Burcu Bayoğlu

Istanbul University-Cerrahpaşa

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Müjgan Cengiz

Istanbul University-Cerrahpaşa

Ahmet Dırıcan

Istanbul University-Cerrahpaşa

Neşe Kocabaşoğlu

Istanbul University-Cerrahpaşa

Caner Arslan

Kocaeli Üniversitesi

Hüseyin Altuğ Çakmak

State Hospital

Bilgehan Karadağ

Istanbul University-Cerrahpaşa

Gül Karaçetin

Bakırköy Psychiatric Hospital

Günay Can

Istanbul University-Cerrahpaşa

Serkan Burç Deşer

Istanbul University

Hüsniye Yüksel

Istanbul University

Cooperative Institutions

Istanbul University

Istanbul University-Cerrahpaşa

Bakırköy Psychiatric Hospital

Sağlık Bilimleri Üniversitesi

Consejo Nacional de Investigaciones Científicas y Técnicas

Turkish Society of Hematology

Istanbul Bilim University

Fujita Health University

Universitat de Barcelona

Hokkaido University

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Serotonin-2a receptor and catechol-O-methyltransferase polymorphisms in panic disorder

Progress in Neuro-Psychopharmacology and Biological Psychiatry (2011)

Gül Karaçetin Burcu Bayoğlu Müjgan Cengiz Türkay Demir Neşe Kocabaşoğlu

Agoraphobia

10.1016/j.pnpbp.2011.10.010

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Citations (14)

Review for "Molecular genetic associations between a prominent serotonin transporter gene polymorphism (5‐HTTLPR/rs25531) and individual differences in tendencies toward autistic traits and generalized internet use disorder in China and Germany"

Burcu Bayoğlu

5-HTTLPR

10.1002/brb3.2747/v1/review2

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Citations (0)

Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease

Experimental and Therapeutic Medicine (2017)

Caner Arslan Burcu Bayoğlu Cigdem Tel Müjgan Cengiz Ahmet Dırıcan

Oxidized low-density lipoprotein receptor 1 (OLR1) and interleukin 17A (IL17A) have pro-inflammatory roles in the development of cardiovascular disorders. The present study evaluated the association of OLR1 and IL17A and their polymorphisms with the development of femoropopliteal (FP) artery disease. The mRNA expression of OLR1 and IL17A in peripheral blood mononuclear cells as well as the frequency of OLR1 rs11053646 and IL17A rs8193037 and rs3819025 polymorphisms were assessed by polymerase chain reaction in 70 patients with FP artery disease and 80 age-matched disease-free controls. Furthermore, the levels of plasma cytokines were assessed by multiplex immunoassay. OLR1 and IL17A mRNA expression was significantly higher in patients with FP artery disease compared with that in controls (P<0.001). No significant difference was observed in the genotypic frequencies of OLR1 rs11053646 (P=0.87) or in IL17A rs8193037 and rs3819025 (P=0.80 and 0.92, respectively) polymorphisms between patients with FP artery disease and controls. Plasma IL4, -6, -10, -22, -31 and -33 as well as soluble cluster of differentiation 40 ligand and tumor necrosis factor-α levels were significantly increased among FP artery disease patients compared with controls (P<0.05). Furthermore, OLR1 expression was positively correlated with triglyceride (r=0.463, P<0.001), low-density lipoprotein cholesterol (r=0.507, P<0.001) and total cholesterol levels (r=0.357, P=0.006) in patients with FP artery disease. To the best of our knowledge, the present study was the first to identify an association between OLR1 and IL17A genes and FP artery disease. OLR1 and IL17A mRNA transcripts may be associated with blood lipid parameters and with the development of FP artery disease.

