Ryszard Maciejewski

John Paul II Catholic University of Lublin

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i-10 index

Research Trends

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Document Type

Co-Authors

Kamil Torres

Medical University of Lublin

Anna Torres

Medical University of Lublin

Grzegorz Staśkiewicz

Medical University of Lublin

Jacek Baj

Medical University of Lublin

Robert Sitarz

Medical University of Lublin

Robert Ręjdak

Medical University of Lublin

Andrzej Drop

Medical University of Lublin

Wojciech Polkowski

Medical University of Lublin

Cezary Grochowski

Medical University of Lublin

Franciszek Burdan

Medical University of Lublin

Cooperative Institutions

KU Leuven

378

Medical University of Lublin

330

Hospices Civils de Lyon

276

Hôpital Louis Pradel

269

Hospital Universitario Reina Sofía

257

Jessa Hospital

238

Oslo University Hospital

223

Centro Cardiologico Monzino

169

University Medical Center Utrecht

162

Faculty (United Kingdom)

141

Author Statistics

Papers

Citation

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Gastroenterostoma after Billroth antrectomy as a premalignant condition.

PubMed (2012)

Robert Sitarz Ryszard Maciejewski Wojciech Polkowski G. J. A. Offerhaus

Gastric stump carcinoma (GSC) following remote gastric surgery is widely recognized as a separate entity within the group of various types of gastric cancer. Gastrectomy is a well established risk factor for the development of GSC at a long time after the initial surgery. Both exo- as well as endogenous factors appear to be involved in the etiopathogenesis of GSC, such as achlorhydria, hypergastrinemia and biliary reflux, Epstein-Barr virus and Helicobacter pylori infection, atrophic gastritis, and also some polymorphisms in interleukin-1β and maybe cyclo-oxygenase-2. This review summarizes the literature of GSC, with special reference to reliable early diagnostics. In particular, dysplasia can be considered as a dependable morphological marker. Therefore, close endoscopic surveillance with multiple biopsies of the gastroenterostomy is recommended. Screening starting at 15 years after the initial ulcer surgery can detect tumors at a curable stage. This approach can be of special interest in Eastern European countries, where surgery for benign gastroduodenal ulcers has remained a practice for a much longer time than in Western Europe, and therefore GSC is found with higher frequency.

Atrophic gastritis

Achlorhydria

Gastroenterostomy

10.3748/wjg.v18.i25.3201

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Citations (25)

Deleterious effects of traditional Chinese medicine preparations on the course of psoriasis--a case report.

PubMed (2013)

Aldona Pietrzak Joanna Bartosińska Jacob Dreiher Jacek C. Szepietowski Urszula Gawlik‐Dziki

Psoriasis is a chronic, systemic and difficult to treat condition which negatively affects the patient's quality of life. Frustrated and unsatisfied with the conventional therapies, psoriatic patients start looking for alternative treatment which they believe to be safe and effective. Very common traditional Chinese medicine (TCM) appears to offer various topical and systemic herbal preparations, as well as massages, acupuncture, diet and lifestyle alternations. The presented study concerns a 48-year-old female patient with exacerbated psoriatic skin lesions (tending to become erythrodermic), and certain systemic complications that appeared after taking a TCM herbal medication, Fu Fang Quing Dai Wan, as well as the use of a Chinese herbal bath gel and staying on a diet rich in meat. After in vitro examinations were made of the herbal preparation and its biological properties determined, it was concluded that the TCM herbal preparation should not be considered harmless. Therefore, patients should be made aware of its adverse reactions.

Phytotherapy

Herbal Extracts

Source

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Citations (2)

CD44, TGM2 and EpCAM as novel plasma markers in endometrial cancer diagnosis

BMC Cancer (2019)

Anna Torres Małgorzata Pac-Sosińska Krzysztof Wiktor Tomasz Paszkowski Ryszard Maciejewski

