Xiaonan Li

Dongguan People’s Hospital

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Nan Zhou

National Institute for Parasitic Diseases

Mengying Chen

Fujian Agriculture and Forestry University

Cuiting Min

Second Affiliated Hospital of Nanjing Medical University

Qianqi Liu

Second Affiliated Hospital of Nanjing Medical University

Fan Yang

Xinxiang Medical University

Wei Zhou

Inner Mongolia University for Nationalities

Susu Du

Second Affiliated Hospital of Nanjing Medical University

Luting Peng

Second Affiliated Hospital of Nanjing Medical University

Guanming Lu

Nanjing University of Posts and Telecommunications

Yanyan Dai

Wenzhou Central Hospital

Cooperative Institutions

Pontifical Catholic University of Rio de Janeiro

323

Universidade Estadual de Londrina

319

A. Alikhanyan National Laboratory

315

Université Libre de Bruxelles

292

Beijing Normal University

290

Institute of High Energy Physics

286

Chinese Academy of Sciences

245

China Institute of Atomic Energy

200

China Academy of Space Technology

192

Federico Santa María Technical University

186

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Pilot Study for Secondary Gastric Tissue Damage in the Patients with Upper Gastrointestinal Bleeding

Xiaonan Li

Objective:To assess oxidative gastric tissue damage linked to hypovolemia in patients with upper gastrointestinal bleeding.Methods:The study included 22 patients who presented with acute upper gastrointestinal bleeding and 22 controls.Each patient's multiple biopsies of the gastric antrum were obtained at diagnostic endoscopy on admission(day1) and 7 days later.A set of antral biopsies was also collected from each control subject.Each tissue specimen was analyzed for levels of SOD and CAT activity,and level of MDA by ELISA.Results:First day SOD and CAT levels were significantly lower and MDA levels were higher than on the 7th day,and 1st day and 7th day levels were significantly different from controls(p0.05).Conclusion:Oxygen free radical activity changed significantly in patients with upper gastrointestinal bleeding,and led to secondary gastric mucosa tissue damage.

Hypovolemia

Upper Gastrointestinal Bleeding

Gastrointestinal bleeding

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Enlarged Perivascular Space and Its Correlation with Polysomnography Indicators of Obstructive Sleep Apnea

Nature and Science of Sleep (2021)

Yanlu Jia Chunling Liu Hui Li Xiaonan Li Jun Wu

There is increasing evidence of a causal interaction between obstructive sleep apnea (OSA) and white matter hyperintensity (WMH). WMH and enlarged perivascular space (EPVS) are the neuroimaging markers for cerebral small vessel disease (CSVD). Thus, this study aimed to determine whether a contextual relationship existed between OSA and EPVS. In this study, 107 participants underwent 1-night polysomnography, brain magnetic resonance imaging (MRI) and health screening examinations and were classified as 63 OSA patients (mild, moderate, and severe groups), and 44 healthy controls. We assessed the sleep characteristics in OSA group, quantified the total EPVS from MRI and related them to the measures of polysomnography-obtained sleep parameters. Polysomnography revealed that 63 OSA patients had sleep architecture alteration. A higher proportion of N2 phase sleep (N2%), lower percentage of N3 sleep (N3%) and REM sleep (REM%), as well as increased arousal index (AI), oxygen desaturation index (ODI) and decreased lowest arterial oxygen saturation (LSaO2) were detected. The results also indicated a higher prevalence and a larger number of EPVS, and a lower Mini Mental State Scale (MMSE) scale score in OSA group. LSaO2, N3% and REM% were negatively correlated with the total EPVS, whereas ODI, AI and N2% were positively correlated with the total EPVS. The findings suggested that OSA patients had sleep disturbances with a higher incidence and more severe EPVS. Furthermore, the EPVS in OSA might be secondary to sleep disturbances, intermittent hypoxemia and the respiratory event-related hemodynamic changes. Thus, our findings highlighted that increased risk for EPVS in OSA is a potential contributor to increased stroke risk in OSA.

