ÖF

Ömer Faruk Beşer

Istanbul University-Cerrahpaşa

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

FÇ

Fügen Çokuğraş

Istanbul University-Cerrahpaşa

Tufan Kutlu

Istanbul University-Cerrahpaşa

Tülay Erkan

Istanbul University-Cerrahpaşa

HÇ

Haluk Çokuğraş

Istanbul University-Cerrahpaşa

F. Cokugras

Istanbul University-Cerrahpaşa

T. Erkan

Istanbul University

Ahsen Dönmez Türkmen

Istanbul University-Cerrahpaşa

Didem Gülcü Taşkın

Adana Numune Eğitim ve Araştırma Hastanesi

ÖK

Özgür Kasapçopur

Istanbul University-Cerrahpaşa

Tuğçe Damla Dilek

Istanbul University-Cerrahpaşa

Cooperative Institutions

Istanbul University-Cerrahpaşa

Istanbul University

Sağlık Bilimleri Üniversitesi

Ministry of Health

University of Health Science

Pediatrics and Genetics

University of Health Sciences

University of Health Sciences Antigua

Okmeydanı Eğitim ve Araştırma Hastanesi

Istanbul Medeniyet University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

European Young Pediatricians Association: Laying the Foundations for Collaboration, Integration, and Networking among Pediatricians of the Future

The Journal of Pediatrics (2016)

Sebastian Gray Roberto Raschetti Ömer Faruk Beşer Pinar Urenden Elicin Salvatore Aversa

Excellence

Professional association

10.1016/j.jpeds.2015.12.013

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Citations (5)

The effects of nutritional status and intervention on pulmonary functions in pediatric cystic fibrosis patients

Pediatrics International (2020)

Ayşe Ayzıt Kılınç Ömer Faruk Beşer Ebru Pelin Ugur Fügen Çokuğraş Haluk Çokuğraş

Abstract Background Cystic fibrosis (CF) causes malabsorption of nutrients that exacerbate pulmonary problems. Nutritional interventions can improve pulmonary functions. We aimed to evaluate the effects of nutritional intervention in CF patients with malnutrition, and to determine if there is a correlation between nutritional status and pulmonary functions. Methods The study included 143 CF patients (67 females) with a mean 2 year follow‐up time. Patients’ sociodemographic data, presenting symptoms and history were recorded. Height‐for‐age, weight‐for‐age, weight‐for‐length/height (WFL/H), and body mass index (BMI) were calculated in all patients. Patients were grouped as well nourished, mild malnutrition, moderate malnutrition, and severe malnutrition. These four groups were compared in terms of pulmonary function test results, lung infections, and the hospitalization rate. Results Among the patients with a WFL/H or BMI z ‐scores that decreased, the frequency of lung infection was 74.1% and the hospitalization rate was 40.7%, versus 34% and 12.3%, respectively among the patients with a WFL/H or BMI z ‐scores that increased. The difference was significant ( P = 0.02 and P = 0.01, respectively). The difference in bacterial lung infections differed significantly between the four nutritional status groups ( P = 0.002). Patients in the well‐nourished group had significantly higher pulmonary function test scores than the other groups. The forced expiratory volume in the first second differed significantly between the patients with and without an increase in the WFL/H or BMI z ‐scores ( P = 0.001). Conclusions The appropriate nutritional intervention to pediatric CF patients with malnutrition, decrease the frequency of lung infections, and improve respiratory function.

10.1111/ped.14417

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Citations (9)

The Power of Share Wave Elastography in Evaluating Portal Hypertension Signs in Children

Cerrahpasa Medical Journal (2023)

Didem Gülcü Taşkın Mehmet Cingöz Hasret Ayyıldız Civan Ömer Faruk Beşer İbrahim Adaletli

10.5152/cjm.2023.22110

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Prevalence and Clinical Features of Celiac Disease in Healthy School-Aged Children

Digestive Diseases and Sciences (2018)

Ömer Faruk Beşer Emine Gulluelli Fügen Çokuğraş Tülay Erkan Tufan Kutlu

Transplant surgery

10.1007/s10620-018-5320-0

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Citations (4)

Association of familial Mediterranean fever in Turkish children with inflammatory bowel disease

Türk Pediatri Arşivi (2014)

