Objective To investigate the effect of axial stress stimulation on tibial and fibular open fractures healing after Taylor space stent fixation. Methods The data of 45 cases with tibial and fibular open fractures treated by Taylor space stent fixation who meet the selection criteria between January 2015 and June 2016 were retrospectively analysed. The patients were divided into trial group (23 cases) and control group (22 cases) according to whether the axial stress stimulation was performed after operation. There was no significant difference in gender, age, affected side, cause of injury, type of fracture, and interval time from injury to operation between 2 groups ( P>0.05). The axial stress stimulation was performed in trial group after operation. The axial load sharing ratio was tested, and when the value was less than 10%, the external fixator was removed. The fracture healing time, full weight-bearing time, and external fixator removal time were recorded and compared. After 6 months of external fixator removal, the function of the limb was assessed by Johner-Wruhs criteria for evaluation of final effectiveness of treatment of tibial shaft fractures. Results There were 2 and 3 cases of needle foreign body reaction in trial group and control group, respectively, and healed after symptomatic anti allergic treatment. All the patients were followed up 8-12 months with an average of 10 months. All the fractures reached clinical healing, no complication such as delayed union, nonunion, or osteomyelitis occurred. The fracture healing time, full weight-bearing time, and external fixator removal time in trial group were significantly shorter than those in control group ( P<0.05). After 6 months of external fixator removal, the function of the limb was excellent in 13 cases, good in 6 cases, fair in 3 cases, and poor in 1 case in trial group, with an excellent and good rate of 82.6%; and was excellent in 5 cases, good in 10 cases, fair in 4 cases, and poor in 3 cases in control group, with an excellent and good rate of 68.2%, showing significant difference between 2 groups ( Z=-2.146, P=0.032). Conclusion The axial stress stimulation of Taylor space stent fixation can promote the healing of tibial and fibular open fractures and promote local bone formation at fracture site.
The aim of this study was to observe the clinical efficacy and side effects of verapamil combined with antitumor drugs via Pleural Catheter Perfusion (PCC). From December 2004 to December 2014, a total of 79 patients with Malignant Pleural Effusion (MPE) were randomly divided into the control group (C, n=37) and the treatment group (T, n=42). Group C was perfused with interleukin-2, 5-fluorouracil, and cisplatin, and group T was perfused with verapamil, interleukin-2, 5-fluorouracil, and cisplatin. The post-treatment clinical efficacy, side effects, median survival time, and overall survival were evaluated and compared between the two groups. After the treatment, the efficacy rate (CR+PR) of group C was 51.35%, and that of group T was 80.95%. There was significant difference between the two groups (P 0.05). No significant side effect in the cardiovascular system appeared. This study can improve the clinical treatment of MPE and prolong the survival time.
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