This study aimed the evaluation of the prevalence, characteristics, types of dens invaginatus (DI) and co-observed dental anomalies to understand dental treatment requirements in anterior teeth that are susceptible to developmental anomalies by using cone-beam computed tomography (CBCT).In this retrospective study, the anterior teeth of 958 patients were evaluated by using CBCT for the presence of DI. The demographic features, types of DI and treatment requirements were also recorded. The association between sex and the presence of DI was evaluated using chi-squared test.Seventy-three DI anomalies were detected in the anterior teeth of 49 patients (18 females, 31 males). The frequency of DI was 5.11% and the most frequently involved teeth were lateral (57.53%). Forty-six teeth were classified as Type I (63.01%), 24 as Type II (32.87%), and three as Type III (4.10%). Apical pathosis was found to be 20.54% in all DIs detected and accounted for all Type III and one-third of Type II.CBCT imaging can be effective in the detection of dental anomalies such as DI and planning for root canal therapy and surgical treatments. Prophylactic interventions might be possible to prevent apical pathosis with the data obtained from CBCT images.
Rekurrent aftoz stomatitler (RAS) oral mukozanin en sik gorulen lezyon larindandir. Klinikte minor, major ve herpetiform ulserler olarak karsilas tigimiz bu lezyonlarin etyolojisi halen acikliga kavusmamistir. Bununla birlikte yiyeceklere hassasiyetten, hormonal bozukluga, travmadan virus lere ve sistemik hastaliklara (Crohn hastaligi, ulseratif kolit, colyak hastaligi, Behcet sendromu) kadar farkli durumlar rekurrent aftoz stoma titlerin etyolojisinde adi gecen faktorlerdir. ayrica sigara icenlerde sigara icilmesinin birakilmasini takiben RAS goruldugu veya sikliginin arttigi da bilinmektedir.Calismamizda sigara icmeyen 164 RAS olgusunun retrospek tif olarak analizi yapilmistir. Olgularimizin 100'u kadin 64'u erkek olup yas ortalamasi 36.5 (yas araligi: 6-75)'tir. Olgularimizin 146'sinda yalnizca minor aftoz stomatit, 15'inde yalniz major aftoz stomatit gorulurken, 3 olgumuzda da hem minor hemde major aftoz stomatitlere rastlanmistir. behcet hastaligi acisindan yapilan tetkiklerde sadece 4 olgumuz Behcet acisindan pozitif olarak degerlendirilmistir. Olgularin tam kan sayimlari incelendiginde, kadinlarda % 33 oraninda demir eksikligi anemisine rastlanmistir. Ayrica olgularimizin icinde, calisan erkeklerde kadinlara oranla anlamli bir derecede (p<0.001) fazla rekurret aftoz stomatit gor ulmustur. Bu sonuclara dayanarak minor aftoz stomatitlerin en sik rastlanan rekurrent aftoz stomatitler oldugu, kadinlarda erkeklerden daha sik goruldugu ve kadinlarda gorulen rekurrent aftoz stomatitin etyolojisinde demir eksikligi anemisinin, erkeklerde gorulen rekurrent afttoz stomatitlerde ise calisma hayatinin yarattigi stresin daha etkili oldugu kanisina varilmistir. Anahtar Kelimeler : Rekurrent aftoz stomatit, etyoloji, demir eksikligi anemisi,stres
Aim: The aim of this study is to investigate the expressions of IGF-1R, EZH2 and Laminin-5 antibodies in biopsy samples of leukoplakia and squamous cell carcinoma of the oral mucosa by immunohistochemistry method. Materials and Methods: The study consisted of three groups; oral squamous cell carcinoma leukoplakia and control groups. The control group consisted of lesions with oral fibrous hyperplasia diagnosis. Biopsies of 38 patients for oral squamous cell carcinoma, 32 patients for leukoplakia and 15 patients for control group were examined and evaluated degree of staining of antibodies. Antibodies were evaluated as negative (0-10%):0, 1 positive (11-30%):+, 2 positive (31-60%):++, 3 positive (61-100%):+++ according to staining percentages. The staining degrees of antibodies were compared with Mann Whitney U test in study and control groups. Gender distribution between groups was compared with LSD test and SPSS 21 program was used for calculations. The results were statistically significancant is p ˂0.05. Results: According to the findings obtained in this study antibodies revealed significantly higher staining in the oral squamous cell carcinoma group and leukoplakia group compared to with control groups. Conclusion: In this study, it was shown that EZH2, IGF-1R and Laminin-5 may have roles in cancer development. Key words: Squamous cell carcinoma, leukoplakia LÖKOPLAKİ VE ORAL SKUAMÖZ HÜCRELİ KARSİNOMDA IGF-1R, EZH2, LAMININ-5 EKSPRESYONU ÖZET Amaç:. Çalışmanın amacı oral mukozada lökoplaki ve skuamöz hücreli karsinom biyopsi örneklerinde IGF-1R, EZH2 ve Laminin-5 antikorlarının immünhistokimyasal methodla ekspresyonlarının araştırılmasıdır. Gereç ve Yöntem: Çalışmayı oral skuamöz hücreli karsinom, lökoplaki ve kontrol grubu olmak üzere üç grup oluşturmaktadır. Kontrol grubunu oral fibröz hiperplazi tanılı lezyonlar oluşturmuştur. Oral skuamöz hücreli karsinomda 38, lökoplakide 32 ve kontrol grubunda 15 biyopsi örneğinde IGF-1R, EZH2 ve Laminin-5 antikorlarının boyanma dereceleri incelendi ve değerlendirildi. Antikorlar boyanma yüzdelerine göre negatif (%0-10):0, 1 pozitif (%11-30):+, 2 pozitif (%31-60):++, 3 pozitif (%61-100):+++ olarak değerlendirildi. Çalışma ve kontrol gruplarında EZH2, IGF-1R ve Laminin-5 antikorları ile boyanma dereceleri Mann Whitney U testiyle karşılaştırılmıştır. Gruplar arasındaki cinsiyet dağılımı karşılaştırılması LSD (Least Significant Difference) testiyle, hesaplamalar SPSS 21 programıyla yapılmıştır. Anlamlılık sınırı p˂0.05tir. Bulgular: Bu çalışmada elde edilen bulgulara göre IGF-1R, EZH2 ve Laminin-5 antikorlarının kontrol grubuyla karşılaştırıldığında lökoplaki ve oral skuamöz hücreli karsinom gruplarında önemli derecede yüksek boyanma göstermiştir. Sonuç: Bu çalışmada EZH2, IGF-1R ve Laminin-5'in kanser gelişiminde rolleri olabileceği gösterilmiştir. Anahtar Kelimeler: Skuamöz hücreli karsinom, lökoplaki
We aimed to investigate a possible association of the MCP-1 and CCR2 polymorphisms with the risk of developing oral squamous cell carcinoma (OSCC).MCP-1 A2518G and CCR2 V64I gene polymorphisms were performed by polymerase chain reaction and restriction fragment length polymorphism, in 129 patients with OSCC and 140 healthy control subjects.Individuals who had G allele and GG genotype of MCP-1, and 64I allele and wt/64I genotype of CCR2 had increased risk for OSCC (P<0.05.) In contrast, individuals with CCR2 wt/wt genotype seem to be protected from OSCC (P < 0.01). Haplotype analysis revealed that MCP-1G: CCR2 64I haplotype frequencies were significantly higher in patients than those of controls (P = 0.001).We can suggest that the G allele of MCP-1 and 64I allele of CCR2 may be risk factors for OSCC.
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