RT-PCR-based examination of papilloma samples obtained from patients with relapsing papillomatosis of the larynx showed an incidence rate of human papilloma virus (HPV) amounting to 89%. The viral load level of the studied samples, when measured by concurrent RT-PCR HPV, differed by more than 130 times. It made, in the untreated patient, 1.2 x 10(9) hormonal equivalents/ml, i.e. 13-fold higher versus the patient who received pathogenetic therapy. Thus, the approach in question provides for a possibility to monitor the activity of papilloma viral infection and to evaluate the efficiency of different variations of pathogenetic therapy because the "classic" variant of PCR-detection is not informative in the discussed case.
The authors of the article analyze observations of 240 patients with respiratory papillomatosis (aged 7 months to 56 years), treated in the ETN clinic of Moscow Regional Research Clinical Institute in 1984-2003 using endolaringeal microsurgical techniques, such as ultrasound desintegration and laser photodestruction of papillomas. Additional therapy included immunocorrection with T-activin and leukomax, discrete plasmopheresis, antiviral therapy with zovirax, and photodynamic therapy. Having compared various methods and their combinations, the authors conclude that clinical recovery (no relapses within more than 2.5 years), was achieved in 41.4 +/- 0.5% - 77.8 +/- 0.2% patients.
