The objective of this study was to investigate the effect of intranasal phototherapy on nasal microbial flora in patients with allergic rhinitis. This prospective, self-comparised, single blind study was performed on patients with a history of at least two years of moderate-to-severe perennial allergic rhinitis that was not controlled by anti-allergic drugs. Thirty-one perennial allergic rhinitis patients were enrolled in this study. Before starting the test population on their intranasal phototherapy, the same trained person took a nasal culture from each subject by applying a sterile cotton swab along each side of the nostril and middle meatus. Each intranasal cavity was irradiated three times a week for two weeks with increasing doses of irradiated. At the end of the intranasal phototherapy, nasal cultures were again obtained from the each nostril. The study found that after intranasal phototherapy, the scores for total nasal symptoms decreased significantly but bacterial proliferation was not significantly different before and after phototherapy. We have shown that intranasal phototherapy does not change the aerobic nasal microbial flora in patients with perennial allergic rhinitis.
Nasal polyposis is chronic inflammatory disease of the nasal mucosa of the nose and sinuses, often associated with chronic non-allergic rhinitis, aspirin intolerance and non-allergic asthma. The etiology of nasal polyposis is unknown. Multiple factors contribute to the development of nasal polyps including genetic predisposition.This study was conducted on patients applied due to nasal polyps. Blood samples were collected peripheral vein and stored at 4°C until analysis for DNA extraction. Genomic DNA was extracted from peripheral blood by a standard method, samples were studied in real time PCR. All patients were evaluated about the possible association of DSG1 (rs7236477-G, 96 rxn), DSG3 (rs1941184-C, 96 rxn), PDE4D (rs1588265) and RORA (rs11071559) gene.32 patients (17 male, 15 female) with nasal polyposis were included to the study. The mean age was 34.9 ± 17.7 years, ranging between 18 and 55 years. Control group was consisted with 50 healthy volunteers without a history of nasal polyp. DSG1, DSG3 and RORA values of the study group were not statistically different from control group (p > 0.05). PDE4D values of the study group were significantly different from control group (p < 0.05).Multiple factors contribute to the pathogenesis of nasal polyps including genetic predisposition. The PDE4D family has gained interest in the complex pathogenesis of nasal polyposis. This is likely linked to the mucosal inflammatory response.
Objective The aim of this study was to evaluate the efficacy of rehydration of Merocel nasal packs with prilocaine or levobupivacaine on reducing pain and discomfort of nasal packing removal in patients who had undergone septoplasties or endoscopic sinus surgery. Study Design Prospective clinical study. Setting Tertiary referral center. Methods This prospective study was conducted on 72 patients, aged 18 to 55 years, who had undergone septoplasty, bilateral functional endoscopic sinus surgery, or both. The patients were divided into 2 groups: prilocaine group (group P, n = 36), who received 2.5 mL of 2% prilocaine, and levobupivacaine group (group L, n = 36), who received 2.5 mL of levobupivacaine hydrochloride dilution. These solutions were diluted with 2.5 mL saline to a final volume of 5 mL, which was then injected into the Merocel packing 15 minutes before removal of the pack. In both groups, 5 mL of saline was injected into the packing in the contralateral nostril as a control 15 minutes before removal of the pack. Visual analog score (VAS) and the Ramsay sedation score were recorded. Results Statistically significant differences were found in VAS and Ramsay sedation scale scores of levobupivacaine and prilocaine groups compared to controls. No significant difference was noted between the groups in terms of levobupivacaine and prilocaine. Conclusions Levobupivacaine or prilocaine infiltration before removal of nasal packs in patients who undergo septoplasties or endoscopic sinus surgery can decrease discomfort and improve patient tolerability.
Objectives: Adenoidectomy and the placement of tympanostomy tubes are among the most commonly performed surgical procedures in ear nose and throat clinics.Systemic and local causes have been implicated in the pathophysiology leading to these procedures.The aim of this study was to investigate a possible association between levels of vitamin A, vitamin D, iron, and zinc need to undergoing adenoidectomy and placement of tympanostomy tubes.Material and Methods: Demographic and disease-specific data were obtained from 31 Turkish children undergoing adenoidectomy and the placement of tympanostomy tubes, and 14 controls.Blood samples were taken for measurement of vitamin A, zinc, iron, and 25-hydroxy vitamin D (25[OH]D).All measurements were done in the same laboratory by the same researcher. Results:The study group comprised 13 (41.9%)girls and 18 (58.1%)boys, and the control group 7 (50%) girls and 7 (50%) boys.There were no statistically significant differences between study and control groups in plasma 25(OH)D, iron, zinc, or vitamin A levels (p>0.05).Conclusions: This pilot study did not show an association between serum vitamin D, iron, zinc, and vitamin A and the need to have an adenoidectomy and placement of tympanostomy tubes.
OBJECTIVES In this study, the existence, distribution and characteristics of cervical lymph nodes metastases in patients with laryngeal, hypopharyngeal and intraoral squamous cell cancer were investigated. PATIENTS AND METHODS A retrospective review of the charts of 81 laryngeal, hypopharyngeal and intraoral cancer patients (10 females, 71 males; mean age 55.9 years; range 30 and 81 years) surgically treated and followed up in Haseki Training and Research Hospital Ear, Nose and Throat Clinic between January 2004 and October 2007 was evaluated. The demographic data of the patients, tumor localization sites, surgical techniques, TNM stages and regional neck metastases were evaluated. RESULTS In laryngeal cancer patients, metastatic lymph nodes were found in 36 of 83 (43%) neck specimens. Patients with intraoral tumors had metastases in six (36.4%) of 20 neck specimens. In hypopharynx tumor patients in six of seven (85.7%) showed metastasis. CONCLUSION These results suggest that elective neck treatment in patients with head and neck squamous cell cancers, should include neck levels I, II, III, IV and V. Upper aerodigestive system squamous cell cancers have specific patterns of invasion in cervical region. According to the localization of the primary tumor, high risk sites of metastases were detected. Selective neck dissections were planned according to these invasion patterns of tumors.
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