Elena López-Díez

University Hospital Complex Of Vigo

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Sonia Pérez‐Castro

Galicia Sur Biomedical Foundation

Amparo Iñarrea

University Hospital Complex Of Vigo

Raquel Carballo

University Hospital Complex Of Vigo

Manuel Carballo

Instituto de Oncología de Rosario

Sheila Almuster

Universidade de Vigo

Alexandre Pérez‐González

University Hospital Complex Of Vigo

Angel de la Orden

Universidade de Vigo

M. J. Purriños

Xunta de Galicia

Jacobo Limeres Posse

Universidade de Santiago de Compostela

Moises Rodríguez

Universidade de Vigo

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University Hospital Complex Of Vigo

Universidade de Vigo

Complexo Hospitalario Universitario A Coruña

Servicio Gallego de Salud

Galicia Sur Biomedical Foundation

Hospital Xeral Calde

Universidade de São Paulo

Instituto de Investigación Sanitaria de Santiago

Clínica Santa María

Universidade de Santiago de Compostela

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Fraction of high-grade cervical intraepithelial lesions attributable to genotypes targeted by a nonavalent HPV vaccine in Galicia, Spain

Virology Journal (2017)

Sonia Pérez‐Castro Amparo Iñarrea Ramón Pérez‐Tanoira M T Gil Elena López-Díez

Human papillomavirus (HPV) bivalent and quadrivalent vaccines have been widely implemented in worldwide organized immunization programs. A nonavalent HPV vaccine is now available in several countries. The objective was to describe the fraction of squamous non-invasive high-grade cervical intraepithelial lesions attributable to genotypes targeted by bi-quadrivalent vaccines and by nonavalent vaccine according to age and diagnosis in women living in the city of Vigo (Galicia, Spain). Cervical scrapings (2009–2014) of women with histological diagnosis of cervical intraepithelial neoplasia grade 2 (CIN2, n = 145) and grade 3-carcinoma in situ (CIN3-CIS, n = 244) were tested with Linear Array HPV Genotyping test (Roche diagnostics, Mannheim, Germany). Hierarchical estimation of the fraction attributable to HPV 16/18 or HPV 31/33/45/52/58 detected alone or in combination was calculated. Absolute additional fraction attributable to genotypes targeted by nonavalent vaccine compared to genotypes targeted by bi-quadrivalent vaccines was calculated as the increment of attributable cases with respect to all studied cases. Age group 1, 2 and 3 included women 18 to 34, 35–44 and ≥45 years old, respectively. EPIDAT 3.1 was used. Fraction attributable to genotypes targeted by bi-quadrivalent vaccines was 59% CIN2 vs. 69% CIN3-CIS (p < 0.001). It was 63/51/50% of CIN2 and 78/66/45% of CIN3-CIS in age group 1, 2, 3, respectively. Fraction attributable to genotypes targeted by nonavalent vaccine was 86% CIN2 and 86% CIN3-CIS. It was 87/91/75% of CIN2 and 90/86/76% of CIN3-CIS in age group 1, 2, 3, respectively. Fraction attributable to genotypes targeted by these vaccines tended to decrease as age increased (p-trend <0.05). Globally, absolute additional attributable fraction was 16%, 26% and 29% in age group 1, 2 and 3, respectively (p < 0.005). Absolute additional fraction of CIN2 and CIN3-CIS attributable to genotypes targeted by nonavalent vaccine was observed in women of any age, especially in those over 35 years old.

10.1186/s12985-017-0879-1

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Correction: Lifestyle factors and oncogenic papillomavirus infection in a high-risk male population

PLoS ONE (2018)

Elena López-Díez Sonia Pérez‐Castro Manuel Carballo Amparo Iñarrea Angel de la Orden

[This corrects the article DOI: 10.1371/journal.pone.0184492.].

10.1371/journal.pone.0197138

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Prevalencia de la infección orogenital por VPH en una población no vacunada de HSH-VIH en el noroeste de España

Galicia Clínica (2022)

Alexandre Pérez‐González Sonia Pérez‐Castro Raquel Carballo Elena López-Díez Jacobo Limeres Posse

Human papillomavirus (HPV) infection is the most common sexually transmitted infection (STI) in many countries, including United States 1 and some South European regions 2 .HPV is the main cause of cervical cancer in woman 3 and anal cancer in HIV-MSM( 4 ).Moreover, HPV is a major cause of penile cancer 5 and oropharyngeal carcinoma 6 .HPV genotypes are classified in four categories based on their oncogenic risk: high oncogenic risk (i.e., HPV-16, HPV-18), probably high-risk (i.e., HPV-53), low risk (i.e., HPV-6, HPV-11) and indeterminate risk (i.e., HPV-25) 7 .Prior studies have reported an incidence of HPV anal infection in MSM-HIV patients between 24 and 33/100 person-years, higher than MSM HIV negative subjects 8 .On the other hand, previous studies reported an HPV penile incidence around 11/100 persons-year in people living with HIV (PLWH) 9 .Incidence is also higher in HIV-MSM individuals compared to men-who-have-sex-with-women (MSW).In regard of oral HPV infection, our research group

10.22546/66/2689

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Correction to: Fraction of high-grade cervical intraepithelial lesions attributable to genotypes targeted by a nonavalent HPV vaccine in Galicia, Spain

Virology Journal (2018)

Sonia Pérez‐Castro Amparo Iñarrea Ramón Pérez‐Tanoira M T Gil Elena López-Díez

After publication of the article [1], it was brought to our attention that the author E. López-Díez is missing their second affiliation. The author would also like to indicate an affiliation to "Universidade de Vigo, Pontevedra, Spain".

