Cui Sheng-miao

Guangdong Pharmaceutical University

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Chunshun Zhao

China Medical University

Zhonggui He

Shenyang Pharmaceutical University

Mina Yan

Fudan University

Weijing Chu

University of Queensland

Ke Zeng

Beijing Normal University

Dawei Chen

Shenyang Pharmaceutical University

Yunhui Liao

Hunan University of Science and Engineering

Yihui Deng

Shenyang Pharmaceutical University

Jin Sun

Shenyang Pharmaceutical University

Zhaoguo Zhang

Kunming University of Science and Technology

Cooperative Institutions

Sun Yat-sen University

Shenyang Pharmaceutical University

Fudan University

Guangdong Pharmaceutical University

Shanghai Jiao Tong University

Capital Medical University

Huazhong University of Science and Technology

Shandong University

Ministry of Education of the People's Republic of China

China Medical University

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Self-Microemulsifying Drug Delivery Systems (SMEDDS) for Improving In Vitro Dissolution and Oral Absorption of Pueraria Lobata Isoflavone

Drug Development and Industrial Pharmacy (2005)

Cui Sheng-miao Chunshun Zhao Dawei Chen Zhonggui He

The aim of our investigation was to develop and characterize self-microemulsifying drug delivery systems (SMEDDS) of Pueraria lobata isoflavone to improve its in vitro dissolution and oral absorption in beagle dogs. SMEDDS consisted of oil (ethyl oleate), a surfactant (Tween 80), and a cosurfactant (Transcutol P). In all the SMEDDS, the level of Pueraria lobata isoflavone was fixed at 20% w/w of the vehicle. The in vitro self-microemulsification properties and droplet size analysis of SMEDDS were studied following their addition to water under mild agitation. A pseudoternary phase diagram was constructed identifying the efficient self-microemulsification region. From these investigations, an optimized formulation was selected and its dissolution and bioavailability were compared with a tablet formulation in beagle dogs. The in vitro dissolution rate of puerarin from SMEDDS was more than threefold faster than that from Yufengningxin tablets (Pueraria lobata isoflavone tablets). A 2.5-fold increase in the relative bioavailability was observed for the SMEDDS compared with Yufengningxin tablets. The absolute bioavailability of the SMEDDS was 82.32 ± 15.51%, which was significantly improved compared with that of Yufengningxin tablets. These results demonstrate the potential of SMEDDS as an efficient way of improving the oral absorption of Pueraria lobata isoflavone.

Lobata

10.1081/ddc-54309

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Citations (33)

[Determination of vitexin in plasma by HPLC-MS/MS method and its pharmacokinetics in rats].

PubMed (2012)

Cui Sheng-miao Xiufang Wei Jian Zhang Zhenzhen Ye Hua-Wei Liao

To establish a HPLC-MS/MS method for the determination of vitexin in rat plasma and its pharmacokinetics.The HPLC-MS/MS method used Capcell Pak C18 column (50 mm x 2.0 mm I. D., 5 microm). The mobile phase was methanol and water (95:5, V/V, containing 0.1% formic acid) at a flow rate of 0.2 mL/min. Electrospray ionization (ESI) in negative ion mode and multiple reaction monitoring (MRM) was used for the quantification of vitexin with a monitored transitions m/z 431-->311 for vitexin and m/z 269-->225 for internal standard (I. S., emodin).Linear calibration curves were obtained over the concentration range of 0.5-2000 ng/mL (r = 0.9960) with the lowest limit of quantification (LLOQ) of 0.5 ng/mL. The recovery was in the range of 76.1%-89.0%. The relative standard deviations for the intra-day and inter-day validation were less than 11%.The method is simple, accurate, fast, sensitive and suitable for the pharmacokinetic study of vitexin in rats.

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Study on extraction process of total flavonoids from Gynostemma pentaphyllum

Journal of Guangdong Pharmaceutical University (2012)

Cui Sheng-miao

Objective To optimize the extraction process of total flavonoids from Gynostemma pentaphyllum.Methods The L9(34) orthogonal test was designed to investigate the effect of ethanol concentration,material-liquid ratio,extraction temperature and extraction time with the content of total flavonoids as index.UV-spectrophotometry was used for the determination of total flavonoids.Results The optimum conditions were as follows: 60% ethanol,material liquid ratio of 1∶60,extraction temperature at 90 ℃ and extracting time for 2 h.Conclusion The extraction process is feasible and suitable for extracting total flavonoids from Gynostemma pentaphyllum.

