Surgical resection is still the main means for clinical treatments of breast cancer, but the postoperative immunosuppressive microenvironment and neoangiogenesis of the residual tumors easily lead to tumor metastasis and recurrence, which will further endanger patients' lives. The combination of antiangiogenic therapy and immunotherapy may promote the mutually reinforced cycle of immune reprogramming and vascular normalization to avoid tumor metastasis and recurrence. Herein, we prepared polydopamine nanoparticles for improving tissue adhesion and enriching tumor-associated antigens. This nanoregulator together with regorafenib (REG) was further incorporated into a hydrogel developed from grafting adipic acid dihydrazide onto 2,2,6,6-tetramethylpiperidine-1-oxyl radical oxidized chitin and oxidized hyaluronic acid, which was injectable at the cavity after subcutaneous tumor surgery with good mechanical properties and degradability. The system showed long-term release of REG. After combining with anti-PD-L1, the hydrogel applied to the surgical wound exhibited a reduction in tumor metastasis and recurrence. This effect was achieved by suppressing angiogenesis and enhancing antitumor immunity, characterized by increased levels of effector T lymphocytes and activation of dendritic cells within tumors, spleens, and draining lymph nodes. The injectable hydrogel offers a promising strategy for postoperative management aimed at preventing tumor metastasis and recurrence.
Objective To observe the effect of inferior vena cava filter (IVCF) on prevention of bone cement implantation syndrome (BCIS). Methods Ten sheep were divided into 2 even groups, BCIS and LVCF intervention ones. First IVCF was implanted into the inferior vena cava through cervical vena-right atrium pathway under fluoroscopic monitoring to observe the influence of IVCF on BCIS. Then BCIS was es-tablished in the same sheep by compressing 10 mL of bone cement into a sheep medullary canal after mutilation of the left femur. Arterial blood pressure, heart rate, central venous pressure (CVP) and blood gas were monitored, while an ultrasonic device was utilized to monitor fat embolisms in the right atriums of the sheep. Oil red staining was performed to detect fat embolisms in pulmonary arteries after the sheep were executed. Results In BCIS group, dotted uneven resonances were found in the right atrium and right ventricle when the medullary canal pressure was increased to 120 mm Hg, indicating embolisms in the right chambers. The dotted resonances were increased to ponderous, snowflake-like ones as the medullary canal pressure climbed up. At the same time, blood pressure and Pa02 dropped significantly, the systolic blood pressure dropped to (80±11) mm Hg and PaO to the minimum 25 minutes after cone cement implantation. The heart rate and CVP increased continuously. The blood gas assay indicated respiratory and metabolic acidosis. The oil red staining showed bulk fat embolus in pulmonary arteries. But in IVCF group, the similar resonances were not observed throughout the surgery and the medullary canal pressure climbed to 400 mm Hg, reaching the maximum of our pressure gage range. The blood pressure, PaO2, heart rate and CVP did not change much compared to those before implantation. The blood gas and pulmonary oil red staining showed few changes either. Conclusion IVCF implantation can prevent the genesis of BCIS.
Key words:
Pulmonary embolism; Vena cava filter; Bone cement
The remote sensing image airplane object detection tasks remain a challenge such as missed detection and misdetection, and that is due to the low resolution occupied by airplane objects and large background noise. To address the problems above, we propose an AE-YOLO (Accurate and Efficient Yolov4-tiny) algorithm and thus obtain higher detection precision for airplane detection in remote sensing images. A multi-dimensional channel and spatial attention module is designed to filter out background noise information, and we also adopt a local cross-channel interaction strategy without dimensionality reduction so as to reduce the loss of local information caused by the scaling of the fully connected layer. The weighted two-way feature pyramid operation is used to fuse features and the correlation between different channels is learned to improve the utilization of features. A lightweight convolution module is exploited to reconstruct the network, which effectively reduce the parameters and computations while improving the accuracy of the detection model. Extensive experiments validate that the proposed algorithm is more lightweight and efficient for airplane detection. Moreover, experimental results on the airplane dataset show that the proposed algorithm meets real-time requirements, and its detection accuracy is 7.76% higher than the original algorithm.
We report a new peptidyl boronic acid-based fluorescent probe with an aggregation-induced emission (AIE) characteristic. Through specific recognition between the boronic acid group and the cancer-associated sialic acid (SA), this fluorescent probe shows an ability for targeted labelling and imaging of cancer cells.
In-situ formed Si3N4 bonding Mg O-C materials were prepared by using high quality fused magnesia,silicon powder,and flake graphite as raw materials,liquid calcium lignosulfonate with a concentration of 1.25 g/m L as binder.Then the prepared materials were sintered under N2 atmosphere via two-stage sintered process that low-temperature stage with 1350 ℃ for 2h and high-temperature stage with 1500 ℃ for 3 h,respectively.The phase compositions and microstructure of the Mg O-C materials were investigated by X-ray diffraction( XRD) and scanning electron microscope( SEM),the physical properties including apparent porosity,bulk density and cold crushing strength were also investigated.A large number of α-Si3N4,β-Si3N4 and a small number of Si C phases were formed in the nitriding process,and the composition was hardly affected with the briquetting pressure,whereas a specific MgSiN2 phase formed at the briquetting pressure of 500MPa.The β-Si3N4 crystals presented a columnar morphology.When the briquetting pressure is 400 MPa,the sizes of β-Si3N4 crystals possessed the maximum,and the specimen possessed the lowest apparent porosity and highest cold crushing strength at this briquetting pressure.
Chemotherapy (CT) can significantly inhibit tumor growth, metastasis, and recurrence during cancer therapy. People have widely used platinum drugs in cancer treatment. However, as most chemotherapeutic drugs, platinum drugs still have shortcomings such as poor solubility, low cell uptake, nonspecific distribution, multidrug resistance, and adverse side effects. Therefore, we synthesized hollow copper sulfide (CuS) nanocubes with photothermal and photodynamic properties as carriers for Pt(IV) drugs. Hollow CuS nanocubes have attracted considerable interest in the field of cancer photothermal therapy (PTT) using multiple biological windows. Under near-infrared (NIR) laser irradiation, Cu
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