Malignant mesothelioma (MM) is a primary malignant tumour with a very bad prognosis, which develops from the mesothelial cells lining the serosal surfaces, especially the pleura. Because MM can show a wide variety of histological patterns and its cyto-morphological features are quite extensive, various diagnosis problems are encountered with lung adenocarcinomas (LAC) and sometimes reactive mesothelial hyperplasia (RMH). In solving this problematic situation, the immunohistochemical examination method was identified as the most helpful method for the distinction. In this study, we aimed to determine the value of suprabasin and DARS2 markers in the differential diagnosis of RMH, MM and LAC.Thirty MM, 30 LAC and 30 RMH samples selected from the archive of Fırat University Hospital Pathology Department Laboratory were included in this study. Suprabasin and DARS2 markers were applied to the samples immunohistochemically and their place in the differential diagnosis was examined. Although DARS2 expression was observed in RMH, MM and adenocarcinoma samples, Suprabasin expression was only observed in adenocarcinoma. There was a significant difference between the groups in terms of DARS2 and Suprabasin expression. No suprabasin expression was detected in MM and RMH.As a result; Suprabasin and DARS2 may be proposed as new biomarkers to differentiate MM from LAC.
This study aims to compare the Magnetic Resonance Imaging (MRI) and Shear Wave Elastography (SWE) data and investigate their contribution to diagnosis when both are individually used and combined. This study included the consent of 46 diagnostic biopsy patients after their breast MRI examination was performed. Mass appearance patients in the sonographic evaluation were SWE examined before the biopsy. In MR examination, lesion localization, size, contrast curves, contrast enhancement features, intensity in the fat-suppressed T2A sequence, Emean value in SWE examination, and histopathological results were examined. Individual and combined use of MRI and SWE findings were evaluated with histopathological results. The diagnosis consistency was compared according to the histopathological results of the malignant-benign defined lesions. Higher sensitivity in MRI; higher specificity and accuracy in SWE were acquired when both methods were compared. The accuracy of MRI improved when MRI use is combined with SWE. The combined use of SWE with MRI increases the diagnostic accuracy in breast lesion characterization. We observed that lesions showing a type 3 enhancement curve and iso-hypointense on the T2W sequence in breast MRI could be predicted to show a stiff elasticity pattern on SWE due to higher elastography values.
Bobrek Hucreli Karsinom (BHK) eriskinlerdeki malign tumorlerin %2’ sini, butun malign renal tumorlerin%80’ini olusturan en sik malign renal tumorlerdir. BHK’ler en sik 6. ve 7.dekadda ve erkeklerde kadinlarda 2kat fazla gorulur.Biz 1992-2013 yillari arasinda retrospektif olarak 79 bobrek tumorunu degerlendirdik. Yetmis dokuz vakanin51’i (%65) erkek, 28’i (%35) kadindi. Biz de calismamizda en sik gorulen BHK tipinin klasik BHK’i oldugunutespit ettik. Bulgularimiz literatur bilgisiyle uyumluydu.Bu calismada, anabilim dalimizin deneyimlerini literatur bilgileri esliginde paylasmayi istedik
Invasive mole is a benign gestational trophoblastic disease that arises from the myometrial invasion of any gestational event via direct extension through tissue or vascular structures. Invasive mole (and other gestational trophoblastic diseases) may present with life-threatening complications including uterine perforation, excessive bleeding, acute hemoperitoneum, and abdominal pain. We report a case of invasive mole presenting as abdominal distention in a 51-year-old perimenopausal woman (gravida 12, para 12, abortion 0). The patient was admitted to the gynecology clinic with a giant uterine mass filling the pelvic and abdominal cavity. To our knowledge, this is the first case in the literature of a gestational trophoblastic neoplasia presenting with uterine mass of 28 weeks' gestational size in this age group. Interestingly, complications such as uterine rupture or invasion of the adjacent structures (such as parametrial tissues or blood vessels) had not developed in our patient despite the considerable enlargement of the uterus.
Introduction: Approximately two-thirds of pituitary adenomas secrete excess hormones. The increase in prolactin level suppresses the hypothalamic-pituitary-gonadal axis and can cause osteoporosis and infertility. Polyangiitis granulomatosis is a systemic disease with small vessel vasculitis. Anti-neutrophil cytoplasmic antibodies (ANCA) and especially anti-proteinase 3 (PR3) ANCA are thought to be associated with polyangiitis granulomatosis. Case: A 41-year-old male patient had an 8x5 mm adenoma in the previous pituitary MR imaging. The patient with the diagnosis of proclactinoma and hypogonadotropic hypogonadism applied to our outpatient clinic with complaints of nausea, vomiting and joint pain. On further investigations, acute renal failure and microscopic hematuria and positive C-ANCA were detected and treatment was started immediately. Glucocorticoid and cyclophosphamide treatment was used as the treatment protocol. The patient had previously received hormone replacement therapy due to infertility due to hypogonadotropic hypogonadism caused by pituitary adenoma. Discussion: Polyangiitis granulomatosis is a vasculitis that can have a mortal course, and rapid diagnosis and initiation of treatment significantly reduces the mortality rate. In our case, he was additionally diagnosed with prolactinoma. By carrying these two conditions, it is a rare condition.