10.2147/nss.s305465

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Feeding Infants Formula With Probiotics or Milk Fat Globule Membrane: A Double-Blind, Randomized Controlled Trial

Frontiers in Pediatrics (2019)

Xiaonan Li Yongmei Peng Zailing Li Britt Christensen Anne B. Heckmann

Purpose: To evaluate effects on growth and infection rates of supplementing infant formula with the probiotic Lactobacillus paracasei ssp. paracasei strain F19 (F19) or bovine milk fat globule membrane (MFGM). Methods: In a double-blind, randomized controlled trial, 600 infants were randomized to a formula supplemented with F19 or MFGM, or to standard formula (SF). A breastfed group was recruited as reference (n=200). The intervention lasted from age 21±7 days until 4 months, and infants were followed until age one year. Results: Both experimental formulas were well tolerated and resulted in high compliance. The few reported adverse events were not likely related to formula, with the highest rates in the SF group, significantly higher than for the F19-supplemented infants (p=0.046). Weight or length gain did not differ during or after the intervention among the formula-fed groups, with satisfactory growth. During the intervention, overall, the experimental formula groups did not have more episodes of diarrhea, fever, or days with fever than the breastfed infants. However, compared to the breastfed infants, the SF group had more fever episodes (p=0.021) and days with fever (p=0.036), but not diarrhea. Compared with the breastfed group, the F19 -supplemented infants but not the other two formula groups had more visits/unscheduled hospitalizations (p=0.015) and borderline more episodes of upper respiratory tract infections (p=0.048). Conclusions: Both the MFGM- and F19-supplemented formulas were safe and well tolerated, leading to few adverse effects, similar to the breastfed group and unlike the SF group. During the intervention, the MFGM-supplemented infants did not differ from the breastfed infants in any primary outcome.

Lactobacillus paracasei

10.3389/fped.2019.00347

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Environmental factors in the etiology of isolated and nonisolated esophageal atresia in a Chinese population: A case–control study

Birth Defects Research (2016)

Yu Feng Runsen Chen Xiaonan Li Xuming Mo

Background Esophageal atresia (EA) is a common birth defect that occurs with tracheoesophageal fistula (TEF), although etiological studies on EA/TEF have produced inconsistent results. Methods The aim of this study was to examine the association between environmental factors during pregnancy and the risk of EA/TEF in a Chinese population. Cases of isolated EA and nonisolated EA and unaffected controls were identified between July 2005 and November 2015, and face‐to‐face questionnaires concerning exposure to environmental factors were administered to the birth mothers of 130 cases and 400 controls. The adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated to assess the association between environmental factors and the risk of EA/TEF. Results The results of this case–control study suggest that lower maternal education (p < 0.0001), maternal binge drinking (OR = 2.63; 95% CI, 1.05–6.6) and pickled food consumption (OR = 2.04; 95% CI, 1.31–3.71) during pregnancy increase the risk of EA in offspring, while maternal folic acid supplementation (OR = 0.45; 95% CI, 0.29–0.71) is significantly associated with a decreased risk of EA. Conclusion These results suggest a role for environmental exposures in the etiology of EA/TEF; however, further studies are needed to replicate the observed associations. Birth Defects Research (Part A) 106:840–846, 2016. © 2016 Wiley Periodicals, Inc.

Etiology

Tracheoesophageal Fistula

10.1002/bdra.23550

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Sparse representation based facial expression classification for pain assessment in neonates

Guanming Lu Cheng Yang Mengying Chen Xiaonan Li

Facial expressions are considered a reliable indicator in neonatal pain assessment. This paper proposes a new neonatal pain expression recognition method, which utilizes the feature descriptors based on weighted Local Binary Pattern (LBP) and the classifier based on sparse representation. Firstly, the normalized facial image is described using a feature vector, which is histogram sequence obtained by concatenating the weighted histograms of the LBP maps of all the local blocks. Then, the Principal Component Analysis (PCA) method is used to reduce the dimension of the feature vector. Finally, the classifier based on sparse representation is applied to classify test sample into four classes of facial expressions: calm, crying, moderate pain, severe pain. The objective of this study is to assist the clinicians in assessing neonatal pain by utilizing computer-based image analysis techniques. The experimental results on neonate facial image database show the effectiveness of the proposed algorithm. The classification accuracy is up to 85.50%.

