Hari Manev

University of Illinois Chicago

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Tolga Uz

University of Illinois Chicago

Radmila Manev

University of Illinois Chicago

Svetlana Dzitoyeva

Federal State Budgetary Institution of Science Federal Scientific Center "Vladikavkaz Scientific Center of the Russian Academy of Sciences"

Marta Imbesi

Northwestern University

Nikola Dimitrijević

Metropolitan University

Danka Peričić

Rudjer Boskovic Institute

Marco Favaron

Alessandro Manzoni Hospital

Pietro Giusti

University of Padua

Alessandro Guidotti

University of Bologna

Alexander Kharlamov

Rotterdam University of Applied Sciences

Cooperative Institutions

University of Illinois Chicago

University of Illinois Urbana-Champaign

University of Padua

Fidia Farmaceutici (Italy)

Rudjer Boskovic Institute

Georgetown University

Johns Hopkins University

University of Zagreb

University of Chicago

Illinois College

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Effect of aging on 5-hydroxymethylcytosine in brain mitochondria

Neurobiology of Aging (2012)

Svetlana Dzitoyeva Hu Chen Hari Manev

5-Hydroxymethylcytosine

10.1016/j.neurobiolaging.2012.02.006

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Citations (186)

Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro

European Journal of Pharmacology (2001)

Hari Manev Tolga Uz Neil R. Smalheiser Radmila Manev

Bromodeoxyuridine

Subgranular zone

Desipramine

Thymidine

10.1016/s0014-2999(00)00904-3

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Citations (221)

Intra-abdominal injection of double-stranded RNA into anesthetized adult Drosophila triggers RNA interference in the central nervous system

Molecular Psychiatry (2001)

Svetlana Dzitoyeva Nikola Dimitrijević Hari Manev

RNA Silencing

10.1038/sj.mp.4000955

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Citations (130)

The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system

Molecular Brain Research (2005)

Tolga Uz Ahmet Arslan Murat Kürtüncü Marta Imbesi Mustafa Akhisaroğlu

Dopaminergic pathways

10.1016/j.molbrainres.2005.01.002

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Citations (156)

Chapter 27 Gangliosides in the protection against glutamate excitotoxicity

Progress in brain research (1994)

E. Costa D.M. Armstrong Alessandro Guidotti Alexander Kharlamov Lech Kiedrowski

This chapter explores the application of gangliosides in the protection against glutamate excitotoxicity. In experimental studies, it is found that natural gangliosides and LIGA compounds in doses that reduce the increase of [3H] PDBU binding in the area penumbra and fail to block glutamate channel gating are completely ineffective in preventing the expression of the IEG. This suggests that IEG induction is the direct consequence of the Ca2+ influx through the glutamate gated ionotropic channel. In fact, stimulation with specific agonists of AMPA receptors that are less permeable to Ca2+ than NMDA receptors fail to induce IEG. It is concludes that natural and lysogangliosides also in vivo fail to modify the glutamate gating of ionotropic channels. These are blocked by MK801 which virtually abolishes IEG induction in the area penumbra. Thus, one can infer that the ganglioside block of Ca2+ amplification occurs downstream from the glutamate channel gating. Because MK801, the natural gangliosides and LIGA 4 and 20 reduce neuronal death in area penumbra, it is clear that excitotoxicity requires Ca2+ amplification mechanisms but not IEG induction.

Excitotoxicity

10.1016/s0079-6123(08)61962-7

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Citations (17)

Nomen est Omen: do antidepressants increase p11 or S100A10?

Journal of Biomedical Discovery and Collaboration (2006)

Hari Manev Radmila Manev

Occasionally, multiple names are given to the same gene/protein. When this happens, different names can be used in subsequent publications, for example in different research areas, sometimes with little or no awareness that the same entity known under a different name may have a major role in another field of science. Recent reports about the protein p11 presented findings that this protein, commonly known as S100A10, may play a crucial role in depression and antidepressant treatment mechanisms. One set of data showed an increased expression of this protein in the brain of mice treated with antidepressants. P11/S100A10 is only one of several S100 proteins expressed in the brain. Interestingly, it has been previously noted that antidepressant treatment increases the brain content of another S100 protein, S100B. It appears that up-regulating the brain content of various S100 proteins might be a common feature of antidepressants. In cells coexpressing S100A10 and S100B, these proteins may interact and exert opposite regulatory roles. Nevertheless, S100A10 is predominantly expressed in certain types of neurons whereas S100B is more abundant in glia. Thus, an interplay among multiple members of the S100 proteins might be important in determining the region and cell specificity of antidepressant mechanisms. Calling the p11 protein by its other name, S100A10, may prompt more investigators from different fields to participate in this new direction of neurobiological research.

Omen

Depression

10.1186/1747-5333-1-5

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Citations (7)

Is the heterologous expression of metabotropic glutamate receptors (mGluRs) an appropriate method to study the mGluR function? Experience with human embryonic kidney 293 cells transfected with mGluR1

Neurochemistry International (1994)

Nadia Gabellini Radmila M. Manev Hari Manev

HEK 293 cells

Heterologous expression

10.1016/0197-0186(94)90004-3

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