Protective Effect of Nigella sativa and Onion Extract against 5-Fluorouracil-Induced Hepatic Toxicity
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Aim: The present study intended to compare the antioxidant, anti-lipid peroxidation, and anti-inflammatory potentials of Nigella Sativa (NS) and onion extract on 5-FU-induced liver damage in rats. Material and methods: 48 rats were divided into control, control group of the onion extract, control group of the NS extract, 5-FU-treated, concomitant NS-treated, and concomitant onion extract-treated. Liver sections were processed for histological analysis (light and electron microscopic examination). Liver enzymes (ALT, AST, and ALP), inflammatory markers (TNF-α and IL-1), antioxidant markers (SOD, GSH, and GSH/GSSG ratio), 4-HNE, NF-κB, and Nrf2 were evaluated. Results: The 5-FU-treated group exhibited inflammation, congested hepatic sinusoid, and steatosis. Improvement with few pathological residues was seen in the concomitant extract-treated groups. The 5-FU-treated group showed higher liver enzymes. The enzymes decreased in the concomitantly treated groups. 5-FU induced liver damage through oxidative stress, inflammation, and lipid peroxidation. Concomitantly using NS and onion extracts resulted in a reduction in oxidative stress, lipid peroxidation, and inflammation. Conclusion: NS and onion extracts attenuated 5-FU-induced liver damage via antioxidative, anti-lipid peroxidative, and anti-inflammatory mechanisms. NS's role was exceptional when compared with onion extract.Keywords:
Nigella sativa
Steatosis
Nigella sativa
Ranunculaceae
Cannabis sativa
Thymoquinone
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Nigella sativa
Thymoquinone
Ranunculaceae
Alloxan
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Nigella sativa (black seeds) is a very famous and popular herb used for centuries in many communities. N. sativa has been shown to possess therapeutic potential to many illnesses. Hypoglycemic effect of N. sativa has been studied extensively in the literature. This review gathered and analyzed the results reported in the literature related to the hypoglycemic effect of N. sativa. A search was done for N. sativa and black seeds as key words in PubMed and Google scholar databases. Published studies document a hypoglycemic effect of N. sativa in normal and diabetic animals and humans. Volatile oil and thymoquinone seem to be the most effective fractions of the seed in producing its hypoglycemic effect. The mechanism of N. sativa hypoglycemic effect is multifactorial including increasing insulin level, decreasing insulin resistance, stimulating β cells activity, direct insulin-like effect, and decreasing intestinal glucose absorption. Further, basic followed by clinical research to explore N. sativa ingredient responsible for its promising hypoglycemic effect is recommended.
Nigella sativa
Thymoquinone
Cannabis sativa
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Female infertility cases have been increased worldwide by several factors including lifestyle. Nigella sativa is a well-known medicinal plant which has been used globally for prevention and cure of many diseases. Nigella sativa with its active components were thought to be a solution for the infertility problem. Thus in this experiment, the effects of Nigella sativa on the number of oocytes and number of fertilized oocytes were investigated. This was carried out by treating 20 Balb/c female mice divided equally into groups of four; i) control group (no treatment given), ii) treated with 25mg/kg per body weight of Nigella sativa, iii) treated with 50mg/kg per body weight of Nigella sativa, and iv) treated with 75mg/kg per body weight of Nigella sativa. The treatments were given daily for five days (estrous cycle) via intraperitoneal (i.p.) injection. Then, they were sacrificed and oocytes were obtained, followed by in vitro fertilization process. Total number of oocytes obtained was calculated and total number of fertilized oocytes was recorded. This study discovered that Nigella sativa supplementation did not indicate any significant difference (p>0.05) in the effect of different doses of Nigella sativa with total number of oocytes produced as well as the total number of fertilized oocytes. It was concluded that Nigella sativa did not increase the number of oocytes and the number of fertilized oocytes produced in mice.
Nigella sativa
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Objective. Nigella sativa is a plant that contains a lot of antioxidants. Nigella sativa is an important medicinal herb that has been utilized for centuries. Given Nigella sativa efficacy in treating a variety of disorders, this systematic study attempts to assess Nigella sativa effect on the female reproductive system. Materials and methods. This systematic review was conducted on the Randomize Control Trial (RCT) through electronic databases such as Google Scholar, Science Direct, Pubmed, Scopus and Proquest from January 2012 to January 2022. The keywords or phrases used were Nigella sativa, Black Seeds, Black Cumin, Thymoquinonee, Infertility, Women dan Female. Results. 14 articles were selected for analysis. The results showed that Nigella sativa and its constituent, Thymoquinone can reduce MDA levels, increase SOD, increase TAS, increase the number of ovarian follicles, and increase body weight. Conclusion. Nigella sativa can improve reproductive parameters in women.