Local Binary Patterns

Feature vector

Feature (linguistics)

Discriminative model

10.1109/fskd.2016.7603418

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Downregulation of STEAP4, a highly-expressed TNF-α-inducible gene in adipose tissue, is associated with obesity in humans

Acta Pharmacologica Sinica (2008)

Chunmei Zhang Xia Chi Bin Wang Min Zhang Yuhui Ni

Adipose tissue macrophages

10.1111/j.1745-7254.2008.00793.x

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Citations (44)

Differences in Neuregulin 4 Expression in Children: Effects of Fat Depots and Obese Status

Endocrine Research (2020)

Ran Wang Wei Zhou Xiaolei Zhu Nan Zhou Fan Yang

Purpose To observe the expression of Nrg4, uncoupling protein-1 (UCP1), tumor necrosis factor α (TNFα), CD31, VE-cadherin/CDH5 and vascular endothelial growth factor A (VEGF-A) mRNA in abdominal subcutaneous (SC), omental (OM) adipose tissue in children with relation to anthropometric parameters. Further to verify the effect of inflammatory mediators on Nrg4 and UCP1 mRNA expression in adipocytes.Methods Paired SC and OM adipose tissues were obtained from 58 children. In vitro, the adipocytes isolated from primary inguinal adipose tissue of mice were treated with TNFα (50 ng/ml) for 12–48 h. mRNA levels of Nrg4, UCP1 and TNFα were determined by real-time PCR.Results Nrg4, UCP1, VEGF-A and CDH5 mRNA levels in SC were significantly higher than those in OM adipose tissue and the mRNA level of TNFα showed the opposite result. Moreover, Nrg4 and UCP1 mRNA in SC were significantly lower in overweight children compared to normal weight children. Nrg4 in SC and OM was negatively associated with BMISDS, WHtR. CDH55 mRNA in OM was negatively associated with WHR. VEGF-A was positively correlated with Nrg4 in SC. In vitro, Nrg4 and UCP1 mRNA levels in adipocytes were dose- and time-dependently decreased under TNFα treatment.Conclusions Nrg4, UCP1, VEGF-A and CDH5 mRNA expression in adipose tissues display a depot-specific pattern. Nrg4 mRNA levels in adipose tissue are decreased with obesity and associated with WAT browning and angiogenesis. TNFα may be involved in the regulation of Nrg4 level in adipose tissue, which may be one of the causes of the down-regulation of Nrg4 expression in obesity with chronic inflammatory response.

10.1080/07435800.2020.1721528

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Resveratrol protects against oxidative stress by activating the Keap‑1/Nrf2 antioxidant defense system in obese‑asthmatic rats

Experimental and Therapeutic Medicine (2018)

Xiaonan Li Lu‐Yi Ma Hong Ji Yuanhua Qin Shanshan Jin

The aim of the present study was to investigate the potential mechanism underlying the anti‑obesity‑asthmatic effects of resveratrol (RSV) in a rat model of obese‑asthma. Rat models of obesity and asthma were established using a high‑fat diet and the administration of ovalbumin, respectively. Rats were divided into 7 different groups: A normal control, a normal obese, a normal asthma, a normal obese + asthma, a RSV obese, a RSV asthma and a RSV obese + asthma group. Body weight, Lee index, body fat and lung histopathological changes were evaluated. Serum lipid levels were evaluated using calorimetric methods. Levels of reactive oxygen species (ROS) were examined using enzyme‑linked immunosorbent assays. Cellular antioxidant enzyme activities were measured using commercial kits. Levels of kelch‑like ECH associated protein 1 (Keap‑1) and nuclear factor erythroid 2‑related factor 2 (Nrf2) was examined using western blot analysis. The results indicated that obese and asthma rat models were successfully established. It was also demonstrated that RSV decreased fasting blood glucose in obese, asthmatic and obese‑asthmatic rats. RSV altered serum lipid levels; it significantly increased high density lipoprotein cholesterol levels and significantly decreased serum triglyceride, serum total cholesterol and very low density lipoprotein levels, compared with untreated obese, asthmatic and obese‑asthmatic rats (P<0.05). ROS levels were significantly decreased in the RSV treatment group compared with obese, asthmatic and obese‑asthmatic rats (P<0.05). RSV treatment significantly increased catalase, glutathione, glutathione peroxidase and total superoxide dismutase levels compared with untreated obese, asthmatic and obese‑asthmatic rats (P<0.05). Furthermore, RSV treatment significantly downregulated Keap‑1 and upregulated Nrf2 levels in the heart, lung and kidney tissues of rats compared with untreated controls. Therefore, the results demonstrate that RSV protects against oxidative stress by activating the Keap‑1/Nrf2 antioxidant defense system in obese‑asthmatic rat models.

