Peter Jarčuška

University of Pavol Jozef Šafárik

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Martin Janíčko

University of Pavol Jozef Šafárik

Sylvia Dražilová

University of Pavol Jozef Šafárik

Daniel Pella

University of Pavol Jozef Šafárik

Pavol Kristián

University of Pavol Jozef Šafárik

Eduard Veselíny

University of Pavol Jozef Šafárik

Andrea Madarasová Gecková

Comenius University Bratislava

Ivan Schréter

University of Pavol Jozef Šafárik

Mária Mareková

University of Pavol Jozef Šafárik

Monika Halánová

University of Pavol Jozef Šafárik

Robert Flisiak

Medical University of Białystok

Cooperative Institutions

European Foundation for the Study of Chronic Liver Failure

217

Center for Disease Analysis

158

University of Pavol Jozef Šafárik

137

Univerzitná Nemocnica Louisa Pasteura

UNSW Sydney

University College London

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Tel Aviv University

Technical University of Košice

Sheba Medical Center

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Autoimmune hepatitis triggered by adalimumab and allergic reactions after various anti-TNFα therapy agents in a patient with rheumatoid arthritis.

PubMed (2015)

Jana Petríková Peter Jarčuška Marián Švajdler Daniel Pella Želmíra Macejová

Autoimmune Hepatitis

Source

Cite

Citations (2)

Roma Ethnicity and Sex-Specific Associations of Serum Uric Acid with Cardiometabolic and Hepatorenal Health Factors in Eastern Slovakian Population: The HepaMeta Study

International Journal of Environmental Research and Public Health (2020)

Mária Pallayová Marek Brenišin Alina Putrya Martin Vrsko Sylvia Dražilová

Health characteristics associated with uric acid (UA) in the Roma minority remain less well known. The study sought to determine the ethnicity- and sex-specific associations of serum UA with health factors in Eastern Slovakian Roma and non-Roma populations.

Cross-sectional study

10.3390/ijerph17207673

Cite

Citations (8)

Strategies to manage hepatitis C virus (HCV) infection disease burden – volume 2

Journal of Viral Hepatitis (2015)

Edward Gane David Kershenobich Carole Seguin‐Devaux Pavol Kristián Inka Aho

Summary The hepatitis C virus ( HCV ) epidemic was forecasted through 2030 for 15 countries, and the relative impact of two scenarios was considered: (i) increased treatment efficacy while holding the treated population constant and (ii) increased treatment efficacy and increased annual treated population. Increasing levels of diagnosis and treatment, in combination with improved treatment efficacy, were critical for achieving substantial reductions in disease burden. In most countries, the annual treated population had to increase several fold to achieve the largest reductions in HCV ‐related morbidity and mortality. This suggests that increased capacity for screening and treatment will be critical in many countries. Birth cohort screening is a helpful tool for maximizing resources. In most of the studied countries, the majority of patients were born between 1945 and 1985.

Hepatitis C

10.1111/jvh.12352

Cite

Citations (52)

Clinical and Biochemical Determinants of Metabolic Syndrome among Roma and Non-Roma Subjects in the Eastern Part of Slovakia

Central European Journal of Public Health (2014)

Ján Fedačko Daniel Pella Peter Jarčuška Leonard Siegfried Martin Janíčko

Background: The metabolic syndrome (MS) is a clustering of cardiovascular risk. The high prevalence of metabolic syndrome among populations of lower socioeconomic status is a cause of concern and calls for an effective public health response. Objectives: The aim of this study was to determine the prevalence of metabolic syndrome in the Roma population compared with the non-Roma population in the eastern part of Slovakia and to determine the parameter which has the strongest association with metabolic syndrome. Results: 123 Roma and 79 non-Roma patients with metabolic syndrome were evaluated. In the subgroup of Roma men, we found that waist circumference conferred the highest chance of MS (more than 12-times), followed by triglycerides (TG) (3.670-times). In the subgroup of non-Roma men, we found that waist circumference conferred the highest chance of MS (more than 16-times), followed by high-density lipoprotein (HDL) (4.348-times increased risk per one unit decrease in HDL). In the subgroup of Roma women as well as non-Roma women, we found that serum TG conferred the highest chance of MS, followed by waist circumference for Roma women. Comparing non-classical risk factors for MS we found that only age (with OR 1.977) and high-sensitivity C-reactive protein (hsCRP) (OR 1.887) were significant and independent predictors of MS in Roma men. Among Roma women apolipoprotein B100 was also found to be an independent predictor of MS, besides age and hsCRP. Conclusion: Our study confirmed that the prevalence of metabolic syndrome is strongly associated with hypertriglyceridemic waist, besides other risk factors, a marker of the atherogenic metabolic triad among younger Roma population, which may be the reason for the increased cardiovascular (CV) morbidity and mortality in elderly Roma compared with non-Roma. In light of these results, better prevention of CV events for Roma minority settlements in Slovakia should be provided.

