Marco Aurélio Fornazieri

Universidade de São Paulo

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Richard Louis Voegels

Universidade de São Paulo

Fábio de Rezende Pinna

Universidade de São Paulo

Richard L. Doty

University of Pennsylvania

Eduardo Macoto Kosugi

Universidade Federal de São Paulo

Fabrizio Ricci Romano

Universidade de São Paulo

Marcus Miranda Lessa

Universidade Federal da Bahia

Otávio Bejzman Piltcher

Universidade Federal do Rio Grande do Sul

Ellen Cristine Duarte Garcia

Universidade Estadual de Londrina

Renato Roithmann

Universidade Luterana do Brasil

Thiago Freire Pinto Bezerra

Universidade Federal de Pernambuco

Cooperative Institutions

Universidade Estadual de Londrina

110

Universidade de São Paulo

Universidade Federal de São Paulo

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Monell Chemical Senses Center

Universidade Estadual de Campinas (UNICAMP)

Pontifícia Universidade Católica do Paraná

Universidade de Ribeirão Preto

Associação Brasileira de Alergia e Imunologia

Universidade Federal do Paraná

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Foreign-body in external auditory meatus: evaluation of 462 cases

DOAJ (DOAJ: Directory of Open Access Journals) (2010)

Marco Aurélio Fornazieri Daniel Cutolo Jemima Herrero Moreira Paulo de Lima Navarro Lúcio Eidy Takemoto

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Citations (0)

Main causes and diagnostic evaluation in patients with primary complaint of olfactory disturbances

Brazilian Journal of Otorhinolaryngology (2014)

Marco Aurélio Fornazieri Bruno Barros Pinto Borges Thiago Freire Pinto Bezerra Fábio de Rezende Pinna Richard Louis Voegels

Introduction: Establishing a diagnosis in patients with olfactory disturbances has always been challenging for physicians.One reason for this is the rarity of some of the diseases that affect this sense, such as Kallmann's syndrome and post-viral olfactory loss.Objective: To identify the major causes of olfactory disturbances and to describe the diagnostic evaluation in outpatients attended to at an ambulatory clinic specialized in olfaction disorders.Methods: A retrospective analysis was performed in outpatients with primary olfactory complaint attended to between June 1, 2011 and September 30, 2013 in a center specialized in olfactory disorders.Patient history, nasofibroscopy, and the University of Pennsylvania Smell Identification Test (UPSIT) comprised the examination.Results: Sixty-two patients were evaluated.The major causes were chronic rhinosinusitis (31%); rhinitis, primarily the allergic type (19%); post-viral olfactory loss (13%); and post-traumatic loss (8%).UPSIT scores were statistically different among different etiologies (p = 0.01). Conclusions:The major diagnoses that should be part of the physician assessment when a patient complains of olfactory disturbance are chronic rhinosinusitis with and without polyps, allergic rhinitis, post-viral olfactory loss, and post-traumatic loss.

Etiology

Anosmia

10.1016/j.bjorl.2014.02.001

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Citations (16)

Analysis of oral risk-factors for ventilator-associated pneumonia in critically ill patients

Research Square (Research Square) (2020)

Ademar Takahama Vitoria Iaros de Sousa Elisa Emi Tanaka Evelise Ono Fernanda Akemi Nakanishi Ito

Abstract Objective: This a cross-sectional study to evaluate the association between oral health findings and ventilator-associated pneumonia (VAP) among critically ill patients in intensive care units (ICU). Material and Methods: Data were collected from medical records, and a detailed oral physical examination was performed on 663 critically ill patients on mechanical ventilation. Data were statistically analysed using univariate and logistic regression models relating the development of VAP with the oral findings. Results: At oral physical examination, the most frequent findings were tooth loss (568 - 85.67%), coated tongue (422 - 63.65%) and oral bleeding (192 - 28.96%). Patients with a coated tongue or oral bleeding on the first day of ICU hospitalization developed more VAP than did patients without these conditions (20.14% vs 13.69%: p=0.02; 23.44% vs 15.50%: p=0.01, respectively). In the logistic regression, a coated tongue and oral bleeding were considered independent risk factors for VAP development [OR=1.60 (1.02-2.47) and OR=1.59 (1.05 – 2.44), respectively]. Conclusions: The presence of a coated tongue and oral bleeding in ICU admission could be considered markers for the development of VAP. Clinical relevance: The results of this paper reinforces the importance of proper maintenance of oral hygiene before intubation, which may lead to a decrease in the incidence of VAP in the ICU. This is particularly important in the COVID-19 current scenario, where more people are expected to need mechanical ventilation, consequently increasing cases of VAP.

