Matthias Fischer

Alb Fils Kliniken

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Co-Authors

Frank Westermann

German Cancer Research Center

108

Barbara Hero

University Hospital Cologne

Jan‐Thorsten Gräsner

University Hospital Schleswig-Holstein

André Oberthuer

University of Cologne

Jo Vandesompele

Ghent University

Frank Speleman

Ghent University Hospital

Glenn M. Marshall

Children's Cancer Institute Australia

Benedikt Brors

German Cancer Research Center

Jan Wnent

University Hospital Schleswig-Holstein

Frank Berthold

University of Cologne

Cooperative Institutions

University of Lübeck

304

University Hospital Schleswig-Holstein

286

Heidelberg University

233

University of Antwerp

223

Ambulance Care (Sweden)

200

Health Service Executive

198

Inclusione Andicap Ticino

192

Ludwig-Maximilians-Universität München

181

University Hospital Heidelberg

137

Charité - Universitätsmedizin Berlin

135

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Effect of video laryngoscopy for non-trauma out-of-hospital cardiac arrest on clinical outcome: A registry-based analysis

Resuscitation (2023)

Joachim Riße Matthias Fischer Karl Matteo Meggiolaro Kaschoz Fariq-Spiegel Dirk Pabst

Videolaryngoscopy (VL) is a promising tool to provide a safe airway during cardiopulmonary resuscitation (CPR) and to ensure early reoxygenation. Using data from the German Resuscitation Registry, we investigated the outcome of non-traumatic out-of-hospital cardiac arrest (OHCA) patients treated with VL versus direct laryngoscopy (DL) for airway management.We analysed retrospective data of 14,387 patients from 1 January 2018 until 31 December 2021 (VL group, n = 2201; DL group, n = 12186). Primary endpoint was discharge with cerebral performance categories one and two (CPC1/2). Secondary endpoints were the rate of return of spontaneous circulation (ROSC), hospital admission, hospital admission with ongoing cardiopulmonary resuscitation, 30-day survival/ hospital discharge and airway management complications. We used multivariate binary logistic regression analysis to identify the effects on outcome of known influencing variables and of VL vs DL.The multivariate regression model revealed that VL was an independent predictor of CPC1/2 survival (OR = 1.34, 95% CI = 1.12-1.61, p = 0.002) and of hospital discharge/30-day survival (OR = 1.26, 95% CI = 1.08-1.47, p = 0,004).VL for endotracheal intubation (ETI) at OHCA was associated with better neurological outcome in patients with ROSC. Therefore, the use of VL for OHCA offers a promising perspective. Further prospective studies are required.

Clinical endpoint

10.1016/j.resuscitation.2023.109688

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Citations (8)

Diagnostic impact and sensitivity of skin biopsies in Sneddon's syndrome. A report of 15 cases

British Journal of Dermatology (2001)

Johannes Wohlrab Matthias Fischer Manfred Wolter W. C. Marsch

Journal Article Diagnostic impact and sensitivity of skin biopsies in Sneddon's syndrome. A report of 15 cases Get access J. Wohlrab, J. Wohlrab Department of Dermatology and Venereology, Martin Luther University Halle‐Wittenberg, Ernst‐Kromayer‐Str. 5–6, D‐06097 Halle (Saale), Germany Johannes Wohlrab. E‐mail: johannes.wohlrab@medizin.uni‐halle.de Search for other works by this author on: Oxford Academic Google Scholar M. Fischer, M. Fischer Department of Dermatology and Venereology, Martin Luther University Halle‐Wittenberg, Ernst‐Kromayer‐Str. 5–6, D‐06097 Halle (Saale), Germany Search for other works by this author on: Oxford Academic Google Scholar M. Wolter, M. Wolter Department of Dermatology and Venereology, Johann Wolfgang Goethe University, Frankfurt (Main), Germany Search for other works by this author on: Oxford Academic Google Scholar W.C. Marsch W.C. Marsch Department of Dermatology and Venereology, Martin Luther University Halle‐Wittenberg, Ernst‐Kromayer‐Str. 5–6, D‐06097 Halle (Saale), Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 2, 1 August 2001, Pages 285–288, https://doi.org/10.1046/j.1365-2133.2001.04348.x Published: 01 August 2001

Skin biopsy

10.1046/j.1365-2133.2001.04348.x

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Citations (76)

Erfassung von Mangelernährung bei geriatrischen Traumapatienten

Der Unfallchirurg (2019)

Juliane Barthel Matthias Fischer René Aigner Juliana Hack Benjamin Bücking

10.1007/s00113-018-0595-3

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Citations (3)

Data from Differential Expression of Neuronal Genes Defines Subtypes of Disseminated Neuroblastoma with Favorable and Unfavorable Outcome