Ömer Faruk Beşer Fügen Çokuğraş Tufan Kutlu Ethem Erginöz Didem Gülcü Taşkın

Familial Mediterranean fever (FMF) and inflammatory bowel disease (IBD) carry similar clinical and biological properties. Both are characterized with chronic inflammation attacks and neutrophil migration and impaired apoptosis mechanism are present in the areas of damage in both conditions. In our study, we aimed to determine the frequency of association of FMF in patients with IBD, to compare the demographic, clinical, laboratory and treatment response properties in these patients with the ones in other IBD patients and to determine association of FMF especially in treatment-resistant patients.Fifty-three patients who were being followed up with a diagnosis of IBD aged between 0 and 18 years were included in the study. The patient group included the patients who were diagnosed with IBD according to clinical, serological, endoscopic and histopathological criteria, who were being followed up and whose therapies were continuing. Genetic analysis in terms of MEFV gene mutations was performed in all patients with a diagnosis of IBD. Acute phase reactants, complete blood count, immunoglobulin levels, stool analysis, "perinuclear anti-neutrophil cytoplasmic antibodies" (pANCA) and "anti-Saccharomyces cerevisiae antibodies" (ASCA) were studied at the time of diagnosis. The diagnosis of FMF was made according to detailed history, physical examination findings, laboratory tests and the results of genetic analyses in terms of MEFV gene mutations in accordance with the criteria defined in 2009.We found that FMF accompanied in 14 (26.4%) of the patients who had a diagnosis of IBD. 3 of these 14 patients in whom FMF accompanied were being followed up with a diagnosis of Crohn disease and 11 were being followed up with a diagnosis of ulcerative colitis. All of these patients had MEFV gene mutation. These mutations included M694V (50%), K695R (21.4%), M680I (14.3%) and R202Q (14.3%) in order of frequency. When the laboratory data were compared between the patients who had a diagnosis of IBD alone and who had a diagnosis of IBD plus FMF, it was observed that the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values were statistically significantly higher in the IBD+FMF group.FMF is a common condition in the Turkish population and M694V mutation is found most commonly. In our study, this status did not change in cases where FMF accompanied IBD, but K695R mutation was found more frequently compared to FMF alone. We think that it should be kept in mind that other inflammatory conditions including mainly FMF may accompany IBD, if a case of IBD does not have an expected course or is resistant to treatment.

MEFV

Panca

10.5152/tpa.2014.1998

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Citations (24)

Exploring the Influence of Concurrent Nutritional Therapy on Children with Spinal Muscular Atrophy Receiving Nusinersen Treatment

Children (2024)

Eymen Pınar Bilal Berke Ayvaz Erkan Akkuş İpek Ülkersoy Tuğçe Damla Dilek

Background This study examines spinal muscular atrophy (SMA), a neuromuscular disease associated with malnutrition. Our goals are to assess how effectively screening tools can detect malnutrition and evaluate the impact of nutritional interventions on neurological outcomes, particularly motor functions. Methods Thirty-seven genetically diagnosed SMA patients (types 1, 2, and 3) under nusinersen therapy were included in the study. The nutritional status of these patients was assessed by using anthropometric measurements, including height for age (HFA), weight for height (WFH), and body mass index (BMI) before and after the study. Additionally, the risk of malnutrition was determined using screening tools, namely the Pediatric Yorkhill Malnutrition Score (PYMS) and the Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP). Nutritional counseling followed the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) guidelines and considered the patients' dietary history, including content and administration method. Motor functions were assessed by validated tests: the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP-INTEND) and the Hammersmith Functional Motor Scale-Expanded (HFMSE). Result The study showed an improvement in HFA, by a change from -0.95 to -0.65 (

Progressive muscular atrophy

10.3390/children11080886

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Citations (0)

Clinical Features of Interleukin 10 Receptor Gene Mutations in Children With Very Early–Onset Inflammatory Bowel Disease

Journal of Pediatric Gastroenterology and Nutrition (2014)

Ömer Faruk Beşer Cecilia Domínguez Conde Nina K. Serwas Fügen Çokuğraş Tufan Kutlu

ABSTRACT Objectives: In the present study, we studied a cohort of patients with very early onset inflammatory bowel disease (IBD) to determine the frequency of mutations in the interleukin 10 ( IL10 ) receptor genes as a cause of early‐onset IBD. Methods: Sanger sequencing was performed to determine the presence of IL10 and/or IL10 receptor mutations in 17 patients with a diagnosis of very early onset IBD (disease onset <2 years of age in 15 patients, between 3 and 4 years in the other 2). Mutation screening was performed including all of the coding regions of the IL10 , IL10RA , and IL10RB genes. We then compared the follow‐up findings of the patients with IL10 receptor mutations in terms of demographic, clinical, laboratory, and treatment response properties with those of patients diagnosed as having very early onset IBD with no mutation. Results: We identified 3 patients bearing mutations in the IL10 or IL10 receptor genes, including 1 mutation in IL10RB that has been described recently (c.G477A, p.Trp159*) and 2 novel mutations affecting the IL10RA gene (c.T192G, p.Tyr64 * and c.T133G, p.Trp45Gly). Collectively, these mutations thus provided genetic etiology for 17.6% of the cohort under investigation. The presence of a family history of IBD and the clinical course of Crohn disease differed between patients with mutations in the IL‐10 pathway and those without such mutations. Although perianal fistulas were found in all of the patients with IL10 receptor mutations, they were found in only 14.3% of those without such mutations. The lower values of weight‐for‐age and height‐for‐age z scores, necessity for more intensive therapy, achievement of longer periods until remission, and frequent relapses in the patients bearing mutations in the IL10 receptor genes all underlined the severity of the disease and its relatively poor response to treatment. Conclusions: In spite of the small number of patients with mutations affecting the IL‐10 signaling pathway in our study, in all of the patients with IL10 receptor mutations, the disease onset occurs at an early age, the prognosis is poor, and the response to treatment is insufficient.

10.1097/mpg.0000000000000621

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Citations (51)

Increased in recent years, the diagnosis of Eosinophilic Esophagitis in patients with Refractory Gastroesophagial Reflux

Ömer Faruk Beşer Emre Çelik T. Erkan Tufan Kutlu F. Cokugras

Eosinophilic Esophagitis

Refractory (planetary science)

Reflux esophagitis

Esophagitis

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Citations (0)