A comprehensive and objective post-evaluation of rural electric network reformation (RENR) will bring a scientific suggestion for decision-making with the financing is shortage. In this paper, on the base of analyzing methods used in post-evaluation before, a new model, which integrated with fuzzy theory, interval number and analytic hierarchy process (AHP), is proposed. Multi-factors and information of quantization and non-quantization are considered in this model. The human influence is reduced by making fuzzy evaluation weights through interval number and AHP, which is useful in practice. Finally, a demonstration of post-evaluation of RENR is given. The result shows that this model is feasible and more objective compared with others.
Colorectal cancer (CRC), a common malignant tumor, is one of the main causes of death in cancer patients in the world. Therefore, it is critical to understand the molecular mechanism of CRC and identify its diagnostic and prognostic biomarkers. The purpose of this study is to reveal the genes involved in the development of CRC and to predict drug candidates that may help treat CRC through bioinformatics analyses. Two independent CRC gene expression datasets including The Cancer Genome Atlas (TCGA) database and GSE104836 were used in this study. Differentially expressed genes (DEGs) were analyzed separately on the two datasets, and intersected for further analyses. 249 drug candidates for CRC were identified according to the intersected DEGs and the Crowd Extracted Expression of Differential Signatures (CREEDS) database. In addition, hub genes were analyzed using Cytoscape according to the DEGs, and survival analysis results showed that one of the hub genes, TIMP1 was related to the prognosis of CRC patients. Thus, we further focused on drugs that could reverse the expression level of TIMP1. Eight potential drugs with documentary evidence and two new drugs that could reverse the expression of TIMP1 were found among the 249 drugs. In conclusion, we successfully identified potential biomarkers for CRC and achieved drug repurposing using bioinformatics methods. Further exploration is needed to understand the molecular mechanisms of these identified genes and drugs/small molecules in the occurrence, development and treatment of CRC.
Er3+-doped Al2O3 films were deposited on silicon substrates by reactive closed-field unbalanced magnetron sputtering. The process parameters, such as target bias voltage, substrate bias voltage, O2 gas flows, sputtering gas pressure, were studied. The 1.53 µm photoluminescence characteristics from Er3+ were measured. The relations among the PL peak intensity, annealing temperatures, and pump power were experimentally investigated.
To monitor and study the molecular epidemiology, evolution and pathogenicity of infectious bronchitis viruses (IBVs) in China in recent years and further our knowledge of the evolution of IBVs.Thirty-seven IBV isolates were isolated from commercial chickens in China. The isolates were characterized by RT-PCR, sequencing, typing and analyzing the entire S1 gene. In addition, 4 selected IBV isolates were used to experimentally infect the specific pathogen-free chickens to study their pathogenicity.Three types of IBV have been cocirculating in chicken flocks in China in recent years. Unique insertions and deletions in S1 protein regions were identified among different types of IBV. Moreover, a new IBV strain was isolated and identified in a layer hen. S1 gene analysis showed that a recombination event had occurred in the virus's evolutionary process. In addition, experimental infection has shown that IBV isolates have been nephropathogenic in China in recent years.Mutations, insertions, deletions and recombination of the S1 protein gene contribute to the genetic diversity of IBV in China. Cocirculation of multiple types of IBV in field conditions in China renders its epidemiology and evolution very complicated, indicating the necessity for development of new vaccines or vaccine strategies.
The green and red up-conversion emissions centred at about 534, 549 and 663nm of wavelength, corresponding respectively to the 2H11/2 → 4I15/2, 4S3/2 → 4I15/2 and 4F9/2 → 4I15/2 transitions of Er3+ ions, have been observed for the Er3+-doped silicate glass excited by a 978nm semiconductor laser beam. Excitation power dependent behaviour of the up-conversion emission intensity indicates that a two-photon absorption up-conversion process is responsible for the green and red up-conversion emissions. The temperature dependence of the green up-conversion emissions is also studied in a temperature range of 296–673 K, which shows that Er3+-doped silicate glass can be used as a sensor in high-temperature measurement.
We sought to identify potential role of BNIP3, a proapoptotic member of the Bcl‐2 family of death‐regulating proteins that promote programmed cell death, in Oxygen–glucose deprivation (OGD) treated primary cultures of rat oligodendrocyte lineage cells (OLs). OGD induced cytotoxic injury to various maturational stages of OLs. Survival assays revealed that oligodendrocyte precursor cells (OPCs) and later‐stage precursors were highly vulnerable, whereas more mature OLs were relatively resistant. Exposure of OLs to OGD resulted in a significant increase in BNIP3 expression. Knockdown of BNIP3 with shRNA reduced OGD‐triggered OL apoptosis. Thirty minutes ischemic preconditioning (IPC) of later‐stage precursors and more mature OLs down‐regulated the BNIP3 expression and shown cytoprotection. Interestingly, OPCs were more susceptible to OGD after IPC pretreatment, concurrent with highly BNIP3 expression. These studies unveil BNIP3 as an important mediator in OLs death and reveal a novel mechanism of action of IPC on stage‐specific OLs cultures, which may contribute to a better understanding of white matter injury in cerebral ischemia.
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