Aim: The aim of this prospective study is to report the short-term results of the change in taste and food tolerance after SG, RYGB and OAGB using a modified Suter Questionnaire and analyze whether these components can affect patient's weight loss, quality of eating, and state of health. Methods: From May 2017 to December 2017, 81 morbid obese patients were divided into 3 groups: group A (27 patients for SG), group B (26 patients for RYGB), and group C (28 patients for OAGB). Nutritional assessment and dietary counseling occurred 3 months before the surgery (baseline) and at 1 week, followed by 1, 3, 6, and 12 months post-surgery. At 6 and 12 months, the quality of food was assessed by a modified Suter Questionnaire, which included additional questions evaluating changes in taste and food choices. Results: We observed in all the groups an optimal weight loss with no statistical differences at 1 year FU among the groups. Data analysis showed a good food tolerance that improved within the first year after surgery, and there was a progressive enhancement of proper eating habits. We obtained a decrease from 6 to 12 months in the consumption and interest for fatty and sweet foods. Conclusion: There was a significant reduction in negative habits, which was due to taste change, weight loss and improvement in health conditions. Our study demonstrates the importance of the nutritionist during the pre-operative period and during the follow up to ensure good nutritional habits and achieve long-term results.
Summary objective To investigate whether skeletal muscle uncoupling protein‐2 (UCP2) and uncoupling protein‐3 (UCP3) gene expression is altered in massive obesity and whether it correlates with in vivo insulin sensitivity and with metabolic and hormonal status. design Quantification of UCP2 and UCP3 gene expression in skeletal muscle of obese and lean subjects displaying different degrees of insulin sensitivity. patients Fourteen obese and 10 age‐ and sex‐matched healthy control subjects with a mean body mass index (BMI) of 43·6 ± 1·4 and 22·8 ± 1·8 (± SEM), respectively. measurements Insulin sensitivity by glucose clamp, body composition by bio‐impedance, fasting plasma glucose, insulin, leptin and free fatty acids (FFA). Skeletal muscle UCP2 and UCP3 mRNA levels by quantitative reverse transcription polymerase chain reaction (RT–PCR). results No significant differences in UCP2 or UCP3 mRNA levels were found between obese and control subjects. No significant correlation was observed, in both groups, between UCP2 or UCP3 mRNA levels and both anthropometrical and metabolic parameters . In contrast, a highly significant correlation was observed between skeletal muscle UCP3, but not UCP2, mRNA levels and plasma FFA in the obese, but not in the lean, group. Furthermore, exposure of human myocytes to FFA for 24 h strongly induced both UCP3 and peroxisome proliferator‐activated receptor‐γ (PPARγ) but not UCP2 gene expression. conclusions FFA levels correlate strongly with skeletal muscle UCP3 mRNA levels in obese, but not in lean, subjects; in addition, in human myocytes, high FFA concentrations promote UCP3 expression. Our studies therefore provide evidence that supports a role for increased plasma FFA concentrations in the regulation of human skeletal muscle UCP3 gene expression.
Background & Aims. Multiparametric Magnetic Resonance Imaging has increased our ability to diagnoseprostate cancer but questions remain about its proper use. Herein we evaluated potential differences betweenthe clinically and multiparametric Magnetic Resonance Imaging-indicated and the non-clinically but multiparametricMagnetic Resonance Imaging-indicated fusion prostate biopsy.Methods. Outcomes of 99 fusion prostate biopsies (Group A) were compared with those of a matched populationhaving undergone standard prostate biopsy (Group B).Results. The overall cancer detection rate was 60.6% in Group A and 29.2% in Group B (p 75y.Conclusions. Fusion prostate biopsy provided better cancer detection rate than standard prostate biopsyproviding proper clinical indications. The misuse of multiparametric Magnetic Resonance Imaging in patientswith no clinical indication for prostate biopsy led, particularly in the elderly, to an extremely high number ofunnecessary biopsies with their inherent problems.
The aim of this study was to analyze short-term outcomes focusing on readmissions after laparoscopic bariatric metabolic surgery (BMS) in an Italian academic Bariatric Center of Excellence IFSO-European Chapter (EC).
Hiatal surface area (HSA) measurement has been recently proposed as useful tool for tailored treatment of hiatal defects. Multidetector CT scan (MDCT) of the hiatal area was shown to be useful in hiatal hernia (HH) management.MDCT preoperative HSA measurements validation as a useful method in the surgical repair decision making process of hiatal defects in candidates to antireflux ± bariatric surgery.Twenty-five obese patients (group A), candidates to laparoscopic cruroplasty ± bariatric surgery, were prospectively evaluated preoperatively and after one year, using an original MDCT algorithm, compared with intraoperative HSA measurement. Twelve non-obese (group B) and 12 obese patients (group C), without GERD or HH, were used as control groups.Median preoperative HSA was 7.9 cm2, (interquartile IQR 5.97-9.80) while intraoperative median HSA was 6 cm2 (6-9.5), p = .84. Postoperative median HSA was 3.8 cm2 (3.21-4.8), showing the efficacy of cruroplasty, comparable with HSA calculated in the control groups (3.98 for B and 3.69 cm2 for C, p = .8547). No statistically significant difference between MDCT preoperative measurement and intraoperative findings was observed.Preliminary results demonstrate MDCT scan HSA measurements as a valid, non-invasive method to predict intraoperative findings. It allows the HSA monitoring in order to correlate the symptoms onset and failure of cruroplasty.
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