Estefanía Burgos‐Morón

Universidad de Sevilla

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José Manuel Calderón‐Montaño

Universidad de Sevilla

Miguel López‐Lázaro

Universidad de Sevilla

Manuel Luís Orta

Universidad de Sevilla

Julio José Jiménez‐Alonso

Universidad de Sevilla

Emilio Guillén-Mancina

Universidad de Sevilla

Santiago Mateos

Universidad de Sevilla

Nuria Pastor

Universidad de Sevilla

Thomas Helleday

Science for Life Laboratory

Víctor Jiménez-González

Universidad de Sevilla

Andreas Höglund

Ericsson (Sweden)

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Universidad de Sevilla

Science for Life Laboratory

Karolinska Institutet

Uppsala University

Svenska Örtmedicinska Institute

Centre National de la Recherche Scientifique

Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana

Hospital Universitario Doctor Peset

Universitat de València

Instituto de Biomedicina de Sevilla

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Comment on ‘Quiescence and γH2AX in neuroblastoma are regulated by Ouabain/Na,K-ATPase’: ouabain and cancer

British Journal of Cancer (2013)

José Manuel Calderón‐Montaño Estefanía Burgos‐Morón Miguel López‐Lázaro

Comment on ‘Quiescence and γH2AX in neuroblastoma are regulated by Ouabain/Na,K-ATPase’: ouabain and cancer

10.1038/bjc.2013.234

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Citations (4)

Dietary and Non-Dietary Phytochemicals and Cancer

MDPI eBooks (2017)

Estefanía Burgos‐Morón José Manuel Calderón‐Montaño Manuel Luís Orta Carmela Fimognari Nilgun Tumer

Munich, Germany, she focused her research on cancer chemoprevention and therapy by natural compounds and synthetic analogues with cytostatic and cell death-inducing potential.As an example,

10.3390/books978-3-03842-379-9

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Citations (1)

Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

Journal of Medicinal Chemistry (2017)

Sabin Llona‐Minguez Andreas Höglund Artin Ghassemian Matthieu Desroses José Manuel Calderón‐Montaño

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 InhibitorsSabin Llona-Minguez*, Andreas Höglund, Artin Ghassemian, Matthieu Desroses, José Manuel Calderón-Montaño, Estefanía Burgos Morón, Nicholas C. K. Valerie, Elisee Wiita, Ingrid Almlöf, Tobias Koolmeister, André Mateus, Cindy Cazares-Körner, Kumar Sanjiv, Evert Homan, Olga Loseva, Pawel Baranczewski, Masoud Darabi, Amir Mehdizadeh, Shabnam Fayezi, Ann-Sofie Jemth, Ulrika Warpman Berglund, Kristmundur Sigmundsson, Thomas Lundbäck, Annika Jenmalm Jensen, Per Artursson, Martin Scobie, and Thomas Helleday*Cite this: J. Med. Chem. 2017, 60, 17, 7614Publication Date (Web):September 1, 2017Publication History Published online1 September 2017Published inissue 14 September 2017https://doi.org/10.1021/acs.jmedchem.7b01137Copyright © 2017 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views916Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (315 KB) Get e-Alerts Get e-Alerts

10.1021/acs.jmedchem.7b01137

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Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

Journal of Medicinal Chemistry (2017)

Sabin Llona‐Minguez Andreas Höglund Artin Ghassemian Matthieu Desroses José Manuel Calderón‐Montaño

The dCTP pyrophosphatase 1 (dCTPase) is a nucleotide pool "housekeeping" enzyme responsible for the catabolism of canonical and noncanonical nucleoside triphosphates (dNTPs) and has been associated with cancer progression and cancer cell stemness. We have identified a series of piperazin-1-ylpyridazines as a new class of potent dCTPase inhibitors. Lead compounds increase dCTPase thermal and protease stability, display outstanding selectivity over related enzymes and synergize with a cytidine analogue against leukemic cells. This new class of dCTPase inhibitors lays the first stone toward the development of drug-like probes for the dCTPase enzyme.

Pyrophosphatases

Catabolism

10.1021/acs.jmedchem.7b00182

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Citations (21)

Consumption of the Dietary Flavonoids Quercetin, Luteolin and Kaempferol and Overall Risk of Cancer - A Review and Meta-Analysis of the Epidemiological Data

J. D Tena Estefanía Burgos‐Morón José Manuel Calderón‐Montaño I García Sanz Jorge Sainz

Nutritional Epidemiology

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A 30-s exposure to ethanol 20% is cytotoxic to human keratinocytes: possible mechanistic link between alcohol-containing mouthwashes and oral cancer

Clinical Oral Investigations (2018)

José Manuel Calderón‐Montaño Julio José Jiménez‐Alonso Emilio Guillén-Mancina Estefanía Burgos‐Morón Miguel López‐Lázaro

10.1007/s00784-018-2602-z

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Effect of DNA Repair Deficiencies on the Cytotoxicity of Drugs Used in Cancer Therapy - A Review

Current Medicinal Chemistry (2014)

José Manuel Calderón‐Montaño Estefanía Burgos‐Morón Manuel Luís Orta Miguel López‐Lázaro

Tumor cells often have defects in DNA repair pathways that make them vulnerable to specific DNA-damaging anticancer agents. The identification of DNA repair defects in tumor cells and the evaluation of their influence on the cytotoxicity of anticancer drugs are active areas of scientific investigation that may help rationalize and improve cancer chemotherapy. This article reviews the available data on the influence of defects in proteins involved in the major DNA repair pathways (i.e., homologous recombination, non-homologous end joining, base excision repair, nucleotide excision repair, mismatch repair, Fanconi anemia repair, translesion synthesis and direct reversal repair) on the cytotoxicity of the FDAapproved anticancer drugs. It is shown that specific deficiencies in these DNA repair pathways alter the cytotoxicity of 60 anticancer drugs, including classical DNA-targeting drugs (e.g., alkylating agents, cytotoxic antibiotics, DNA topoisomerase inhibitors and antimetabolites) and other drugs whose primary pharmacological target is not the DNA (e.g., antimitotic agents, hormonal and targeted therapies). This information may help predict response to anticancer drugs in patients with tumors having specific DNA repair defects. Keywords: Anticancer, chemotherapy, DNA damage, DNA damage response.

