Xiaoran Zheng

UNSW Sydney

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ROS‐mediated anticancer effects of EGFR‐targeted nanoceria

Journal of Biomedical Materials Research Part A (2023)

Kochurani K. Johnson Pramod Koshy Chantal Kopecky Michelle Devadason Joanna Biazik

Abstract The therapeutic effectiveness of anticancer drugs, including nanomedicines, can be enhanced with active receptor‐targeting strategies. Epidermal growth factor receptor (EGFR) is an important cancer biomarker, constitutively expressed in sarcoma patients of different histological types. The present work reports materials and in vitro biomedical analyses of silanized (passive delivery) and/or EGF‐functionalized (active delivery) ceria nanorods exhibiting highly defective catalytically active surfaces. The EGFR‐targeting efficiency of nanoceria was confirmed by receptor‐binding studies. Increased cytotoxicity and reactive oxygen species (ROS) production were observed for EGF‐functionalized nanoceria owing to enhanced cellular uptake by HT‐1080 fibrosarcoma cells. The uptake was confirmed by TEM and confocal microscopy. Silanized nanoceria demonstrated negligible/minimal cytotoxicity toward healthy MRC‐5 cells at 24 and 48 h, whereas this was significant at 72 h owing to a nanoceria accumulation effect. In contrast, considerable cytotoxicity toward the cancer cells was exhibited at all three times points. The ROS generation and associated cytotoxicity were moderated by the equilibrium between catalysis by ceria, generation of cell debris, and blockage of active sites. EGFR‐targeting is shown to enhance the uptake levels of nanoceria by cancer cells, subsequently enhancing the overall anticancer activity and therapeutic performance of ceria.

10.1002/jbm.a.37656

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Citations (2)

High-temperature corrosion of Cr2O3-forming alloys in CO-CO2-N2 atmospheres

Oxidation of Metals (1994)

Xiaoran Zheng David J. Young

Partial pressure

10.1007/bf01052021

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Citations (96)

Decoupling the Impacts of Engineering Defects and Band Gap Alignment Mechanism on the Catalytic Performance of Holey 2D CeO₂₋_x‐Based Heterojunctions

Advanced Functional Materials (2021)

Xiaoran Zheng Sajjad S. Mofarah Claudio Cazorla Rahman Daiyan Ali Asghar Esmailpour

Abstract Critical catalysis studies often lack elucidation of the mechanistic role of defect equilibria in solid solubility and charge compensation. This approach is applied to interpret the physicochemical properties and catalytic performance of a free‐standing 2D–3D CeO 2− x scaffold, which is comprised of holey 2D nanosheets, and its heterojunctions with MoO 3− x and RuO 2 . The band gap alignment and structural defects are engineered using density functional theory (DFT) simulations and atomic characterization. Further, the heterojunctions are used in hydrogen evolution reaction (HER) and catalytic ozonation applications, and the impacts of the metal oxide heteroatoms are analyzed. A key outcome is that the principal regulator of the ozonation performance is not oxygen vacancies but the concentration of Ce 3+ and Ce vacancies. Cation vacancy defects are measured to be as high as 8.1 at% for Ru‐CeO 2− x . The homogeneous distribution of chemisorbed, Mo‐oxide, heterojunction nanoparticles on the CeO 2− x holey nanosheets facilitates intervalence charge transfer, resulting in the dominant effect and resultant ≈50% decrease in overpotential for HER. The heterojunctions are tested for aqueous‐catalytic ozonation of salicylic acid, revealing excellent catalytic performance from Mo doping despite the adverse impact of Ce vacancies. The present study highlights the use of defect engineering to leverage experimental and DFT results for band alignment.

