Supplementary Table 6B from High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma

Each of the seven mating types of Tetrahymena thermophila is determined by a pair of large genes, MTA and MTB, whose expression peaks at early conjugation. Each protein consists of a mating-type specific domain and a common transmembrane domain. To assess variation in natural populations, regions of both domains from wild isolates expressing mating types V and VII were analyzed. Corresponding regions of amicronucleates incapable of mating also were examined. MTA and MTB showed high haplotype diversity, with greater sequence variation in MTB. Mating type VII was less variable than mating type V, suggesting more recent origin. No polymorphism distinguished between mat1- and mat2-like alleles encoding different arrays of mating types, nor did polymorphisms give evidence of population structure. MTA and MTB variants have different phylogenies, suggesting independent rather than concerted evolution, and are under weak purifying selection. Codon usage is less biased than for housekeeping genes, and reassigned glutamine encoding stop codons are preferentially used. Amicronucleate T. thermophila and closely related nsp15 and nsp25 have higher levels of nucleotide and amino acid substitution, consistent with cox1 distances. The results suggest that complete sequencing of mating type genes of wild isolates coupled with functional analysis will be informative.

10.1111/jeu.12233

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Dinucleotide repeat polymorphisms at the D5S257 and D5S268 loci on chromosome 5p

Nucleic Acids Research (1991)

L.E. Bernard Craig N. Kreklywich Stephen Wood

Journal Article Dinucleotide repeat polymorphisms at the D5S257 and D5S268 loci on chromosome 5p Get access L.E. Bernard, L.E. Bernard Department of Medical Genetics, 6174 University Boulevard, University of British ColumbiaVancouver, BCV6T1Z3, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar C.N. Kreklywich, C.N. Kreklywich Department of Medical Genetics, 6174 University Boulevard, University of British ColumbiaVancouver, BCV6T1Z3, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Wood S. Wood Department of Medical Genetics, 6174 University Boulevard, University of British ColumbiaVancouver, BCV6T1Z3, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 20, 25 October 1991, Page 5794, https://doi.org/10.1093/nar/19.20.5794 Published: 25 October 1991

Dinucleotide Repeat

10.1093/nar/19.20.5794

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Gene conversions within the Cup1 r region from heterologous crosses in Saccharomyces cerevisiae

MGG Molecular & General Genetics (1991)

Juliet W. Welch Daniel H. Maloney Seymour Fogel

Heterologous

Human genetics

10.1007/bf00272164

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A HindIII polymorphism identified by the human early growth response gene 2 (EGR2) on chromosome 10

Nucleic Acids Research (1988)

Jingshi Wu Joseph Loren Vikas P. Sukhatme Kenneth K. Kídd

10.1093/nar/16.24.11855

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Citations (1)

Evolutionary dynamics of full genome content in Escherichia coli

The EMBO Journal (2000)

Howard Ochman

ORFS

10.1093/emboj/19.24.6637

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Genetic characterization of late‐flowering traits induced by DNA hypomethylation mutation in Arabidopsis thaliana

The Plant Journal (1997)

Tetsuji Kakutani

Arabidopsis DNA hypomethylation mutation, ddm1 , results in a variety of developmental abnormalities by slowly inducing heritable lesions at unlinked loci. Here, late‐flowering traits observed at high frequencies in independently‐established ddm1 lines were genetically characterized. In all of the four late‐flowering lines examined the traits were dominant and mapped to the same chromosomal region, which is close or possibly identical to the FWA locus. The ddm1 ‐induced phenotypic onsets are apparently not random mutation events, but specific to a group of genes, suggesting the underlying epigenetic mechanism. The DNA methylation mutant provide useful system for identifying epigenetically‐regulated genes important for plant development.

RNA-Directed DNA Methylation

10.1046/j.1365-313x.1997.12061447.x

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Evidence of non-neutral polymorphism in Plasmodium falciparum gamete surface protein genes Pfs47 and Pfs48/45

Molecular and Biochemical Parasitology (2007)

Tracy G. Anthony Spencer D. Polley Alfried P. Vogler David J. Conway

Balancing selection

10.1016/j.molbiopara.2007.07.008

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Viral K-ras detects two TaqI polymorphisms, one for KRAS1 on chromosome 6 and the other for KRAS2 on chromosome 12

Nucleic Acids Research (1988)

Mitsumasa Okamoto C. Sato Nobuo Tsuchida Michihiro C. Yoshida C. Ezawa

Journal Article Viral K-ras detects two TaqI polymorphisms, one for KRAS1 on chromosome 6 and the other for KRAS2 on chromosome 12 Get access M. Okamoto, M. Okamoto Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Sato, C. Sato Search for other works by this author on: Oxford Academic PubMed Google Scholar N. Tsuchida, N. Tsuchida 1Department of Oral Microbiology, Tokyo Medical and Dental UniversityYushima, Tokyo 113, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar M.C. Yoshida, M.C. Yoshida 2Chromosome Research Unit, Hokkaido UniversitySapporo 060, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Ezawa, C. Ezawa Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Miyaki M. Miyaki Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 5, 11 March 1988, Page 2363, https://doi.org/10.1093/nar/16.5.2363 Published: 11 March 1988

TaqI

10.1093/nar/16.5.2363

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