The development of mental health care has changed greatly from ancient civilisations to the present day. Today, teachers' mental health and well-being are in a precarious state, and when lack of training is added, it becomes clear how difficult it is for teachers to provide adequate support to students. This can be exacerbated by specific contexts and cultures in which teachers may feel uncomfortable seeking help. The lack of support for teachers can lead to the development of long-term mental health problems, with negative personal, professional, and social consequences. Because teacher well-being directly impacts student well-being, achievement, and success, it is crucial to promote teachers' mental health. Qigong may be considered a patient-guided psychophysiological feedback technique that enables subjects to learn and control bodily functions and processes. The present study aimed to investigate the potential impact of Qigong on teachers' anxiety, depression, and stress levels, and to explore the feasibility of integrating it into the school context. Eighty-four participants were recruited and randomly divided into two groups. The experimental group received the Qigong intervention and the control group received a placebo intervention, both for 4 weeks. The outcomes were anxiety, depression and stress levels and were assessed using various scales and complementary physiological parameters. Regarding anxiety, the experimental group showed significant improvements in all outcome measures, while the placebo group showed similar scores in the pre- and post-measurements. The post-intervention results even showed a significant difference between the two groups in terms of state anxiety. In terms of depression and stress, the results suggest that Qigong can significantly improve symptoms. The placebo group showed no significant changes. However, no significant differences were found between the groups in the final assessment. The results of this study suggest that Qigong can help improve teachers' mental health and can be implemented in schools.
Aim. In the present study, we investigated the antiangiogenic properties of 59 plants used in traditional Korean medicine. Selected phytochemicals were investigated in more detail for their modes of action. Methods. A modified chicken-chorioallantoic-membrane (CAM) assay using quail eggs was applied to test for antiangiogenic effects of plant extracts. A molecular docking in silico approached the binding of plant constituents to the vascular endothelial growth factor receptors 1 and 2 (VEGFR1, VEGFR2). Microarray-based mRNA expression profiling was employed to correlate the 50% inhibition concentrations (IC50) of a panel of 60 NCI cell lines to these phytochemicals. Results. Extracts from Acer mono leaves, Reynoutria sachalniensis fruits, Cinnamomum japonicum stems, Eurya japonica leaves, Adenophora racemosa whole plant, Caryopteris incana leaves-stems, and Schisandra chinensis stems inhibited angiogenesis more than 50% in quail eggs. Selected phytochemicals from Korean plants were analyzed in more detail using microarray-based mRNA expression profiles and molecular docking to VEGFR1 and VEGFR2. These results indicate multifactorial modes of action of these natural products. Conclusion. The antiangiogenic activity of plants used in traditional Korean medicine implicates their possible application for diseases where inhibition of blood vessel formation is desired, for example, cancer, macular degeneration, diabetic retinopathy and others.
Cancer is a leading cause of mortality and the annual incidence of new cancer cases is rising worldwide. Due to the frequent development of resistance and the side effects of established anti-cancer drugs, the quest for new drugs with improved therapeutic features goes on. In contrast to cytotoxic chemotherapy of the past, the concept of targeted chemotherapy attempts to increase specificity of therapy by attacking tumor-related mechanisms. A novel emerging treatment concept represents the inhibition of centrosomal clustering. The centrosome regulates mitotic spindle formation assuring uniform separation of chromosomes to daughter cells. Many tumors contain supernumerary centrosomes, which contribute to aneuploidy induction via multipolar mitotic spindle formation. As spindle multipolarity leads to cell death, tumor cells developed centrosomal clustering mechanism to prevent multipolar spindle formation by coalescence of multiple centrosomes into two functional spindle poles. Inhibition of centrosome clustering represents a novel strategy for drug development and leads to the formation of multipolar spindles and subsequent cell death. In the present review, we report advances in understanding the biology of centrosomal clustering as well as enlist compounds capable of inducing the formation of multipolar spindles such as indolquinolizines, integrin-linked kinase inhibitors (QLT-0267), noscapinoids (EM011), phthalamide derivatives (TC11), griseofulvin, phenanthridines (PJ-34), CCC1-01, CW069 GF-15, colcemid, nocodazole, paclitaxel, and vinblastine. We also present in silico result of compounds that bind to γ-tubulin under the ambit of centrosomal clustering inhibition. We observed maximum binding efficacy in GF-15, CW069, paclitaxel and larotaxel with GF-15 exhibiting least energy of -8.4 Kcal/mol and 0.7 μM Pki value. Keywords: Cancer, centrosomal clustering, multipolar spindle inducers, natural products, supernumerary centrosomes.