10.3892/etm.2018.6747

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Citations (44)

Relationship between methylation status of ERCC1 promoter and radiosensitivity in glioma cell lines

Cell Biology International (2009)

Zhigang Liu Huayun Chen Jing‐Jian Cheng Zhong‐Ping Chen Xiaonan Li

Ionizing radiation represents one of the most important therapies for glioma, a lethal primary brain tumor, while radiotherapy remains a challenge for radiation oncologist because of radioresistance. Radiosensitivity of gliomas determines radiotherapy efficacy. Evidence demonstrated that methylation of CpG Island in the promoter region may result in gene silencing. This study was designed to determine the relationship between methylation status of ERCC1 promoter region and radiosensitivity in glioma cell lines. We investigated the expression levels of ERCC1 transcripts and protein in GBM cell lines. Colony forming experiments was used to measure surviving fraction at 2Gy (SF2) in four human glioma cell lines, MGR1, MGR2, SF767 and T98G. Methylation status in the promoter region of ERCC1 in these glioma cell lines was determined by using bisulphate sequencing and MSP analysis. Radiosensitivity was examined to be heterogeneous in these glioma cell lines. There was a statistical difference in the radiosensitivity between glioma cell lines with and without methylation of ERCC1 gene promoter CpG islands. Furthermore, we promoted ERCC1 expression by 5-azacytidine treatment which resulted in the reduction of radiation-induced cell killing in radiosensitive cell lines. Our data indicate that methylation status of ERCC1 is associated with radiosensitivity in glioma cell lines. It could be used as a new biomarker for predicting the radiosensitivity of human gliomas.

Radiosensitivity

Radioresistance

ERCC1

CpG site

10.1016/j.cellbi.2009.07.004

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Citations (23)

Automatic detection of interictal ripples on scalp EEG to evaluate the effect and prognosis of ACTH therapy in patients with infantile spasms

Epilepsia (2021)

Wei Wang Hua Li Jiaqing Yan Herui Zhang Xiaonan Li

We aimed to explore the feasibility of using scalp-recorded high-frequency oscillations (HFOs) to evaluate the efficacy and prognosis of adrenocorticotropic hormone (ACTH) treatment in patients with infantile spasms.Thirty-nine children with infantile spasms were enrolled and divided into seizure-free and non-seizure-free groups after ACTH treatment. Patients who were seizure-free were further divided into relapse and non-relapse subgroups based on the observations made during a 6-month follow-up period. Scalp ripples were detected and compared during the interictal periods before and after 2 weeks of treatment.After ACTH treatment, the number and channels of ripples were significantly lower, whereas the percentage decrease in the number, spectral power, and channels of ripples was significantly higher in the seizure-free group than in the non-seizure-free group. In addition, the relapse subgroup showed higher number and spectral power and wider distribution of ripples than did the non-relapse subgroup. Changes in HFOs in terms of number, spectral power, and channel of ripples were closely related to the severity of epilepsy and can indicate disease susceptibility.Scalp HFOs can be used as an effective biomarker to monitor the effect and evaluate the prognosis of ACTH therapy in patients with infantile spasms.

10.1111/epi.17018

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Citations (20)