10.3892/etm.2017.4081

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Citations (16)

Roles of OLR1 and IL17A variants on clinical phenotypes of Turkish patients undergoing coronary artery bypass surgery

Turkish Journal of Biochemistry (2022)

Eymen Recep Burcu Bayoğlu Caner Arslan Deniz Göksedef Gökhan İpek

Abstract Objectives Coronary artery disease (CAD) is a pathological condition resulting from atherosclerosis in the coronary arteries. IL17A has been shown to recruit and activate macrophages in atherosclerotic lesions, thereby participating in plaque destabilization. Currently, whether OLR1 and IL17A variants are involved in the pathogenesis of CAD is unclear. This case-control study aimed to investigate their roles in CAD etiology and prognosis. Methods In this study, 100 severe CAD patients who had undergone the coronary artery bypass graft surgery and 100 healthy controls were genotyped for OLR1 rs11053646, IL17A rs3819025, and rs8193037 variants via RT-PCR. Results The patients with OLR1 rs11053646 CG + GG genotype demonstrated a higher frequency of multi-vessel stenosis (18%) than single- (11.10%) or double-vessel (13.30%) stenosis (p=0.77). Additionally, although not statistically significant, this group of patients had 6.280 times more CAD risk than CC genotype carriers (p=0.089). Furthermore, logistic regression analysis revealed significant associations between the three variants and the risk factors for CAD development, namely waist circumference (p=0.002), body mass index (p=0.013), fasting glucose level (p=0.006), and triglyceride levels (p=0.035). Conclusions OLR1 rs11053646, IL17A rs3819025, and rs8193037 variants do not increase the risk for CAD development. However, this conclusion should be confirmed with a larger cohort.

Coronary arteries

10.1515/tjb-2021-0214

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Citations (1)

Chromosome 9p21 rs10757278 polymorphism is associated with the risk of metabolic syndrome

Molecular and Cellular Biochemistry (2013)

Burcu Bayoğlu Hüseyin Altuğ Çakmak Hüsniye Yüksel Günay Can Bilgehan Karadağ

10.1007/s11010-013-1629-3

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Citations (16)

BDNF Val66Met polymorphism is associated with negative symptoms in early-onset schizophrenia spectrum and other psychotic disorders

The European Journal of Psychiatry (2021)

Gül Karaçetin Burcu Bayoğlu Tuğba Eseroğlu Melike Topal Esra Bulanık Koç

rs6265

10.1016/j.ejpsy.2021.04.002

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Citations (2)

OP-149 THE ASSESSMENT OF RELATIONSHIP BETWEEN VARIANTS AT 9p21 CHROMOSOME AND CORONARY ARTERY DISEASE IN TURKISH POPULATION

International Journal of Cardiology (2012)

Hüseyin Altuğ Çakmak Burcu Bayoğlu Eser Durmaz Servet Altay Günay Can

Turkish population

10.1016/s0167-5273(12)70090-6

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Genetic variants rs1994016 and rs3825807 in ADAMTS7 affect its mRNA expression in atherosclerotic occlusive peripheral arterial disease

Journal of Clinical Laboratory Analysis (2017)

Burcu Bayoğlu Caner Arslan Cigdem Tel Turgut Ulutin Ahmet Dırıcan

Aim Peripheral artery disease ( PAD ) is a vascular disease affecting peripheral circulation. Recently, genome‐wide association studies revealed a relationship between single nucleotide polymorphisms ( SNP s) in ADAMTS 7 (a disintegrin and metalloprotease with thrombospondin motif 7) and atherosclerosis. In this study, we aimed to determine ADAMTS 7 expression in peripheral blood mononuclear cells ( PBMC s) and the frequency of ADAMTS 7 rs1994016 and rs3825807 polymorphisms in a sample of Turkish patients with PAD , and to evaluate the association of matrix metalloproteinase ( MMP ) levels with PAD development. Methods In this case – control study, ADAMTS 7 mRNA and protein expression was determined using reverse transcription quantitative real‐time polymerase chain reaction ( RT ‐ qPCR ) and western blot, respectively, and rs1994016 and rs3825807 variants in ADAMTS 7 were determined by real‐time PCR in 115 PAD patients and 116 healthy controls. Plasma levels of nine MMP s were determined using a multiplex immunoassay system. Results ADAMTS 7 mRNA levels were significantly higher in PAD patients than in controls ( t =−2.75, P =.007). There was no significant difference in the frequencies of rs1994016 and rs3825807 between PAD patients and controls ( P >.05). In PAD patients, ADAMTS 7 mRNA levels were significantly increased for the CC genotype of rs1994016 ( t =−2.31, P =.026) and TT genotype of rs3825807 ( t =−2.23, P =.032). Furthermore, plasma levels of MMP ‐1, MMP ‐3, MMP ‐7, MMP ‐10, MMP ‐12, and MMP ‐13 were significantly higher in PAD patients than in controls ( P <.05). Conclusion This is the first report of the relationship between PAD and ADAMTS 7 expression and the effects of the rs1994016 and rs3825807 variants on PAD development. ADAMTS 7 may be associated with PAD development.

