Roles of OLR1 and IL17A variants on clinical phenotypes of Turkish patients undergoing coronary artery bypass surgery
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Abstract Objectives Coronary artery disease (CAD) is a pathological condition resulting from atherosclerosis in the coronary arteries. IL17A has been shown to recruit and activate macrophages in atherosclerotic lesions, thereby participating in plaque destabilization. Currently, whether OLR1 and IL17A variants are involved in the pathogenesis of CAD is unclear. This case-control study aimed to investigate their roles in CAD etiology and prognosis. Methods In this study, 100 severe CAD patients who had undergone the coronary artery bypass graft surgery and 100 healthy controls were genotyped for OLR1 rs11053646, IL17A rs3819025, and rs8193037 variants via RT-PCR. Results The patients with OLR1 rs11053646 CG + GG genotype demonstrated a higher frequency of multi-vessel stenosis (18%) than single- (11.10%) or double-vessel (13.30%) stenosis (p=0.77). Additionally, although not statistically significant, this group of patients had 6.280 times more CAD risk than CC genotype carriers (p=0.089). Furthermore, logistic regression analysis revealed significant associations between the three variants and the risk factors for CAD development, namely waist circumference (p=0.002), body mass index (p=0.013), fasting glucose level (p=0.006), and triglyceride levels (p=0.035). Conclusions OLR1 rs11053646, IL17A rs3819025, and rs8193037 variants do not increase the risk for CAD development. However, this conclusion should be confirmed with a larger cohort.Keywords:
Coronary arteries
C-reactive protein, a marker of chronic, low-grade inflammation, is strongly associated with current central adiposity, and has been linked to elevated risk of cardiovascular disease. Less is known about the contribution of longitudinal change in waist circumference to current inflammation. We evaluated the extent to which current waist circumference and change over an 11-year interval contribute independently to low-grade systemic inflammation measured in a group of 1,294 women, 35-69 years, participating in the Cebu Longitudinal Nutrition and Health Survey in the Philippines. Waist circumference was measured at the time of blood draw for CRP analysis in 2005 and during an earlier survey in 1994. A waist circumference delta variable was constructed by subtracting current circumference from past circumference. We used logistic regression models to predict having an elevated plasma CRP concentration (3 mg L(-1) < CRP < 10 mg L(-1)). Waist circumference in 2005 was a strong predictor of elevated CRP (OR 1.10, 95% CI = 1.08, 1.12, P < 0.001). In combined models, increase in circumference over 11 years was a significant and independent predictor of elevated CRP risk (OR = 1.023, 95% CI = 1.00, 1.05, P < 0.05). Considering the average increase over time, the cumulative risk of elevated CRP due to increased central adiposity was 25.7%. However, women who reduced their waist circumference between 1994 and 2005 had greatly reduced risk (6.2%), suggesting that even long-term inflammatory burden can be reversed by weight loss. Although current waist circumference is an important contributor to risk of elevated systemic inflammation in this as in other populations, history of central adiposity may be an independent phenomenon.
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Waist-to-height ratio
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Coronary arteries
Circumflex
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We evaluated the accuracy of self-reported home-assessed and self-measured waist circumference in 101 men and eighty-three women aged 28-67 years. The main outcome measures were subjects' self-reported and self-measured waist circumference, and self-classification according to the previously defined waist action level 1 (940 mm in men, 800 mm in women) and action level 2 (1020 mm in men, 880 mm in women), and waist circumference measured by the investigator using the 'Waist Watcher' tape-measure, as the reference method. The mean errors (95% CI limits of agreement) for subjects' self-reported waist circumference (self-reported minus reference; mm) were -67 (95% CI -210, 77) in men and -43 (95% CI -211, 123) in women, and for self-measured waist circumference (mm) using the 'Waist Watcher' (self-measured minus reference) were -5 (95% CI -62, 52) in men and -4 (95% CI -50, 42) in women. The proportions of subjects classified into waist action level 1 or action level 2 by the investigator were used as the reference method. Self-reported waist circumference of men and women respectively would be classified correctly in different categories based on action level 1 with sensitivities of 58.3 and 78.7%, and specificities of 92.5 and 91.7%, and action level 2 with sensitivities of 35.3 and 44.9%, and specificities of 98.5 and 90.7%. Using the 'Waist Watcher' with different colour bands based on the action levels, male and female subjects respectively classified themselves into correct categories according to action level 1 with sensitivities of 100 and 95.7%, and specificities of 95.1 and 97.2%, and according to action level 2 with sensitivities of 97.1 and 100%, and specificities of 100% for both sexes. Only 2% of the sample misclassified themselves into the wrong categories according to waist circumference action levels. In conclusion, people tend to underestimate their waist circumference, but the 'Waist Watcher' tape-measure offers advantages over self-reported home-assessed measurement, and may be used as a screening tool for self-classifying the risk of ill health through intra-abdominal fat accumulation.