10.1186/s12985-018-0953-3

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Benefits of nonavalent vaccine in a high risk male population

European Urology Supplements (2019)

Elena López-Díez Michelle Alessandra de Castro Lyzette Blanco J.M. Diaz Alvarez Javier Villanueva Sánchez

10.1016/s1569-9056(19)30032-6

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Lifestyle factors and oncogenic papillomavirus infection in a high-risk male population

PLoS ONE (2017)

Elena López-Díez Sonia Pérez‐Castro Manuel Carballo Amparo Iñarrea Angel de la Orden

High risk human papillomavirus (HR-HPV) infection in males is a health issue with implications for HPV-related lesions in their partners. The identification of risk factors for male infection may improve our understanding of HR-HPV transmission and prevention. The aim of this study was to evaluate the relationships between lifestyle, genital warts and HR-HPV infection. The study was focused on men with an increased risk of HR-HPV infection: male sexual partners of women diagnosed with high-grade squamous intraepithelial cervical lesions.Men were enrolled and prospectively recruited within the first six months after diagnosis of cervical lesions in their female partners (n = 175, 2013-2016). Epidemiological and sexual behaviour data were obtained. The presence of genital warts was established by visual inspection. Detection and genotyping of HR-HPV infection in genital samples were performed with a Linear Array HPV Genotyping Test. All HR-HPV positive men were offered a follow-up exam at 12 months. SPSS version 19 was used for statistical analysis.The prevalence of HR-HPV infection in men was 45.1% (79/175). Genital warts were observed in 10.3% (18/175) of the subjects. Detection of genital warts (OR 3.5, p = 0.015), smoking habits (OR 2.3, p = 0.006) and sexual debut before 16 years old (OR 2, p = 0.035) were associated with an increased risk for HR-HPV infection (univariate analysis). This association was also observed for genital warts and smoking status in a multivariate analysis. The same genotype was found after one year in 71.4% (20/28) of subjects.The presence of genital warts and smoking habits seem to be associated with a higher risk of HR-HPV infection in males. Earlier sexual debut may increase this risk. Extensive knowledge of the natural history of HR-HPV infection in males is an absolute requirement for the design and implementation of prevention strategies for the general population as well as for specific populations such as couples after treatment for high-grade cervical lesions.

Genital warts

Sex organ

Univariate analysis

10.1371/journal.pone.0184492

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Diagnosis and Prevalence of High-Risk Human Papillomavirus Infection in Heterosexual Men

InTech eBooks (2016)

Elena López-Díez Sonia Pérez‐Castro Amparo Iñarrea

A better understanding of human papillomavirus (HPV) infection in men is an essential component of prevention programs aimed to reduce cervical cancer and other HPV-related diseases. A screening test capable of detecting asymptomatic/subclinical genital HPV infection in men at a reasonable price and causing minimal discomfort to the patient would be very valuable. The following chapter focuses on acetowhite test usefulness in the detection of asymptomatic/subclinical genital high-risk (HR) HPV infection in high-risk men populations, HR-HPV prevalence in sexually active healthy male partners of women diagnosed of high-grade cervical intraepithelial neoplasia and genotype-specific concordance between partners, addressing the preventive strategies that would reduce HPV infection in men. We present data from 125 men, sexual partners of women with preneoplastic cervical lesions. Prevalence of HR-HPV infection in male was high (50, 24% HPV16) and genotype concordance within the 60 infected couples was remarkable (62% shared at least one genotype). Acetowhite (AW) test was positive in 27% patients, showing low sensitivity for the identification of HR-HPV infection but allowed the diagnosis of subclinical HPV-related lesions in more than 10%. Current smoking and genital warts were associated with an increased risk of HR-HPV infection in men (OR: 2.4 and 5.6, respectively).

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Subclinical infection

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Genital warts

10.5772/62948

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Observational study of HPV genitalia and oral infection in an unvaccinated population of men who have sex with men infected with HIV in Northwest Spain

medRxiv (Cold Spring Harbor Laboratory) (2021)

Alexandre Pérez‐González Sonia Pérez‐Castro Raquel Carballo Elena López-Díez Jacobo Limeres Posse

Abstract Background Human papillomavirus (HPV) infection is the most common sexual transmitted disease (STD) and a risk factor for penile, oral and anal cancer. Human immunodeficiency virus (HIV) coinfection increases the risk of cancer. While HPV anal infection is well studied in men-who-have-sex-with-men (MSM), HPV genitalia and oral infection is less known. Methods This prevalence study of HPV infection in genitalia and oral cavity in HIV-MSM patients included 107 HPV non-vaccinated subjects. HPV-DNA was detected with Anyplex™ II HPV28 method. Participants completed a questionnaire on lifestyle and sexual behavior. Results Median age was 43 years (range 35-54 years); 97 patients were on antiretroviral treatment (ART); 81 (75.7%) had undetectable HIV-RNA; median CD4-lymphocyte count was 746 cell/mm 3 ; 70 (65.4%) participants had a previous STD. HPV was detected in genitalia in 37 (34.6%) subjects; 26 (24.3%) in oral cavity and 12 (11.2%) in both locations. High-risk HPV genotypes were detected in 24 (22.4%) patients in genitalia and 15 (14%) in oral cavity. Conclusions HPV infection is common in unvaccinated HIV-MSM patients. Detectable HIV-RNA was associated with higher HPV prevalence in genitalia. High oncogenic risk HPV genotypes were more common in genitalia than in mouth. Summary text HPV infection is common in HIV infected subjects and it is a risk factor for many types of cancer. Although anal conduct is the most studied location, HPV can also infect genitalia and oral cavity. However, the frequency and distribution of HPV strains is different in both locations.

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10.1101/2021.08.09.21261786

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