A NEPHROPATHY manifested by hyperuricemia, azotemia, oliguria and occasionally complete anuria has been described as a complication during therapy of neoplasms of the hematopoietic system.1 2 3 The syndrome is assumed to result from intrarenal or extrarenal urinary obstruction by uric acid crystals. Awareness of this complication is prevalent although reports of its occurrence in children are seldom found in the literature.1 , 4 Prevention of this nephropathy depends upon recognition of the conditions under which it occurs so that adequate measures may be promptly taken to increase the solubility of uric acid in the urine. The administration of large quantities of fluid and . . .
Interferon-alpha is the only approved and effective treatment for hepatitis C. Psychiatric side effects are common and have frequently required a decrease in dose or discontinuation of therapy. We here report a case of interferon-alpha-induced depression in a 40-yr-old man with hepatitis C successfully treated with the antidepressant fluoxetine, which allowed completion of interferon treatment.
Abstract 3-Phosphoglycerate dehydrogenase, phosphoserine phosphatase, d-glycerate dehydrogenase, and serine dehydratase have been measured in rats fet diets containing variable amounts of protein. Rats fed 2% casein diets for 7 days had a marked increase in 3-P-glycerate dehydrogenase and P-serine phosphatase and a simultaneous decline in serine dehydratase when compared to rats fed chow or a 25% casein diet. The increased enzyme levels were prevented by the addition of 1% cysteine to the 2% casein diet but this did not alter the decline in serine dehydratase. On 88% casein diets a depression of 3-P-glycerate dehydrogenase and P-serine phosphatase resulted, while prompt increase in serine dehydratase occurred. No reproducible changes in d-glycerate dehydrogenase occurred on any of the diets studied. The administration of actinomycin D on several schedules consistently caused an inhibition of the changes noted with the 2% casein diet. These observations plus studies with cycloheximide suggest that the observed alterations in enzyme concentrations may be mediated by altered rates of enzyme synthesis. Studies of potential feedback inhibitors of the reactions measured were negative for 3-P-glycerate dehydrogenase and d-glycerate dehydrogenase. Inhibition of P-serine phosphatase by l-serine may have physiological significance in mammals. The inhibition of serine dehydratase by l-cysteine is described.
Article15 June 1992Residency Reform: A Perspective from the Association of Professors of MedicineHarold J. Fallon, MDHarold J. Fallon, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-12-1041 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptProfound changes in the science and practice of medicine have occurred during the past decade. Simultaneously, external factors have dramatically altered the conduct and location of patient care and the financial stability of academic health centers. These changes have diminished the relevance of a residency curriculum developed for an era of less specialization, less sophisticated medical technology, and a different health care delivery system. Virtually all constituencies in internal medicine have affirmed the need for fundamental changes in the curriculum to educate internists better in the science and technology of medicine and in how internists can provide efficient and effective... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Harold J. Fallon, MDAffiliations: Medical College of Virginia Richmond, VA 23298-0500 Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAssociations between subspecialty fellowship interest and knowledge of internal medicine: A hypothesis-generating study of internal medicine residentsRedesigning Residency Education in Internal Medicine: A Position Paper from the Association of Program Directors in Internal MedicineJohn P. Fitzgibbons, MD, Donald R. Bordley, MD, Lee R. Berkowitz, MD, Beth W. Miller, MD, and Mark C. Henderson, MDReforming internal medicine residency trainingConfidence of academic general internists and family physicians to teach ambulatory proceduresWhat is the cost of ambulatory education?The experiential curriculum: an alternate model for anaesthesia educationTime analysis of a general medicine serviceThe case history in historical perspectiveThe Economics of Survival for Academic Psychiatry 15 June 1992Volume 116, Issue 12_Part_2 Page: 1041-1041 Keywords Health care Mean corpuscular volume Patients Residency ePublished: 1 December 2008 Issue Published: 15 June 1992 PDF downloadLoading ...
The effect of acute and chronic ethanol intake on hepatic glycerolipid biosynthesis in the hamster was studied by in vivo and in vitro techniques. The results were compared with those from control hamsters receiving isocaloric amounts of glucose. Both chronic and acute ethanol intake elevated serum and hepatic triglyceride concentrations and induced a rapid rise in the capacity of neutral glycerolipid formation from sn[1,3-14C]glycerol-3-phosphate by hamster liver homogenate and microsomal fractions. Ethanol intake also produced a corresponding increase in the incorporation of [1,3-14C]glycerol into hepatic neutral glycerolipids by the intact animal. The ethanol-induced rise in the capacity of neutral glycerolipid production by liver as measured in vivo and in vitro correlated well with an increase in hepatic phosphatidate phosphohydrolase activity. Therefore, the rise in hepatic and serum triglyceride levels associated with ethanol intake may be explained in part by an increase in the activity of the enzyme.
The effect of feeding diets containing 75% glucose or fructose on liver triglyceride formation in the rat was studied by both in vivo and in vitro techniques. The results were compared with those from control rats fed laboratory chow.