Endometrial cancer (EC) is the most common malignancy of the female reproductive tract. Despite years of research, the accurate screening strategy is still not available in this disease and it is usually diagnosed only after the clinical signs are present. The recent technological advances in analytical methodologies enabled detection of multiple molecules in one, small sample of biological materials. Such approach was undertaken in the presented study.Concentrations of aldehyde dehydrogenase 1 family, member A1 (ALDH1A1), carbonic anhydrase IX (CA9), CD44, epithelial cell adhesion molecule (EpCAM), hepsin, kallikrein-6, mesothelin, midkine, neural cell adhesion molecule L1 (L1CAM), and transglutaminase 2 (TGM2) were measured using MAGPIX®System in plasma samples of 45 EC, 20 healthy controls and 11 patients with endometriosis.Significantly increased concentration in EC as compared to healthy controls were found in case of CD44 (p < 0.001), EpCAM (p = 0.033) and TGM2 (p < 0.001). EpCAM and mesothelin concentrations differed based on FIGO stages. Regression analysis revealed marker panels with high accuracy in detection of EC. The highest AUC 0.937 was attributed to the 3-marker panel of CD44/TGM2/EpCAM (84% sensitivity, 100% specificity), FIGO IA samples were discriminated from more advanced stages of EC with the mesothelin/grade 1 model featuring AUC of 0.911 (95.24% sensitivity, 78.26% specificity).Novel plasma biomarkers presenting good accuracy in diagnosing EC were found with TGM2 reported for the first time as plasma marker. It was also revealed that endometriosis may share similarities in the pattern of markers alterations characteristic for EC.

Surgical oncology

10.1186/s12885-019-5556-x

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Citations (26)

The Relationship between Mental Disorders and the COVID-19 Pandemic—Course, Risk Factors, and Potential Consequences

International Journal of Environmental Research and Public Health (2022)

Agnieszka Markiewicz-Gospodarek Aleksandra Górska Renata Markiewicz Zuzanna Chilimoniuk Marcin Czeczelewski

In this review the authors discuss that COVID-19 has already had a direct impact on the physical health of many people and that it appears to have put at risk the mental health of large populations. In this review, we also discuss the relationship between mental disorders and the SARS-CoV-2 infection. We convey the disorders’ risk factors and the more serious mental disorder consequences of COVID-19. People with mental health disorders could be more susceptible to the emotional responses brought on by the COVID-19 epidemic. The COVID-19 pandemic may adversely influence the mental health of patients with already diagnosed mental disorders. For the aim of dealing better with the psychological problems of people afflicted by the COVID-19 pandemic, new psychological procedures are required.

Pandemic

2019-20 coronavirus outbreak

10.3390/ijerph19159573

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Citations (16)

Risk of peritoneal dissemination in stomach cancer

Current Issues in Pharmacy and Medical Sciences (2017)

Robert Sitarz Wojciech Polkowski Ryszard Maciejewski G. Johan A. Offerhaus

Abstract With regard to gastric cancer, an important disease and a public health problem, it is expected that understanding the molecular make up of carcinomas will provide us with more precise targets for therapy. Indeed advanced molecular technology has made it possible to classify according to genotype instead of phenotype. For advanced stomach cancer, however, surgery is still the only option for cure. Yet, also after surgery, more than 50% of the patients will die of peritoneal dissemination of their disease. This review looks at the molecular mechanism of peritoneal spread of stomach cancer in order to arrive at a risk profile that enables medical personnel to raise the index of suspicion for peritoneal carcinomatosis. The peritoneal cancer index (PCI) provides a scoring system to measure the extent of peritoneal spread during laparoscopic staging. A recently developed device called the ‘MacSpec pen’ maybe of use to confirm the presence of tumor when there is doubt about the diagnosis. Treatment of peritoneal dissemination consists of cytoreduction, combined with hyperthermic peritoneal chemotherapy (HIPEC).

Stomach cancer

Hyperthermic Intraperitoneal Chemotherapy

Cancer surgery

10.1515/cipms-2017-0034

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Citations (0)

Assessment of the Concentration of 51 Elements in the Liver and in Various Parts of the Human Brain—Profiling of the Mineral Status

Nutrients (2023)

Jacek Baj Beata Kowalska Wojciech Flieger Elżbieta Radzikowska-Büchner Alicja Forma

The anthropogenic environment and diet introduce many metals into the human body, both essential and toxic. Absorption leads to systemic exposure and accumulation in body fluids and tissues. Both excess and deficiency of trace elements are health hazards. The primary aim of the present study was to evaluate the concentration of 51 elements in liver samples and 11 selected brain regions obtained at post-mortem examination from a population of adults living in south-eastern Poland (n = 15). A total of 180 analyses were performed by inductively coupled plasma mass spectrometry in two independent replicates. The collected data show very high individual variability in the content of the investigated elements. Macroelements such as sodium, magnesium, phosphorus, potassium, calcium, iron, and zinc occurred in the highest concentrations and with the greatest statistically significant variations. Although the elemental content of the brain and liver differed significantly, the strongest positive correlation between liver and polus frontalis was observed for the essential element selenium (0.9338) and the strongest negative one for manganese (-0.4316) and lanthanum (-0.5110). The brain areas studied have different requirements for phosphorus, manganese, iron, and molybdenum. In addition, males had a significantly (p < 0.05) higher brain content of lanthanides and actinides than females. The results of this study show that the inhabitants of south-eastern Poland are exposed to a fairly uniform accumulation of aluminum and vanadium in the brain, which have the highest affinity to the thalamus dorsalis. This result proves that there is environmental exposure to these elements.