Circumference

10.21101/cejph.a3905

Cite

Citations (10)

Is elimination of HCV in 2030 realistic in Central Europe

Liver International (2021)

Robert Flisiak Dorota Zarębska‐Michaluk Soňa Fraňková Ivica Grgurević Béla Hunyady

Abstract According to the recent data presented by Central‐European HCV experts, the estimated prevalence of HCV is between 0.2% and 1.7% in certain countries in this region. There are no financial limitations to access to treatment in most countries. Patients in these countries have access to at least one pangenotypic regimen. The most common barriers to the elimination of HCV in Central Europe are a lack of established national screening programmes and limited political commitment to the elimination of HCV. Covid‐19 has significantly affected the number of patients who have been diagnosed and treated, thus, delaying the potential elimination of HCV. These data suggest that the elimination of HCV elimination projected by WHO before 2030 will not be possible in the Central Europe.

Regimen

European region

Hepatitis C

10.1111/liv.14834

Cite

Citations (13)

Seroprevalence to Toxoplasma gondii in Roma and non-Roma inhabitants of Eastern Slovakia

Annals of Parasitology/Wiadomości Parazytologiczne (2016)

Daniela Antolová Peter Jarčuška Martin Janíčko Monika Halánová L Cechová

Seroprevalence

Toxoplasmosis

Source

Cite

Citations (0)

Surveillance of hepatocellular carcinoma in Slovakia

Gastroenterologie a hepatologie (2020)

Světlana Adamcová Selčanová Ľubomír Skladaný Jana Čiefová Sylvia Dražilová T. Köller

Background: Certain trials have demonstrated that surveillance of hepatocellular carcinoma (HCC) lowers mortality via earlier diagnosis and therapy. We aimed to analyse surveillance performance in order to define targets for improvement. Methods: We retrospectively analysed consecutive patients (pts) ELIGIBLE for surveillance between January 2001 and December 2010, with three questions: 1. How many have had surveillance RECOMMENDED and 2. PERFORMED, and by which method and 3. with what outcome. We divided the pts into three groups by diagnosis of cirrhosis or HBV infection (ELIGIBLE), written recommendation for surveillance (RECOMMENDED) and ≥ 2 US or alpha-fetoprotein (AFP) exams six months apart (PERFORMED). We recorded the demographics, liver disease characteristics, ultrasound (US), AFP, new lesions, their size and mortality. We excluded patients without data for analysis. Results: We identified 445 and excluded 52 of the ELIGIBLE pts. The remaining 393 pts formed the RECOMMENDED group: 334 (85%) with cirrhosis, 59 (15%) with HBV infection. The median age was 55 years, 34% were females. The most prevalent aetiologies were alcohol-related liver disease (ALD, 46%), non-alcoholic steatohepatitis (NASH, 17%) and hepatitis C virus (HCV, 12%). Surveillance was PERFORMED in 322 (82%) of the RECOMMENDED pts by US only in 1%, AFP in 40% and US with AFP in 31% of the pts, respectively. New lesions were detected in 2.2% of the pts, aged 63.5 years (53–79), with diameter of 31.5 mm (9–120) in 8 surveillance pts and 75 mm (35–115) in 2 pts without surveillance (p = 0.296). Conclusion: This quality control study has shown that the uptake of HCC surveillance in pts with valid indication was suboptimal, the methods used deviated considerably from the guidelines and the diameter of newly-detected lesions was larger than would be required for surveillance to be effective.

Liver disease

Demographics

Steatohepatitis

Hepatitis B

10.14735/amgh2020380

Cite

Citations (0)

Regional and ethnical aspects of viral hepatitis B in pregnant women in Slovakia

International Journal of Infectious Diseases (2010)