Ventilator-associated Pneumonia

Univariate analysis

10.21203/rs.3.rs-23662/v1

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Erratum on “Anatomical terminology of the internal nose and paranasal sinuses: cross-cultural adaptation to Portuguese”

Brazilian Journal of Otorhinolaryngology (2018)

Thiago Freire Pinto Bezerra Aldo Cassol Stamm Wilma Teresinha Anselmo‐Lima Marco Aurélio Fornazieri Nelson D’Ávila Melo

10.1016/j.bjorl.2018.11.001

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Development of a Melting-Curve-Based Multiplex Real-Time PCR Assay for the Simultaneous Detection of Viruses Causing Respiratory Infection

Microorganisms (2023)

Eliandro Reis Tavares Thiago Ferreira de Lima Guilherme Bartolomeu-Gonçalves Isabela Madeira de Castro Daniel Gaiotto de Lima

The prompt and accurate identification of the etiological agents of viral respiratory infections is a critical measure in mitigating outbreaks. In this study, we developed and clinically evaluated a novel melting-curve-based multiplex real-time PCR (M-m-qPCR) assay targeting the RNA-dependent RNA polymerase (RdRp) and nucleocapsid phosphoprotein N of SARS-CoV-2, the Matrix protein 2 of the Influenza A virus, the RdRp domain of the L protein from the Human Respiratory Syncytial Virus, and the polyprotein from Rhinovirus B genes. The analytical performance of the M-m-qPCR underwent assessment using in silico analysis and a panel of reference and clinical strains, encompassing viral, bacterial, and fungal pathogens, exhibiting 100% specificity. Moreover, the assay showed a detection limit of 10 copies per reaction for all targeted pathogens using the positive controls. To validate its applicability, the assay was further tested in simulated nasal fluid spiked with the viruses mentioned above, followed by validation on nasopharyngeal swabs collected from 811 individuals. Among them, 13.4% (109/811) tested positive for SARS-CoV-2, and 1.1% (9/811) tested positive for Influenza A. Notably, these results showed 100% concordance with those obtained using a commercial kit. Therefore, the M-m-qPCR exhibits great potential for the routine screening of these respiratory viral pathogens.

Multiplex

Melting curve analysis

Rhinovirus

10.3390/microorganisms11112692

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Citations (4)

Olfactory Dysfunction in Frontline Health Care Professionals During COVID-19 Pandemic in Brazil

Frontiers in Physiology (2021)

Mariana Ferreira Sbrana Marco Aurélio Fornazieri Alexandre Bruni‐Cardoso Vivian Iida Avelino‐Silva Deborah Schechtman

