Dania S. Waggas

Soliman Fakeeh Hospital

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Protective Effect of Nigella sativa and Onion Extract against 5-Fluorouracil-Induced Hepatic Toxicity

Nutrition and Cancer (2021)

Sherif Zaki Dania S. Waggas

Aim: The present study intended to compare the antioxidant, anti-lipid peroxidation, and anti-inflammatory potentials of Nigella Sativa (NS) and onion extract on 5-FU-induced liver damage in rats. Material and methods: 48 rats were divided into control, control group of the onion extract, control group of the NS extract, 5-FU-treated, concomitant NS-treated, and concomitant onion extract-treated. Liver sections were processed for histological analysis (light and electron microscopic examination). Liver enzymes (ALT, AST, and ALP), inflammatory markers (TNF-α and IL-1), antioxidant markers (SOD, GSH, and GSH/GSSG ratio), 4-HNE, NF-κB, and Nrf2 were evaluated. Results: The 5-FU-treated group exhibited inflammation, congested hepatic sinusoid, and steatosis. Improvement with few pathological residues was seen in the concomitant extract-treated groups. The 5-FU-treated group showed higher liver enzymes. The enzymes decreased in the concomitantly treated groups. 5-FU induced liver damage through oxidative stress, inflammation, and lipid peroxidation. Concomitantly using NS and onion extracts resulted in a reduction in oxidative stress, lipid peroxidation, and inflammation. Conclusion: NS and onion extracts attenuated 5-FU-induced liver damage via antioxidative, anti-lipid peroxidative, and anti-inflammatory mechanisms. NS's role was exceptional when compared with onion extract.

Nigella sativa

Steatosis

10.1080/01635581.2021.2019794

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Citations (6)

Integrated Computational Analysis of Physicochemical Features, Biological Properties, Kinase Target Prediction and Biotransformation Pathways in Drug Discovery

International Journal of Pharmacology (2024)

Mohamed Sabri Bensaad Dhiya Eddine Bensaad Mohamed Amine Kahoul Dania S. Waggas Roua S. Baty

Biotransformation

Drug target

10.3923/ijp.2024.748.767

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Assessment of Multiple Sclerosis Awareness and Knowledge among the Community of Jeddah, Saudi Arabia

Journal of Neurosciences in Rural Practice (2021)

Eyas K. Farran Dania S. Waggas Tala A. Alkhunani Safwan A. Almuwallad Rola A. Aljohani

Objective Multiple sclerosis (MS) is a degenerative disease of the central nervous system that can lead to lifelong disabilities. There is a significant increase in the global incidence of the disease. In Saudi Arabia (SA), the western region has the greatest number of MS cases. However, there is a lack of studies and research to assess public knowledge in the region. Thus, we aim to assess the public's knowledge of MS in Jeddah, SA. Methodology We conducted a cross-sectional study surveying 468 participants from the general population of Jeddah. A validated MS knowledge questionnaire (MSKQ-25) was used. Results Most participants were female 347 (74.1%) with a mean age of 35.73 ± 14.71 standard deviation (SD). MS was found in 14 (3%) of the participants. The average score of the (MSKQ) was 7.42 SD ± 4.568 versus the average score of people with MS with a mean of 13.92 SD ± 3.33 and a p value > 0.001. No significant variation was found in knowledge between gender and age groups, but there was a significant correlation between the educational level and the knowledge level. Conclusion The mean knowledge score was below average, which indicates poor knowledge of MS. Since the western region has the highest number of MS cases in SA, the level of understanding needs to increase. This can be improved by conducting educational programs using various types of media.

10.1055/s-0041-1734009

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Assessment of nursing students’ attitudes and stigma towards mental illness: A cross-sectional study

Journal of Nursing Education and Practice (2020)

Mohamamd Shammari Dania S. Waggas Abd Al-Hadi Hasan

This study aimed to assess nursing students’ attitudes toward mental illness in Saudi Arabia. The research design was cross sectional survey. A convenience sample of 315 nursing students. The attitudes towards patients with mental illness questionnaire (AMI) was employed. The results of analysis found that nursing students had favorable attitudes (social relationships) toward people affected by mental illness. Their AMI1 score was slightly higher than the neutral score 20.82. In addition, the findings suggested that students showed slightly affirmative attitudes of tendency to inform others in case oneself or a close relative being mentally ill. 10.50 was the score of AMI2. Nursing students had favorable attitudes towards mental illness despite having negative stereotyped attitudes toward mental illness.

Stigma

Mentally ill

Cross-sectional study

10.5430/jnep.v10n9p1

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Citations (13)

Psychological wellbeing and associated factors among nurses exposed to COVID 19: Findings from a cross sectional study

International Journal of Disaster Risk Reduction (2022)

Abd Alhadi Hasan Dania S. Waggas

Cross-sectional study

Pandemic

Marital status

Psychological Trauma

10.1016/j.ijdrr.2022.103025

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Citations (9)

Successful use of platelet-rich plasma as a regeneration technique for a non-healing diabetic leg ulcer with chronic osteomyelitis: A case report

Journal of Musculoskeletal Surgery and Research (2024)