10.1002/adfm.202103171

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Citations (36)

Engineering Multifunctional Stratified LiCoO₂ Catalysts: Structural Disorder to Microstructural Exfoliation

ACS Applied Energy Materials (2022)

Kevin Pachuta Xiaoran Zheng Sajjad S. Mofarah Charles C. Sorrell Constantine Tsounis

The stratified nature of LiCoO2 (LCO) makes such materials suitable for rechargeable Li-ion batteries. The existing synthesis technology for LCO, however, results in a low surface area, low activity, and a limited density of active sites, which limit its applications in catalysis, in which the material's functionality is determined by the reactions that occur on its surface. The present work reports a simplified and high-yield strategy for using bulk LCO in multifunctional two-dimensional (2D) catalysts. The recovery involves ordered and/or disordered leaching of Li+ as a result of H+ intercalation and formation of catalytically active oxygen vacancies at high concentrations (∼32 atom %). This is followed by exfoliation of the LCO into porous nanosheets through intercalation of tetramethylammonium hydroxide. The catalytic performance of the etched and exfoliated LCOs was investigated; the 1 M HCl-etched LCO exhibited the highest photocatalytic dye degradation (99.9%) under simulated solar light, while the etched and fully exfoliated LCO showed outstanding CO oxidation, with a T90% = 140 °C, which is significantly lower than that of the bulk LCO catalyst (T90% = 360 °C).

Tetramethylammonium hydroxide

Exfoliation joint

Tetramethylammonium

Degradation

10.1021/acsaem.2c02846

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Citations (1)

Transforming Innovation Systems into Innovation Ecosystems: The Role of Public Policy

Sustainability (2022)

Xiaoran Zheng Yuzhuo Cai

This study investigated the role of public policy in transforming innovation systems into innovation ecosystems. Despite the numerous studies that examined the role of innovation policies in promoting innovation systems and the increasing attention paid to the transition from innovation systems to innovation ecosystems in the literature, research on the role of public policy in facilitating this transition is sparse. To develop an analytical framework that identifies factors to be considered in policies that facilitate the transition towards innovation ecosystems, we synthesised the literature that investigated (1) the role of policy in innovation systems, (2) new features of innovation ecosystems and (3) the relations between (transformative) policies and innovation ecosystems. To identify these factors, we also drew on the concept of policy layering and the neo-Triple Helix model of innovation ecosystems. Specifically, we identified the following factors: the willingness and capacity of innovation actors to develop cross-boundary interactions on a global scale; an institutionalised civil society based on bottom-up media; and the prevailing sustainability ethos in economic, social and environmental dimensions. These can be used to design and evaluate policies that promote sustainable innovation and development as core features of innovation ecosystems.

Transformative Learning

Innovation Management

10.3390/su14127520

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Citations (9)

Tin‐containing layered double hydroxides: Synthesis and application in poly(vinyl chloride) cable formulations

Fire and Materials (2011)

Xiaoran Zheng Paul A. Cusack

SUMMARY Layered double hydroxides (LDHs) and Sn‐containing LDHs have been synthesized using a co‐precipitation method, and the resulting products have been characterized by X‐ray diffraction (XRD), transmission electron microscopy (TEM), Fourier‐transform infrared spectroscopy (FTIR) and Brunauer‐Emmett‐Teller(BET) surface area measurement, clearly showing that Sn‐containing LDH hybrids have been successfully prepared. TEM shows the ‘house‐of‐cards’ structure of the Sn‐LDHs produced, resulting from the edge‐to‐face interaction of the LDH layers. Higher tin levels lead to an additional magnesium hydroxystannate, MgSn(OH) 6 , (‘MHS’) phase that is present in the form of approximately 40‐nm cubic particles in an LDH/MHS hybrid structure. FTIR and XRD suggest that, at low levels of Sn, the Sn 4+ may exist in the form of amorphous hydrated tin(IV) oxide rather than being incorporated into the LDH lattice. These powders have been compounded into poly(vinyl chloride) (PVC), and their fire performance has been evaluated using limited oxygen index and cone calorimeter techniques. Peak rate of heat release and smoke parameter can be reduced by 64% and 81%, respectively, when replacing 10 wt% of the primary ATH fire‐retardant filler by the synthesized Sn‐LDHs, while keeping the total fire‐retardant loading at 100 phr. Thermogravimetric analysis indicates that Sn‐LDH is an effective char promoter for PVC. Copyright © 2011 John Wiley & Sons, Ltd.