Matthias Fischer André Oberthuer Benedikt Brors Yvonne Kahlert Matthias Skowron

<div>AbstractPurpose: Identification of molecular characteristics of spontaneously regressing stage IVS and progressing stage IV neuroblastoma to improve discrimination of patients with metastatic disease following favorable and unfavorable clinical courses.Experimental Design: Serial analysis of gene expression profiles were generated from five stage IVS and three stage IV neuroblastoma. Differential expression of candidate genes was evaluated by real-time quantitative reverse transcription-PCR in 76 pretreatment tumor samples (stage IVS n = 27 and stage IV n = 49). Gene expression-based outcome prediction was determined by Prediction Analysis for Microarrays using 38 tumors as a training set and 38 tumors as a test set.Results: Comparison of serial analysis of gene expression profiles from stage IV and IVS neuroblastoma revealed ∼500 differentially expressed transcripts. Genes related to neuronal differentiation were observed more frequently in stage IVS tumors as determined by associating transcripts to Gene Ontology annotations. Forty-one candidate genes were evaluated by quantitative reverse transcription-PCR and 18 were confirmed to be differentially expressed (P ≤ 0.001). Classification of patients according to expression patterns of these 18 genes using Prediction Analysis for Microarrays discriminated two subgroups with significantly differing event-free survival (96 ± 6% versus 40 ± 8% at 3 years; P < 0.0001) and overall survival (100% versus 72 ± 7% at 3 years; P = 0.0003). This classifier was the only independent covariate marker in a multivariate analysis considering the variables stage, age, MYCN amplification, and gene signature.Conclusions: Spontaneously regressing and progressing metastatic neuroblastoma differ by specific gene expression patterns, indicating distinct levels of neuronal differentiation and allowing for an improved risk estimation of children with disseminated disease.</div>

Candidate gene

10.1158/1078-0432.c.6518629

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Einfluss des Qigong auf die Lebensqualität onkologischer Patienten

Forum (2012)

C. Schmauser Dirk Kilian Matthias Fischer

10.1007/s12312-012-0807-7

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Data from Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature

Katleen De Preter Joëlle Vermeulen Benedikt Brors Olivier Delattre Angelika Eggert

<div>AbstractPurpose: Reliable prognostic stratification remains a challenge for cancer patients, especially for diseases with variable clinical course such as neuroblastoma. Although numerous studies have shown that outcome might be predicted using gene expression signatures, independent cross-platform validation is often lacking.Experimental Design: Using eight independent studies comprising 933 neuroblastoma patients, a prognostic gene expression classifier was developed, trained, tested, and validated. The classifier was established based on reanalysis of four published studies with updated clinical information, reannotation of the probe sequences, common risk definition for training cases, and a single method for gene selection (prediction analysis of microarray) and classification (correlation analysis).Results: Based on 250 training samples from four published microarray data sets, a correlation signature was built using 42 robust prognostic genes. The resulting classifier was validated on 351 patients from four independent and unpublished data sets and on 129 remaining test samples from the published studies. Patients with divergent outcome in the total cohort, as well as in the different risk groups, were accurately classified (log-rank P < 0.001 for overall and progression-free survival in the four independent data sets). Moreover, the 42-gene classifier was shown to be an independent predictor for survival (odds ratio, >5).Conclusion: The strength of this 42-gene classifier is its small number of genes and its cross-platform validity in which it outperforms other published prognostic signatures. The robustness and accuracy of the classifier enables prospective assessment of neuroblastoma patient outcome. Most importantly, this gene selection procedure might be an example for development and validation of robust gene expression signatures in other cancer entities. Clin Cancer Res; 16(5); 1532–41</div>

Gene signature

10.1158/1078-0432.c.6518833.v1

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Lobomykose Erfolgreiche Therapie mit Clofazimin und Itrakonazol bei einem 46-jährigen Patienten nach 32-jähriger Krankheitsdauer

Der Hautarzt (2002)

Matthias Fischer Anette Chrusciak Talhari D. Reinel Sinésio Talhari

Clofazimine

10.1007/s00105-002-0351-y

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Citations (37)

Supplementary Table 6A from High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma

Johannes H. Schulte Hagen S. Bachmann Bent Brockmeyer Katleen De Preter André Oberthür

XLS file - 56K

10.1158/1078-0432.22443797

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Supplementary Table 6B from High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma

Johannes H. Schulte Hagen S. Bachmann Bent Brockmeyer Katleen De Preter André Oberthür

XLS file - 61K

10.1158/1078-0432.22443794

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Supplementary Table 1 from Differential Expression of Neuronal Genes Defines Subtypes of Disseminated Neuroblastoma with Favorable and Unfavorable Outcome

Matthias Fischer André Oberthuer Benedikt Brors Yvonne Kahlert Matthias Skowron

Supplementary Table 1 from Differential Expression of Neuronal Genes Defines Subtypes of Disseminated Neuroblastoma with Favorable and Unfavorable Outcome

Table (database)

Expression (computer science)

10.1158/1078-0432.22441651

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