Abstract All biological–medical treatments need a ground regulation in the intermeshed control loop system in animate matter. The focus of our contribution is to suggest a possible mechanism in this interconnected system that will work in order to supply/assist a higher ordered servo loop. Bonghan ducts indicate similarities to so-called meridians or conduits that are the central part in Chinese Medicine for the energy Qi. It is assumed that the nervous system demands a highly redundant and rapid communication system (RCS) probably established via the extracellular matrix (ECM) and triggered by a threshold value for the entire body. Metabolic processes could work in the picosecond’s range while the nervous system is on the time scale at least one order of magnitude lower; probably most of them in the millisecond range. Long-range coherent electromagnetic phenomena and recent experiments indicate a structured superconducting-like system with the Josephson-effect behavior in biological systems. In the ECM are the components proteoglycans and glycosaminoglycans (PG/GAGs) and among them the ubiquitarian hyaluronic acid plays probably an important role and can behave as liquid crystals while the charge transport is performed via proton “jumping” in the proton-chains. Therefore, the water molecules have to be confident on a nanometer scale, lowering their energy states, and set up a phase transition with a rapid jumping of the protons through the water–carbon-chains. These partial chains could probably be modeled by tiny pyramids of the atoms. We propose that in order to set up those long-range coherent effects, a vortex is created. By doing Qi Gong, an energetic vortex through the body is established and the entire body can be modeled by two-base plane-faced pyramids acting as a tunable cavity resonator obeying electrodynamics laws. Therefore, the phenomenon’s of pyramids should be considered in animate and inanimate matter in order to achieve long-range coherent effects, which by now controversially discussed and to go new ways to come over the clutter.
'/%3e%3cuse xlink:href='%23a' transform='rotate(23.036 .093 25.536)'/%3e%3cuse xlink:href='%23a' transform='rotate(45.87 1.273 16.18)'/%3e%3cuse xlink:href='%23a' transform='rotate(69.945 .996 12.078)'/%3e%3cuse xlink:href='%23a' transform='rotate(20.66 -19.689 31.932)'/%3e%3c/svg%3e)
'/%3e%3c/g%3e%3cuse xlink:href='%23d' x='45.714'/%3e%3cuse xlink:href='%23e' transform='matrix(-1 0 0 1 479.792 0)'/%3e%3cg id='f' fill='%23fff'%3e%3cpath fill='%23039' d='M232.636 202.406v.005c0 2.212.85 4.227 2.212 5.69 1.365 1.466 3.245 2.377 5.302 2.377 2.067 0 3.944-.905 5.303-2.365 1.358-1.459 2.202-3.472 2.202-5.693v-10.768l-14.992-.013-.028 10.766'/%3e%3ccircle cx='236.074' cy='195.735' r='1.486'/%3e%3ccircle cx='244.392' cy='195.742' r='1.486'/%3e%3ccircle cx='240.225' cy='199.735' r='1.486'/%3e%3ccircle cx='236.074' cy='203.916' r='1.486'/%3e%3ccircle cx='244.383' cy='203.905' r='1.486'/%3e%3c/g%3e%3cuse xlink:href='%23f' y='-26.016'/%3e%3cuse xlink:href='%23f' x='-20.799'/%3e%3cuse xlink:href='%23f' x='20.745'/%3e%3cuse xlink:href='%23f' y='25.784'/%3e%3c/svg%3e)