. Of these, 9.6% had a prepathway intervention, 89.5% underwent a traditional pathway of staged palliation and 6.4% of infants underwent a hybrid pathway. Patients undergoing prepathway procedures or the hybrid pathway were more complex, exhibiting higher rates of prematurity and acquired comorbidity. Prepathway intervention was associated with the highest in-hospital mortality (34.0%).44.6% of patients had an off-pathway procedure after their primary procedure, most frequently stenting or dilation of residual or recoarctation and most commonly occurring between stage 1 and stage 2.The survival rate at 1 year and 5 years was 60.7% (95% CI 57.5 to 63.7) and 56.3% (95% CI 53.0 to 59.5), respectively. Patients with an antenatal diagnosis (multivariable HR (MHR) 1.63 (95% CI 1.12 to 2.38)), low weight (<2.5 kg) (MHR 1.49 (95% CI 1.05 to 2.11)) or the presence of an acquired comorbidity (MHR 2.04 (95% CI 1.30 to 3.19)) were less likely to survive.Treatment pathways among patients with HLHS are complex and variable. It is essential that the long-term outcomes of conditions like HLHS that require serial interventions are studied to provide a fuller picture and to inform quality assurance and improvement.

10.1136/heartjnl-2017-312448

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Citations (28)

Temporary iatrogenic fetal tricuspid valve atresia in a case of twin to twin transfusion syndrome.

Heart (1994)

Kurt Hecher Ian D. Sullivan K. H. Nicolaides

This report describes the sequence of events in the development and subsequent spontaneous resolution of functional tricuspid valve atresia in the donor fetus in a case of twin to twin transfusion syndrome. Fetoscopic laser coagulation of the placental anastomoses was performed at 20 weeks' gestation. Subsequently, there was evidence of increased placental vascular resistance in the donor twin and major impairment of right ventricular function with no forward flow through the tricuspid valve. During the next four weeks, however, there was spontaneous and complete recovery of ventricular function and resolution of the functional tricuspid valve atresia. These findings suggest that alterations in fetal haemodynamics may result in structural cardiac abnormality and may be the precursors of some forms of congenital heart disease.

Tricuspid atresia

10.1136/hrt.72.5.457

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Citations (11)

Outcome after preterm delivery of infants antenatally diagnosed with congenital heart disease

The Journal of Pediatrics (2006)

Rachel Andrews John Simpson Gurleen Sharland Ian D. Sullivan Robert Yates

Fetal echocardiography

10.1016/j.jpeds.2005.10.034

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Citations (57)

Interventional catheterization in congenital heart disease

Current Opinion in Cardiology (1987)

Ian D. Sullivan

Cardiac catheterization

10.1097/00001573-198701010-00024

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Citations (0)

Late ventricular arrhythmia is rare after early repair of tetralogy of Fallot

Journal of the American College of Cardiology (1994)

H S Joffe Dimitri Georgakopoulos David S. Celermajer Ian D. Sullivan John Deanfield

Sudden Death

Cardiac arrhythmia

10.1016/0735-1097(94)90603-3

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Citations (49)

Comparative trial of iohexol 350, a non-ionic contrast medium, with diatrizoate (Urografin 370) in left ventriculography and coronary arteriography.

Heart (1984)

Ian D. Sullivan R J Wainwright John Reidy E Sowton

In a prospective double blind randomised study in 25 consecutive patients a conventional ionic contrast medium (Urografin 370) was compared with the new non-ionic medium iohexol 350 ( Omnipaque ) in left ventriculography and coronary arteriography. In left ventriculography there was a clear patient preference for iohexol by both a visual analogue scale and independent observer assessment. Iohexol also induced a smaller increase in heart rate or decrease in systolic blood pressure than Urografin. In coronary arteriography iohexol resulted in a smaller reduction in heart rate and systolic blood pressure, a smaller maximum increase in RR interval, less prolongation of the PQ and QT intervals and QRS duration, and a lower incidence of induced chest pain, ST segment depression, or T wave deflection.

Iohexol

Diatrizoate Meglumine

10.1136/hrt.51.6.643

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Citations (24)