This study aimed to explore the value of combined detection of serum thyroglobulin (Tg), interferon - γ (IFN - γ) and thyroglobulin antibody (TgAb) in the diagnosis and prognosis of thyroid adenoma (TA). For this purpose, 100 patients with TA in our hospital from January 2017 to December 2020 were selected as the observation group, and they were divided into good prognosis group (83 cases) and poor prognosis group (17 cases) according to the surgical treatment; another 50 healthy people who received physical examination in our hospital. The levels of serum Tg, IFN - γ and TgAb in each group were detected and compared; the diagnostic and prognostic value of combined detection of serum Tg, IFN - γ and TgAb in thyroid adenoma were analyzed. Results showed that compared with the control group, the levels of Tg and TgAb in the observation group were significantly increased, and the levels of IFN - γ were significantly decreased (P < 0.05); compared with the poor prognosis group, the levels of Tg and TgAb in the good prognosis group were significantly decreased, and the levels of IFN - γ were significantly increased (P < 0.05); The area under curve (AUC) of the combined detection of serum Tg, IFN-γ and TgAb for TA diagnosis and prognosis assessment was significantly higher than the value detected by a single indicator. In general, the combined detection of serum Tg, IFN - γ and TgAb has high diagnostic and prognostic value for TA, and has high clinical reference value.
Purpose: Pneumatosis intestinalis (PI) is increasingly being detected in recent years with the more frequent use of computerized tomography (CT). The present study was performed to evaluate the clinico-radiologic characteristic presentation of PI and to determine the prognostic factors for mortality. Methods: Fifteen patients who were diagnosed with PI on CT between June 2000 and May 2010 were retrospectively reviewed. Age, sex, location of PI, presence of portal vein gas, time to diagnosis, American Society of Anesthesiologists (ASA) classification, Acute Physiology And Chronic Health Evaluation II (APACHE II), acidosis, shock, and other associated findings were analyzed for their association with outcome. Results: Fifteen patients (7 males and 8 females, average age, 60.3 years) were diagnosed with PI. Mortality rate was 47% (7 patients). The mortality rate in patients with septic shock, APACHE II score (18), acidosis (pH＜7.36) were all 100%, 87%, 100%, respectively (P＜0.05). Age, sex, location of PI, portal vein gas, time to diagnosis, ASA classification, associated findings did not show statistical difference. Conclusion: Shock, APACHE II score (18) and acidosis were associated with high mortality in patients with PI. So, more intensive management and interest are recommended in patients with shock, APACHE II score (18),
To investigate the effect of preoperative chemotherapy and radiotherapy for cervical carcinoma in stage Ⅱ. The patients were divided into three groups according to pre-operative adjuvant treatment:thirty-six patients with pre-operative interventional chemotherapy( group 1),24 patients with interventional chemotherapy and radiotherapy(group 2),and 21 patients with radiotherapy (group 3).Short-term effect and pathologic changes were analysed.The short-term response rates with group 1 and group 2 were 97.2% and 100% respectively.Those were significantly higher than that in group 3 (P0 001). The overall rate of positive node (11.7%),of deep muscle invasion (10%),of parametrium invasion (5%),and of vascular space involvement (10%)were significantly lower than those of group 3 respectively (38.1%,42.9%,42.9%,42.9%).[Conclusions]Either preoperative interventional chemotherapy or radiotherapy is effective to cervical carcinoma in stage Ⅱ.
The Korean Breast Cancer Society (KBCS) has reported a nationwide breast cancer data since 1996. We present a comprehensive report on the facts and trends of breast cancer in Korea in 2013. Data on the newly diagnosed patients in the year 2013 were collected from 99 hospitals by using nationwide questionnaire survey. Clinical characteristics such as stage of cancer, histologic types, biological markers, and surgical management were obtained from the online registry database. A total of 19,316 patients were newly diagnosed with breast cancer in 2013. The crude incidence rate of female breast cancer including carcinoma in situ was 76.2 cases per 100,000 women. The median age at diagnosis was 50 years, and the proportions of postmenopausal women with breast cancer accounted for more than half of total patients. The proportion of early breast cancer increased consistently, and the pathologic features have changed accordingly. Breast-conserving surgery was performed in more cases than total mastectomy in the year. The total number of breast reconstruction surgeries markedly increased approaching 3-fold in last 11 years. According to annual percentile change of invasive cancer incidence, the incidence increased rapidly until 2010. And thereafter the increase of it became steadier. For ductal carcinoma in situ, the incidence consistently increased during the same period without any joinpoint. Analysis of nationwide registry data will contribute to defining of the trends and characteristics of breast cancer in Korea.
Here, we report on a case of acute phlegmonous gastritis (PG) complicated by delayed perforation.A 51-year-old woman presented with severe abdominal pain and septic shock symptoms.A computed tomography scan showed diffuse thickening of the gastric wall and distention with peritoneal fluid.Although we did not find definite evidence of free air on the computed tomography (CT) scan, the patient's clinical condition suggested diffuse peritonitis requiring surgical intervention.Exploratory laparotomy revealed a thickened gastric wall with suppurative intraperitoneal fluid in which Streptococcus pyogenes grew.There was no evidence
Objective To evaluate effects of UA on imiquimod- induced psoriasis-like lesions in mice and its possible mechanisms. Methods Forty female BALB / c mice were randomly divided into 4 groups: control,model,low-dose UA and high-dose UA group. Psoriasis-like lesions were induced by daily application of 5% imiquimod to both the back and ears of mice for 6 days. Mice in UA group were intragastrically given UA while being treated with 5% imiquimod. The changes in the back skin lesions were observed and scored,and the thickness of the ears was also measured. On the seventh day,skin biopsies were taken for HE staining and immunohistochemical staining of IL-33,ST2,CD4 and CD8. Results Compared with the control group,increased ear thickness,and erythema and scales on the back of the mice were observed in model group; Pathological changes of back skin lesion included epidermal thickening,elongation of rete ridges,and microabscess along with parakeratosis. However,UA treatment,particularly at high dose,attenuated imiquimod-induced changes in erythema,scales and the epidermal thickness. Moreover,the expression levels of IL-33,ST2,CD4 and CD8 were higher in lesions of model group in comparison with the control group. Furthermore,UA treatments reduced the expression levels of IL-33,ST2,CD4 and CD8 in imiquimod-treated skin. More dramatic reductions in IL-33,ST2,CD4 and CD8 expression were observed after treatments with high-dose UA. Conclusion UA could alleviate imiquimod-induced psoriasis-like lesions possibly through modulating T lymphocytes and IL-33.
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