Accumulating evidence support the notion that acute myeloid leukemia(AML) is organized in a hierarchical system, originating from a special proportion of leukemia stem cells(LSC). Similar to their normal counterpart, hematopoietic stem cells(HSC), LSC possess selfrenewal capacity and are responsible for the continued growth and proliferation of the bulk of leukemia cells in the blood and bone marrow. It is believed that LSC are also the root cause for the treatment failure and relapse of AML because LSC are often resistant to chemotherapy. In the past decade, we have made significant advancement in identification and understanding the molecular biology of LSC, but it remains a daunting task to specifically targeting LSC, while sparing normalHSC. In this review, we will first provide a historical overview of the discovery of LSC, followed by a summary of identification and separation of LSC by either cell surface markers or functional assays. Next, the review will focus on the current, various strategies for eradicating LSC. Finally, we will highlight future directions and challenges ahead of our ultimate goal for the cure of AML by targeting LSC.
There are two states for the coal-mass on the goaf-side which is in stress equilibrium: the state of limit equilibrium(the bearing stress in the coal-mass equals its ultimate bearing stress) and the state of nonultimate equilibrium(the bearing stress in the coal-mass is less than its ultimate bearing stress). To analyze the bearing characteristics of a coal pillar in the state of limit equilibrium and guide the design of pillar width, we established a mechanical analytical model of the non-ultimate equilibrium zone in the coal-mass on the goaf-side combined with the limit equilibrium theory as well as adopting the methods of theory analysis and mechanical analysis based on the assumption of a state of non-ultimate equilibrium. The width correction coefficient of the limit equilibrium zone has been given. The influence of mining depth, stress concentration coefficient of the surrounding rock, the non-limit strength of the coal-mass and stability of the coal rock interface has been studied. On this basis, we have confirmed that when the width of a longwall mining face roadway protection coal pillar is between 11.6 m and 13.16 m in No. 4 coal seam of Xinrui coal mine in Lvliang in Shanxi province the elastic core region in the coal pillar can be assured and the roadway will be located in the area of lower stress which is outside the peak stress. So the revised width of the limit equilibrium zone is more practical.
In this paper,an active network measurement platform is proposed which is a combination of hardware and software.Its innovation lies in the high performance of hardware combined with features that the software is easy to program,which retains software flexibility at the same time.By improving the precision of packet timestamp programmable hardware equipment,it provides packet sending control more accurately and supports the microsecond packet interval.We have implemented a model on the NetMagic platform,and done some experiments to analyze the accuracy difference of the user,the kernel and hardware timestamp.
Based on the engineering background of gob-side entry retaining in fully-mechanized longwall with top coal caving(GER-FLTC) on N2105 working face of Yuwu coal mine, by adopting the methods of theoretical analysis and numerical calculation, the control techniques of surrounding rocks in GER-FLTC working face are studied in this paper. The two main difficulties of stability of surrounding rocks at gob-side retained entry in fully-mechanized longwall working face are the stability control of top coal and control of large deformation of GER-FLTC working face. Interaction mechanical model between roofing and roadside backfilling in GER-FLTC is established and the equations for the calculation of roof-cutting resistance of roadside backfilling are derived. Results of numerical calculation show that the damage zones of top coal can be categorized into the delaminating zone of top coal above the backfilling, tensile damage zone of top coal above the retained roadway and shear damage zone of the upper rib of the solid coal. Stability control of top coal is the critical part to success of GER-FLTC. With consideration of large deformation of surrounding rocks of gob-side retained entry in fully-mechanized longwall, the support technique of‘‘roofing control and wall strengthening’’ is proposed where high strength and highly prestressed anchor rods and diagonal tensile anchor cables support are used for top coal, high strength and highly prestressed yielding anchor rod support is used for solid coal and roadside prestressed load-carrying backfilling is constructed by high-water material, in order to maintain the integrity of the top coal, transfer load, high resistance yielding load-carrying of solid coal, roof-cutting of roadside backfilling and support,and to achieve GER-FLTC. Results from this study are successfully applied in engineering practice.
Floor heave is the most common convergence in gob-side entry retaining.The paper analyzes the form,process and characteristics of gob-side entry retaining with the comprehensive methods of theoretical analysis,numerical simulation and the field trial.Research results present that bending and folding floor heave is the main factor in the stage of the first panel mining;squeezing and fluidity floor heave plays a great role in the stable stage of gob-side entry retaining;the combination of the former two factors affects mainly the stage of the second mining ahead;abutment pressure is a fundamental contribution to the serious floor heave of gob-side entry retaining,and sides corners of solid coal body are key part in the case of floor heave controlling of gob-side entry retaining.Floor heave of gob-side entry retaining can be significantly controlled by reinforcing sides and corners of solid coal body,and influence rules on the floor heave of gob side entry retaining of sides supporting strength and the bottom bolt orientation in solid coal side are obtained.Research results have been successfully applied in gob-side entry retaining of G20-F23070 face haulage roadway in #2 coal mine of Pingmei Group,and the field observation shows that the proposed technique is an effective way in controlling the floor heave of gob-side entry retaining.
A new approach named as steel pile method is innovatively proposed in this study to control severe floor heaves in gob-side entry retaining. It is required that the steel piles be installed in the floor corners with a certain interval before the influence of the dynamic pressure induced by current panel extraction. Using numerical simulation and theoretical analysis, this study investigated the interaction between the steel piles and the floor rocks during the service life of the steel piles, and revealed the mechanism of the steel piles in controlling floor heaves. The effect of the steel pile parameters on the control of floor heaves was presented and elaborated. It is found that the effectiveness of the steel piles in controlling floor heaves can be enhanced with greater installed dip angle, longer length and smaller interval of the steel piles.Compared with traditional methods, e.g., using floor anchor bolts and floor restoration, the advantages using steel pile were successfully defined in terms of controlling effect and economic benefits. It is hoped that the proposed method can contribute to the development of gob-side entry retaining technique.
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