Pavol Kristián Ivan Schréter Zuzana Paraličová Peter Jarčuška Leonard Siegfried

Background: The estimated prevalence of HBsAg in Slovak population is <2% with supposed regional differences and higher prevalence of HBV infection in Roma population. Pregnant women constitute a special subgroup, that is subject to routine HBsAg screening because of the risk of vertical transmission, and also pregnancy can modify the course of hepatitis B infection. The aim of this study was to determine the prevalence of HBV infection in pregnant women in districts of eastern Slovakia with diverse prevalence of Roma population and to determine the subset of women with chronic hepatitis B and increased risk of vertical transmission. Methods: We have analyzed data from 9 regional Departments of Clinical Microbiology from January 2008 till June 2009. We have evaluated the portion of HBsAg positive findings from the overall examined samples and among pregnant women. Available sera from HBsAg positive pregnant women were also screened for ALT, HBeAg and HBV DNA. Results: Overall, 44,912 sera samples were examined, with 10,739 from pregnancy screening. The number of HBsAg positive samples overall and during pregnancy was 803 (1.79%) and 251 (2.34%) respectively. Comparing districts with higher (>4%) and lower (<3%) prevalence of Roma population, there was no notable difference in the overall HBsAg prevalence (1.85% vs. 1.68%), however in the subgroup of pregnant women (2.69% vs. 1.25%) this difference was highly significant (p < 0.001). HBV DNA was evaluated in 158 pregnant women, 19 patients had viral load >105 copies/ml, 27 in the range of 104-105 copies/ml and 112 patients < 104 or negative. HBeAg positivity was confirmed in 17 of 146 examined samples (11.6%) and elevated ALT in 11 of 69 cases (15.9%). Twelve out of 58 patients with normal ALT (21%) had viral load >104 copies/ml, 3 of them were simultaneously HBeAg positive. Conclusion: The prevalence of HBV infection in pregnant women in eastern Slovakia exceeds the overall estimated Slovak prevalence, and in districts with higher Roma population confirms presumed higher prevalence of HBV infection in this population. Majority of infected women are HBsAg carriers, but we have confirmed several cases of pregnant women with high viral load and increased risk of vertical transmission. We consider evaluation of ALT in pregnancy as insufficient for ruling out chronic hepatitis B. This study was supported by VEGA grant No.1/0050/08. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive

HBeAg

Hepatitis B

10.1016/j.ijid.2010.02.1994

Cite

Citations (0)

External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis

Canadian Journal of Gastroenterology and Hepatology (2021)

Jakub Gazda Martin Janíčko Sylvia Dražilová Ivica Grgurević Tajana Filipec Kanižaj

Ursodeoxycholic acid response score (URS) is a prognostic model that estimates the baseline probability of treatment response after 12 months of ursodeoxycholic acid (UDCA) therapy in patients with primary biliary cholangitis (PBC).To independently evaluate the predictive performance of the URS model.We used a cohort of Slovak and Croatian treatment-naïve PBC patients to quantify the discrimination ability using the area under receiver operating characteristic curve (AUROC) and its 95% confidence interval (CI). Furthermore, we evaluated the calibration using calibration belts. The primary outcome was treatment response after 12 months of UDCA therapy defined as values of alkaline phosphatase ≤1.67 × upper limit of normal.One hundred and ninety-four patients were included. Median pretreatment age was 56 years (interquartile range 49-62). Treatment response was achieved in 79.38% of patients. AUROC of the URS was 0.81 (95% CI 0.73-0.88) and the calibration belt revealed that response rates were correctly estimated by predicted probabilities.Our results confirm that the URS can be used in treatment-naïve PBC patients for estimating the treatment response probability after 12 months of UDCA therapy.

Ursodeoxycholic acid

Interquartile range

Clinical endpoint

Surrogate endpoint

10.1155/2021/9928065

Cite

Citations (6)

Artificial Intelligence and Its Application to Minimal Hepatic Encephalopathy Diagnosis

Journal of Personalized Medicine (2021)

Jakub Gazda Peter Drotár Sylvia Dražilová Juraj Gazda Matej Gazda

Hepatic encephalopathy (HE) is a brain dysfunction caused by liver insufficiency and/or portosystemic shunting. HE manifests as a spectrum of neurological or psychiatric abnormalities. Diagnosis of overt HE (OHE) is based on the typical clinical manifestation, but covert HE (CHE) has only very subtle clinical signs and minimal HE (MHE) is detected only by specialized time-consuming psychometric tests, for which there is still no universally accepted gold standard. Significant progress has been made in artificial intelligence and its application to medicine. In this review, we introduce how artificial intelligence has been used to diagnose minimal hepatic encephalopathy thus far, and we discuss its further potential in analyzing speech and handwriting data, which are probably the most accessible data for evaluating the cognitive state of the patient.

Hepatic Encephalopathy

Gold standard (test)

Covert

Hepatic dysfunction

10.3390/jpm11111090

Cite

Citations (7)