Hasan Kafalı

Burdur Mehmet Akif Ersoy Üniversitesi

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Co-Authors

Yakup Ergül

Sağlık Bilimleri Üniversitesi

NÖ

Nilgün Öztürk Turhan

University of Batna 1

İK

İkbal Kaygusuz

Yüksek İhtisas Üniversitesi

Serap Simavlı

Istanbul Yeni Yüzyıl University

Alper Güzeltaş

Burdur Mehmet Akif Ersoy Üniversitesi

Aydın Köşüş

Turgut Özal University

İİ

İlknur İnegöl Gümüş

Turkish Society of Hematology

Nermin Köşüş

Turgut Özal University

Esra Aktepe Keskin

Turgut Özal University

Deniz Hızlı

Turgut Özal University

Cooperative Institutions

Charité - Universitätsmedizin Berlin

128

Walter de Gruyter (Germany)

121

Sağlık Bilimleri Üniversitesi

102

Fatih University

Adli Tıp Kurumu

Turgut Özal University

Burdur Mehmet Akif Ersoy Üniversitesi

Istanbul University

Ankara University

University of Health Science

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Is N-terminal pro-brain natriuretic peptide a reliable marker for body fluid status in children with chronic kidney disease?

Archives of Medical Science (2019)

Hülya Nalçacıoğlu Ozan Özkaya Hasan Kafalı Demet Tekcan Bahattin Avcı

Brain natriuretic peptides, released in response to left ventricular stress, have a strong prognostic value in dialysis patients. However, their role in detecting abnormalities of fluid status is under debate; the relationship between volume status and brain natriuretic peptides (BNPs) differs among various studies. The aim of our study was to evaluate the clinical utility of N-terminal proBNP in the assessment of fluid status and cardiovascular risk in this setting.The study included 65 children: 10 pre-dialysis, 13 hemodialysis, 12 peritoneal dialysis patients and 30 healthy controls. Volume status was determined by multifrequency bioimpedance and NT-pro-BNP, as well as echocardiography to estimate the left ventricle structure and function.The median log NT-proBNP values of hemodialysis and peritoneal dialysis patients were 3.66 (2.05-4.90) and 3.57 (2.51-4.13) pg/ml, respectively, and significantly higher compared with the control group (p < 0.001, p < 0.001). On simple correlation, NT-proBNP was correlated with markers of volume overload and cardiac dysfunction. On multivariate regression analysis, only left ventricle mass index (β = 0.402, p = 0.003) and left atrium diameter (β = 0.263, p = 0.018) were independently associated with NT-proBNP (adjusted R2 of the model: 0.707, p < 0.001).Our research suggested that NT-proBNP, which was correlated with LV systolic and diastolic dysfunction and fluid overload as assessed by bioimpedance, can be used to evaluate cardiovascular states in a chronic kidney disease (CKD) population. From the early stages of CKD, periodic monitoring of NT-proBNP levels may be essential for early detection of patients with high risk of cardiovascular events, and for taking preventive intervention as soon as possible.

Volume overload

Intravascular volume status

Brain natriuretic peptide

10.5114/aoms.2019.85460

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Citations (16)

The Transjugular Approach: An Alternative Route to Improve Ablation Success in Right Anteriorly and Anterolaterally-Located Supraventricular Tachycardia Substrates in Children

Pediatric Cardiology (2018)

Yakup Ergül Senem Özgür Gülhan Tunca Şahin Hasan Kafalı Sinem B. Celebi

Vascular surgery

Supraventricular Tachycardia

10.1007/s00246-018-1987-4

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Citations (10)

Effects of the etonogestrel contraceptive implant (Implanon^®) on bone metabolism during lactation: a prospective study

Journal of Family Planning and Reproductive Health Care (2016)

Candan İltemir Duvan Yüksel Onaran Esra Aktepe Keskin Ebru Yüce Burcu Yanık

Aim To evaluate the effects of the etonogestrel contraceptive implant (Implanon ® ) on bone metabolism in lactating women using markers for bone formation and resorption. Study design This single-centre, prospective cohort study was conducted in Turgut Ozal University Medical Faculty Obstetrics and Gynecology Department with healthy lactating women aged between 24 and 38 years to compare the effect on bone metabolism of 6 months’ use of either the implant or a non-hormonal contraceptive method. The study group ( n =25) used an implant and the control group ( n =25) used a non-hormonal contraceptive intrauterine device inserted 40 days’ postpartum. Bone metabolism differences at the time of insertion and after 6 months were assessed quantitatively by biochemical analysis of serum and urine samples. Results At baseline, serum levels of bone metabolism parameters were similar for the two groups. In the implant group, serum alkaline phosphatase (ALP) levels decreased ( p =0.004) and total protein levels increased ( p =0.045) at 6 months. In the control group, serum levels of bone metabolism parameters did not change at 6 months compared to baseline. However, serum levels of phosphorus ( p =0.013) and ALP ( p =0.003) decreased at 6 months compared to baseline. Conclusion Six months’ postpartum use of Implanon was found to have no deleterious impact on bone turnover in healthy lactating women.