Upper respiratory viral infections can decrease the sense of smell either by inflammatory restriction of nasal airflow that carries the odorant molecules or through interference in olfactory sensory neuron function. During the coronavirus disease 2019 (COVID-19) pandemic, triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), worldwide reports of severe smell loss (anosmia/hyposmia) revealed a different type of olfactory dysfunction associated with respiratory virus infection. Since self-reported perception of smell is subjective and SARS-CoV-2 exposure is variable in the general population, we aimed to study a population that would be more homogeneously exposed to the virus. Here, we investigated the prevalence of olfactory loss in frontline health professionals diagnosed with COVID-19 in Brazil, one of the major epicenters of the disease. We also analyzed the rate of olfactory function recovery and the particular characteristics of olfactory deficit in this population. A widely disclosed cross-sectional online survey directed to health care workers was developed by a group of researchers to collect data concerning demographic information, general symptoms, otolaryngological symptoms, comorbidities, and COVID-19 test results. Of the 1,376 health professionals who completed the questionnaire, 795 (57.8%) were working directly with COVID-19 patients, either in intensive care units, emergency rooms, wards, outpatient clinics, or other areas. Five-hundred forty-one (39.3%) participants tested positive for SARS-CoV-2, and 509 (37%) were not tested. Prevalence of olfactory dysfunction in COVID-19-positive subjects was 83.9% (454 of 541) compared to 12.9% (42 of 326) of those who tested negative and to 14.9% (76 of 509) of those not tested. Olfactory dysfunction incidence was higher in those working in wards, emergency rooms, and intensive care units compared to professionals in outpatient clinics. In general, remission from olfactory symptoms was frequent by the time of responses. Taste disturbances were present in 74.1% of infected participants and were significantly associated with hyposmia. In conclusion, olfactory dysfunction is highly correlated with exposure to SARS-CoV-2 in health care professionals, and remission rates up to 2 weeks are high.

Anosmia

Hyposmia

Cross-sectional study

Pandemic

10.3389/fphys.2021.622987

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Citations (13)

Prevalence and factors associated with olfactory impairment among patients with acne treated with oral isotretinoin: a cross-sectional study

Brazilian Journal of Otorhinolaryngology (2024)

Rogério Nabor Kondo Hélio Amante Miot Elouise Zwirtes Frare Ellen Cristine Duarte Garcia Abner Hiraku Yamakami

This study aimed to investigate the prevalence and factors associated with olfactory dysfunction in individuals exposed to Isotretinoin (ISO) for the treatment of acne, using the University of Pennsylvania Smell Identification Test (UPSIT®).

Hyposmia

Anosmia

Cross-sectional study

10.1016/j.bjorl.2024.101461

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Biópsia do epitélio olfatório do septo nasal superior: é possível obter neurônios sem prejudicar o olfato?

Ellen Cristine Duarte Garcia Lucas de Almeida Luz Lucas Kanieski Anzolin José Lucas Barbosa da Silva Richard L. Doty

10.1016/j.bjorlp.2022.06.004

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Reducing the exposure of the tonsillar fossa does not impact postoperative pain levels in children undergoing tonsillectomy: A double-blind randomized controlled trial

International Journal of Pediatric Otorhinolaryngology (2018)

Marco Aurélio Fornazieri Edson Satoshi Miyazato Henrique Massamiti Yamamoto Paulo de Lima Navarro Fábio de Rezende Pinna

Fossa

10.1016/j.ijporl.2018.05.029

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Citations (5)

Position paper on olfactory dysfunction: 2023

Rhinology Journal (2023)

Katherine L. Whitcroft Aytuğ Altundağ Patrick Balungwe Paolo Boscolo‐Rizzo Richard Douglas

Background: Since publication of the original Position Paper on Olfactory Dysfunction in 2017 (PPOD-17), the personal and so- cietal burden of olfactory disorders has come sharply into focus through the lens of the COVID-19 pandemic. Clinicians, scientists and the public are now more aware of the importance of olfaction, and the impact of its dysfunction on quality of life, nutrition, social relationships and mental health. Accordingly, new basic, translational and clinical research has resulted in significant pro- gress since the PPOD-17. In this updated document, we present and discuss currently available evidence for the diagnosis and management of olfactory dysfunction. Major updates to the current version include, amongst others: new recommendations on olfactory related termino- logy; new imaging recommendations; new sections on qualitative olfactory dysfunction (OD) and COVID-19 olfactory dysfunc- tion; and an updated management section. Recommendations were agreed by all co-authors using a modified Delphi process. Conclusions: We have provided an overview of current evidence and expert-agreed recommendations for the definition, inves- tigation, and management of olfactory dysfunction. As for our original Position Paper, we hope that this updated document will encourage clinicians and researchers to adopt a common language, and in so doing, increase the methodological quality, consis- tency, and generalisability of work in this field.

Position paper

Delphi Method

10.4193/rhin22.483

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Citations (71)