10.2174/0929867321666140601203816

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Citations (20)

Screening for selective anticancer activity of plants from Grazalema Natural Park, Spain

Natural Product Research (2018)

José Manuel Calderón‐Montaño Sara María Martínez-Sánchez Estefanía Burgos‐Morón Emilio Guillén-Mancina Julio José Jiménez‐Alonso

Since plants are an important source of anticancer drugs, we have carried out a random screening for selective anticancer activity of 57 extracts from 45 plants collected in Grazalema Natural Park, an area in the South of Spain of high plant diversity and endemism. Using lung cancer cells (A549) and lung non-malignant cells (MRC-5), we found that several extracts were more cytotoxic and selective against the cancer cells than the standard anticancer agent cisplatin. Five active extracts were further tested in cancer and normal cell lines from other tissues, including three skin cell lines with increasing degree of malignancy. An extract from the leaves of Daphne laureola L. (Thymelaeaceae) showed a striking potency and selectivity on lung cancer cells and leukemia cells; the IC50 values against these cancer cells were approximately 10,000-fold lower than against the normal cells. Daphnane-type diterpene orthoesters may be responsible for this highly selective anticancer activity.

Thymelaeaceae

10.1080/14786419.2018.1480620

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Artificial Diets with Altered Levels of Sulfur Amino Acids Induce Anticancer Activity in Mice with Metastatic Colon Cancer, Ovarian Cancer and Renal Cell Carcinoma

International Journal of Molecular Sciences (2023)

Julio José Jiménez‐Alonso Emilio Guillén-Mancina José Manuel Calderón‐Montaño Víctor Jiménez-González Patricia Díaz-Ortega

Sulfur-containing amino acids methionine (Met), cysteine (Cys) and taurine (Tau) are common dietary constituents with important cellular roles. Met restriction is already known to exert in vivo anticancer activity. However, since Met is a precursor of Cys and Cys produces Tau, the role of Cys and Tau in the anticancer activity of Met-restricted diets is poorly understood. In this work, we screened the in vivo anticancer activity of several Met-deficient artificial diets supplemented with Cys, Tau or both. Diet B1 (6% casein, 2.5% leucine, 0.2% Cys and 1% lipids) and diet B2B (6% casein, 5% glutamine, 2.5% leucine, 0.2% Tau and 1% lipids) showed the highest activity and were selected for further studies. Both diets induced marked anticancer activity in two animal models of metastatic colon cancer, which were established by injecting CT26.WT murine colon cancer cells in the tail vein or peritoneum of immunocompetent BALB/cAnNRj mice. Diets B1 and B2B also increased survival of mice with disseminated ovarian cancer (intraperitoneal ID8 Tp53-/- cells in C57BL/6JRj mice) and renal cell carcinoma (intraperitoneal Renca cells in BALB/cAnNRj mice). The high activity of diet B1 in mice with metastatic colon cancer may be useful in colon cancer therapy.

Intraperitoneal injection

10.3390/ijms24054587

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Citations (3)

Artificial Diets with Altered Levels of Sulfur Amino Acids Induce Anticancer Activity in Mice with Metastatic Colon Cancer, Ovarian Cancer and Renal Cell Carcinoma

Julio José Jiménez‐Alonso Emilio Guillén-Mancina José Manuel Calderón‐Montaño Víctor Jiménez-González Patricia Díaz-Ortega

The sulfur-containing amino acids methionine (Met), cysteine (Cys) and taurine (Tau) are common dietary constituents with important cellular roles. Met restriction is already known to exert in vivo anticancer activity. However, since Met is a precursor of Cys, and Cys produces Tau, the role of Cys and Tau in the anticancer activity of Met-restricted diets is poorly understood. In this work, we screened the in vivo anticancer activity of several Met-deficient artificial diets supplemented with Cys, Tau or both. Diet B1 (6% casein, 2.5% leucine, 0.2% Cys and 1% lipids) and diet B2B (6% casein, 5% glutamine, 2.5% leucine, 0.2% Tau and 1% lipids) showed the highest activity and were selected for further studies. Both diets induced a marked anticancer activity in two animal models of metastatic colon cancer, which were established by injecting CT26.WT murine colon cancer cells in the tail vein or peritoneum of immunocompetent BALB/cAnNRj mice. Diets B1 and B2B also increased the survival of mice with disseminated ovarian cancer (intraperitoneal ID8 Tp53 -/- cells in C57BL/6JRj mice) and renal cell carcinoma (intraperitoneal Renca cells in BALB/cAnNRj mice). The high activity of diet B1 in mice with metastatic colon cancer may be useful in colon cancer therapy.

Intraperitoneal injection

10.20944/preprints202301.0376.v1

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Citations (3)