Layered double hydroxides

Thermogravimetric analysis

Cone calorimeter

Limiting oxygen index

10.1002/fam.1129

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Citations (21)

Influence of yttrium on the high temperature corrosion of chromium and Fe-28Cr in CO-CO2-N2(-SO2) atmospheres

Corrosion Science (1998)

Xiaoran Zheng David J. Young

10.1016/s0010-938x(97)00176-5

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Citations (7)

Sono‐Piezo‐Photosynthesis of Ethylene and Acetylene from Bioethanol under Ambient Conditions

Advanced Functional Materials (2025)

Yue Jiang Jiajun Zhang Hongyang Ma Yingtang Zhou Hsun‐Yen Lin

Abstract The catalytic conversion of bioethanol to ethylene (C 2 H 4 ) and acetylene (C 2 H 2 ) offers a transformative approach to sustainable production of two industrial cornerstones for organic compound and polymer syntheses, thereby offering significant economic and environmental advantages. In contrast, current methods for the synthesis of these C 2 hydrocarbons rely on energy‐ and carbon‐intensive processes that require high temperatures and pressures. The present work addresses these limitations with a novel, low‐energy, bioethanol‐conversion strategy operating at room temperature and ambient pressure using sono‐piezo‐photocatalysts. A novel heterostructure of graphene oxide fragments (GO) and sodium bismuth titanate (NBT) within a core‐shell microstructure achieved outstanding C 2 H 4 and C 2 H 2 production rates of 134.1 and 55.5 µmol/g/h, respectively. The conversion mechanism is driven by (1) bubble collapse during ultrasound irradiation, generating localized high temperatures (≈4000 K) and pressures (≈100 MPa), and (2) piezo‐photocatalytic tuning of GO/NBT by enhanced charge separation and transfer. DFT simulations revealed detailed sono‐piezo‐photocatalytic conversion pathways, showing significant reductions in energy barriers for C 2 H 4 (22.0 kcal mol −1 ) and C 2 H 2 (48.0 kcal mol −1 ) formation. These findings emphasize the critical role of the catalyst in cleaving both C─H and C─O bonds effectively, leading to the desired product formation.

Acetylene

10.1002/adfm.202425784

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Principles of Design and Synthesis of Metal Derivatives from MOFs (Adv. Mater. 24/2023)

Advanced Materials (2023)

Thibault De Villenoisy Xiaoran Zheng Vienna Wong Sajjad S. Mofarah Hamidreza Arandiyan

MOF-Derived Materials Despite the instability and low electrical conductivity of metal–organic frameworks (MOFs), metal-based derivatives (MDs) retain the intricate nanostructures of MOFs while boasting improved stability and significantly higher electrical conductivities. In article number 2210166, Thibault De Villenoisy and co-workers delve into the nanostructural design of MDs, discussing various established and potential future materials, and also identifying and rationalizing design parameters with the aim to guide optimal composition and performance.

Rational design

Material Design

10.1002/adma.202370174

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Citations (2)

Specific crystallographic site occupancy induced water-stability: Towards facilitating ‘aqueous processing’ of ‘layered’ Na- transition metal oxide cathodes for Na-ion batteries

Journal of Materials Chemistry A (2025)

Bachu Sravan Kumar A. Goswami Rahul Kumar Xiaoran Zheng Anil Kumar Paidi

Severe compositional/structural instability of ‘layered’ Na- transition metal (TM) oxide cathode materials for Na-ion batteries upon exposure to air/water renders handling/storage challenging and mandates the use of toxic/hazardous-cum expensive chemicals...

10.1039/d4ta08214a

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