The aim of this study was to show the preventative effects of dexpanthenol in radiation injuries caused by radiotherapy (RT) through the use of lung perfusion scintigraphy in the pre-RT and post-RT periods.Six male New Zealand rabbits (5-6 months of age and ∼2.5-3 kg in weight) were the used in this study. The animals were subjected to Tc-macroaggregated albumin lung perfusion scintigraphy in the pre-RT and post-RT (i.e. 2 weeks after treatment) periods. The scintigraphies were performed with the same dose by the same staff and the methodology used the same acquisition parameters. The rabbits were divided into two groups: group I (administered RT only) and group II (also administered intramuscular 500 mg dexpanthenol injections for 14 consecutive days after RT). Quantification was performed to compare the groups and the quantification variables were compared using a paired samples t-test, with P value less than 0.05 considered to be statistically significant. Histopathological analysis was also carried out.The post-RT scintigraphies indicated a decrease in the counts in both lungs, suggesting early post-RT injury. The difference between the counts obtained from both lungs in groups I and II was significantly different and favoured group II. Histopathological results confirmed the scintigraphy results.It is possible to estimate post-RT changes in the early period (in contrast to previous data) by lung perfusion scintigraphy. Dexpanthenol may also reduce the effects of RT to a degree. Although this is the first study to report the preventive effects of dexpanthenol on RT injuries, further studies are warranted in this area.
Objective: Malignant mesothelioma (MM) is a primary malignant tumor developing from mesothelial cells lining the serosal surfaces and particularly the pleura, and has a very poor prognosis.It may display a variety of histological patterns and has a wide spectrum of cytomorphological characteristics, causing problems in its diff erential diagnosis from lung adenocarcinomas and sometimes from benign mesothelial proliferations.Immunohistochemical examination is the most useful method for this distinction.In our study, we aimed to determine the value of glucose transporter isoform-1 (GLUT-1) and K homology domain-containing protein (KOC) markers in the diff erential diagnosis of reactive mesothelial hyperplasia, malignant mesothelioma and lung adenocarcinoma. Material and Method:Our study included 30 samples of malignant mesothelioma, 30 samples of pulmonary adenocarcinoma and 30 samples of reactive mesothelial hyperplasia selected from the archives of the Fırat University Hospital's Pathology Department Laboratory.Th e samples were applied GLUT-1 and KOC markers by immunohistochemistry and the place of these markers in the diff erential diagnosis was examined.Results: GLUT-1 was found positive in 80% of malignant mesothelioma cases, 83.3% of adenocarcinoma cases and 6.6% of reactive mesothelial hyperplasia cases.KOC was positive in 83.3% of malignant mesothelioma cases, 76.6% of adenocarcinoma cases and 46.6% of reactive mesothelial hyperplasia cases.Th ere was no statistically significant diff erence between malignant mesothelioma and lung adenocarcinoma cases in terms of the diff useness and intensity of staining with GLUT-1, whereas a significant diff erence was established when these groups were compared with reactive mesothelial hyperplasia cases.However, the KOC staining diff useness and intensity results were similar to those obtained with GLUT-1. Conclusion:In conclusion, GLUT-1 and KOC markers do not diff erentiate malignant mesotheliomas from pulmonary adenocarcinomas but can be useful in diff erentiating reactive mesothelial hyperplasia from malignant mesothelioma and lung adenocarcinoma.
Suprabasin is a newly discovered protein linked to various human diseases including cancer. It may does have an effect on the development and expression of some non-melanoma skin cancers such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC is the most common non-melanoma skin cancers worldwide, while SCC comes as the second in terms of prevalence. In certain cases, it is very important to distinguish between these two carcinomas from each other and from normal skin samples. This study was aimed at investigating the characteristics of suprabasin expression in squamous cell carcinoma and basal cell carcinoma and whether it can be used as a biomarker.Thirty control, ninety SCC and thirty BCC cases obtained from the archives of the Department of Pathology, Faculty of Medicine, Fırat University, were examined by immunohistochemical staining for suprabasin.Increased suprabasin expression was observed in tumour tissues and normal skin samples in SCC. As the grade increased in SCC, suprabasin expression decreased. No suprabasin expression was observed in the lesion area in BCC.Suprabasin can be reported as a biomarker for SCC and used to differentiate SCC from BCC. Expression of suprabasin in SCC can be used to determine grade. Absence of suprabasin expression in BCC can be used for differential diagnosis.