Gynostemma pentaphyllum

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Quantitative structure-retention relationship studies using immobilized artificial membrane chromatography I: Amended linear solvation energy relationships with the introduction of a molecular electronic factor

Journal of Chromatography A (2006)

Jie Li Jin Sun Cui Sheng-miao HE Zhong-gui

Molecular descriptor

Kovats retention index

Capacity factor

10.1016/j.chroma.2006.07.073

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Determination of nimodipine in self-microemulsified soft capsules by HPLC

Journal of Guangdong Pharmaceutical College (2009)

Cui Sheng-miao

Objective To establish the HPLC method for the determination of nimodipine in self-microemulsified soft capsules.Methods The chromatographic condition was Diamonsil C18 column(250 mm×4.6 mm,5 μm),a mixture of water-methanol-acetonitrile(25∶35∶40) as the mobile phase with a flow rate of 1.0 mL/min,and the detection wavelength was set at 237 nm at 40 ℃.Results The linear range of nimodipine was 10.16～81.28 μg/mL,r=0.999 9.The average recovery of nimodipine was 100.57%,RSD=0.71%.Conclusions The method was accurate and could be used in the determination of nimodipine in self-microemulsified soft capsules.

Nimodipine

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Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma

Acta Pharmacologica Sinica (2006)

Wen Xu Jin Sun Tingting Zhang Bo Ma Cui Sheng-miao

Plasma levels

10.1111/j.1745-7254.2006.00440.x

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Citations (49)

Improvement of pharmacokinetic and antitumor activity of layered double hydroxide nanoparticles by coating with PEGylated phospholipid membrane

International Journal of Nanomedicine (2014)

Chunshun Zhao Mina Yan Zhaoguo Zhang Cui Sheng-miao Ming Lei

Abstract: Layered double hydroxide (LDH) has attracted considerable attention as a drug carrier. However, because of its poor in vivo behavior, polyethylene glycolylated (PEGylated) phospholipid must be used as a coformer to produce self-assembled core–shell nanoparticles. In the present study, we prepared a PEGylated phospholipid-coated LDH (PLDH) (PEG-PLDH) delivery system. The PEG-PLDH nanoparticles had an average size of 133.2 nm. Their core–shell structure was confirmed by transmission electron microscopy and X-ray photoelectron spectroscopy. In vitro liposome-cell-association and cytotoxicity experiments demonstrated its ability to be internalized by cells. In vivo studies showed that PEGylated phospholipid membranes greatly reduced the blood clearance rate of LDH nanoparticles. PEG-PLDH nanoparticles demonstrated a good control of tumor growth and increased the survival rate of mice. These results suggest that PEG-PLDH nanoparticles can be a useful drug delivery system for cancer therapy. Keywords: lipid membrane, positive charge, delivery system, cancer therapy

10.2147/ijn.s69729

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Self-emulsifying delivery systems and its application on preparations of poorly soluble Chinese materia medica

Zhonghua zhongyiyao zazhi (2012)

Cui Sheng-miao

The dissolution and the bioavailability of water-insoluble drugs can be improved by the utilization of self-emulsifying delivery systems(SEDDS),so SEDDS has a promising application in the field of Chinese medicine.The definition,characterization,indexes in vivo and in vitro evaluations,application to preparations of poorly soluble Chinese materia medica,problems and countermeasures are reviewed.

Materia medica

Water soluble

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pH-responsive hyaluronic acid-based nanoparticles for targeted curcumin delivery and enhanced cancer therapy

Colloids and Surfaces B Biointerfaces (2020)

Hualu Lai Xin Ding Junxian Ye Jie Deng Cui Sheng-miao

Nanocarriers

10.1016/j.colsurfb.2020.111455

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Citations (51)

Preparation of hawthorn leaves flavonoids dispersible tablets

Strait Pharmaceutical Journal (2009)

Cui Sheng-miao

OBJECTIVE To investigate the preparation method for dispersible tablets of Hawthorn leaves flavonoids.METHODS The formula of hawthorn leaves flavonoids dispersible tablets was optimized by orthogonal experiment with the disintegrating time as index.Test the dissolution on the optimized Hawthorn leaves flavonoids dispersible tablets.RESULTS The dispersible tablets could be disaggregated in 30 seconds,the dispersible uniformity test proved that it could pass through No.2 sieve.The dissolution rate of Hawthorn leaves flavonoids dispersible tablets was much better than that of Hawthorn leaves flavonoids obtained from market.CONCLUSION The technology of the tablet is feasible.

Sieve (category theory)

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