ADAMTS

SNP

10.1002/jcla.22174

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Citations (13)

Genetic polymorphism of angiotensin I‐converting enzyme (ACE), but not angiotensin II type I receptor (ATr1), has a gender‐specific role in panic disorder

Psychiatry and Clinical Neurosciences (2012)

Burcu Bayoğlu Müjgan Cengiz Gül Karaçetin Ömer Uysal Neşe Kocabaşoğlu

Aims: Angiotensins were shown to have some role in the development of panic disorder (PD). In this study, we aimed to determine the frequency of polymorphisms in two angiotensin‐related genes, angiotensin I‐converting enzyme ( ACE ) and angiotensin II type I receptor ( ATr1 ), in a sample of Turkish patients with PD and to evaluate their association with PD development. Methods: Polymerase chain reaction and restriction fragment length polymorphism was used to analyze ATr1 A1166C polymorphism, and only polymerase chain reaction was used to analyze functional ACE insertion/deletion polymorphism in 123 patients with PD and in 169 similarly aged disease‐free controls. Results: There was no significant difference in the genotype distribution between PD patients and controls for each polymorphism ( P > 0.05). Allele frequency of ACE insertion/deletion was borderline statistically significant between the groups ( P = 0.055; odds ratio: 1.39; 95% confidence interval: 0.99–1.95), and allele frequency of ATr1 A1166C was not significantly different between the groups ( P = 0.32; odds ratio: 0.81; 95% confidence interval: 0.53–1.22). Conclusion: This study suggests that polymorphisms of ACE I/D and ATr1 A1166C are not associated with risk of PD in Turkish patients. However, in ACE insertion/deletion polymorphism, the insertion allele was found to be more frequent in the male subgroup of patients (χ 2 = 4.61, P = 0.032) than in controls, suggesting a potential male‐specific role of the less active ACE insertion allele in the pathogenesis of PD.

10.1111/j.1440-1819.2011.02318.x

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Citations (11)

NEGR1 can influence symptom severity in fluoxetine treated major depression disorder patients

Research Square (Research Square) (2024)

Burcu Bayoğlu Gulseren Akdeniz Neşe Kocabaşoğlu Burç Çağrı Poyraz Ahmet Dırıcan

Abstract NEGR1 (neuronal growth regulator 1) is a cell adhesion molecule of the immunoglobulin (Ig) superfamily related to IgLON subgroup. NEGR1 promotes cell-cell adhesion and stimulates neurite growth of hypothalamic neurons and inhibits synapse formation. NEGR1 is one of the genomic regions significantly associated with major depression disorder (MDD). The functional role of NEGR1 on MDD is still unknown. Fluoxetine, a selective serotonin reuptake inhibitor, is used in the treatment of MDD. Thus, we aimed to investigate the effects of fluoxetine on NEGR1 expression in MDD and to examine correlations between NEGR1 levels and symptom severity. In this study, mRNA expression of NEGR1 in fluoxetine-treated and non-treated cultured peripheral blood mononuclear cells (PBMC) were detected by qPCR in 40 patients with MDD and 40 age‑matched healthy controls. The protein levels of NEGR1 in cultured PBMCs were detected by ELISA method. Hamilton Rating-Scale for Depression (HRSD) and Beck Depression Inventory (BDI) were used to evaluate depressive symptom severity. PBMC of MDD patients exhibited elevated NEGR1 protein levels when compared with healthy controls in both fluoxetine treated and non-treated groups (p = 0.01). Besides, a positive correlation was found between NEGR1 protein levels and Beck scores in fluoxetine treated MDD group (r = 0.33, p = 0.036). However, no significant relationship was observed in NEGR1 mRNA levels between MDD patients and controls in both fluoxetine treated and non-treated group (p > 0.05). Fluoxetine had no effect on the protein levels of NEGR1 directly. On the other hand, NEGR1 protein levels may affect symptom severity in MDD patients treated with fluoxetine.

Depression

10.21203/rs.3.rs-4421084/v1

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