Etonogestrel

Bone remodeling

Desogestrel

Contraceptive implant

Levonorgestrel

10.1136/jfprhc-2015-101375

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Citations (5)

Evaluation of serum and follicular fluid levels of soluble Fas, soluble Fas ligand and oxidative stress parameters of patients undergoing IVF

Fertility and Sterility (2013)

Aslıhan Pekel Aymelek Gönenç Nilgün Öztürk Turhan Hasan Kafalı Şaban Gürcan

Follicular fluid

Malondialdehyde

10.1016/j.fertnstert.2013.07.206

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Citations (1)

Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women

TURKISH JOURNAL OF MEDICAL SCIENCES (2014)

İkbal Kaygusuz Serap Simavlı Ayla Eser İlknur İnegöl Gümüş Selcen Yüksel

To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease.This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population.Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV levels and other cardiovascular disease risk markers in women receiving HRT compared to women in the control group.Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.

Drospirenone

Mean platelet volume

Hormone Therapy

Lipid Profile

10.3906/sag-1311-88

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Citations (4)

Relationship between placental localisation, birth weight, umbilical Doppler parameters, and foetal sex

TURKISH JOURNAL OF MEDICAL SCIENCES (2014)

Müzeyyen Duran Erdolu Aydın Köşüş Nermin Köşüş Gülçin Dilmen Hasan Kafalı

The aim of this study is to examine the relationship between placental localisation, birth weight, and foetal sex. It also evaluates umbilical artery Doppler parameters and their relationship with placental localisation.This is a retrospective study of 500 healthy pregnant women who gave birth at our university. All women had undergone a detailed ultrasound and Doppler examination at 20-23 weeks. The ultrasonography results of the patients were examined retrospectively. Foetal biometry, birth weight, and umbilical artery Doppler parameters were recorded and compared according to placental localisation.Birth weight was significantly higher in foetuses with anteriorly located placenta. The incidence of female foetuses was higher (62%) in relation to anteriorly located placentas, whereas male incidence was higher (51.9%) in relation to posterior placentas. A comparison of Doppler parameters betiveen groups revealed significantly higher pulsatility index (PI) and resistance index (RI) values in posteriorly located placentas.Foetal sex might affect placental localisation. Doppler parameters and birth weight might also differ according to placental side. These factors should be taken into consideration during the evaluation of obstetric patients.

Umbilical artery

Doppler ultrasound

10.3906/sag-1311-36

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Citations (4)

Combined oral contraceptive use increases serum prostate-specific antigen levels in patients with polycystic ovary syndrome

Nilgün Öztürk Turhan Deniz Hızlı Zeynep Kamalak Aydın Köşüş Nermin Köşüş

29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE) - JUL 07-10, 2013 - London, ENGLAND

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Citations (0)

The Effect of Coasting on Intracytoplasmic Sperm Injection Outcome in Antagonist and Agonist Cycle.

DOAJ (DOAJ: Directory of Open Access Journals) (2017)

Zehra Candan İltemir Duvan Müberra Namlι Kalem Yüksel Onaran Esra Aktepe Keskin Aylin Ayrım

Coasting can reduce the ovarian hyperstimulation syndrome (OHSS) risk in ovulation induction cycles before intracytoplasmic sperm injection (ICSI). This study aimed to investigate the effect of gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist protocols to controlled ovarian hyperstimulation (COH) cycles with coasting on the parameters of ICSI cycles and the outcome.In a retrospective cohort study, 117 ICSI cycles were per- formed and coasting was applied due to hyperresponse, between 2006 and 2011. The ICSI outcomes after coasting were then compared between the GnRH agonist group (n=91) and the GnRH antagonist group (n=26).The duration of induction and the total consumption of gonadotropins were found to be similar. Estradiol (E2) levels on human chorionic gonadotropin (hCG) day were found higher in the agonist group. Coasting days were similar when the two groups were compared. The number of mature oocytes and the fertilization rates were similar in both groups; however, the number of grade 1 (G1) embryos and the number of transferred embryos were higher in the agonist group. Implantation rates were significantly higher in the antagonist group compared to the agonist group. Pregnancy rates/embryo transfer rates were higher in the antagonist group; however, this difference was not statistically significant (32.8% for agonist group vs. 39.1% for antagonist group, P>0.05).The present study showed that applying GnRH-agonist and GnRH-antago- nist protocols to coasted cycles did not result in any differences in cycle parameters and clinical pregnancy rates.