Trace element

Mercury

Human nutrition

10.3390/nu15122799

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Citations (7)

Ochrona wartości chrześcijańskich w opiece nad dzieckiem

Teka Komisji Prawniczej PAN Oddział w Lublinie (2019)

Ryszard Maciejewski Jarosław Sak

Autorzy analizują historyczne i społeczne zjawiska instrumentalizacji i degradacji podmiotowości dziecka. W świetle ustaleń wstępnych wskazują na konieczność społecznej i kulturowej weryfikacji wartości, na których fundowane są relacje z dziećmi. Poddając refleksji znaczenie wartości chrześcijańskich w opiece nad dzieckiem wskazują na funkcję rodziny w kształtowaniu macierzy życia społecznego. Akcentują rolę rodziny w przekazywaniu podstawowych zasad życia społecznego i moralnego.

10.32084/tekapr.2019.12.2-14

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Citations (1)

Medical diagnosis and treatment using high-resolution manometry with computer-aided system

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (2010)

Tomasz Pedowski Piotr Wąsiewicz Ryszard Maciejewski Grzegorz Wallner

Nowadays computers analyze medical data almost in every diagnosis and treatment steps. We develop new technology which gives us better and more precise diagnosis. We chose esophageal high resolution manometry with impedance (HRMI) which has been considered as a "gold standard" test for esophageal motility. HRMI is the next generation of manometry explanation which is more sensitive and accurate to EFT. Examination allows physicians to ger information about esophageal peristalsis, amplitude and duration of the esophageal contraction and liquid/viscous bolus transit time from mouth through stomach. In 2008 we examined 80 patients using "old" EFT manometry and 80 patients in 2009 using high resolution manometry (HRMI). Everybody got manometry, endoscopy and x-ray examination. We asked about symptoms which we correlate and connect with data from EFT and HRMI. We tried to find a good algorithm for this purpose in order to do a simple and helpful tool for physician to make righta diagnosis and treatment decision. Connection between data and symptoms seems to be right and clear, but finding a good algorithm for given data is the main problem.

High resolution manometry

Peristalsis

Esophageal motility disorder

Gold standard (test)

Bolus (digestion)

10.1117/12.872155

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Citations (0)

Medical Embryology and its Importance in the 21st Century Curriculum: A mini review

Italian Journal of Anatomy and Embryology (2022)

Amr Maani Alicja Forma Jacek Baj Ryszard Maciejewski

Embryology is an essential tool in clinical practice especially for managing various medical disorders. As a course in medical schools, it is neither easy nor straightforward to understand and teach in the 21st century curriculum, as such, it is easy to overlook. As a discipline, embryology has entered a phase of unparalleled transition in its understanding base. This translates to a phase of abundant modification in the medical curriculum. A main critical issue of learning embryology is how extensively newer molecular medical embryology can be paired with the traditional approach to developmental of anatomy. Another issue would be which venue to be considered most effective in embryology instruction. The medical curriculum in during 21st century have different objectives, as well as different educational approach. As a consequence, this paper outlines a variety of aspects in which embryology could be presented as well as how it may be incorporated within the medical curriculum.

Embryology

10.36253/ijae-12966

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Citations (1)

An Overview of Recent Developments in the Management of Burn Injuries

International Journal of Molecular Sciences (2023)

Elżbieta Radzikowska-Büchner Inga Łopuszyńska Wojciech Flieger Michał Tobiasz Ryszard Maciejewski

According to the World Health Organization (WHO), around 11 million people suffer from burns every year, and 180,000 die from them. A burn is a condition in which heat, chemical substances, an electrical current or other factors cause tissue damage. Burns mainly affect the skin, but can also affect deeper tissues such as bones or muscles. When burned, the skin loses its main functions, such as protection from the external environment, pathogens, evaporation and heat loss. Depending on the stage of the burn, the patient’s condition and the cause of the burn, we need to choose the most appropriate treatment. Personalization and multidisciplinary collaboration are key to the successful management of burn patients. In this comprehensive review, we have collected and discussed the available treatment options, focusing on recent advances in topical treatments, wound cleansing, dressings, skin grafting, nutrition, pain and scar tissue management.

Skin grafting

10.3390/ijms242216357

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Citations (39)