Majd M. Alrayes Abdulrahman A. Alghamdi Dania S. Waggas Ziyad Alharbi

Chronic diabetic leg ulcers can be challenging to manage, particularly when osteomyelitis coexists resulting in serious or even life-threatening conditions if not managed appropriately. Such cases require very long periods of treatment with several debridements, antibiotic bead implants, skin grafts or even amputations in many unfortunate cases. Despite that, conventional management appears to be inadequate with poor outcomes and a higher relapse rate. We report a case of a 26-year-old type 1 diabetic female patient presented with a history of non-healing diabetic leg ulcer complicated by chronic osteomyelitis of the left leg. Several wound debridements were performed with the application of vacuum-assisted closure, and culture-guided antibiotics were given. However, only minimal improvements were observed. Eventually, the leg was labeled as an unsalvagable limb due to poor blood supply based on an ankle-brachial index. Platelet-rich plasma (PRP) was tried showing promising results and significant improvement as confirmed by a gallium scan, which showed evidence of osteomyelitis remission. Two months later, the patient improved significantly with the ulcer healed and the osteomyelitis resolved. Autologous PRP promotes wound healing by providing necessary growth factors, reducing inflammation, and showing bactericidal activity. All efforts must be taken to preserve any limb before labeling it non-salvageable. This case report aimed to draw attention to the method that can be implemented to manage non-healing diabetic leg ulcers complicated by chronic osteomyelitis.

Diabetic ulcers

Diabetic foot ulcer

10.25259/jmsr_249_2023

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Early Career Achievements of Medical Personnel

Journal of Nursing and Women s Health (2023)

Ghaleb Abdo Al-Mekhlafi Dania S. Waggas Abdulrahman Alotaibi

Background: There has been a recent uptick in cases of burnout throughout the world, with sufferers reporting increased levels of professional exhaustion, emotional tiredness, depersonalization, and dissatisfaction.Since these issues have such a profound effect on the medical staff, very few studies of this kind have been done by the private sector.Objective: The purpose of this research was to determine how often burnout occurs in the medical profession.Design: Cross-sectional descriptive study using the Maslach Burnout Inventory for Human Service survey (MBI-HSS).Settings: A single, private tertiary center.Results: 102 respondents answered the survey, of whom 53% were female, 79.5% were young, 60% were married, and 53% were non-physicians.A significant difference in emotional exhaustion was observed among the younger, unmarried, and non-physician groups with p=0.01, p=0.05, and p=0.04, respectively.Depersonalization significantly seen among males, young people, and unmarried groups with p=0.03, p=0.01, and p=0.04, respectively.When compared to a married senior, unmarried young employee feels they are less capable and have achieved less in their work, p=0.01 and P=0.05, respectively.Conclusions: It appears that working in private hospitals are associated with low levels of personal accomplishments among unmarried medical personnel in their early careers.Moreover, this is accompanied by a high level of burnout.

10.29011/2577-1450.100085

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Efficacy of forskolin as a promising therapy for chronic olfactory dysfunction post COVID-19

European Archives of Oto-Rhino-Laryngology (2024)

Mohamed H. Abdelazim Faisal Alsenani Mohammed Alnuhait Abdullah S. Alshammari Abdullah H. Altemani

2019-20 coronavirus outbreak

10.1007/s00405-024-08802-x

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Neuroprotective effects of Lepidium meyenii (Maca) and macamides against amyloid‐beta (25‐35) induced toxicity in B‐35 neuroblastoma cells (657.13)

The FASEB Journal (2014)

Ali Alquraini Dania S. Waggas Mark Böhlke Toby M. Maher Alejandro Pino‐Figueroa

Production and deposition of Amyloid‐beta (Aβ) peptide is a hallmark of Alzheimer’s disease. The Maca plant ( Lepidium meyenii ) has been used as a traditional medicine to treat several diseases. It contains macamides, compounds which are structurally similar to the endocannabinoids which have neuroprotective effects. The purpose of this study was to evaluate the neuroprotective effects of a Maca pentane extract (5‐50 µg/mL) and some of the component macamides: N ‐benzylpalmitamide, N ‐benzyloleamide and N ‐(3‐methoxybenzyl)palmitamide (1‐30 µM) on the B‐35 neuroblastoma cell line. B‐35 cells were pre‐treated with extract or macamides and subsequently exposed to a neurotoxic concentration (10 µM) of Aβ (25‐35). A cell viability assay utilizing 3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2H‐tetrazolium (MTS) was performed to evaluate the neuroprotective effects. The results demonstrated that the Maca extract and N ‐(3‐methoxybenzyl)palmitamide counteracted the toxicity produced by Aβ (25‐35), demonstrating significant increases in cell viability (34% and 21% respectively). Furthermore, when the tested compounds were evaluated for antioxidant activity and their effects on caspase 3, neither the Maca extract nor N ‐(3‐methoxybenzyl)palmitamide demonstrated an antioxidant effect or caspase 3 inhibition. These results suggest that the Maca extract and macamides may produce neuroprotective effects against Aβ by mechanisms other than caspase 3 inhibition or an antioxidant effect.

Viability assay

Amyloid beta

10.1096/fasebj.28.1_supplement.657.13

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Citations (6)

Cost-effectiveness analysis of Manuka honey-Omega-3 combination treatments in treating oxidative stress of pediatric β-thalassemia major.

PubMed (2024)

M M Gamaleldin Ivo Abraham Mohamed Meabed Ahmed A. Elberry Sherif Abdelhalim

Oxidative stress represents a ruthless complication of β-thalassemia that worsens the severity of that medical condition. There is no conclusive evidence on the best antioxidant used for that issue. Our earlier clinical study concluded that omega-3 and Manuka honey add-on to the conventional therapy had a potential therapeutic impact on reducing oxidative stress. However, there is no research evaluating their cost-effectiveness. This paper compares the cost-effectiveness of Omega-3 and Manuka honey supplementation to conventional therapy in treating oxidative stress among children with β-thalassemia major.

Manuka Honey

10.26355/eurrev_202402_35353

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