Ovarian hyperstimulation syndrome

Controlled ovarian hyperstimulation

Human chorionic gonadotropin

10.22074/ijfs.2016.5144

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Citations (3)

Is meconium stained amniotic fluid related to occult myocardial injury in term low risk pregnancies?

Early Human Development (2012)

Deniz Hızlı Şadıman Kiykaç Altinbaş Nermin Köşüş Aydın Köşüş Abdullah Ayyıldız

Cord blood

10.1016/j.earlhumdev.2012.10.002

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Citations (1)

Bakri Balloon Application in Postpartum Haemorrhage; Our 6-Year Experience

Turkiye Klinikleri Journal of Gynecology and Obstetrics (2015)

Ayla Eser Aydın Köşüş Sevgi YILDIRIM ASLANER İlknur İnegöl Gümüş İkbal Kaygusuz

Amaç: Postpartum kanama tedavisinde Bakri balonun etkinliğini değerlendirmek. Postpartum kanama dünyada doğum sonrası anne ölümlerinin en yaygın sebebidir. Hem vajinal hem de sezaryenle doğumlarda potansiyel ölümcül bir komplikasyondur. Medikal tedavilerle kanama kontrolünün başarısız olduğu postpartum kanama olgularında hem konservatif hem de invaziv cerrahi müdahaleler gereklidir. Son aşamada histerektomi gerekli olabilir. İnvaziv cerrahi müdahaleler komorbidite ve gelecekteki fertilitenin etkilenme potansiyeli ile ilişkilidir. Bakri balon gibi intrauterin balon tamponad sistemleri daha konservatif müdahaleler arasındadır. Gereç ve Yöntemler: Bu retrospektif gözlemsel çalışmada Turgut Özal Universitesi Hastanesi Kadın Hastalıkları ve Doğum kliniğinde Ocak 2009 ve Ağustos 2014 tarihleri arasında postpartum kanama nedeni ile tedavi edilen 25 hastaya ait kayıtlar incelendi. Yapılan müdahalelerin sıklığı ve histerektomiye gerek duyulmadan kanamanın durdurulması açısından müdahalelerin etkisi araştırıldı. Bulgular: Bakri balon uygulaması yapılan 12 hastanın tamamında kanama histerektomiye gerek kalmadan durduruldu. Buna karşın arteriyel ligasyon uygulanan 9 kadının %77,8?inde histerektomiye gerek duyulmuşken, arteriyel ligasyon uygulanmayan 16 kadının %31,3'ünde histerektomi gerekli olmuştur. Tek bir cerrahi uygulamaya kıyasla birden fazla cerrahi tekniğin birlikte uygulanması da yüksek histerektomi riskiyle önemli ölçüde ilişkilidir. Sonuç: Bakri balon uygulaması histerektomi gerektirmeksizin postpartum kanamanın durdurulmasında oldukça etkili bir yöntemdir. Objective: To evaluate effectiveness of Bakri Balloon in post-partum haemorrhage treatment. Post-partum haemorrhage is the most common cause of maternal death in the world. It is potentially fatal complication of both vaginal and caesarean deliveries. In situations where medical interventions are unsuccessful in achieving haemostasis in cases of post-partum haemorrhage, either conservative or invasive surgical therapies are needed. Ultimately hysterectomy may be required. Invasive surgical interventions are associated with co-morbidities and potential implications for future fertility. Among the more conservative interventions are intrauterine balloon tamponade such as the Bakri balloon. Material and Methods: In this retrospective, observational study, records of 25 patients who were treated for post-partum haemorrhage in the Obstetrics and Gynecology Clinic of Turgut Ozal University Hospital, between January 2009 and August 2014 were examined. Frequency and efficacy of interventions were investigated in terms of haemostasis achievement without recourse to hysterectomy. Results: In 12 women who underwent Bakri balloon placement, haemostasis was achieved in all patients without subsequent hysterectomy. By contrast, of 9 women who underwent arterial ligation, 77.8% required hysterectomy as opposed to 31.3% of the 16 women who did not undergo arterial ligation. Use of combinations of surgical techniques was also significantly associated with higher risk of hysterectomy when compared to single techniques. Conclusion: Use of Bakri balloon is a highly effective method in achieving haemostasis in post-partum haemorrhage without necessity of hysterectomy.

10.5336/gynobstet.2015-45817

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Citations (1)