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Thymoquinone
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Medicinal plants can be potential source to improve general health and perhaps for the treatment of various diseases. However, despite the fact that herbal medicine has been used among various civilizations worldwide, scientific research regarding many herbal medicines was still limited. Nigella sativa (N. sativa), commonly known as fennel flower, black caraway, black cumin, jintan hitam, or kalonji, is a widely used medicinal plant that has been used for the treatment of various health problems. N. sativa contains some compounds that are potentially beneficial for health and wellness, particularly thymoquinone (TQ). Studies have shown some therapeutic benefits of N. sativa, however most them require further investigations to evaluate its efficacy and safety profile. This paper provides summary of available studies and reviews of N. sativa, including findings and limitations of the studies.
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Thymoquinone
Cannabis sativa
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Background: Many studies have showed that Nigella sativa is used as a natural remedy in treating various diseases across the globe. Indonesia is famous for its rich spices, one of which is the "Black Cumin" seed extract (Nigella Sativa N.S). Purpose: To analyze the effects of Nigella sativa as an antioxidant to inhibit oxidative stress caused by ionizing-free radiation. Result: Nigella sativa is widely used to diagnose, treat disease, and decrease the level of malondialdehyde (MDA) as one of the final markers of oxidative stress. Nigella sativa has been used as a treatment for various types of diseases in the world. Through the components contained in Nigella sativa it is believed to have uses as an antimicrobial, anti-inflammatory, antibacterial, antiviral, and as an antioxidant. Th[e mechanism of action of Nigella sativa depends on the type of disease. The contents of Nigella sativa are essential oils and thymoquionoe, dithymoquinone, thymol, carvacrol, nigellicine, nigellidine, nigellimine-N-oxide and alpha-hedrine. As well as some vitamins and omega 3 contained in it. The content of Nigella sativa will work together by inhibiting the okidasin reaction. Conclusion: Nigella Sativa can be used in herbal medicine because it has pharmacological effects; antibacterial, antifungal, antiviral and antioxidant. Nigella sativa has many health benefits. Nigella sativa contains thymoquinone which can reduce lipid peroxidation and increase antioxidant enzymes. The effectiveness of Nigella sativa as a radioprotector can prevent the occurrence of free radicals caused by ionizing radiation.
Nigella sativa
Thymoquinone
Thymol
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Nigella sativa
Thymoquinone
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Nigella sativa seed, commonly known as black seed, has been employed as a natural remedy for many ailments for centuries in many cultures. It contains many active components including thymoquinone, thymohydroquinone, dithymoquinone, thymol, carvacrol, nigellimine, nigellicine, nigellidine and alphahederin. It was reported to possess numerous pharmacological effects related to several organs of the body. In this article, the literature pertaining to dermatological effects of N. sativa is reviewed. To the best of our knowledge this is the first review in this subject and we expect it stimulates further studies on the dermatological effects and application of N. sativa.
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Thymoquinone
Carvacrol
Thymol
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The study aimed to determine the effects of black cumin extract (Nigella sativa) and determine the optimal dose of black cumin extract (Nigella sativa) on total erythrocytes and leukocytes broilers. This research was conducted from December 2019 to January 2020 at the Integrated Field Laboratory Unit of the Faculty of Agriculture, University of Lampung. The research data were analyzed at Pramitra Biolab Indonesia Laboratory, Bandar Lampung. The research material was 60 female broilers (strain Cobb CP 707). This study used a Completely Randomized Design with 4 treatments and 3 replications. The treatments in this study were drinking water without Nigella sativa (P0), drinking water with Nigella sativa 36 mg/kg BW/day (P1), drinking water with Nigella sativa 72 mg/kg BW/day (P2) and drinking water with Nigella sativa 144 mg/kg BW/day (P3). Data obtained from observations were arranged in the form of simple tabulations and displayed in the form of histograms for descriptive analysis. Research showed that female broilers given black cumin (Nigella sativa) in their drinking water affected on the total erythrocytes which was in the normal range and the total leukocytes which were above the normal range in all treatment. The best dose of black cumin (Nigella sativa) in drinking water for each parameters was 144 mg/kg BW/day for total erythrocytes and 72 mg/kg BW/day for total leukocytes.
Keywords: Black cumin (Nigella sativa), Erythrocytes, Female broilers, Immunomodulator , Leukocytes
Nigella sativa
Completely randomized design
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