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保健指導には，BMI（Body Mass Index，以下BMI）を初め，多くの健康指標が用いられているが，ウエスト値は，研究が少ないのが現状である．そこで，ウエスト値とBMIの関連，食生活・日常生活習慣との関連を明らかにするために調査を行った．A建設会社に勤務する35歳以上の男性社員213名を対象とし，定期健康診断時に，自記式質問紙と，ウエスト値測定，血液生化学検査による調査を行った．BMI，収縮期血圧，拡張期血圧，中性脂肪，GPT，γ-GTP，空腹時血糖値での異常値群は，正常値群と比較し，有意にウエスト値が太かった（p＜0.04）．ウエスト値と日常生活習慣の関連においては，揚げ物および外食を週4-5回以上摂取している群（p＝0.004），運動習慣が週に2-3回以下の群（p＝0.025）はウエスト値が有意に太かった．ロジスティック解析では，ウエスト値に関連が見られたものが疾病の有無（オッズ比2.10，p＝0.046），検査値異常の有無（オッズ比3.54，p＝0.009）であった．以上より，ウエスト値は健康指標の1つとして使用可能と考えられ，揚げ物や外食を控えたり，運動習慣を改善したりすることでウエスト値をコントロールし，内臓肥満予防に繋げることが出来るのではないかと考える．
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Objective To explore the relationship of body mass index(BMI) and waist circumference to blood pressure and hypertension prevalence in employees in Shougang Shuicheng iron and steel corporation.Methods Two thousand four hundred and ninety-six employees in Shougang Shuicheng iron and steel corporation were surveyed using a multi-stage random cluster sampling method.Medical examination included blood pressure measurement(SBP and DBP),height,BMI and waist circumference.Results The BMI was(23.18±3.34) kg·m-2and waist circumference was(80.37±10.02) cm.Among the 2 496 employees,the overweight and obesity accounted for 38.22%(954/2 496) and abdominal obesity accounted for 36.26%(905/2 496).The hypertension prevalence in male participants(BMI:18,≥18-24,≥24-28,≥28 kg·m-2or waist circumference:75,≥75-85,≥85 cm) were significantly higher than that in female participants(all P0.05).The hypertension prevalence in male participants(BMI 24 kg·m-2,waist circumference 85 cm;BMI 24 kg·m-2,waist circumference ≥85 cm;BMI 24-27.9 kg·m-2,waist circumference85 cm;BMI 24-27.9 kg·m-2,waist circumference ≥85 cm;BMI ≥28 kg·m-2,waist circumference ≥85 cm) were obviously higher than that in female participants(BMI24 kg·m-2,waist circumference80 cm;BMI24 kg·m-2,waist circumference ≥80 cm;BMI 24-27.9 kg·m-2,waist circumference80 cm;BMI 24-27.9 kg·m-2,waist circumference≥80 cm;BMI≥28 kg·m-2,waist circumference≥80 cm)(P0.05 or P0.01).Conclusion The hypertension prevalence in male employees is significantly higher than that in female employees in Shougang Shuicheng iron and steel corporation.The control of BMI and waist circumference is beneficial to the prevention of hypertension.
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Lumen (anatomy)
Left coronary artery
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128 human hearts including 70 males and 58 females in all age groups were used for the present study. Coronary arteries were dissected out from all the human hearts. The luminal diameter was studied in all the four major coronary arteries, namely, right coronary artery (RCA), left coronary artery (LCA), left anterior descending artery (LAD) and left circumflex coronary artery (LCX) in both the sexes. The histological sections were stained with H & E stain and the diameter was measured with the help of ocular micrometer. Among the four major coronary arteries luminal diameter is found to be more in LCA followed by LAD, RCA and LCX. Luminal diameter was found to be more in males as compared to females in all the four major coronary arteries. The data of present study can be useful for doing any instrumentation of coronary artery.
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Background: Prior studies have supported that waist circumference correlates with abdominal (central) obesity, and values higher than normal are associated with increased prevalence of hypertension. . Objective: To evaluate the association of waist circumference with increased prevalence of hypertension among population in Kirkuk city. Materials and Methods: Across-sectional study was conducted comprising 300 male and female, their ages ranged from 20-72 years with an average mean of 53 year from Kirkuk city. The waist circumference was measured in centimeters, together with other data designed in the data sheet for this study, hypertensive people were identified and recorded. Patients who had coexisted Diabetes Mellitus and hypertension were excluded from the study. Results: The total number of females was 218, out of them, 176(80.7%) had increased waist circumference, this included 74(42%) hypertensive, compared with 42(19.2%) women with normal waist circumference and included 6(14.2%) hypertensive. (P < 0.05). Out of 82 males, 46(56%) had increased waist circumference (>102cm), this included 17(37%) hypertensive; compared with 36(44%) with normal waist circumference, which included 7(19.4%) hypertensive. P. value ˂0.001 Waist circumference was positively correlated with hypertension Conclusions: Increasing waist circumference was significantly associated with increased prevalence of hypertension, reduction in the occurrence of hypertension in male and female can be achieved if the waist circumference is decreased in these populations.
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Suction type stabilizers are popular for off-pump coronary artery bypass. However, arteries running deeply underneath fatty tissue are not stabilized well because the soft tissues act as cushions between the coronary artery and the stabilizer. We propose a simple method to stabilize and visualize intra fat coronary arteries. After dissection of target arteries, 5-0 polypropylene continuous over-and-over sutures are placed on the fat tissues along both sides of the coronary artery. These sutures are pulled laterally, and a suction stabilizer is placed so that the sutures lie under the legs of the stabilizer. Sutures fixed to the stabilizer legs with suction force reduce motion of the target vessel. Visualization of the coronary arteries is also improved because the banks of fat tissue become flat by pulling the sutures laterally.
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Stabilizer (aeronautics)
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